An affinity-directed phosphatase, AdPhosphatase, system for targeted protein dephosphorylation

Authors: Simpson, Luke M., Fulcher, Luke J., Sathe, Gajanan, Brewer, Abigail, Zhao, Jin-Feng, Squair, Daniel R., Crooks, Jennifer, Wightman, Melanie, Wood, Nicola T., Gourlay, Robert, Varghese, Joby, Soares, Renata F., Sapkota, Gopal P.

Source: In Cell Chemical Biology 16 February 2023 30(2):188-202

Acute depletion of the ARID1A subunit of SWI/SNF complexes reveals distinct pathways for activation and repression of transcription

Authors: Blümli, Seraina, Wiechens, Nicola, Wu, Meng-Ying, Singh, Vijender, Gierlinski, Marek, Schweikert, Gabriele, Gilbert, Nick, Naughton, Catherine, Sundaramoorthy, Ramasubramanian, Varghese, Joby, Gourlay, Robert, Soares, Renata, Clark, David, Owen-Hughes, Tom

Source: In Cell Reports 2 November 2021 37(5)

Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling

Authors: Bustos, Francisco, Segarra-Fas, Anna, Nardocci, Gino, Cassidy, Andrew, Antico, Odetta, Davidson, Lindsay, Brandenburg, Lennart, Macartney, Thomas J., Toth, Rachel, Hastie, C. James, Moran, Jennifer, Gourlay, Robert, Varghese, Joby, Soares, Renata F., Montecino, Martin, Findlay, Greg M.

Source: In Developmental Cell 7 December 2020 55(5):629-647

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Characterisation of the biochemical and cellular roles of native and pathogenic amelogenesis imperfecta mutants of FAM83H

Authors: Tachie-Menson, Theresa, Gázquez-Gutiérrez, Ana, Fulcher, Luke J., Macartney, Thomas J., Wood, Nicola T., Varghese, Joby, Gourlay, Robert, Soares, Renata F., Sapkota, Gopal P.

Source: In Cellular Signalling August 2020 72

Polyubiquitin Binding to Optineurin Is Required for Optimal Activation of TANK-binding Kinase 1 and Production of Interferon β

Authors: Gleason, Catherine E., Ordureau, Alban, Gourlay, Robert, Arthur, J. Simon C., Cohen, Philip

Source: In Journal of Biological Chemistry 14 October 2011 286(41):35663-35674

A Screen for Novel Phosphoinositide 3-kinase Effector Proteins

Authors: Dixon, Miles J. ^‡, Gray, Alexander ^‡, Boisvert, François-Michel ^§, Agacan, Mark ^‖, Morrice, Nicholas A. ^{¶, **}, Gourlay, Robert ^¶, Leslie, Nicholas R. ^‡, Downes, C. Peter ^‡, Batty, Ian H. ^{‡, ‡‡}

Source: In Molecular & Cellular Proteomics April 2011 10(4)

Method and apparatus for sleeve for hose coupling

Co-ordinated control of the ADP-heptose/ALPK1 signalling network by the E3 ligases TRAF6, TRAF2/c-IAP1 and LUBAC.

Authors: Snelling, Tom, Shpiro, Natalia, Gourlay, Robert, Lamoliatte, Frederic, Cohen, Philip

Source: Biochemical Journal; 10/15/2022, Vol. 479 Issue 20, p2195-2216, 22p

Subject Terms: LIGASES, UBIQUITIN ligases, INFLAMMATORY mediators, PROTEIN kinases, UBIQUITIN, UBIQUITINATION

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain.

Authors: Malik, Asad U., Karapetsas, Athanasios, Nirujogi, Raja S., Chatterjee, Deep, Phung, Toan K., Wightman, Melanie, Gourlay, Robert, Morrice, Nick, Mathea, Sebastian, Knapp, Stefan, Alessi, Dario R.

Source: Biochemical Journal; Sep2022, Vol. 479 Issue 18, p1941-1965, 25p

Subject Terms: GUANOSINE triphosphatase, PROTEIN kinase C, PARKINSON'S disease, MISSENSE mutation, KINASES

Liquid measurement system having a plurality of differential pressure probes

LIQUID MEASUREMENT SYSTEM HAVING A PLURALITY OF DIFFERENTIAL PRESSURE PROBES

INHALATION DETECTOR

Inhalation detector

LETTERS.

Authors: Attwater, Sheila, Howes, Ray, Yamore, Noah, Anthony, Anne, Debbie, Pendergast, Kerry, Gourlay, Robert, Tom, Korlaet, Sanja, Williams, Jane

Source: Nexus; Oct/Nov2022, Vol. 29 Issue 6, p4-85, 4p, 2 Color Photographs

Subject Terms: ARTIFICIAL intelligence, GEOMAGNETISM

An ERK5-KLF2 signalling module regulates early embryonic gene expression and telomere rejuvenation in stem cells.

Authors: Brown, Helen A., Williams, Charles A. C., Houjiang Zhou, Rios-Szwed, Diana, Fernandez-Alonso, Rosalia, Mansoor, Saria, McMulkin, Liam, Toth, Rachel, Gourlay, Robert, Peltier, Julien, Dieguez-Martinez, Nora, Trost, Matthias, Lizcano, Jose M., Stavridis, Marios P., Findlay, Greg M.

Source: Biochemical Journal; Dec2021, Vol. 478 Issue 23, p4119-4136, 18p

Subject Terms: GENE expression, MITOGEN-activated protein kinases, GENETIC regulation, STEM cells, EXTRACELLULAR signal-regulated kinases

Living with structured water.

Authors: Gourlay, Robert

Source: Nexus; Aug/Sep2022, Vol. 29 Issue 5, p53-58, 6p, 4 Color Photographs, 1 Diagram

Subject Terms: FORCE & energy, AQUATIC biology, MOLECULAR shapes, ALPHA rays, EMBRYOLOGY

Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms.

Authors: Malik, Asad U., Karapetsas, Athanasios, Nirujogi, Raja S., Mathea, Sebastian, Chatterjee, Deep, Pal, Prosenjit, Lis, Pawel, Taylor, Matthew, Purlyte, Elena, Gourlay, Robert, Dorward, Mark, Weidlich, Simone, Toth, Rachel, Polinski, Nicole K., Knapp, Stefan, Tonelli, Francesca, Alessi, Dario R.

Source: Biochemical Journal; Feb2021, Vol. 478 Issue 3, p553-578, 26p

Subject Terms: PHORBOL esters, PARKINSON'S disease, PHOSPHORYLATION, MASS spectrometry, PROTEINS

Earth-generated water.

Authors: Gourlay, Robert

Source: Nexus; Jun/Jul2021, Vol. 28 Issue 4, p27-35, 9p, 8 Color Photographs, 1 Map

Subject Terms: APPLIED sciences, INTERNAL structure of the Earth, EARTH sciences, STRUCTURAL geology

Basic principles of waterfront development.

Authors: GOURLAY, Robert S.

Source: American City; July 1914, Vol. 11, p33-35, 3p