SF1-specific deletion of the energy sensor AMPKγ2 induces obesity

Authors: Freire-Agulleiro, Óscar ^{1, 2}, Estévez-Salguero, Ánxela ^{1, 2}, Ferreira, Vitor ^{1, 2}, Holleman, Cassie Lynn ^{3, 4}, García-Currás, Julia ⁵, González-García, Ismael ^{1, 2}, Nogueiras, Rubén ^{1, 2}, Tena-Sempere, Manuel ^{2, 6}, García-Cáceres, Cristina ^{3, 4, 7}, Diéguez, Carlos ^{1, 2}, López, Miguel ^{1, 2, ⁎}

Source: In Molecular Metabolism February 2025 92

Ceramides in the central control of metabolism

Authors: López, Miguel ^{1, 2, ⁎, @}, Diéguez, Carlos ^{1, 2}, Tena-Sempere, Manuel ^{2, 3, 4}, González-García, Ismael ^{1, 2, ⁎, @}

Source: In Trends in Endocrinology & Metabolism January 2025 36(1):11-14

Neuroprotective effect of small extracellular vesicle-mediated targeting of AMPKα2 in cerebral ischemia

Authors: Ouro, Alberto ^{a, b}, Rodríguez-Díaz, Amanda ^{c, d}, López-González, Tania ^{a, c, d}, Romaus-Sanjurjo, Daniel ^{a, b}, Estévez-Salguero, Ánxela ^{c, d}, Iglesias-Rey, Ramón ^e, Rodríguez-Arrizabalaga, Mariña ^a, Fernández-Sanmartín, Paola ^c, Castro-Mosquera, Mónica ^a, Debasa-Mouce, Manuel ^a, Custodia, Antía ^{a, b}, Aramburu-Núñez, Marta ^{a, b}, Muñoz-González, María ^{a, b, f, g}, Aguiar, Pablo ^{b, f, g}, González-García, Ismael ^{c, d}, Schneeberger, Marc ^h, Nogueiras, Rubén ^{c, d}, Diéguez, Carlos ^{c, d}, Castillo, José ^e, Sobrino, Tomás ^{a, b, ⁎}, López, Miguel ^{c, d, ⁎⁎}

Source: In Metabolism June 2025 167

HDAC5 controls a hypothalamic STAT5b-TH axis, the sympathetic activation of ATP-consuming futile cycles and adult-onset obesity in male mice

Authors: Contreras, Raian E., Gruber, Tim, González-García, Ismael, Schriever, Sonja C., De Angelis, Meri, Mallet, Noemi, Bernecker, Miriam, Legutko, Beata, Kabra, Dhiraj, Schmidt, Mathias, Tschöp, Matthias H., Gutierrez-Aguilar, Ruth, Mellor, Jane, García-Cáceres, Cristina, Pfluger, Paul T.

Source: In Molecular Metabolism December 2024 90

Hypothalamic free fatty acid receptor-1 regulates whole-body energy balance

Authors: Dragano, Nathalia R.V., Milbank, Edward, Haddad-Tóvolli, Roberta, Garrido-Gil, Pablo, Nóvoa, Eva, Fondevilla, Marcos F., Capelli, Valentina, Zanesco, Ariane Maria, Solon, Carina, Morari, Joseane, Pires, Leticia, Estevez-Salguero, Ánxela, Beiroa, Daniel, González-García, Ismael, Barca-Mayo, Olga, Diéguez, Carlos, Nogueiras, Ruben, Labandeira-García, José L., Rexen Ulven, Elisabeth, Ulven, Trond, Claret, Marc, Velloso, Licio A., López, Miguel

Source: In Molecular Metabolism January 2024 79

High-calorie diets uncouple hypothalamic oxytocin neurons from a gut-to-brain satiation pathway via κ-opioid signaling

Authors: Gruber, Tim, Lechner, Franziska, Murat, Cahuê, Contreras, Raian E., Sanchez-Quant, Eva, Miok, Viktorian, Makris, Konstantinos, Le Thuc, Ophélia, González-García, Ismael, García-Clave, Elena, Althammer, Ferdinand, Krabichler, Quirin, DeCamp, Lisa M., Jones, Russell G., Lutter, Dominik, Williams, Rhiannan H., Pfluger, Paul T., Müller, Timo D., Woods, Stephen C., Pospisilik, John Andrew, Martinez-Jimenez, Celia P., Tschöp, Matthias H., Grinevich, Valery, García-Cáceres, Cristina

