Potentiation of the M1 muscarinic acetylcholine receptor normalizes neuronal activation patterns and improves apnea severity in Mecp2+/− mice

Authors: Smith, Mackenzie ^{a, b}, Dodis, Grace E. ^{a, b}, Vanderplow, Amanda M. ^{a, b}, Gonzalez, Sonia ^{a, b}, Rhee, Yewon ^{a, b}, Scrogin, Karie ^{a, b}, Gogliotti, Rocco G. ^{a, b, ⁎}

Source: In Neurobiology of Disease May 2025 208

MeCP2 gene therapy ameliorates disease phenotype in mouse model for Pitt Hopkins syndrome

Authors: Dennys, Cassandra N., Vermudez, Sheryl Anne D., Deacon, Robert J.M., Sierra-Delgado, J. Andrea, Rich, Kelly, Zhang, Xiaojin, Buch, Aditi, Weiss, Kelly, Moxley, Yuta, Rajpal, Hemangi, Espinoza, Francisca D., Powers, Samantha, Ávila, Ariel S., Gogliotti, Rocco G., Cogram, Patricia, Niswender, Colleen M., Meyer, Kathrin C.

Source: In Neurotherapeutics September 2024 21(5)

Clinical and Preclinical Evidence for M1 Muscarinic Acetylcholine Receptor Potentiation as a Therapeutic Approach for Rett Syndrome

Authors: Smith, Mackenzie, Arthur, Bright, Cikowski, Jakub, Holt, Calista, Gonzalez, Sonia, Fisher, Nicole M., Vermudez, Sheryl Anne D., Lindsley, Craig W., Niswender, Colleen M., Gogliotti, Rocco G.

Source: In Neurotherapeutics July 2022 19(4):1340-1352

Exploration of group II metabotropic glutamate receptor modulation in mouse models of Rett syndrome and MECP2 Duplication syndrome

Authors: Vermudez, Sheryl Anne D., Buch, Aditi, Weiss, Kelly, Gogliotti, Rocco G., Niswender, Colleen M.

Source: In Neuropharmacology 15 May 2022 209

Activating mGlu3 Metabotropic Glutamate Receptors Rescues Schizophrenia-like Cognitive Deficits Through Metaplastic Adaptations Within the Hippocampus

Authors: Dogra, Shalini, Stansley, Branden J., Xiang, Zixiu, Qian, Weilun, Gogliotti, Rocco G., Nicoletti, Ferdinando, Lindsley, Craig W., Niswender, Colleen M., Joffe, Max E., Conn, P. Jeffrey

Source: In Biological Psychiatry 15 September 2021 90(6):385-398

A Coordinated Attack: Rett Syndrome Therapeutic Development

Authors: Gogliotti, Rocco G., Niswender, Colleen M.

Source: In Trends in Pharmacological Sciences April 2019 40(4):233-236

Mechanisms underlying prelimbic prefrontal cortex mGlu3/mGlu5-dependent plasticity and reversal learning deficits following acute stress

Authors: Joffe, Max E., Santiago, Chiaki I., Stansley, Branden J., Maksymetz, James, Gogliotti, Rocco G., Engers, Julie L., Nicoletti, Ferdinando, Lindsley, Craig W., Conn, P. Jeffrey

Source: In Neuropharmacology January 2019 144:19-28

Total RNA Sequencing of Rett Syndrome Autopsy Samples Identifies the M4 Muscarinic Receptor as a Novel Therapeutic Target

Authors: Gogliotti, Rocco G., Fisher, Nicole M., Stansley, Branden J., Jones, Carrie K., Lindsley, Craig W., Conn, P. Jeffrey, Niswender, Colleen M. ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics May 2018 365(2):291-300

Profiling beneficial and potential adverse effects of MeCP2 overexpression in a hypomorphic Rett syndrome mouse model

Authors: Vermudez, Sheryl Anne D., Gogliotti, Rocco G., Arthur, Bright, Buch, Aditi, Morales, Clarissa, Moxley, Yuta, Rajpal, Hemangi, Conn, P. Jeffrey, Niswender, Colleen M.

Source: Genes, brain, and behavior. 21(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100142209239.0x000001&indx=1&recIds=ETOCvdc_100142209239.0x000001

Impact of MeCP2 Overexpression on Myelination Defects Found in Pitt‐Hopkins Syndrome Model Mice

Authors: Freitas, Geanne A., Vermudez, Sheryl A. D., Gogliotti, Rocco G., Niswender, Colleen M.

