Targeting protein kinase C-α prolongs survival and restores liver function in sepsis: Evidence from preclinical models

Authors: Xiong, Ling ^{a, b}, Beyer, Dustin ^{a, b}, Liu, Na ^{a, b}, Lehmann, Tina ^c, Neugebauer, Sophie ^d, Schaeuble, Sascha ^e, Sommerfeld, Oliver ^{a, b}, Ernst, Philipp ^f, Svensson, Carl-Magnus ^g, Nietzsche, Sandor ^c, Scholl, Sebastian ^f, Bruns, Tony ^h, Gaßler, Nikolaus ⁱ, Gräler, Markus H. ^{a, b}, Figge, Marc Thilo ^{b, g, j, k}, Panagiotou, Gianni ^{e, j, k}, Bauer, Michael ^{a, b}, Press, Adrian T. ^{a, b, l, ⁎}

Source: In Pharmacological Research February 2025 212

Rapid determination of sphingosine 1-phosphate association with carrier molecules by flow-induced dispersion analysis to predict sepsis outcome

Authors: Seidita, Isabelle ^{1, 6}, Ziegler, Anke ¹, Qalaj, Auron ¹, Winkler, Martin Sebastian ², Nierhaus, Axel ³, Kluge, Stefan ³, Levkau, Bodo ⁴, Gräler, Markus H. ^{1, 5, 7, ∗}

Source: In iScience 15 November 2024 27(11)

Increased peritoneal B1-like cells during acute phase of human septic peritonitis

Authors: von Loeffelholz, Christian ^{1, 11, ∗}, Winkler, René ^{2, 8, 11}, Weigel, Cynthia ^{1, 3, 9}, Piskor, Eva-Maria ^{2, 10}, Vivas, Wolfgang ^{1, 4, 6}, Rauchfuß, Falk ⁵, Settmacher, Utz ⁵, Rubio, Ignacio ^{1, 7}, Weis, Sebastian ^{1, 4, 6}, Gräler, Markus H. ^{1, 3, 7}, Bauer, Michael ^{1, 7}, Kosan, Christian ^{2, 7, 12, ∗∗}

Source: In iScience 19 July 2024 27(7)

S1PR3 agonism and S1P lyase inhibition rescue mice in the severe state of experimental sepsis

Authors: Ziegler, Anke C., Haider, Raphael S., Hoffmann, Carsten, Gräler, Markus H.

Source: In Biomedicine & Pharmacotherapy May 2024 174

Sphingosine‐1‐phosphate improves outcome of no‐reflow acute myocardial infarction via sphingosine‐1‐phosphate receptor 1

Authors: Polzin, Amin, Dannenberg, Lisa, Benkhoff, Marcel, Barcik, Maike, Keul, Petra, Ayhan, Aysel, Weske, Sarah, Ahlbrecht, Samantha, Trojovsky, Kajetan, Helten, Carolin, Haberkorn, Sebastian, Flögel, Ulrich, Zeus, Tobias, Müller, Tina, Gräler, Markus H., Kelm, Malte, Levkau, Bodo

Source: ESC heart failure. 10(1):334-341

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100172694826.0x000001&indx=1&recIds=ETOCvdc_100172694826.0x000001

Altered Serum Phospholipids in Atopic Dermatitis and Association with Clinical Status

Authors: Sakai, Takashi, Herrmann, Nadine, Maintz, Laura, Nümm, Tim Joachim, Welchowski, Thomas, Claus, Ralf A., Gräler, Markus H., Bieber, Thomas

Source: In JID Innovations March 2022 2(2)

The role of ceramide accumulation in human induced pluripotent stem cell-derived cardiomyocytes on mitochondrial oxidative stress and mitophagy

Authors: Bekhite, Mohamed, González-Delgado, Andres, Hübner, Sascha, Haxhikadrija, Pëllumb, Kretzschmar, Tom, Müller, Tina, Wu, Jasmine M.F., Bekfani, Tarek, Franz, Marcus, Wartenberg, Maria, Gräler, Markus, Greber, Boris, Schulze, P. Christian

Source: In Free Radical Biology and Medicine 1 May 2021 167:66-80

Validation of a monoclonal antibody directed against the human sphingosine 1-phosphate receptor type 1

Authors: Thuy, Andreas V., Jeya Paul, Jefri, Weigel, Cynthia, Ziegler, Anke C., Guntinas-Lichius, Orlando, Gräler, Markus H.

Source: In Journal of Immunological Methods March 2021 490

Sphingosine 1-phosphate in sepsis and beyond: Its role in disease tolerance and host defense and the impact of carrier molecules

Authors: Ziegler, Anke C., Müller, Tina, Gräler, Markus H.

Source: In Cellular Signalling February 2021 78

Serum sphingosine‐1‐phosphate is elevated in atopic dermatitis and associated with severity

Authors: Sakai, Takashi, Herrmann, Nadine, Maintz, Laura, Nümm, Tim Joachim, Welchowski, Thomas, Claus, Ralf A., Gräler, Markus H., Bieber, Thomas

Source: Allergy. 76(8):2592-2595

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100141110027.0x000001&indx=1&recIds=ETOCvdc_100141110027.0x000001

Flotillin-Dependent Membrane Microdomains Are Required for Functional Phagolysosomes against Fungal Infections

Authors: Schmidt, Franziska, Thywißen, Andreas, Goldmann, Marie, Cunha, Cristina, Cseresnyés, Zoltán, Schmidt, Hella, Rafiq, Muhammad, Galiani, Silvia, Gräler, Markus H., Chamilos, Georgios, Lacerda, João F., Campos, António, Jr., Eggeling, Christian, Figge, Marc Thilo, Heinekamp, Thorsten, Filler, Scott G., Carvalho, Agostinho, Brakhage, Axel A.

