Two cases of severe pulmonary toxicity from highly active mesothelin-directed CAR T cells

Authors: Haas, Andrew R., Golden, Ryan J., Litzky, Leslie A., Engels, Boris, Zhao, Linlin, Xu, Fangmin, Taraszka, John A., Ramones, Melissa, Granda, Brian, Chang, Wan-Jung, Jadlowsky, Julie, Shea, Kim-Marie, Runkle, Adam, Chew, Anne, Dowd, Emily, Gonzalez, Vanessa, Chen, Fang, Liu, Xiaojun, Fang, Chongyun, Jiang, Shuguang, Davis, Megan M., Sheppard, Neil C., Zhao, Yangbing, Fraietta, Joseph A., Lacey, Simon F., Plesa, Gabriela, Melenhorst, J. Joseph, Mansfield, Keith, Brogdon, Jennifer L., Young, Regina M., Albelda, Steven M., June, Carl H., Tanyi, Janos L.

Source: Molecular therapy. 31(8):2309-2325

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194917364.0x000001&indx=1&recIds=ETOCvdc_100194917364.0x000001

Clearance of plasma PCSK9 via the asialoglycoprotein receptor mediated by heterobifunctional ligands

Authors: Bagdanoff, Jeffrey T., Smith, Thomas M., Allan, Martin, O’Donnell, Peter, Nguyen, Zachary, Moore, Elizabeth A., Baird, Jason, Wang, Shuangxi, Subramanian, Vanitha, Tigani, Bruno, Nettleton, David O., Monovich, Lauren G., Lewis, Ian, Flyer, Alec N., Granda, Brian, Blankenship, John W., Barnes-Seeman, David, Clairmont, Kevin B.

Source: In Cell Chemical Biology 19 January 2023 30(1):97-109

Preclinical discovery and initial clinical data of WVT078, a BCMA × CD3 bispecific antibody

Authors: Raab, Marc S., Cohen, Yael C., Schjesvold, Fredrik, Aardalen, Kimberly, Oka, Adwait, Spencer, Andrew, Wermke, Martin, Souza, Anita D., Kaufman, Jonathan L., Cafro, Anna Maria, Ocio, Enrique M., Doki, Noriko, Henson, Kristin, Trabucco, Gina, Carrion, Ana, Bender, Florent C., Juif, Pierre-Eric, Fessehatsion, Adonai, Fan, Liqiong, Stonehouse, Jeffrey P., Blankenship, John W., Granda, Brian, De Vita, Serena, Lu, Haihui

Source: Leukemia; June 2023, Vol. 37 Issue: 6 p1349-1360, 12p

ANTIBODY QUANTITATION

Biophysical Investigation of the Mode of Inhibition of Tetramic Acids, the Allosteric Inhibitors of Undecaprenyl Pyrophosphate Synthase.

Authors: Lee, Lac V., Granda, Brian, Dean, Karl

Source: Biochemistry; June 29 2010, Vol. 49 Issue 25, p5366-5376, 11p

PIT565, a First-in-Class Anti-CD19, Anti-CD3, Anti-CD2 Trispecific Antibody for the Treatment of B Cell Malignancies

Authors: Lu, Haihui, Oka, Adwait ^*, Coulson, Michelle ^*, Polli, Joseph Ryan ^*, Aardalen, Kimberly ^*, Ramones, Melissa ^*, Walker, Dana B ^*, Carrion, Ana ^*, Alexander, Dylan ^*, Klopfenstein, Matthieu ^*, Akiyama, Masaki ^*, Rucci, Francesca ^*, Granda, Brian ^*, Pastore, Alessandro

Source: In Blood 15 November 2022 140 Supplement 1:3148-3148

Identification and Development of PHE885: A Novel and Highly Potent Fully Human Anti-BCMA CAR-T Manufactured with a Novel T-Charge TM Platform for the Treatment of Multiple Myeloma

Authors: Bu, Dexiu, Bennett, Paul, Barton, Nathaniel, Bradshaw, Laura, Pinon-Ortiz, Maria, Li, Xiangen, Vaidya, Poonam, Zhu, Xu, Mansfield, Keith, Granda, Brian, Guimaraes, Carla P, Treanor, Louise M, Brogdon, Jennifer L

Source: In Blood 23 November 2021 138 Supplement 1:2770-2770

In vitro metabolism of trazodone by CYP3A: inhibition by ketoconazole and human immunodeficiency viral protease inhibitors

Authors: Zalma, Alysa, von Moltke, Lisa L., Granda, Brian W., Harmatz, Jerold S., Shader, Richard I., Greenblatt, David J. ^*

Source: In Biological Psychiatry 2000 47(7):655-661

Citalopram and desmethylcitalopram in vitro: human cytochromes mediating transformation, and cytochrome inhibitory effects

Authors: von Moltke, Lisa L. ^*, Greenblatt, David J., Grassi, Jeffrey M., Granda, Brian W., Venkatakrishnan, Karthik, Duan, Su Xiang, Fogelman, Steven M., Harmatz, Jerold S., Shader, Richard I.

