Cell Models of Castration Resistant and High Dose Testosterone-Resistant Prostate Cancer Recapitulate the Heterogeneity of Response Observed in Clinical Practice.

Authors: Graham, Laura S.¹ (AUTHOR) laura.graham@cuanschutz.edu, Su, Lih-Jen¹ (AUTHOR) joseph.petraccione@cuanschutz.edu, Nicklawsky, Andrew² (AUTHOR) andrew.nicklawsky@cuanschutz.edu, Feng, Frances Xiuyan³ (AUTHOR) frances.feng@cuanschutz.edu, Orlicky, David³ (AUTHOR) david.orlicky@cuanschutz.edu, Petraccione, Joseph¹ (AUTHOR) maren.salzmann-sullivan@cuanschutz.edu, Salzmann-Sullivan, Maren¹ (AUTHOR) thomas.flaig@cuanschutz.edu, Nordeen, Steven K.³ (AUTHOR) steve.nordeen@cuanschutz.edu, Flaig, Thomas W.¹ (AUTHOR)

Source: Cancers. Feb2025, Vol. 17 Issue 4, p593. 12p.

Subject Terms: *PROSTATE tumors treatment, *CASTRATION-resistant prostate cancer, *TESTOSTERONE, *ANTIANDROGENS, *BIOLOGICAL models, *IN vitro studies, *DRUG resistance in cancer cells, *RESEARCH funding, *CLINICAL trials, *IN vivo studies, *MICE, *CELL lines, *HORMONE therapy, *DRUG efficacy, *ANIMAL experimentation, *EVALUATION

Activity of Platinum Chemotherapy in Men With Prostate Cancer With and Without DNA Damage Repair Mutations

Authors: Lakritz, Stephanie ^{1, ⁎}, Nicklawsky, Andrew ¹, Alami, Vida ¹, Kohli, Manish ², Moskaluk, Chris ³, Riedlinger, Greg ⁴, Salhia, Bodour ⁵, Singer, Eric A. ⁶, Naqash, Abdul Rafeh ⁷, Nepple, Ken ⁸, Edge, Stephen ⁹, Myint, Zin ¹⁰, Kolesar, Jill ¹⁰, Adra, Nabil ¹¹, Flaig, Thomas ¹, Graham, Laura S. ¹

Source: In Clinical Genitourinary Cancer February 2025 23(1)

Transcriptome- and proteome-wide association studies identify genes associated with renal cell carcinoma

Authors: Purdue, Mark P., Dutta, Diptavo, Machiela, Mitchell J., Gorman, Bryan R., Winter, Timothy, Okuhara, Dayne, Cleland, Sara, Ferreiro-Iglesias, Aida, Scheet, Paul, Liu, Aoxing, Wu, Chao, Antwi, Samuel O., Larkin, James, Zequi, Stênio C., Sun, Maxine, Hikino, Keiko, Hajiran, Ali, Lawson, Keith A., Cárcano, Flavio, Blanchet, Odile, Shuch, Brian, Nepple, Kenneth G., Margue, Gaëlle, Sundi, Debasish, Diver, W. Ryan, Folgueira, Maria A.A.K., van Bokhoven, Adrie, Neffa, Florencia, Brown, Kevin M., Hofmann, Jonathan N., Rhee, Jongeun, Yeager, Meredith, Cole, Nathan R., Hicks, Belynda D., Manning, Michelle R., Hutchinson, Amy A., Rothman, Nathaniel, Huang, Wen-Yi, Linehan, W. Marston, Lori, Adriana, Ferragu, Matthieu, Zidane-Marinnes, Merzouka, Serrano, Sérgio, Magnabosco, Wesley J., BioBank Japan Project Consortium, Vilas, Ana, Decia, Ricardo, Carusso, Florencia, Graham, Laura S., Anderson, Kyra, Bilen, Mehmet A., Arciero, Cletus, Pellegrin, Isabelle, Ricard, Solène, FinnGen, Scelo, Ghislaine, Banks, Rosamonde E., Vasudev, Naveen S., Soomro, Naeem, Stewart, Grant D., Adeyoju, Adebanji, Bromage, Stephen, Hrouda, David, Gibbons, Norma, Patel, Poulam, Sullivan, Mark, Protheroe, Andrew, Nugent, Francesca I., Fournier, Michelle J., Zhang, Xiaoyu, Martin, Lisa J., Komisarenko, Maria, Eisen, Timothy, Cunningham, Sonia A., Connolly, Denise C., Uzzo, Robert G., Zaridze, David, Mukeria, Anush, Holcatova, Ivana, Hornakova, Anna, Foretova, Lenka, Janout, Vladimir, Mates, Dana, Jinga, Viorel, Rascu, Stefan, Mijuskovic, Mirjana, Savic, Slavisa, Milosavljevic, Sasa, Gaborieau, Valérie, Abedi-Ardekani, Behnoush, McKay, James, Johansson, Mattias, Phouthavongsy, Larry, Hayman, Lindsay, Li, Jason, Lungu, Ilinca, Bezerra, Stephania M., de Souza, Aline G., Sares, Claudia T.G., Reis, Rodolfo B., Gallucci, Fabio P., Cordeiro, Mauricio D., Pomerantz, Mark, Lee, Gwo-Shu M., Freedman, Matthew L., Jeong, Anhyo, Greenberg, Samantha E., Sanchez, Alejandro, Thompson, R. Houston, Sharma, Vidit, Thiel, David D., Ball, Colleen T., Abreu, Diego, Lam, Elaine T., Nahas, William C., Master, Viraj A., Patel, Alpa V., Bernhard, Jean-Christophe, Freedman, Neal D., Bigot, Pierre, Reis, Rui M., Colli, Leandro M., Finelli, Antonio, Manley, Brandon J., Terao, Chikashi, Choueiri, Toni K., Carraro, Dirce M., Houlston, Richard, Eckel-Passow, Jeanette E., Abbosh, Philip H., Ganna, Andrea, Brennan, Paul, Gu, Jian, Chanock, Stephen J., Guo, Xinyu, Winter, Timothy D., Jahagirdar, Om, Ha, Eunji, Susztak, Katalin