Source: FASEB journal. 36

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100196486325.0x000001&indx=1&recIds=ETOCvdc_100196486325.0x000001

Phenotypic profiling of mGlu7 knockout mice reveals new implications for neurodevelopmental disorders

Authors: Fisher, Nicole M., Gould, Robert W., Gogliotti, Rocco G., McDonald, Annalise J., Badivuku, Hana, Chennareddy, Susmita, Buch, Aditi B., Moore, Annah M., Jenkins, Matthew T., Robb, W. Hudson, Lindsley, Craig W., Jones, Carrie K., Conn, P. Jeffrey, Niswender, Colleen M.

Source: Genes, brain, and behavior. 19(7)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100108054893.0x000001&indx=1&recIds=ETOCvdc_100108054893.0x000001

Optimized Administration of the M4 PAM VU0467154 Demonstrates Broad Efficacy, but Limited Effective Concentrations in Mecp2^+/– Mice.

Authors: Cikowski, Jakub, Holt, Calista, Arthur, Bright, Smith, Mackenzie, Gonzalez, Sonia, Lindsley, Craig W., Niswender, Colleen M., Gogliotti, Rocco G.

Source: ACS Chemical Neuroscience; 6/7/2023, Vol. 14 Issue 11, p1891-1901, 11p

Optimized Administration of the M4 PAM VU0467154 Demonstrates Broad Efficacy, but Limited Effective Concentrations in Mecp2^+/– Mice.

Authors: Cikowski, Jakub, Holt, Calista, Arthur, Bright, Smith, Mackenzie, Gonzalez, Sonia, Lindsley, Craig W., Niswender, Colleen M., Gogliotti, Rocco G.

Source: ACS Chemical Neuroscience; 7/6/2022, Vol. 13 Issue 3, p1891-1901, 11p

Clinical and Preclinical Evidence for M1 Muscarinic Acetylcholine Receptor Potentiation as a Therapeutic Approach for Rett Syndrome.

Authors: Smith, Mackenzie, Arthur, Bright, Cikowski, Jakub, Holt, Calista, Gonzalez, Sonia, Fisher, Nicole M., Vermudez, Sheryl Anne D., Lindsley, Craig W., Niswender, Colleen M., Gogliotti, Rocco G.

Source: Neurotherapeutics; Jul2022, Vol. 19 Issue 4, p1340-1352, 13p

Phenotypic profiling of mGlu7 knockout mice reveals new implications for neurodevelopmental disorders.

Authors: Fisher, Nicole M., Gould, Robert W., Gogliotti, Rocco G., McDonald, Annalise J., Badivuku, Hana, Chennareddy, Susmita, Buch, Aditi B., Moore, Annah M., Jenkins, Matthew T., Robb, W. Hudson, Lindsley, Craig W., Jones, Carrie K., Conn, P. Jeffrey, Niswender, Colleen M.

Source: Genes, Brain & Behavior; Sep2020, Vol. 19 Issue 7, p1-14, 14p

Subject Terms: KNOCKOUT mice, AUTISTIC children, G protein coupled receptors, ATTENTION-deficit hyperactivity disorder, PATHOLOGY, RETT syndrome, ASSOCIATIVE learning

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In Vitro to in Vivo Translation of Allosteric Modulator Concentration-Effect Relationships: Implications for Drug Discovery.

Authors: Gregory, Karen J., Bridges, Thomas M., Gogliotti, Rocco G., Stauffer, Shaun R., Noetzel, Meredith J., Jones, Carrie K., Lindsley, Craig W., Conn, P. Jeffrey, Niswender, Colleen M.

Source: ACS Pharmacology & Translational Science; 12/13/2019, Vol. 2 Issue 6, p442-452, 11p

mGlu5 Positive Allosteric Modulators Facilitate Long-Term Potentiation via Disinhibition Mediated by mGlu5-Endocannabinoid Signaling.

Authors: Zixiu Xiang, Xiaohui Lv, Maksymetz, James, Stansley, Branden J., Ghoshal, Ayan, Gogliotti, Rocco G., Niswender, Colleen M., Lindsley, Craig W., Conn, P. Jeffrey

Source: ACS Pharmacology & Translational Science; 6/14/2019, Vol. 2 Issue 3, p198-209, 12p

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