Induction of steatosis in primary human hepatocytes recapitulates key pathophysiological aspects of metabolic dysfunction-associated steatotic liver disease

Authors: Kwon, Yun, Gottmann, Pascal, Wang, Surui, Tissink, Joel, Motzler, Karsten, Sekar, Revathi, Albrecht, Wiebke, Cadenas, Cristina, Hengstler, Jan G., Schürmann, Annette, Zeigerer, Anja

Source: In Journal of Hepatology January 2025 82(1):18-27

Differences in DNA methylation of HAMP in blood cells predicts the development of type 2 diabetes

Authors: Ouni, Meriem, Eichelmann, Fabian, Jähnert, Markus, Krause, Christin, Saussenthaler, Sophie, Ott, Christiane, Gottmann, Pascal, Speckmann, Thilo, Huypens, Peter, Wolter, Stefan, Mann, Oliver, De Angelis, Martin Hrabé, Beckers, Johannes, Kirchner, Henriette, Schulze, Matthias B., Schürmann, Annette

Source: In Molecular Metabolism September 2023 75

Transcriptomic heterogeneity of non-beta islet cells is associated with type 2 diabetes development in mouse models.

Authors: Gottmann, Pascal, Speckmann, Thilo, Stadion, Mandy, Chawla, Prateek, Saurenbach, Judith, Ninov, Nikolay, Lickert, Heiko, Schürmann, Annette

Source: Diabetologia; Jan2025, Vol. 68 Issue 1, p166-185, 20p

Immunity-related GTPase induces lipophagy to prevent excess hepatic lipid accumulation

Authors: Schwerbel, Kristin, Kamitz, Anne, Krahmer, Natalie, Hallahan, Nicole, Jähnert, Markus, Gottmann, Pascal, Lebek, Sandra, Schallschmidt, Tanja, Arends, Danny, Schumacher, Fabian, Kleuser, Burkhard, Haltenhof, Tom, Heyd, Florian, Gancheva, Sofiya, Broman, Karl W., Roden, Michael, Joost, Hans-Georg, Chadt, Alexandra, Al-Hasani, Hadi, Vogel, Heike, Jonas, Wenke, Schürmann, Annette

Source: In Journal of Hepatology October 2020 73(4):771-782

Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans

Authors: Kluth, Oliver, Stadion, Mandy, Gottmann, Pascal, Aga, Heja, Jähnert, Markus, Scherneck, Stephan, Vogel, Heike, Krus, Ulrika, Seelig, Anett, Ling, Charlotte, Gerdes, Jantje, Schürmann, Annette

Source: In Cell Reports 12 March 2019 26(11):3027-3036

Epigenetic regulation of hepatic Dpp4 expression in response to dietary protein

Authors: Saussenthaler, Sophie, Ouni, Meriem, Baumeier, Christian, Schwerbel, Kristin, Gottmann, Pascal, Christmann, Sabrina, Laeger, Thomas, Schürmann, Annette

Source: In The Journal of Nutritional Biochemistry January 2019 63:109-116

A computational biology approach of a genome-wide screen connected miRNAs to obesity and type 2 diabetes

Authors: Gottmann, Pascal, Ouni, Meriem, Saussenthaler, Sophie, Roos, Julian, Stirm, Laura, Jähnert, Markus, Kamitz, Anne, Hallahan, Nicole, Jonas, Wenke, Fritsche, Andreas, Häring, Hans-Ulrich, Staiger, Harald, Blüher, Matthias, Fischer-Posovszky, Pamela, Vogel, Heike, Schürmann, Annette

Source: In Molecular Metabolism May 2018 11:145-159

Students Diabetes Day der AG Nachwuchs der Deutschen Diabetes Gesellschaft in Potsdam-Rehbrücke – ein voller Erfolg! (German)

Authors: Laaser, Jonas, Speckmann, Thilo, Schürmann, Annette, Gottmann, Pascal, Seufert, Jochen

Source: Diabetologie und Stoffwechsel; Aug2024, Vol. 19 Issue 4, p256-258, 3p

Novel markers and networks related to restored skeletal muscle transcriptome after bariatric surgery.

