Long-term efficacy and safety of sofosbuvir-based direct-acting antiviral regimens in paediatric patients with hepatitis C virus infection: an international registry study

Authors: Gonzalez-Peralta, Regino P ^{a, *}, Wen, Jessica W ^b, Hardikar, Winita ^c, Karnsakul, Wikrom W ^d, Whitworth, Suzanne ^e, Lin, Chuan-Hao ^f, Indolfi, Giuseppe ^g, Rosenthal, Philip ^h, Balistreri, William ⁱ, Schwarz, Kathleen B ^d, Honegger, Jonathan R ^j, Zhang, Xu ^k, Svarovskaia, Evguenia C ^k, Suri, Vithika ^k, Kersey, Kathryn ^k, Leung, Daniel H ^l

Source: In The Lancet Child & Adolescent Health April 2025 9(4):248-254

Maralixibat in progressive familial intrahepatic cholestasis (MARCH-PFIC): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

Authors: Miethke, Alexander G ^*, Moukarzel, Adib, Porta, Gilda, Covarrubias Esquer, Joshue, Czubkowski, Piotr, Ordonez, Felipe, Mosca, Antonella, Aqul, Amal A, Squires, Robert H, Sokal, Etienne, D'Agostino, Daniel, Baumann, Ulrich, D'Antiga, Lorenzo, Kasi, Nagraj, Laborde, Nolwenn, Arikan, Cigdem, Lin, Chuan-Hao, Gilmour, Susan, Mittal, Naveen, Chiou, Fang Kuan, Horslen, Simon P, Huber, Wolf-Dietrich, Jaecklin, Thomas, Nunes, Tiago, Lascau, Anamaria, Longpre, Lara, Mogul, Douglas B, Garner, Will, Vig, Pamela, Hupertz, Vera F, Gonzalez-Peralta, Regino P, Ekong, Udeme, Hartley, Jane, Laverdure, Noemie, Ovchinsky, Nadia, Thompson, Richard J

Source: In The Lancet Gastroenterology & Hepatology July 2024 9(7):620-631

Procedure Costs Associated With Management of Biliary Strictures in Pediatric Liver Transplant Recipients in the Society of Pediatric Liver Transplantation (SPLIT) Registry.

Authors: Valentino, Pamela L., Perkins, James D., Taylor, Sarah A., Feldman, Amy G., Banc‐Husu, Anna M., Fishman, Douglas S., Bucuvalas, John C., Gonzalez‐Peralta, Regino P., Mazariegos, George, Mullapudi, Bhargava, Ng, Vicky L., Sundaram, Shikha S., Yazigi, Nada A., Kennedy, Jennie, Soltys, Kyle, McDiarmid, S., Feist, S., Hawkins, A., Hite, M., Azzam, R.

Source: Pediatric Transplantation; May2025, Vol. 29 Issue 3, p1-10, 10p

The Effect of Mental Health, Neurological Disease, and Liver Disease on Quality of Life in Patients With Wilson Disease

Authors: Camarata, Michelle A., Ala, Aftab, Coskun, Ayse K., Deng, Yanhong, Gonzalez-Peralta, Regino P., Maciejewski, Kaitlin R., Patel, Amar, Rubman, Susan, To, Uyen, Tomlin, Ricarda, Schilsky, Michael L., Zimbrean, Paula C.

Source: In Journal of the Academy of Consultation-Liaison Psychiatry September-October 2021 62(5):528-537

Sofosbuvir–velpatasvir in children 3–17 years old with hepatitis C virus infection.

Authors: Jonas, Maureen M., Romero, Rene, Rosenthal, Philip, Lin, Chuan‐Hao, Verucchi, Gabriella, Wen, Jessica, Balistreri, William F., Whitworth, Suzanne, Bansal, Sanjay, Leung, Daniel H., Narkewicz, Michael R., Gonzalez‐Peralta, Regino P., Mangia, Alessandra, Karnsakul, Wikrom, Rao, Girish S., Shao, Jiang, de Jong, Jan, Parhy, Bandita, Osinusi, Anu, Kersey, Kathryn

Source: Journal of Pediatric Gastroenterology & Nutrition; Jun2024, Vol. 78 Issue 6, p1342-1354, 13p

ESPGHAN recommendations on treatment of chronic hepatitis C virus infection in adolescents and children including those living in resource‐limited settings.