Source: In Biological Psychiatry 1999 46(6):839-849

Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells

Authors: Singh, Nathan, Frey, Noelle V., Engels, Boris, Barrett, David M., Shestova, Olga, Ravikumar, Pranali, Cummins, Katherine D., Lee, Yong Gu, Pajarillo, Raymone, Chun, Inkook, Shyu, Amy, Highfill, Steven L., Price, Andrew, Zhao, Linlin, Peng, Liaomin, Granda, Brian, Ramones, Melissa, Lu, Xueqing Maggie, Christian, David A., Perazzelli, Jessica, Lacey, Simon F., Roy, Nathan H., Burkhardt, Janis K., Colomb, Florent, Damra, Mohammad, Abdel-Mohsen, Mohamed, Liu, Ting, Liu, Dongfang, Standley, Daron M., Young, Regina M., Brogdon, Jennifer L., Grupp, Stephan A., June, Carl H., Maude, Shannon L., Gill, Saar, Ruella, Marco

Source: Nature Medicine; 20210101, Issue: Preprints p1-9, 9p

Discovery of Potent and Selective Antibody–Drug Conjugates with Eg5 Inhibitors through Linker and Payload Optimization.

Authors: Karpov, Alexei S., Nieto-Oberhuber, Cristina M., Abrams, Tinya, Beng-Louka, Edwige, Blanco, Enrique, Chamoin, Sylvie, Chene, Patrick, Dacquignies, Isabelle, Daniel, Dylan, Dillon, Michael P., Doumampouom-Metoul, Lionel, Drosos, Nikolaos, Fedoseev, Pavel, Furegati, Markus, Granda, Brian, Grotzfeld, Robert M., Hess Clark, Suzanna, Joly, Emilie, Jones, Darryl, Lacaud-Baumlin, Marion

Source: ACS Medicinal Chemistry Letters; 2019, Vol. 10 Issue 12, p1674-1679, 6p

Single Chain Variable Fragment Linker Length Regulates CAR Biology and T Cell Efficacy

Authors: Singh, Nathan, Frey, Noelle V., Engels, Boris ^*, Barrett, David M. ^*, Shestova, Olga ^*, Ravikumar, Pranali ^*, Shyu, Amy ^*, Highfill, Steven ^*, Zhao, Linlin ^*, Peng, Liaomin ^*, Granda, Brian ^*, Ramones, Melissa ^*, Lu, Xeuqing Maggie ^*, Christian, David A ^*, Perazzelli, Jessica ^*, Lacey, Simon F, Roy, Nathan ^*, Burkhardt, Janis K ^*, Colomb, Florent ^*, Abdel-Mohsen, Mohamed ^*, Young, Regina M ^*, Brogdon, Jennifer ^*, Grupp, Stephan, June, Carl H, Maude, Shannon L., Gill, Saar I., Ruella, Marco

Source: In Blood 13 November 2019 134 Supplement 1:247-247

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Methylation of p53 by Set7/9 Mediates p53 Acetylation and Activity In Vivo

Authors: Kurash, Julia K., Lei, Hong, Shen, Qiong, Marston, Wendy L., Granda, Brian W., Fan, Hong, Wall, Daniel, Li, En, Gaudet, François

Source: In Molecular Cell 2008 29(3):392-400

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Sialylation Levels Influence Oligosaccharide Quantitation.

Authors: Ganesa, Chandrashekar, Granda, Brian W., Mattaliano, Robert J.

Source: BioPharm International. Jun2003, Vol. 16 Issue 6, p44. 6p. 1 Color Photograph, 8 Graphs.

Subject Terms: Ion exchange chromatography, Oligosaccharides

Relative contributions of CYP2C9 and 2C19 to phenytoin 4-hydroxylation in vitro: inhibition by sulfaphenazole, omeprazole, and ticlopidine.

Authors: Giancarlo, Gina M., Venkatakrishnan, Karthik, Granda, Brian W., von Moltke, Lisa L., Greenblatt, David J.

Source: European Journal of Clinical Pharmacology; Apr2001, Vol. 57 Issue 1, p31-36, 6p

Subject Terms: CYTOCHROMES, HEMOPROTEINS, PHENYTOIN, HYDROXYLATION, ANTICONVULSANTS, MICROSOMES, LIVER

Inhibition of Human Cytochrome P450 Isoforms by Nonnucleoside Reverse Transcriptase Inhibitors.

Authors: von Moltke, Lisa L., Greenblatt, David J., Granda, Brian W., Giancarlo, Gina M., Duan, Su Xiang, Daily, Johanna P., Harmatz, Jerold S., Shader, Richard I.

Source: Journal of Clinical Pharmacology; Jan2001, Vol. 41 Issue 1, p85-91, 7p

Nefazodone, meta-chlorophenylpiperazine, and their metabolites in vitro: cytochromes mediating transformation, and P450-3A4 inhibitory actions.

Authors: von Moltke, Lisa L., Greenblatt, David J., Granda, Brian W., Grassi, Jeffrey M., Schmider, Jürgen, Harmatz, Jerold S., Shader, Richard I., von Moltke, L. L.

Source: Psychopharmacology; 1999, Vol. 145 Issue 1, p113, 10p

Subject Terms: BIOTRANSFORMATION (Metabolism), ANTIDEPRESSANTS, PSYCHOPHARMACOLOGY, CYTOCHROMES, ANALYTICAL chemistry, PHYSIOLOGY

Inhibition of human cytochrome P450 isoforms in vitro by zafirlukast.

Authors: Shader, Richard I., Granda, Brian W., von Moltke, Lisa L., Giancarlo, Gina M., Greenblatt, David J.

Source: Biopharmaceutics & Drug Disposition; 1999, Vol. 20 Issue 8, p385-388, 4p