Authors: Ouni, Meriem, Kovac, Leona, Gancheva, Sofiya, Jähnert, Markus, Zuljan, Erika, Gottmann, Pascal, Kahl, Sabine, de Angelis, Martin Hrabĕ, Roden, Michael, Schürmann, Annette

Source: Obesity (19307381); Feb2024, Vol. 32 Issue 2, p363-375, 13p

Subject Terms: BARIATRIC surgery, SKELETAL muscle, GENE regulatory networks, GENE expression, FREE fatty acids, GASTRIC bypass

MiR‐205 is up‐regulated in islets of diabetes‐susceptible mice and targets the diabetes gene Tcf7l2.

Authors: Ouni, Meriem^1,2 (AUTHOR), Gottmann, Pascal^1,2 (AUTHOR), Westholm, Efraim^1,3 (AUTHOR), Schwerbel, Kristin^1,2 (AUTHOR), Jähnert, Markus^1,2 (AUTHOR), Stadion, Mandy^1,2 (AUTHOR), Rittig, Kilian^4,5 (AUTHOR), Vogel, Heike^1,2,6,7 (AUTHOR), Schürmann, Annette^1,2,5 (AUTHOR) schuermann@dife.de

Source: Acta Physiologica. Aug2021, Vol. 232 Issue 4, p1-20. 20p. 2 Diagrams, 4 Charts, 5 Graphs.

Subject Terms: *ISLANDS, *MICRORNA, *GENE targeting, *WNT genes, *WNT signal transduction, *INSULIN, *GENETIC regulation

Polymorphisms in miRNA binding sites involved in metabolic diseases in mice and humans.

Authors: Gottmann, Pascal^1,2, Ouni, Meriem^1,2, Zellner, Lisa^1,2, Jähnert, Markus^1,2, Rittig, Kilian^3,4, Walther, Dirk⁵, Schürmann, Annette^1,2,4,6 schuermann@dife.de

Source: Scientific Reports. 4/29/2020, Vol. 10 Issue 1, p1-14. 14p.

Subject Terms: *GENETIC polymorphisms, *MICRORNA, *BINDING sites, *METABOLIC disorders, *TYPE 2 diabetes, *OBESITY

Identification of MicroRNAs Associated with Prediabetic Status in Obese Women.

Authors: Kovac, Leona, Speckmann, Thilo, Jähnert, Markus, Gottmann, Pascal, Fritsche, Louise, Häring, Hans-Ulrich, Birkenfeld, Andreas L., Fritsche, Andreas, Schürmann, Annette, Ouni, Meriem

Source: International Journal of Molecular Sciences; Nov2023, Vol. 24 Issue 21, p15673, 13p

Subject Terms: OBESITY in women, TYPE 2 diabetes, ISLANDS of Langerhans, MICRORNA, BLOOD sugar, PANCREATIC beta cells, ADIPOSE tissues, INSULIN

Overexpression of Gjb4 impairs cell proliferation and insulin secretion in primary islet cells

Authors: Gässler, Anneke, Quiclet, Charline, Kluth, Oliver, Gottmann, Pascal, Schwerbel, Kristin, Helms, Anett, Stadion, Mandy, Wilhelmi, Ilka, Jonas, Wenke, Ouni, Meriem, Mayer, Frank, Spranger, Joachim, Schürmann, Annette, Vogel, Heike

Source: Molecular metabolism. 41

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100121482810.0x000001&indx=1&recIds=ETOCvdc_100121482810.0x000001

Alterations of Lipid Profile in Livers with Impaired Lipophagy.

Authors: Jonas, Wenke, Schwerbel, Kristin, Zellner, Lisa, Jähnert, Markus, Gottmann, Pascal, Schürmann, Annette

Source: International Journal of Molecular Sciences; Oct2022, Vol. 23 Issue 19, p11863, 12p

Subject Terms: NON-alcoholic fatty liver disease, FATTY liver, UNSATURATED fatty acids

Heterogeneous Development of β-Cell Populations in Diabetes-Resistant and -Susceptible Mice.