Source: In Cell Reports 18 August 2020 32(7)

S1P lyase inhibition protects against sepsis by promoting disease tolerance via the S1P/S1PR3 axis

Authors: Weigel, Cynthia, Hüttner, Sören S., Ludwig, Kristin, Krieg, Nadine, Hofmann, Susann, Schröder, Nathalie H., Robbe, Linda, Kluge, Stefan, Nierhaus, Axel, Winkler, Martin S., Rubio, Ignacio, von Maltzahn, Julia, Spiegel, Sarah, Gräler, Markus H.

Source: In EBioMedicine August 2020 58

Targeting defective sphingosine kinase 1 in Niemann–Pick type C disease with an activator mitigates cholesterol accumulation

Authors: Newton, Jason ^*, Palladino, Elisa N.D., Weigel, Cynthia, Maceyka, Michael, Gräler, Markus H., Senkal, Can E., Enriz, Ricardo D., Marvanova, Pavlina, Jampilek, Josef, Lima, Santiago, Milstien, Sheldon, Spiegel, Sarah ^*

Source: In Journal of Biological Chemistry 3 July 2020 295(27):9121-9133

The role of sphingosine-1-phosphate signaling in HSV-1-infected human umbilical vein endothelial cells

Authors: Graber, Karina, Khan, Fawad, Glück, Brigitte, Weigel, Cynthia, Marzo, Sara, Doshi, Heena, Ehrhardt, Christina, Heller, Regine, Gräler, Markus, Henke, Andreas ^*

Source: In Virus Research 15 January 2020 276

Lipid metabolic signatures deviate in sepsis survivors compared to non-survivors

Authors: Khaliq, Waqas, Großmann, Peter, Neugebauer, Sophie, Kleyman, Anna, Domizi, Roberta, Calcinaro, Sara, Brealey, David, Gräler, Markus, Kiehntopf, Michael, Schäuble, Sascha, Singer, Mervyn, Panagiotou, Gianni, Bauer, Michael

Source: In Computational and Structural Biotechnology Journal 2020 18:3678-3691

Determinants of Serum- and Plasma Sphingosine-1-Phosphate Concentrations in a Healthy Study Group

Authors: Daum, Günter, Winkler, Martin, Moritz, Eileen, Müller, Tina, Geffken, Maria, von Lucadou, Mirjam, Haddad, Munif, Peine, Sven, Böger, Rainer, Larena-Avellaneda, Axel, Debus, Eike, Gräler, Markus, Schwedhelm, Edzard

Source: TH open. 04(01):e12-e19

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187788082.0x000001&indx=1&recIds=ETOCvdc_100187788082.0x000001

Regulation of ABCA1-mediated cholesterol efflux by sphingosine-1-phosphate signaling in macrophages

Authors: Vaidya, Mithila ^{*, †}, Jentsch, Julian A. ^{*, †}, Peters, Susann ^{*, †}, Keul, Petra ^{*, †}, Weske, Sarah ^{*, †}, Gräler, Markus H. ^{§, **, ††}, Mladenov, Emil ^§§, Iliakis, George ^§§, Heusch, Gerd ^{*, †}, Levkau, Bodo ^{*, †}

Source: In Journal of Lipid Research March 2019 60(3):506-515

Deletion of Sphingosine Kinase 2 Attenuates Acute Kidney Injury in Mice with Hemolytic-Uremic Syndrome.

Authors: Müller, Tina, Krieg, Nadine, Lange-Polovinkin, Antonia I., Wissuwa, Bianka, Gräler, Markus H., Dennhardt, Sophie, Coldewey, Sina M.

Source: International Journal of Molecular Sciences; Jul2024, Vol. 25 Issue 14, p7683, 21p

Subject Terms: SPHINGOSINE kinase, HEMOLYTIC-uremic syndrome, ACUTE kidney failure, MICE, KIDNEY diseases, TOXINS, DIABETIC nephropathies

Sphingosine-1-phosphate: A mediator of the ARB-MI paradox?

Authors: Polzin, Amin, Helten, Carolin, Dannenberg, Lisa, Müller, Tina, Gräler, Markus, Kelm, Malte, Levkau, Bodo

Source: International journal of cardiology. 333:40-42

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100142626636.0x000001&indx=1&recIds=ETOCvdc_100142626636.0x000001

Neural sphingosine 1‐phosphate accumulation activates microglia and links impaired autophagy and inflammation

Authors: Karunakaran, Indulekha, Alam, Shah, Jayagopi, Surendar, Frohberger, Stefan J., Hansen, Jan N., Kuehlwein, Janina, Hölbling, Benedikt V., Schumak, Beatrix, Hübner, Marc P., Gräler, Markus H., Halle, Annett, Echten‐Deckert, Gerhild

Source: Glia. 67(10):1859-1872

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100087262667.0x000001&indx=1&recIds=ETOCvdc_100087262667.0x000001