Authors: Indolfi, Giuseppe, Gonzalez‐Peralta, Regino P., Jonas, Maureen M., Sayed, Manal Hamdy‐El, Fischler, Björn, Sokal, Etienne, Wirth, Stefan, Nicastro, Emanuele, Kohlmaier, Benno, Fitzpatrick, Emer, Gonzales, Emmanuel, Junge, Norman, Mancell, Sarah, Mozer‐Glassberg, Yael, Pop, Tudor, Samyn, Marianne, Stephenne, Xavier, Zellos, Aglaia

Source: Journal of Pediatric Gastroenterology & Nutrition; Apr2024, Vol. 78 Issue 4, p957-972, 16p

Real‐world experience of maralixibat in Alagille syndrome: Novel findings outside of clinical trials.

Authors: Himes, Ryan, Rosenthal, Philip, Dilwali, Natasha, Smith, Kathryn, Venick, Robert, Gonzalez‐Peralta, Regino P.

Source: Journal of Pediatric Gastroenterology & Nutrition; Mar2024, Vol. 78 Issue 3, p506-513, 8p

Impact of early immunosuppression on pediatric liver transplant outcomes within 1 year.

Authors: Raghu, Vikram K., Zhang, Xingyu, Squires, James E., Eisenberg, Elizabeth, Feldman, Amy G., Halma, Jennifer, Peters, Anna L., Gonzalez‐Peralta, Regino P., Ng, Vicky L., Horslen, Simon P., Lobritto, Steven J., Bucuvalas, John, Mazariegos, George V., Perito, Emily R.

Source: Journal of Pediatric Gastroenterology & Nutrition; Feb2024, Vol. 78 Issue 2, p328-338, 11p

Herpes Simplex Virus Hepatitis in Infants: Clinical Outcomes and Correlates of Disease Severity

Authors: McGoogan, Katherine E., Haafiz, Allah B., González Peralta, Regino P.

Source: In The Journal of Pediatrics 2011 159(4):608-611

The Combination of Ribavirin and Peginterferon Is Superior to Peginterferon and Placebo for Children and Adolescents With Chronic Hepatitis C

Authors: Schwarz, Kathleen B., Gonzalez–Peralta, Regino P., Murray, Karen F., Molleston, Jean P., Haber, Barbara A., Jonas, Maureen M., Rosenthal, Philip, Mohan, Parvathi, Balistreri, William F., Narkewicz, Michael R., Smith, Lesley, Lobritto, Steven J., Rossi, Stephen, Valsamakis, Alexandra, Goodman, Zachary, Robuck, Patricia R., Barton, Bruce A.

Source: In Gastroenterology 2011 140(2):450-458

Wilson disease: a summary of the updated AASLD Practice Guidance.

Authors: Alkhouri, Naim, Gonzalez-Peralta, Regino P., Medici, Valentina

Source: Hepatology Communications; Jun2023, Vol. 7 Issue 6, p1-13, 13p

WED-164 Interim safety results of the ongoing international phase I/II GATEWAY gene therapy trial with VTX-801 conducted in adult patients with Wilson disease

Authors: Sandahl, Thomas Damgaard, Lee, William M., Ala, Aftab, Gonzalez-Peralta, Regino P., Medici, Valentina, Askari, Fred, Rudnick, Sean, Lauer, Ulrich, Schmidt, Hartmut, Valero, Sonia, Gonzalez, Gloria, Combal, Jean Philippe, D'Antiga, Lorenzo, Benichou, Bernard, Schilsky, Michael

Source: In Journal of Hepatology June 2024 80 Supplement 1:S714-S715

THU-129 Maralixibat improves growth in patients with progressive familial intrahepatic cholestasis: data from the MARCH/MARCH-ON trials

Authors: Gonzalez-Peralta, Regino P., Miethke, Alexander, Aqul, Amal A., Mogul, Douglas B., Nunes, Tiago, Garner, Will, Vig, Pamela, Thompson, Richard J.

Source: In Journal of Hepatology June 2024 80 Supplement 1:S323-S324

Elbasvir/grazoprevir in children aged 3-18 years with chronic HCV genotype 1 or 4 infection: a pharmacokinetic modeling study.

Authors: Gonzalez-Peralta, Regino P., Wirth, Stefan, Squires, Robert H., Mutschler, Frauke, Lang, Thomas, Pawlowska, Malgorzata, Sluzewski, Wojciech, Majda-Stanislawska, Ewa, Fischler, Bjorn, Balistreri, William F., Jonas, Maureen M., Blondet, Niviann, Rosenthal, Philip, Alkhouri, Naim, Romero, Rene, Grandhi, Anjana, Castronuovo, Patricia, Caro, Luzelena, Lihong Du, Rosenbloom, Daniel I. S.