Source: In Cell Reports 31 October 2023 42(10)

Estradiol regulates leptin sensitivity to control feeding via hypothalamic Cited1

Authors: González-García, Ismael, García-Clavé, Elena, Cebrian-Serrano, Alberto, Le Thuc, Ophélia, Contreras, Raian E., Xu, Yanjun, Gruber, Tim, Schriever, Sonja C., Legutko, Beata, Lintelmann, Jutta, Adamski, Jerzy, Wurst, Wolfgang, Müller, Timo D., Woods, Stephen C., Pfluger, Paul T., Tschöp, Matthias H., Fisette, Alexandre, García-Cáceres, Cristina

Source: In Cell Metabolism 7 March 2023 35(3):438-455

Diet triggers specific responses of hypothalamic astrocytes in time and region dependent manner

Authors: Lutomska, Luiza Maria, Miok, Viktorian, Krahmer, Natalie, González García, Ismael, Gruber, Tim, Le Thuc, Ophélia, Murat, Cahuê DB, Legutko, Beata, Sterr, Michael, Saher, Gesine, Lickert, Heiko, Müller, Timo D., Ussar, Siegfried, Tschöp, Matthias H., Lutter, Dominik, García‐Cáceres, Cristina

Source: Glia. 70(11):2062-2078

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100165618076.0x000001&indx=1&recIds=ETOCvdc_100165618076.0x000001

Olfactomedin 2 deficiency protects against diet-induced obesity

Authors: González-García, Ismael, Freire-Agulleiro, Óscar, Nakaya, Naoki, Ortega, Francisco J., Garrido-Gil, Pablo, Liñares-Pose, Laura, Fernø, Johan, Labandeira-Garcia, José Luis, Diéguez, Carlos, Sultana, Afia, Tomarev, Stanislav I., Fernández-Real, José Manuel, López, Miguel

Source: In Metabolism April 2022 129

Ovarian insufficiency impairs glucose-stimulated insulin secretion through activation of hypothalamic de novo ceramide synthesis

Authors: Meneyrol, Kelly, Estévez-Salguero, Ánxela, González-García, Ismael, Guitton, Jeanne, Taouis, Mohammed, Benomar, Yacir, Magnan, Christophe, López, Miguel, Le Stunff, Hervé

Source: In Metabolism October 2021 123

GLP-1 and GIP agonism has no direct actions in human hepatocytes or hepatic stellate cells.

Authors: da Silva Lima, Natália, Cabaleiro, Alba, Novoa, Eva, Riobello, Cristina, Knerr, Patrick J., He, Yantao, Esquinas-Román, Eva M., González-García, Ismael, Prevot, Vincent, Schwaninger, Markus, Dieguez, Carlos, López, Miguel, Müller, Timo D., Varela-Rey, Marta, Douros, Jonathan D., Nogueiras, Ruben

Source: Cellular & Molecular Life Sciences; 11/28/2024, Vol. 81 Issue 1, p1-16, 16p

Subject Terms: HEPATIC fibrosis, PALMITIC acid, LIVER cells, GLYCEMIC control, DIRECT action, INSULIN

Fezolinetant for menopausal hot flashes and night sweats

Authors: González-García, Ismael, López, Miguel

Source: In Trends in Pharmacological Sciences September 2023 44(9):635-636

Deletion of iRhom2 protects against diet-induced obesity by increasing thermogenesis

Authors: Badenes, Marina, Amin, Abdulbasit, González-García, Ismael, Félix, Inês, Burbridge, Emma, Cavadas, Miguel, Ortega, Francisco José, de Carvalho, Érika, Faísca, Pedro, Carobbio, Stefania, Seixas, Elsa, Pedroso, Dora, Neves-Costa, Ana, Moita, Luís F., Fernández-Real, José Manuel, Vidal-Puig, António, Domingos, Ana, López, Miguel, Adrain, Colin

Source: In Molecular Metabolism January 2020 31:67-84

Ferritin regulates organismal energy balance and thermogenesis

Authors: Blankenhaus, Birte, Braza, Faouzi, Martins, Rui, Bastos-Amador, Patricia, González-García, Ismael, Carlos, Ana Rita, Mahu, Inês, Faisca, Pedro, Nunes, Jose Moura, Ventura, Pedro, Hoerr, Verena, Weis, Sebastian, Guerra, Joel, Cardoso, Silvia, Domingos, Ana, López, Miguel, Soares, Miguel P.