Authors: Gottmann, Pascal, Speckmann, Thilo, Stadion, Mandy, Zuljan, Erika, Aga, Heja, Sterr, Michael, Büttner, Maren, Santos, Patrícia Martínez, Jähnert, Markus, Bornstein, Stefan R., Theis, Fabian J., Lickert, Heiko, Schürmann, Annette schuermann@dife.de

Source: Diabetes. Sep2022, Vol. 71 Issue 9, p1962-1978. 17p.

Subject Terms: *APOPTOSIS, *TYPE 2 diabetes, *ISLANDS of Langerhans, *INSULIN, *DISEASE susceptibility, *MICE, *ANIMALS

Adipose tissue-derived microRNAs as predictors of type 2 diabetes. (German)

Authors: Sehgal, Ratika, Jähnert, Markus, Gottmann, Pascal, Ouni, Meriem, Schürmann, Annette

Source: Diabetologie und Stoffwechsel; 2024 Supplement, Vol. 19, pS51-S52, 2p

The role of non-beta-cell heterogeneity in the pathogenesis of type 2 diabetes. (German)

Authors: Gottmann, Pascal, Speckmann, Thilo, Lickert, Heiko, Schürmann, Annette

Source: Diabetologie und Stoffwechsel; 2024 Supplement, Vol. 19, pS50-S51, 2p

Identification of Novel Genes Involved in Hyperglycemia in Mice.

Authors: Jonas, Wenke, Kluth, Oliver, Helms, Anett, Voß, Sarah, Jähnert, Markus, Gottmann, Pascal, Speckmann, Thilo, Knebel, Birgit, Chadt, Alexandra, Al-Hasani, Hadi, Schürmann, Annette, Vogel, Heike

Source: International Journal of Molecular Sciences; Mar2022, Vol. 23 Issue 6, p3205-3205, 13p

Subject Terms: LOCUS (Genetics), HYPERGLYCEMIA, TYPE 2 diabetes, CALCIUM-binding proteins, GENES

Insulin Directly Regulates the Circadian Clock in Adipose Tissue.

Authors: Tuvia, Neta, Pivovarova-Ramich, Olga, Murahovschi, Veronica, Lück, Sarah, Grudziecki, Astrid, Ost, Anne-Catrin, Kruse, Michael, Nikiforova, Victoria J., Osterhoff, Martin, Gottmann, Pascal, Gögebakan, Özlem, Sticht, Carsten, Gretz, Norbert, Schupp, Michael, Schürmann, Annette, Rudovich, Natalia, Pfeiffer, Andreas F.H., Kramer, Achim

Source: Diabetes; Sep2021, Vol. 70 Issue 9, p1985-1999, 15p

Subject Terms: ADIPOSE tissues, INSULIN, GENE expression, CLOCK genes, MOLECULAR clock

Epigenetic Changes in Islets of Langerhans Preceding the Onset of Diabetes.

Authors: Ouni, Meriem, Saussenthaler, Sophie, Eichelmann, Fabian, Jähnert, Markus, Stadion, Mandy, Wittenbecher, Clemens, Rönn, Tina, Zellner, Lisa, Gottmann, Pascal, Ling, Charlotte, Schulze, Matthias B., Schürmann, Annette

Source: Diabetes; Nov2020, Vol. 69 Issue 11, p2503-2517, 15p

Subject Terms: ISLANDS of Langerhans, RECEIVER operating characteristic curves, PANCREATIC cysts, DNA methylation, EPIGENETICS, TYPE 2 diabetes, HYPERGLYCEMIA, ANIMAL experimentation, BLOOD sugar, BODY composition, BODY weight, COMPARATIVE studies, GENES, LIVER, RESEARCH methodology, MEDICAL cooperation, MICE, RESEARCH, TISSUE culture, EVALUATION research, GENE expression profiling

Geographic Terms: POTSDAM (Germany)