The diagnostic and prognostic value of C1orf174 in colorectal cancer

Authors: Elham Nazari, Ghazaleh Khalili-Tanha, Ghazaleh Pourali, Fatemeh Khojasteh-Leylakoohi, Hanieh Azari, Mohammad Dashtiahangar, Hamid Fiuji, Zahra Yousefli, Alireza Asadnia, Mina Maftooh, Hamed Akbarzade, Mohammadreza Nassiri, Seyed Mahdi Hassanian, Gordon A Ferns, Godefridus J Peters, Elisa Giovannetti, Jyotsna Batra, Majid Khazaei, Amir Avan

Source: BioImpacts, Vol 15, Iss 1, Pp 30566-30566 (2024)

Subject Terms: colorectal cancer, tcga, machine learning, prognostic biomarker, diagnostic biomarker, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://bi.tbzmed.ac.ir/PDF/bi-15-30566.pdf; https://doaj.org/toc/2228-5652; https://doaj.org/toc/2228-5660

Access URL: https://doaj.org/article/7f4c621c71c74fc9adf3cb3215063fb3

Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth

Authors: Luca Costantino, Stefania Ferrari, Matteo Santucci, Outi MH Salo-Ahen, Emanuele Carosati, Silvia Franchini, Angela Lauriola, Cecilia Pozzi, Matteo Trande, Gaia Gozzi, Puneet Saxena, Giuseppe Cannazza, Lorena Losi, Daniela Cardinale, Alberto Venturelli, Antonio Quotadamo, Pasquale Linciano, Lorenzo Tagliazucchi, Maria Gaetana Moschella, Remo Guerrini, Salvatore Pacifico, Rosaria Luciani, Filippo Genovese, Stefan Henrich, Silvia Alboni, Nuno Santarem, Anabela da Silva Cordeiro, Elisa Giovannetti, Godefridus J Peters, Paolo Pinton, Alessandro Rimessi, Gabriele Cruciani, Robert M Stroud, Rebecca C Wade, Stefano Mangani, Gaetano Marverti, Domenico D'Arca, Glauco Ponterini, Maria Paola Costi

Source: eLife, Vol 11 (2022)

Subject Terms: thymidylate synthase, protein dimer destabilizers, cancer growth inhibition, proteasomal degradation, enzyme dissociative inhibition mechanism, target engagement, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/73862; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/6b5ed787a8314e518ea035b5e470ee7c

The Cytidine Analog Fluorocyclopentenylcytosine (RX-3117) Is Activated by Uridine-Cytidine Kinase 2.

Authors: Dzjemma Sarkisjan, Joris R Julsing, Kees Smid, Daniël de Klerk, André B P van Kuilenburg, Rutger Meinsma, Young B Lee, Deog J Kim, Godefridus J Peters

Source: PLoS ONE, Vol 11, Iss 9, p e0162901 (2016)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5017758?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/ecd36541f4fd43e4b410765524e870bd

AKT1 and SELP polymorphisms predict the risk of developing cachexia in pancreatic cancer patients.

Authors: Abolfazl Avan, Amir Avan, Tessa Y S Le Large, Andrea Mambrini, Niccola Funel, Mina Maftouh, Majid Ghayour-Mobarhan, Maurizio Cantore, Ugo Boggi, Godefridus J Peters, Paola Pacetti, Elisa Giovannetti

Source: PLoS ONE, Vol 9, Iss 9, p e108057 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/bebe4ffa80444420a10125426b584cca

DNA-bound platinum is the major determinant of cisplatin sensitivity in head and neck squamous carcinoma cells.

Authors: Sanne R Martens-de Kemp, Simone U Dalm, Fiona M J Wijnolts, Arjen Brink, Richard J Honeywell, Godefridus J Peters, Boudewijn J M Braakhuis, Ruud H Brakenhoff

Source: PLoS ONE, Vol 8, Iss 4, p e61555 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3629194?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/8c26f8b727e7492eae3d6f819991ffa7

Pemetrexed induced thymidylate synthase inhibition in non-small cell lung cancer patients: a pilot study with 3'-deoxy-3'-[¹⁸F]fluorothymidine positron emission tomography.

