Organoid co-culture model of the human endometrium in a fully synthetic extracellular matrix enables the study of epithelial-stromal crosstalk

Authors: Gnecco, Juan S., Brown, Alexander, Buttrey, Kira, Ives, Clara, Goods, Brittany A., Baugh, Lauren, Hernandez-Gordillo, Victor, Loring, Megan, Isaacson, Keith B., Griffith, Linda G.

Source: In Med 11 August 2023 4(8):554-579

Fully synthetic matrices for in vitro culture of primary human intestinal enteroids and endometrial organoids

Authors: Hernandez-Gordillo, Victor, Kassis, Timothy, Lampejo, Arinola, Choi, GiHun, Gamboa, Mario E., Gnecco, Juan S., Brown, Alexander, Breault, David T., Carrier, Rebecca, Griffith, Linda G.

Source: In Biomaterials September 2020 254

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Physiomimetic Models of Adenomyosis.

Authors: Gnecco, Juan S.^1,2 (AUTHOR), Brown, Alex T.^1,2 (AUTHOR), Kan, Ellen L.^1,2 (AUTHOR), Baugh, Lauren^1,2 (AUTHOR), Ives, Clara^1,2 (AUTHOR), Loring, Megan^2,3 (AUTHOR), Griffith, Linda G.^1,2,4 (AUTHOR) griff@mit.edu

Source: Seminars in Reproductive Medicine. 2020, Vol. 38 Issue 2/3, p179-196. 18p.

Subject Terms: *ENDOMETRIOSIS, *EXPERIMENTAL design, *TISSUE engineering, *SMOOTH muscle, *SYSTEMS biology

Human monocyte transcriptional profiling identifies IL-18 receptor accessory protein and lactoferrin as novel immune targets in hypertension.

Authors: Alexander, Matthew R, Norlander, Allison E, Elijovich, Fernando, Atreya, Ravi V, Gaye, Amadou, Gnecco, Juan S, Laffer, Cheryl L, Galindo, Cristi L, Madhur, Meena S

Source: British Journal of Pharmacology; Jun2019, Vol. 176 Issue 12, p2015-2027, 13p, 1 Chart, 5 Graphs

Subject Terms: PROTEIN receptors, LACTOFERRIN, GENE expression profiling, SINGLE nucleotide polymorphisms, HYPERTENSION, GENE expression, ANTIHYPERTENSIVE agents, REVERSE transcriptase polymerase chain reaction, BLOOD pressure, SEQUENCE analysis, BLACK people, MULTIVARIATE analysis, CELL receptors, CASE-control method, GLYCOPROTEINS, RESEARCH funding, POLYMERASE chain reaction, MONOCYTES, PHARMACODYNAMICS

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Hemodynamic forces enhance decidualization via endothelial-derived prostaglandin E2 and prostacyclin in a microfluidic model of the human endometrium.

Authors: Gnecco, Juan S¹ (AUTHOR), Ding, Tianbing² (AUTHOR), Smith, Caroline² (AUTHOR), Lu, Jacky³ (AUTHOR), Bruner-Tran, Kaylon L² (AUTHOR), Osteen, Kevin G⁴ (AUTHOR) Kevin.Osteen@vanderbilt.edu

Source: Human Reproduction. Apr2019, Vol. 34 Issue 4, p702-714. 13p. 2 Diagrams, 5 Graphs.

Subject Terms: *DINOPROSTONE, *ENDOMETRIUM, *ECLAMPSIA, *PROSTACYCLIN, *INFERTILITY, *SHEARING force, *STROMAL cells, *INFERTILITY treatment

Company/Entity: NATIONAL Institutes of Health (U.S.)

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Decidual stromal cell‐derived PGE2 regulates macrophage responses to microbial threat.

Authors: Rogers, Lisa M., Anders, Anjali P., Doster, Ryan S., Gill, Elizabeth A., Gnecco, Juan S., Holley, Jacob M., Randis, Tara M., Ratner, Adam J., Gaddy, Jennifer A., Osteen, Kevin, Aronoff, David M.

Source: American Journal of Reproductive Immunology; Oct2018, Vol. 80 Issue 4, pN.PAG-N.PAG, 1p

Subject Terms: STROMAL cells, MACROPHAGES, CHORIOAMNIONITIS, ESCHERICHIA coli, PHAGOCYTOSIS, STREPTOCOCCUS agalactiae