Flipping the script: Advances in understanding how and why P4-ATPases flip lipid across membranes

Authors: Norris, Adriana C., Mansueto, Alexander J., Jimenez, Mariana, Yazlovitskaya, Eugenia M., Jain, Bhawik K., Graham, Todd R.

Source: In BBA - Molecular Cell Research April 2024 1871(4)

Quantification of Golgi Protein Mislocalization to the Budding Yeast Vacuole

Authors: Jimenez, Mariana, Best, Jordan T., Date, Swapneeta S., Graham, Todd R.

Source: Methods in molecular biology. 2557:17-28

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN630893768&indx=1&recIds=ETOCRN630893768

Type IV P-Type ATPases: Recent Updates in Cancer Development, Progression, and Treatment.

Authors: Yazlovitskaya, Eugenia M.¹ (AUTHOR) eugenia.yazlovitskaya@vanderbilt.edu, Graham, Todd R.¹ (AUTHOR) eugenia.yazlovitskaya@vanderbilt.edu

Source: Cancers. Sep2023, Vol. 15 Issue 17, p4327. 13p.

Subject Terms: *THERAPEUTIC use of antineoplastic agents, *DISEASE progression, *ADENOSINE triphosphatase, *HEALTH, *INFORMATION resources, *TUMORS, *TUMOR markers, *CELL lines, *MEMBRANE proteins, *PHOSPHOLIPIDS, *ENZYME inhibitors, *CARRIER proteins, *CHEMICAL inhibitors

Exofacial membrane composition and lipid metabolism regulates plasma membrane P4-ATPase substrate specificity

Authors: Jain, Bhawik Kumar, Roland, Bartholomew P., Graham, Todd R. ^*

Source: In Journal of Biological Chemistry 25 December 2020 295(52):17997-18009

Mammalian Retromer Is an Adaptable Scaffold for Cargo Sorting from Endosomes

Authors: Kendall, Amy K., Xie, Boyang, Xu, Peng, Wang, Jue, Burcham, Rodger, Frazier, Meredith N., Binshtein, Elad, Wei, Hui, Graham, Todd R., Nakagawa, Terunaga, Jackson, Lauren P.

Source: In Structure 7 April 2020 28(4):393-405

The P4‐ATPase Drs2 interacts with and stabilizes the multisubunit tethering complex TRAPPIII in yeast

Authors: Pazos, Irene, Puig‐Tintó, Marta, Betancur, Laura, Cordero, Jorge, Jiménez‐Menéndez, Nereida, Abella, Marc, Hernández, Altair C, Duran, Ana G, Adachi‐Fernández, Emi, Belmonte‐Mateos, Carla, Sabido‐Bozo, Susana, Tosi, Sébastien, Nezu, Akiko, Oliva, Baldomero, Colombelli, Julien, Graham, Todd R, Yoshimori, Tamotsu, Muñiz, Manuel, Hamasaki, Maho, Gallego, Oriol

Source: EMBO reports. 24(5)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186356080.0x000001&indx=1&recIds=ETOCvdc_100186356080.0x000001

Conserved mechanism of phospholipid substrate recognition by the P4-ATPase Neo1 from Saccharomyces cerevisiae

Authors: Huang, Yannan, Takar, Mehmet, Best, Jordan T., Graham, Todd R.

Source: In BBA - Molecular and Cell Biology of Lipids February 2020 1865(2)

Phospholipid flippases in membrane remodeling and transport carrier biogenesis

Authors: Best, Jordan T, Xu, Peng, Graham, Todd R

Source: In Current Opinion in Cell Biology August 2019 59:8-15

The PQ-loop protein Any1 segregates Drs2 and Neo1 functions required for viability and plasma membrane phospholipid asymmetry

Authors: Takar, Mehmet, Huang, Yannan, Graham, Todd R.

Source: In Journal of Lipid Research May 2019 60(5):1032-1042

Yeast and human P4-ATPases transport glycosphingolipids using conserved structural motifs

Authors: Roland, Bartholomew P., Naito, Tomoki, Best, Jordan T., Arnaiz-Yépez, Cayetana, Takatsu, Hiroyuki, Yu, Roger J., Shin, Hye-Won, Graham, Todd R.

Source: In Journal of Biological Chemistry February 2019 294(6):1794-1806

The danger of flipping an outside lipid to the inside.

Authors: Graham, Todd R.^1,2 tr.graham@vanderbilt.edu

Source: Proceedings of the National Academy of Sciences of the United States of America. 12/24/2024, Vol. 121 Issue 52, p1-3. 3p.