Authors: Virginie Frings, Astrid A M van der Veldt, Ronald Boellaard, Gerarda J M Herder, Elisa Giovannetti, Richard Honeywell, Godefridus J Peters, Erik Thunnissen, Otto S Hoekstra, Egbert F Smit

Source: PLoS ONE, Vol 8, Iss 5, p e63705 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3663749?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/4b96648a251d4e84a78fac5b6c02ba04

High-throughput microRNA (miRNAs) arrays unravel the prognostic role of MiR-211 in pancreatic cancer.

Authors: Elisa Giovannetti, Arjan van der Velde, Niccola Funel, Enrico Vasile, Vittorio Perrone, Leticia G Leon, Nelide De Lio, Amir Avan, Sara Caponi, Luca E Pollina, Valentina Gallá, Hiroko Sudo, Alfredo Falcone, Daniela Campani, Ugo Boggi, Godefridus J Peters

Source: PLoS ONE, Vol 7, Iss 11, p e49145 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23155457/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/78d81e5485f2461cb502a7b869c679ef

Identification of microRNA-21 as a biomarker for chemoresistance and clinical outcome following adjuvant therapy in resectable pancreatic cancer.

Authors: Jin-Hyeok Hwang, Johannes Voortman, Elisa Giovannetti, Seth M Steinberg, Leticia G Leon, Yong-Tae Kim, Niccola Funel, Joo Kyung Park, Min A Kim, Gyeong Hoon Kang, Sun-Whe Kim, Marco Del Chiaro, Godefridus J Peters, Giuseppe Giaccone

Source: PLoS ONE, Vol 5, Iss 5, p e10630 (2010)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2871055?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/281cc288c786485ab873da9b3573edd6

The role of l-leucovorin uptake and metabolism in the modulation of 5-fluorouracil efficacy and antifolate toxicity

Authors: Godefridus J. Peters, Ietje Kathmann, Elisa Giovannetti, Kees Smid, Yehuda G. Assaraf, Gerrit Jansen

Source: Frontiers in Pharmacology, Vol 15 (2024)

Subject Terms: leucovorin stereo-isomers, l-leucovorin, thymidylate synthase, 5-fluorouracil, antifolates, pemetrexed, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2024.1450418/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/f181d697131a47c99e405f990bc122f8

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A New Oxadiazole-Based Topsentin Derivative Modulates Cyclin-Dependent Kinase 1 Expression and Exerts Cytotoxic Effects on Pancreatic Cancer Cells

Authors: Camilla Pecoraro, Barbara Parrino, Stella Cascioferro, Adrian Puerta, Amir Avan, Godefridus J. Peters, Patrizia Diana, Elisa Giovannetti, Daniela Carbone

Source: Molecules, Vol 27, Iss 1, p 19 (2021)

Subject Terms: 1,2,4-oxadiazole, marine alkaloids, topsentin, CDK1 inhibitor, pancreatic cancer, PDAC, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/27/1/19; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/060eab81821e4c8bbf38011113fb46d5

The association of aberrant folylpolyglutamate synthetase splicing with ex vivo methotrexate resistance and clinical outcome in childhood acute lymphoblastic leukemia

Authors: Anna Wojtuszkiewicz, Yehuda G. Assaraf, Mirthe Hoekstra, Rocco Sciarrillo, Gerrit Jansen, Godefridus J. Peters, Rob Pieters, Edwin Sonneveld, Gabriele Escherich, Gertjan J.L. Kaspers, Jacqueline Cloos

Source: Haematologica, Vol 101, Iss 7 (2016)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/7782; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/028ae36423b74afe8de52fe025fb2295

Discovery of N-Hydroxyindole-Based Inhibitors of Human Lactate Dehydrogenase Isoform A (LDH-A) as Starvation Agents against Cancer Cells.