Source: In Molecular Metabolism June 2019 24:64-79

HYPOTHesizing about central comBAT against obesity

Authors: González-García, Ismael, Milbank, Edward, Martinez-Ordoñez, Anxo, Diéguez, Carlos, López, Miguel, Contreras, Cristina

Source: Journal of physiology and biochemistry. 76(2):193-211

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100171963763.0x000001&indx=1&recIds=ETOCvdc_100171963763.0x000001

Estradiol Regulates Energy Balance by Ameliorating Hypothalamic Ceramide-Induced ER Stress

Authors: González-García, Ismael, Contreras, Cristina, Estévez-Salguero, Ánxela, Ruíz-Pino, Francisco, Colsh, Benoit, Pensado, Iván, Liñares-Pose, Laura, Rial-Pensado, Eva, Martínez de Morentin, Pablo B., Fernø, Johan, Diéguez, Carlos, Nogueiras, Rubén, Le Stunff, Hervé, Magnan, Christophe, Tena-Sempere, Manuel, López, Miguel

Source: In Cell Reports 9 October 2018 25(2):413-423

Hypothalamic AMPK-ER Stress-JNK1 Axis Mediates the Central Actions of Thyroid Hormones on Energy Balance

Authors: Martínez-Sánchez, Noelia, Seoane-Collazo, Patricia, Contreras, Cristina, Varela, Luis, Villarroya, Joan, Rial-Pensado, Eva, Buqué, Xabier, Aurrekoetxea, Igor, Delgado, Teresa C., Vázquez-Martínez, Rafael, González-García, Ismael, Roa, Juan, Whittle, Andrew J., Gomez-Santos, Beatriz, Velagapudi, Vidya, Tung, Y.C. Loraine, Morgan, Donald A., Voshol, Peter J., Martínez de Morentin, Pablo B., López-González, Tania, Liñares-Pose, Laura, Gonzalez, Francisco, Chatterjee, Krishna, Sobrino, Tomás, Medina-Gómez, Gema, Davis, Roger J., Casals, Núria, Orešič, Matej, Coll, Anthony P., Vidal-Puig, Antonio, Mittag, Jens, Tena-Sempere, Manuel, Malagón, María M., Diéguez, Carlos, Martínez-Chantar, María Luz, Aspichueta, Patricia, Rahmouni, Kamal, Nogueiras, Rubén, Sabio, Guadalupe, Villarroya, Francesc, López, Miguel

Source: In Cell Metabolism 5 July 2017 26(1):212-229

Pharmacological Inhibition of PI3K Reduces Adiposity and Metabolic Syndrome in Obese Mice and Rhesus Monkeys

Authors: Ortega-Molina, Ana, Lopez-Guadamillas, Elena, Mattison, Julie A., Mitchell, Sarah J., Muñoz-Martin, Maribel, Iglesias, Gema, Gutierrez, Vincent M., Vaughan, Kelli L., Szarowicz, Mark D., González-García, Ismael, López, Miguel, Cebrián, David, Martinez, Sonia, Pastor, Joaquin, de Cabo, Rafael, Serrano, Manuel

Source: In Cell Metabolism 7 April 2015 21(4):558-570

Divide et impera: How mitochondrial fission in astrocytes rules obesity

Authors: González-García, Ismael, Le Thuc, Ophélia, Jastroch, Martin, García-Cáceres, Cristina

Source: Molecular metabolism. 45

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100137075417.0x000001&indx=1&recIds=ETOCvdc_100137075417.0x000001

Insulin action on astrocytes: From energy homeostasis to behaviour

Authors: González‐García, Ismael, Gruber, Tim, García‐Cáceres, Cristina

Source: Journal of neuroendocrinology. 33(4)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100120147681.0x000001&indx=1&recIds=ETOCvdc_100120147681.0x000001