Subject Terms: *LIFE sciences, *PROTEIN-lipid interactions, *MEMBRANE lipids, *DEVELOPMENTAL biology, *SMALL molecules

ATP10A has a protective and sex‐specific role in lipid metabolism

Authors: Norris, Adriana C., Yazlovitskaya, Eugenia, Zhu, Lin, Rose, Bailey, Yu, Sophia, McLean, John A., Stafford, John, Graham, Todd R.

Source: FASEB journal. 36

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100195213100.0x000001&indx=1&recIds=ETOCvdc_100195213100.0x000001

Drs2p-Coupled Aminophospholipid Translocase Activity in Yeast Golgi Membranes and Relationship to in vivo Function

Authors: Natarajan, Paramasivam, Wang, Jiyi, Hua, Zhaolin, Graham, Todd R., Schekman, Randy

Source: Proceedings of the National Academy of Sciences of the United States of America, 2004 Jul . 101(29), 10614-10619.

Access URL: https://www.jstor.org/stable/3372707

Role for Drs2p, a P-Type ATPase and Potential Aminophospholipid Translocase, in Yeast Late Golgi Function

Authors: Chen, Chih-Ying, Ingram, Michael F., Rosal, Peter H., Graham, Todd R.

Source: The Journal of Cell Biology, 1999 Dec . 147(6), 1223-1236.

Access URL: https://www.jstor.org/stable/1619577

The High Osmolarity Glycerol Response (HOG) MAP Kinase Pathway Controls Localization of a Yeast Golgi Glycosyltransferase

Authors: Reynolds, Todd B., Hopkins, B. Diane, Lyons, Matthew R., Graham, Todd R.

Source: The Journal of Cell Biology, 1998 Nov . 143(4), 935-946.

Access URL: https://www.jstor.org/stable/1619021

The Essential Neo1 Protein from Budding Yeast Plays a Role in Establishing Aminophospholipid Asymmetry of the Plasma Membrane

Authors: Takar, Mehmet, Wu, Yuantai, Graham, Todd R.

Source: In Journal of Biological Chemistry 22 July 2016 291(30):15727-15739

Exploring genetic suppression interactions on a global scale

Authors: van Leeuwen, Jolanda, Pons, Carles, Mellor, Joseph C., Yamaguchi, Takafumi N., Friesen, Helena, Koschwanez, John, Ušaj, Mojca Mattiazzi, Pechlaner, Maria, Takar, Mehmet, Ušaj, Matej, VanderSluis, Benjamin, Andrusiak, Kerry, Bansal, Pritpal, Baryshnikova, Anastasia, Boone, Claire E., Cao, Jessica, Cote, Atina, Gebbia, Marinella, Horecka, Gene, Horecka, Ira, Kuzmin, Elena, Legro, Nicole, Liang, Wendy, van Lieshout, Natascha, McNee, Margaret, San Luis, Bryan-Joseph, Shaeri, Fatemeh, Shuteriqi, Ermira, Sun, Song, Yang, Lu, Youn, Ji-Young, Yuen, Michael, Costanzo, Michael, Gingras, Anne-Claude, Aloy, Patrick, Oostenbrink, Chris, Murray, Andrew, Graham, Todd R., Myers, Chad L., Andrews, Brenda J., Roth, Frederick P., Boone, Charles

Source: Science, 2016 Nov 01. 354(6312), 599-599.

Access URL: https://www.jstor.org/stable/44710937

Directed evolution of a sphingomyelin flippase reveals mechanism of substrate backbone discrimination by a P4-ATPase

Authors: Roland, Bartholomew P., Graham, Todd R.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2016 Aug 01. 113(31), E4460-E4466.

Access URL: https://www.jstor.org/stable/26471063

Structural insight into an Arl1–ArfGEF complex involved in Golgi recruitment of a GRIP-domain golgin.

Authors: Duan, H. Diessel, Jain, Bhawik K., Li, Hua, Graham, Todd R., Li, Huilin

Source: Nature Communications; 3/2/2024, Vol. 15 Issue 1, p1-13, 13p

Subject Terms: GUANINE nucleotide exchange factors, GOLGI apparatus, G proteins, HYDROPHOBIC interactions, ELECTROSTATIC interaction

ATP10A deficiency results in male-specific infertility in mice.

Authors: Norris, Adriana C., Yazlovitskaya, Eugenia M., Yang, Tzushan Sharon, Mansueto, Alex, Stafford, John M., Graham, Todd R.

Source: Frontiers in Cell & Developmental Biology; 2024, p1-16, 16p

Subject Terms: MALE reproductive organs, INFERTILITY, MALE infertility, HYPOTHALAMIC-pituitary-gonadal axis, VAS deferens, MENSTRUAL cycle