Authors: Carlotta Granchi, Sarabindu Roy, Chiara Giacomelli, Marco Macchia, Tiziano Tuccinardi, Adriano Martinelli, Mario Lanza, Laura Betti, Gino Giannaccini, Antonio Lucacchini, Nicola Funel, Leticia G. León, Elisa Giovannetti, Godefridus J. Peters, Rahul Palchaudhuri, Emilia C. Calvaresi, Paul J. Hergenrother, Filippo Minutolo

Source: Journal of Medicinal Chemistry; Mar2011, Vol. 54 Issue 6, p1599-1612, 14p

Synthesis and Biological Activity of a Gemcitabine Phosphoramidate Prodrug.

Authors: Weidong Wu, Jennifer Sigmond, Godefridus J. Peters, Richard F. Borch

Source: Journal of Medicinal Chemistry; Jul2007, Vol. 50 Issue 15, p3743-3746, 4p

In Vitro Optimization of Non-Small Cell Lung Cancer Activity with Troxacitabine, l-1,3-Dioxolane-cytidine, Prodrugs.

Authors: Marco Radi, Auke D. Adema, Jonathan R. Daft, Jong H. Cho, Eveline K. Hoebe, Lou-Ella M. M. Alexander, Godefridus J. Peters, Chung K. Chu

Source: Journal of Medicinal Chemistry; May2007, Vol. 50 Issue 9, p2249-2253, 5p

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Increased potentiation of 5-fluorouracil induced thymidylate synthase inhibition by 5,10-methylenetetrahydrofolate (arfolitixorin) compared to leucovorin in patients with colorectal liver metastases; The Modelle-001 Trial

Authors: Helena Taflin, Elisabeth Odin, Göran Carlsson, Bengt Gustavsson, Oskar Hemmingsson, Yvonne Wettergren, Krzysztof Urbanowicz, Jacek Turyn, Ryszard T. Smolenski, Godefridus J. Peters

Source: BJC Reports, Vol 2, Iss 1, Pp 1-8 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2731-9377

Access URL: https://doaj.org/article/dbe0b6d65b514af3a3a23fa46aa693b6

Interrelationship between miRNA and splicing factors in pancreatic ductal adenocarcinoma

Authors: I Gede Putu Supadmanaba, Giulia Mantini, Ornella Randazzo, Mjriam Capula, Ittai B. Muller, Stella Cascioferro, Patrizia Diana, Godefridus J. Peters, Elisa Giovannetti

Source: Epigenetics, Vol 17, Iss 4, Pp 381-404 (2022)

Subject Terms: pdac, splicing deregulation, mirna, interaction, splicing modulation, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1559-2294; https://doaj.org/toc/1559-2308

Access URL: https://doaj.org/article/95e67049e83d471fb22f4dea5968ac00

Pancreatic cancer resistance conferred by stellate cells: looking for new preclinical models

Authors: Pei Pei Che, Alessandro Gregori, Omidreza Firuzi, Max Dahele, Peter Sminia, Godefridus J. Peters, Elisa Giovannetti

Source: Experimental Hematology & Oncology, Vol 9, Iss 1, Pp 1-3 (2020)

Subject Terms: Pancreatic cancer, Therapy resistance, Stellate cells, Deoxycytidine, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40164-020-00176-0; https://doaj.org/toc/2162-3619

Access URL: https://doaj.org/article/3b876c3d1a844d15b44488633c337b48

The prognostic impact of circulating miRNAs in patients with advanced esophagogastric cancer during palliative chemotherapy

Authors: Annette A. van Zweeden, Roza C.M. Opperman, Richard J. Honeywell, Godefridus J. Peters, Henk M.W. Verheul, Hans J. van der Vliet, Dennis Poel

Source: Cancer Treatment and Research Communications, Vol 27, Iss , Pp 100371- (2021)

Subject Terms: Esophagogastric cancer, Cisplatin, Gemcitabine, Vitamin B12, MicroRNA, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2468294221000691; https://doaj.org/toc/2468-2942

Access URL: https://doaj.org/article/b255676a7ac243bd8be6dedf441bc7ad