Source: In The American Journal of Human Genetics 5 September 2024 111(9):1864-1876

Clinical and Genomic Features of Androgen Indifferent Prostate Cancer.

Authors: Masur, Jack, Ratan, Aakrosh, Wierbilowicz, Krzysztof, Ayanambakkam, Adanma, Churchman, Michelle L., Graham, Laura S., Grass, George Daniel, Gupta, Sumati, Kern, Sean Q., King, Jennifer, Myint, Zin, Rounbehler, Robert J., Salhia, Bodour, Singer, Eric A., Zakharia, Yousef, Paschal, Bryce M., Viscuse, Paul V.

Source: International Journal of Molecular Sciences; Jan2025, Vol. 26 Issue 2, p679, 13p

Subject Terms: HOMOLOGOUS recombination, MOLECULAR biology, TUMOR markers, PROSTATE cancer, OXIDATIVE phosphorylation

DNA-Damaging Therapies in Patients With Prostate Cancer and Pathogenic Alterations in Homologous Recombination Repair Genes.

Authors: Graham, Laura S.¹ (AUTHOR), Henderson, Nicholas C.² (AUTHOR), Kellezi, Olesia² (AUTHOR), Hwang, Clara³ (AUTHOR), Barata, Pedro C.⁴ (AUTHOR), Bilen, Mehmet A.⁵ (AUTHOR), Kilari, Deepak⁶ (AUTHOR), Pierro, Michael⁶ (AUTHOR), Thapa, Bicky⁶ (AUTHOR), Tripathi, Abhishek⁷ (AUTHOR), Mo, George⁸ (AUTHOR), Labriola, Matthew⁹ (AUTHOR), Park, Joseph J.⁹ (AUTHOR), Rothstein, Shoshana¹⁰ (AUTHOR), Garje, Rohan¹¹ (AUTHOR), Koshkin, Vadim S.¹² (AUTHOR), Patel, Vaibhav G.¹³ (AUTHOR), Dorff, Tanya¹⁴ (AUTHOR), Armstrong, Andrew J.⁹ (AUTHOR), McKay, Rana R.¹⁵ (AUTHOR)

Source: JCO Precision Oncology. 12/1/2024, Vol. 8, p1-11. 11p.

Subject Terms: *HOMOLOGOUS recombination, *PROSTATE cancer patients, *CYCLIN-dependent kinases, *CHECKPOINT kinase 1, *OVERALL survival

Repeat Next-Generation Sequencing Testing on Progression in Men With Metastatic Prostate Cancer Can Identify New Actionable Alterations.

Authors: Park, Joseph J., Chu, Alec, Li, Jinju, Ali, Alicia, McKay, Rana R., Hwang, Clara, Labriola, Matthew K., Jang, Albert, Kilari, Deepak, Mo, George, Ravindranathan, Deepak, Graham, Laura S., Sokolova, Alexandra, Tripathi, Abhishek, Pilling, Amanda, Jindal, Tanya, Ravindra, Aditya, Cackowski, Frank C., Sweeney, Patrick L., Thapa, Bicky

Source: JCO Precision Oncology; 12/1/2024, Vol. 8, p1-21, 21p

Subject Terms: PROSTATE cancer patients, CIRCULATING tumor DNA, CASTRATION-resistant prostate cancer, HOMOLOGOUS recombination, PROSTATE cancer, NUCLEOTIDE sequencing, INDIVIDUALIZED medicine

Multimodality Treatment of Bilateral Wilms Tumor in a Pregnant Female

Authors: Graham, Laura S., Schade, George R., Schweizer, Michael T.

