Oral Hsp90 inhibitor SNX-5422 attenuates SARS-CoV-2 replication and dampens inflammation in airway cells

Authors: Goswami, Ria, Russell, Veronica S., Tu, Joshua J., Thomas, Charlene, Hughes, Philip, Kelly, Francine, Langel, Stephanie N., Steppe, Justin, Palmer, Scott M., Haystead, Timothy, Blasi, Maria, Permar, Sallie R.

Source: In iScience 17 December 2021 24(12)

A gut check: understanding the interplay of the gastrointestinal microbiome and the developing immune system towards the goal of pediatric HIV remission.

Authors: Soo, Nicole, Farinre, Omotayo, Chahroudi, Ann, Boliar, Saikat, Goswami, Ria

Source: Retrovirology; 10/18/2024, Vol. 21 Issue 1, p1-9, 9p

Subject Terms: HIV-positive children, CHILD patients, GUT microbiome, HIV infection transmission, HIV infections

Fc Characteristics Mediate Selective Placental Transfer of IgG in HIV-Infected Women

Authors: Martinez, David R., Fong, Youyi, Li, Shuk Hang, Yang, Fang, Jennewein, Madeleine F., Weiner, Joshua A., Harrell, Erin A., Mangold, Jesse F., Goswami, Ria, Seage, George R., III, Alter, Galit, Ackerman, Margaret E., Peng, Xinxia, Fouda, Genevieve G., Permar, Sallie R.

Source: In Cell 27 June 2019 178(1):190-201

Pediatric HIV: the Potential of Immune Therapeutics to Achieve Viral Remission and Functional Cure

Authors: Berendam, Stella J., Nelson, Ashley N., Goswami, Ria, Persaud, Deborah, Haigwood, Nancy L., Chahroudi, Ann, Fouda, Genevieve G., Permar, Sallie R.

Source: Current HIV/AIDS reports. 17(3):237-248

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100172193304.0x000001&indx=1&recIds=ETOCvdc_100172193304.0x000001

Polyclonal HIV envelope-specific breast milk antibodies limit founder SHIV acquisition and cell-associated virus loads in infant rhesus monkeys

Authors: Himes, Jonathon E., Goswami, Ria, Mangan, Riley J., Kumar, Amit, Jeffries, Thomas L., Jr., Eudailey, Joshua A., Heimsath, Holly, Nguyen, Quang N., Pollara, Justin, LaBranche, Celia, Chen, Meng, Vandergrift, Nathan A., Peacock, James W., Schiro, Faith, Midkiff, Cecily, Ferrari, Guido, Montefiori, David C., Hernandez, Xavier Alvarez, Aye, Pyone Pyone, Permar, Sallie R.

Source: In Mucosal Immunology November 2018 11(6):1716-1726

Harnessing early life immunity to develop a pediatric HIV vaccine that can protect through adolescence.

Authors: Goswami, Ria¹ (AUTHOR), Berendam, Stella J.¹ (AUTHOR), Li, Shuk Hang¹ (AUTHOR), Nelson, Ashley N.¹ (AUTHOR), De Paris, Kristina^2,3 (AUTHOR), Van Rompay, Koen K. A.⁴ (AUTHOR), Permar, Sallie R.^1,5 (AUTHOR), Fouda, Genevieve G.^1,5 (AUTHOR) genevieve.fouda@duke.edu

Source: PLoS Pathogens. 11/12/2020, Vol. 16 Issue 11, p1-12. 12p.

Subject Terms: *AIDS vaccines, *BLOOD group incompatibility, *HIV infection transmission, *ADOLESCENCE, *NEWBORN infants, *EXCEPTIONAL children, *HIV

Sutterella and its metabolic pathways positively correlate with vaccine-elicited antibody responses in infant rhesus macaques.

Authors: Danting Jiang, Goswami, Ria, Dennis, Maria, Heimsath, Holly, Kozlowski, Pamela A., Ardeshir, Amir, Van Rompay, Koen K. A., De Paris, Kristina, Permar, Sallie R., Surana, Neeraj K.

Source: Frontiers in Immunology; 2023, p1-10, 10p

Subject Terms: RHESUS monkeys, ANTIBODY formation, GUT microbiome, VACCINE effectiveness, SHORT-chain fatty acids

Triple broadly neutralizing antibody (bnAb) combination therapy: a cure for pediatric HIV?

Authors: Bahadir, Zeynep, Pahountis, Ioanna, Vuong, Kenneth, Kosman, Christina, Dankwa, Sedem, Dennis, Maria, McCarthy, Janice, Ngo, Julia T, Enemuo, Chiamaka A, Carnathan, Diane G, Nelson, Ashley, Berendam, Stella J, Silvestri, Guido, Amara, Rama, Permar, Sallie, Goswami, Ria, Chahroudi, Ann, Fouda, Genevieve G

Source: Journal of the Pediatric Infectious Diseases Society; October 2024, Vol. 13 Issue: 1, Number 1 Supplement 4 p19-20, 2p

Human Maternal-Fetal Interface Cellular Models to Assess Antiviral Drug Toxicity during Pregnancy.

Authors: Herbek, Savannah L., Smithgall, Marie C., Murphy, Elisabeth A., Schwartz, Robert E., Chen, Shuibing, Riley, Laura E., Stuhlmann, Heidi, Yang, Yawei J., Goswami, Ria

Source: Reproductive Medicine; Dec2022, Vol. 3 Issue 4, p303-319, 17p

Subject Terms: MATERNAL-fetal exchange, ANTIVIRAL agents, DRUG toxicity, PREGNANCY

Challenges and Opportunities of Therapies Targeting Early Life Immunity for Pediatric HIV Cure.

