Development of assays to support identification and characterization of modulators of DExH-box helicase DHX9

Authors: Gotur, Deepali, Case, April, Liu, Julie, Sickmier, E. Allen, Holt, Nicholas, Knockenhauer, Kevin E., Yao, Shihua, Lee, Young-Tae, Copeland, Robert A., Buker, Shane M., Boriack-Sjodin, P. Ann

Source: In SLAS Discovery December 2023 28(8):376-384

MTA-Cooperative PRMT5 Inhibitors: Mechanism Switching Through Structure-Based Design.

Authors: Cottrell, Kevin M., Whittington, Douglas A., Briggs, Kimberly J., Jahic, Haris, Ali, Janid A., Amor, Alvaro J., Gotur, Deepali, Tonini, Matthew R., Zhang, Wenhai, Huang, Alan, Maxwell, John P.

Source: Journal of Medicinal Chemistry; 2/27/2025, Vol. 68 Issue 4, p4217-4236, 20p

Discovery of novel biaryl sulfonamide based Mcl-1 inhibitors

Authors: Follows, Bruce, Fessler, Shawn, Baumeister, Timm, Campbell, Ann-Marie, Zablocki, Mary Margaret, Li, Hongbin, Gotur, Deepali, Wang, Zhongguo, Zheng, Xiaozhang, Molz, Lisa, Nguyen, Cokey, Herbertz, Torsten, Wang, Liann, Bair, Kenneth

Source: Bioorganic & medicinal chemistry letters. 29(16):2375-2382

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Discovery and optimization of novel piperazines as potent inhibitors of fatty acid synthase (FASN)

Authors: Martin, Matthew W., Lancia, David R., Li, Hongbin, Schiller, Shawn E.R., Toms, Angela V., Wang, Zhongguo, Bair, Kenneth W., Castro, Jennifer, Fessler, Shawn, Gotur, Deepali, Hubbs, Stephen E., Kauffman, Goss S., Kershaw, Mark, Luke, George P., McKinnon, Crystal, Yao, Lili, Lu, Wei, Millan, David S.

Source: Bioorganic & medicinal chemistry letters. 29(8):1001-1006

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100083548413.0x000001&indx=1&recIds=ETOCvdc_100083548413.0x000001

Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP-Deleted Cancers.

Authors: Cottrell, Kevin M., Briggs, Kimberly J., Whittington, Douglas A., Jahic, Haris, Ali, Janid A., Davis, Charles B., Gong, Shanzhong, Gotur, Deepali, Gu, Lina, McCarren, Patrick, Tonini, Matthew R., Tsai, Alice, Wilker, Erik W., Yuan, Hongling, Zhang, Minjie, Zhang, Wenhai, Huang, Alan, Maxwell, John P.

Source: Journal of Medicinal Chemistry; 4/25/2024, Vol. 67 Issue 8, p6064-6080, 17p

Cooperative Activity of GABP with PU.1 or C/EBPε Regulates Lamin B Receptor Gene Expression, Implicating Their Roles in Granulocyte Nuclear Maturation

Authors: Malu, Krishnakumar, Garhwal, Rahul, Pelletier, Margery G. H., Gotur, Deepali, Halene, Stephanie, Zwerger, Monika, Yang, Zhong-Fa, Rosmarin, Alan G., Gaines, Peter

Source: Journal of immunology. 197(3):910-922

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN607216433&indx=1&recIds=ETOCRN607216433

Discovery and Optimization of Quinolinone Derivatives as Potent, Selective, and Orally Bioavailable Mutant Isocitrate Dehydrogenase 1 (mIDH1) Inhibitors.

Authors: Lin, Jian, Lu, Wei, Caravella, Justin A., Campbell, Ann Marie, Diebold, R. Bruce, Ericsson, Anna, Fritzen, Edward, Gustafson, Gary R., Lancia Jr., David R., Shelekhin, Tatiana, Wang, Zhongguo, Castro, Jennifer, Clarke, Andrea, Gotur, Deepali, Josephine, Helen R., Katz, Marie, Diep, Hien, Kershaw, Mark, Yao, Lili, Kauffman, Goss

Source: Journal of Medicinal Chemistry; 7/25/2019, Vol. 62 Issue 14, p6575-6596, 22p

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Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor

Authors: Caravella, Justin A., Lin, Jian, Diebold, R. Bruce, Campbell, Ann-Marie, Ericsson, Anna, Gustafson, Gary, Wang, Zhongguo, Castro, Jennifer, Clarke, Andrea, Gotur, Deepali, Josephine, Helen R., Katz, Marie, Kershaw, Mark, Yao, Lili, Toms, Angela V., Barr, Kenneth J., Dinsmore, Christopher J., Walker, Duncan, Ashwell, Susan, Lu, Wei

Source: Journal of Medicinal Chemistry; February 2020, Vol. 63 Issue: 4 p1612-1623, 12p

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Dynamic Expression of the Lamin B Receptor and Associated Proteins during Myeloid Differentiation: Insight into Mechanisms of Neutrophil Vs. Macrophage Morphogenesis

Authors: Gaines, Peter, Gotur, Deepali ^*, Halene, Stephanie, Olins, Ada L ^*, Olins, Donald E ^*

Source: In Blood 16 November 2008 112(11):3546-3546