Source: In Urology February 2020 136:e42-e44

Gender Differences in Faculty Rank and Subspecialty Choice among Academic Medical Oncologists.

Authors: Graham, Laura S.^1,2 (AUTHOR), Sokolova, Alexandra O.^1,2 (AUTHOR), Khaki, Ali Raza^1,2 (AUTHOR), Wu, Qian "Vicky"^2,3 (AUTHOR), Davidson, Nancy E.^1,2 (AUTHOR)

Source: Cancer Investigation. Jan2021, Vol. 39 Issue 1, p21-24. 4p.

Subject Terms: *ONCOLOGISTS, *SEX distribution, *VOCATIONAL guidance, *CERTIFICATION, *TEACHER development, *CROSS-sectional method, *COLLEGE teacher attitudes, *DESCRIPTIVE statistics, *ODDS ratio

Mismatch repair deficiency in metastatic prostate cancer: Response to PD-1 blockade and standard therapies.

Authors: Graham, Laura S.^1,2 (AUTHOR), Montgomery, Bruce^1,3 (AUTHOR), Cheng, Heather H.^1,2 (AUTHOR), Yu, Evan Y.^1,2 (AUTHOR), Nelson, Peter S.^1,2,4 (AUTHOR), Pritchard, Colin⁵ (AUTHOR), Erickson, Stephanie⁶ (AUTHOR), Alva, Ajjai⁶ (AUTHOR), Schweizer, Michael T.^1,2 (AUTHOR) schweize@uw.edu

Source: PLoS ONE. 5/26/2020, Vol. 15 Issue 5, p1-11. 11p.

Subject Terms: *CASTRATION-resistant prostate cancer, *METASTASIS, *PROSTATE cancer, *PROGRESSION-free survival, *ANDROGEN drugs, *GLEASON grading system

Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions

Authors: Purdue, Mark P., Dutta, Diptavo, Machiela, Mitchell J., Gorman, Bryan R., Winter, Timothy, Okuhara, Dayne, Cleland, Sara, Ferreiro-Iglesias, Aida, Scheet, Paul, Liu, Aoxing, Wu, Chao, Antwi, Samuel O., Larkin, James, Zequi, Stênio C., Sun, Maxine, Hikino, Keiko, Hajiran, Ali, Lawson, Keith A., Cárcano, Flavio, Blanchet, Odile, Shuch, Brian, Nepple, Kenneth G., Margue, Gaëlle, Sundi, Debasish, Diver, W. Ryan, Folgueira, Maria A. A. K., van Bokhoven, Adrie, Neffa, Florencia, Brown, Kevin M., Hofmann, Jonathan N., Rhee, Jongeun, Yeager, Meredith, Cole, Nathan R., Hicks, Belynda D., Manning, Michelle R., Hutchinson, Amy A., Rothman, Nathaniel, Huang, Wen-Yi, Linehan, W. Marston, Lori, Adriana, Ferragu, Matthieu, Zidane-Marinnes, Merzouka, Serrano, Sérgio V., Magnabosco, Wesley J., Vilas, Ana, Decia, Ricardo, Carusso, Florencia, Graham, Laura S., Anderson, Kyra, Bilen, Mehmet A., Arciero, Cletus, Pellegrin, Isabelle, Ricard, Solène, Scelo, Ghislaine, Banks, Rosamonde E., Vasudev, Naveen S., Soomro, Naeem, Stewart, Grant D., Adeyoju, Adebanji, Bromage, Stephen, Hrouda, David, Gibbons, Norma, Patel, Poulam, Sullivan, Mark, Protheroe, Andrew, Nugent, Francesca I., Fournier, Michelle J., Zhang, Xiaoyu, Martin, Lisa J., Komisarenko, Maria, Eisen, Timothy, Cunningham, Sonia A., Connolly, Denise C., Uzzo, Robert G., Zaridze, David, Mukeria, Anush, Holcatova, Ivana, Hornakova, Anna, Foretova, Lenka, Janout, Vladimir, Mates, Dana, Jinga, Viorel, Rascu, Stefan, Mijuskovic, Mirjana, Savic, Slavisa, Milosavljevic, Sasa, Gaborieau, Valérie, Abedi-Ardekani, Behnoush, McKay, James, Johansson, Mattias, Phouthavongsy, Larry, Hayman, Lindsay, Li, Jason, Lungu, Ilinca, Bezerra, Stephania M., Souza, Aline G., Sares, Claudia T. G., Reis, Rodolfo B., Gallucci, Fabio P., Cordeiro, Mauricio D., Pomerantz, Mark, Lee, Gwo-Shu M., Freedman, Matthew L., Jeong, Anhyo, Greenberg, Samantha E., Sanchez, Alejandro, Thompson, R. Houston, Sharma, Vidit, Thiel, David D., Ball, Colleen T., Abreu, Diego, Lam, Elaine T., Nahas, William C., Master, Viraj A., Patel, Alpa V., Bernhard, Jean-Christophe, Freedman, Neal D., Bigot, Pierre, Reis, Rui M., Colli, Leandro M., Finelli, Antonio, Manley, Brandon J., Terao, Chikashi, Choueiri, Toni K., Carraro, Dirce M., Houlston, Richard, Eckel-Passow, Jeanette E., Abbosh, Philip H., Ganna, Andrea, Brennan, Paul, Gu, Jian, Chanock, Stephen J.