Authors: Berendam, Stella J., Nelson, Ashley N., Yagnik, Bhrugu, Goswami, Ria, Styles, Tiffany M., Neja, Margaret A., Phan, Caroline T., Dankwa, Sedem, Byrd, Alliyah U., Garrido, Carolina, Amara, Rama R., Chahroudi, Ann, Permar, Sallie R., Fouda, Genevieve G.

Source: Frontiers in Immunology; 7/13/2022, Vol. 13, p1-17, 17p

Subject Terms: HIV-positive children, CHILD patients, LONG-term non-progressors, CHILDREN'S art, INFANT mortality

Prenatal Immunization to Prevent Viral Disease Outcomes During Pregnancy and Early Life.

Authors: Goswami, Ria¹, rig4007@med.cornell.edu, Pavon, Carolina Garrido², Miller, Itzayana G.¹, Berendam, Stella J.^2,3, Williams, Caitlin A.¹, Rosenthal, Danielle⁴, Gross, Mackensie¹, Phan, Caroline², Byrd, Alliyah², Pollara, Justin^2,5, Permar, Sallie R.¹, Fouda, Genevieve G.^2,3, genevieve.fouda@duke.edu

Source: Frontiers in Virology; 5/19/2022, p1-23, 23p

E-cigarette and food flavoring diacetyl alters airway cell morphology, inflammatory and antiviral response, and susceptibility to SARS-CoV-2.

Authors: Langel, Stephanie N., Kelly, Francine L., Brass, David M., Nagler, Andrew E., Carmack, Dylan, Tu, Joshua J., Travieso, Tatianna, Goswami, Ria, Permar, Sallie R., Blasi, Maria, Palmer, Scott M.

Source: Cell Death Discovery; 2/15/2022, Vol. 8 Issue 1, p1-11, 11p

Maternal Intervention to Prevent Mother-to-Child Transmission of HIV: Moving Beyond Antiretroviral Therapy.

Authors: Mangold, Jesse F., Goswami, Ria, Nelson, Ashley N., Martinez, David R., Fouda, Genevieve G., Permar, Sallie R.

Source: Pediatric Infectious Disease Journal; 2021 Supplement, Vol. 40, pS5-S10, 6p

Understanding Early-Life Adaptive Immunity to Guide Interventions for Pediatric Health.

Authors: Semmes, Eleanor C., Chen, Jui-Lin, Goswami, Ria, Burt, Trevor D., Permar, Sallie R., Fouda, Genevieve G.

Source: Frontiers in Immunology; 1/21/2021, Vol. 11, pN.PAG-N.PAG, 14p

Subject Terms: IMMUNITY, VACCINE effectiveness, HUMORAL immunity, B cells, IMMUNE system

SHIV.CH505-infected infant and adult rhesus macaques exhibit similar HIV.

Authors: Nelson, Ashley N.¹, Goswami, Ria¹, Dennis, Maria¹, Joshua Tu¹, Mangan, Riley J.¹, Saha, Pooja T.², Cain, Derek W.¹, Curtis, Alan D.², Xiaoying Shen¹, Shaw, George M.³, Bar, Katharine³, Hudgens, Michael², Pollara, Justin¹, De Paris, Kristina⁴, Van Rompay, Koen K. A.⁵ sallie.permar@duke.edu, Permar, Sallie R.¹

Source: Journal of Virology. Aug2019, Vol. 93 Issue 15, p1-44. 59p.

Subject Terms: *HIV, *RHESUS monkeys, *T helper cells, *HIV antibodies, *HUMORAL immunity, *INFANTS

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HIV-1 RESISTANCE PROFILES AGAINST bNAb IN INTACT VS DEFECTIVE GENOMES ARE DISTINCT.

Authors: Giorgi, Elena E., Khadka, Pragya, Benko, Erika, Kovacs, Colin, Goswami, Ria, Fouda, Genevieve G., Permar, Sallie R., Caskey, Marina, Jones, R. Brad, Lee, Guinevere Q.

Source: Topics in Antiviral Medicine; Apr2023, Vol. 31 Issue 2, p162-163, 2p

bNAb ESCAPE HIV-ENV VARIANTS IN ORALLY SHIV-INFECTED, ART-TREATED INFANT MACAQUES.

Authors: Goswami, Ria, Berendam, Stella J., Dankwa, Sedem, Giorgi, Elena E., Eudailey, Joshua, Phan, Caroline, Carnathan, Diane G., Yagnik, Bhrugu, Enemuo, Chiamaka A., Obregon-Perko, Veronica, Amara, Rama R., Chahroudi, Ann, Permar, Sallie R., Fouda, Genevieve G.

Source: Topics in Antiviral Medicine; Apr2023, Vol. 31 Issue 2, p158-159, 2p

MATERNAL BROADLY NEUTRALIZING ANTIBODY ACTIVITY AND PERINATAL TRANSMISSION OF HIV-1.

Authors: Karthigeyan, Krithika P., Goswami, Ria, Isaac, John, Giorgi, Elena E., Pollara, Justin, Eudailey, Joshua, Jackie Li, Connors, Megan, Weinbaum, Carolyn

Source: Topics in Antiviral Medicine; Apr2023, Vol. 31 Issue 2, p312-312, 1/3p

COMMENSAL BACTERIA WITHIN THE FAMILY LACHNOSPIRACEAE ROBUSTLY INHIBIT HIV INFECTION.

Authors: Jiang, Danting, Dankwa, Sedem, Ardeshir, Amir, Van Rompay, Koen, De Paris, Kristina, Permar, Sallie R., Goswami, Ria, Surana, Neeraj K.

Source: Topics in Antiviral Medicine; Apr2023, Vol. 31 Issue 2, p101-101, 1/3p