Source: Hepatology Communications; Mar2023, Vol. 7 Issue 3, p1-11, 11p

Subject Terms: PHARMACOKINETICS, ADVERSE health care events, GENOTYPES, FATIGUE (Physiology)

Feasibility of using a patient‐reported outcome measure into clinical practice following pediatric liver transplantation: The Starzl Network experience.

Authors: Ng, Vicky Lee, Dunphy, Claire, Shemesh, Eyal, Lobritto, Steven, Eisenberg, Elizabeth, Pomponi, Claudia, Szolna, Jonathan, Wilkerson, Dawn, Gupta, Nitika, Romero, Rene, Perito, Emily R., DiPaola, Frank, Gonzalez‐Peralta, Regino P., Hsu, Evelyn, Saarela, Katelyn, Mohammad, Saeed, Superina, Riccardo, Logan, Sherrie, Miller, Daniel W., Krise‐Confair, Cassandra

Source: Pediatric Transplantation; Feb2023, Vol. 27 Issue 1, p1-13, 13p

Subject Terms: PATIENT reported outcome measures, LIVER transplantation, MOBILE app development, QUALITY of life, CLINICAL medicine

North American Biliary Stricture Management Strategies in Children After Liver Transplantation: A Multicenter Analysis From the Society of Pediatric Liver Transplantation (SPLIT) Registry.

Authors: Valentino, Pamela L., Wang, Tianhao, Shabanova, Veronika, Ng, Vicky Lee, Bucuvalas, John C., Feldman, Amy G., Gonzalez‐Peralta, Regino P., Gupta, Nitika Arora, Miloh, Tamir A., Mohammad, Saeed, Pace, Erika, Sundaram, Shikha S., Yazigi, Nada A., Soltys, Kyle

Source: Liver Transplantation; May2022, Vol. 28 Issue 5, p819-833, 15p

Pharmacokinetics, Safety, and Efficacy of Glecaprevir/Pibrentasvir in Children With Chronic HCV: Part 2 of the DORA Study.

Authors: Jonas, Maureen M., Rhee, Susan, Kelly, Deirdre A., Del Valle‐Segarra, Antonio, Feiterna‐Sperling, Cornelia, Gilmour, Susan, Gonzalez‐Peralta, Regino P., Hierro, Loreto, Leung, Daniel H., Ling, Simon C., Lobzin, Yuri, Lobritto, Steven, Mizuochi, Tatsuki, Narkewicz, Michael R., Sabharwal, Vishakha, Wen, Jessica, Kei Lon, Hoi, Marcinak, John, Topp, Andrew, Tripathi, Rakesh

Source: Hepatology (02709139); Jul2021, Vol. 74 Issue 1, p19-27, 9p

A Learning Health System for Pediatric Liver Transplant: The Starzl Network for Excellence in Pediatric Transplantation.

Authors: Perito, Emily R., Squires, James E., Bray, David, Bucuvalas, John, Krise-Confair, Cassandra, Eisenberg, Elizabeth, Gonzalez-Peralta, Regino P., Gupta, Nitika, Hsu, Evelyn K., Kosmach-Park, Beverly, Lobritto, Steven, Logan, Beth, Mohammad, Saeed, Ng, Vicky L., Pillari, Tony, Rasmussen, Sara, Shemesh, Eyal, Soltys, Kyle, Szolna, Jonathan, Superina, Riccardo

Source: Journal of Pediatric Gastroenterology & Nutrition; 2021, Vol. 72 Issue 3, p417-424, 8p

Hepatitis C in 2020: A North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition Position Paper.

Authors: Leung, Daniel H, Squires, James E, Jhaveri, Ravi, Kerkar, Nanda, Lin, Chuan-Hao, Mohan, Parvathi, Murray, Karen F, Gonzalez-Peralta, Regino P, Roberts, Eve A, Sundaram, Shikha S

Source: Journal of Pediatric Gastroenterology & Nutrition; Sep2020, Vol. 71 Issue 3, p407-417, 11p

Isoniazid-Induced Severe Hepatotoxicity: An Infrequent but Preventable Cause of Liver Failure in Children Treated for Latent Tuberculosis Infection.

Authors: Desrochers, Dan¹, Gonzalez-Peralta, Regino P.², McClenathan, Daniel T.¹, Wilsey Jr., Michael J.¹, Haafiz, Allah² haafiab@peds.ufl.edu

Source: Clinical Medicine Insights: Pediatrics. 2011, Issue 5, p9-13. 5p. 1 Graph.

Subject Terms: *DRUG therapy for tuberculosis, *HEPATOTOXICOLOGY, *ISONIAZID, *LIVER failure, *PEDIATRICS, *TUBERCULOSIS