Source: Nature Genetics; 20240101, Issue: Preprints p1-10, 10p

Clinical, pathologic, and molecular features of amphicrine prostate cancer.

Authors: Graham, Laura S., Haffner, Michael C., Sayar, Erolcan, Gawne, Agnes, Schweizer, Michael T., Pritchard, Colin C., Coleman, Ilsa, Nelson, Peter S., Yu, Evan Y.

Source: Prostate; May2023, Vol. 83 Issue 7, p641-648, 8p

Management of Advanced Prostate Cancer in the Precision Oncology Era.

Authors: Gillette, Claire M., Yette, Gabriel A., Cramer, Scott D., Graham, Laura S.

Source: Cancers; May2023, Vol. 15 Issue 9, p2552, 17p

Subject Terms: THERAPEUTIC use of monoclonal antibodies, THERAPEUTIC use of antineoplastic agents, IMMUNE checkpoint inhibitors, RADIOIMMUNOIMAGING, CANCER chemotherapy, INDIVIDUALIZED medicine, POSITRON emission tomography computed tomography, METASTASIS, CASTRATION-resistant prostate cancer, PROSTATE-specific membrane antigen, TUMOR markers, DNA damage, PROSTATE tumors, IMMUNOTHERAPY, DIFFUSION of innovations

Mismatch repair deficiency and clinical implications in prostate cancer.

Authors: Graham, Laura S., Schweizer, Michael T.

Source: Prostate; Aug2022 Supplement S1, Vol. 82, pS37-S44, 8p

PROMISE: a real-world clinical-genomic database to address knowledge gaps in prostate cancer

Authors: Koshkin, Vadim S., Patel, Vaibhav G., Ali, Alicia, Bilen, Mehmet A., Ravindranathan, Deepak, Park, Joseph J., Kellezi, Olesia, Cieslik, Marcin, Shaya, Justin, Cabal, Angelo, Brown, Landon, Labriola, Matthew, Graham, Laura S., Pritchard, Colin, Tripathi, Abhishek, Nusrat, Sanober, Barata, Pedro, Jang, Albert, Chen, Shuang R., Garje, Rohan, Acharya, Luna, Hwang, Clara, Pilling, Amanda, Oh, William, Jun, Tomi, Natesan, Divya, Nguyen, Chris, Kilari, Deepak, Pierro, Michael, Thapa, Bicky, Cackowski, Frank, Mack, Alleda, Heath, Elisabeth, Marshall, Catherine H., Tagawa, Scott T., Halabi, Susan, Schweizer, Michael T., Armstrong, Andrew, Dorff, Tanya, Alva, Ajjai, McKay, Rana

Source: Prostate Cancer and Prostatic Diseases; September 2022, Vol. 25 Issue: 3 p388-396, 9p

Targeting backdoor androgen synthesis through AKR1C3 inhibition: A presurgical hormonal ablative neoadjuvant trial in high‐risk localized prostate cancer.

Authors: Graham, Laura S., True, Lawrence D., Gulati, Roman, Schade, George R., Wright, Jonathan, Grivas, Petros, Yezefski, Todd, Nega, Katie, Alexander, Katerina, Hou, Wen‐Min, Yu, Evan Y., Montgomery, Bruce, Mostaghel, Elahe A., Matsumoto, Alvin A., Marck, Brett, Sharifi, Nima, Ellis, William J., Reder, Nicholas P., Lin, Daniel W., Nelson, Peter S.

Source: Prostate; May2021, Vol. 81 Issue 7, p418-426, 9p

Pediatric Oncology Providers' Perceptions of Fertility Preservation in Adolescent and Young Women with Cancer.

Authors: Graham, Laura S., Hullmann, Stephanie E., Lawsin, Catalina, Wilson, Nicole A., Wood-Molo, Mary, Ording, Jeff, Ginder, Curt, Daley, Kristen, Kent, Paul M.

Source: Women's Reproductive Health; 2017, Vol. 4 Issue 1, p1-13, 13p