Cathelicidin-HG alleviates psoriasis by targeting glycoprotein VI to inhibit platelet-neutrophil complexes formation

Authors: Li, Jiali ^{a, b, 1}, Xiong, Weichen ^{b, 1}, Yang, Jianxi ^b, Gao, Yihan ^{a, b}, Chai, Jinwei ^a, Tian, Maolin ^b, Chu, Xinwei ^c, Huang, Xiaowen ^d, Kotsyfakis, Michail ^e, Chen, Xin ^a, Xu, Xueqing ^{a, b, ⁎}

Source: In European Journal of Pharmacology 15 March 2025 991

A glycoprotein VI signaling defect in newly formed platelets generated in stress thrombopoiesis

Authors: Hyslop, Stephanie R. ^{1, 2}, Corbin, Jason ¹, Gangatirkar, Pradnya ¹, Lebois, Marion ¹, Au, Amanda E. ^{1, 2}, Moujalled, Diane ^{1, 2}, Pleines, Irina ^{1, 2}, Sutherland, Kate D. ^{1, 2}, Andrews, Robert K. ³, Gardiner, Elizabeth E. ³, Alexander, Warren S. ^{1, 2}, Josefsson, Emma C. ^{1, 2, 4, 5, ∗}

Source: In Journal of Thrombosis and Haemostasis February 2025

Ultra-high throughput-based screening for the discovery of antiplatelet drugs affecting receptor dependent calcium signaling dynamics

Authors: Delia I. Fernández, Sara Troitiño, Vladimír Sobota, Bibian M. E. Tullemans, Jinmi Zou, Helma van den Hurk, Ángel García, Saman Honarnejad, Marijke J. E. Kuijpers, Johan W. M. Heemskerk

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)

Subject Terms: Collagen, Cytosolic calcium, Glycoprotein VI, Prestwick library, Thrombin, Thrombosis, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/e0e4cce4e1b944baa6e8d33649209870

Sulforaphane attenuates platelet granule secretion through down-regulating glycoprotein VI-mediated p38 MAPK/cPLA2 signaling pathway

Authors: Xinhui Huang, Xinyu Zhou, Chunting Wu, Weiqi Li, Yongjie Ma, Qilian He, Fuli Ya

Source: CyTA - Journal of Food, Vol 21, Iss 1, Pp 189-197 (2023)

Subject Terms: Sulforaphane, glycoprotein VI, platelet granule, P38 MAPK, cytosolic phospholipase A2, thromboxane A2, Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456

File Description: electronic resource

Relation: https://doaj.org/toc/1947-6337; https://doaj.org/toc/1947-6345

Access URL: https://doaj.org/article/60d80479c1ff4d45a982f12f83775eac

Platelet Activation Pathways Controlling Reversible Integrin αIIbβ3 Activation

Authors: Jinmi Zou, Siyu Sun, Ilaria De Simone, Hugo ten Cate, Philip G. de Groot, Bas de Laat, Mark Roest, Johan W.M. Heemskerk, Frauke Swieringa

Source: TH Open, Vol 08, Iss 02, Pp e232-e242 (2024)

Subject Terms: integrin αIIbβ3, glycoprotein VI, P-selectin, protease-activated receptors, protein kinase C, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://doaj.org/toc/2512-9465

Access URL: https://doaj.org/article/a1a44a63b65c416f94bc44b92ad11959

Platelets modulate cardiac remodeling via the collagen receptor GPVI after acute myocardial infarction

Authors: Friedrich Reusswig, Matthias Dille, E. Krüger, J. Ortscheid, Tobias Feige, S. Gorressen, J.-W. Fischer, Margitta Elvers

Source: Frontiers in Immunology, Vol 14 (2024)

Subject Terms: platelets, glycoprotein VI, myocardial infarction, inflammation, remodeling, scar formation, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1275788/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/5e8cc26c7bb64841915ebad161af2c16

An optimized herbal medicine containing Scutellaria baicalensis Georgi, Alisma orientale Juzepzuk, and Atractylodes japonica Koidzumi has potent antiplatelet and antithrombotic activities

Authors: Yeon-Ji Kim, Tae In Kim, Kyungho Kim

Source: Journal of Traditional and Complementary Medicine, Vol 13, Iss 3, Pp 285-296 (2023)

Subject Terms: Platelet, Thrombosis, Herbal medicine, Glycoprotein VI, Reactive oxygen species, Medicine

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2225411023000238; https://doaj.org/toc/2225-4110

Access URL: https://doaj.org/article/56ff89ab18244dc1a4cbd1081d560728

Comprehensive analysis of glycoprotein VI-mediated platelet activation signaling pathway for predicting pan-cancer survival and response to anti-PD-1 immunotherapy

Authors: Shuzhao Chen, Limei Zhang, Lezong Chen, Qianqian Huang, Yun Wang, Yang Liang

Source: Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 2873-2883 (2023)

Subject Terms: Glycoprotein VI-mediated platelet activation signaling pathway, Immune checkpoint blockade therapy, Platelets, EMMPRIN-GPVI, CD40L-GPVI, Biotechnology, TP248.13-248.65

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S200103702300154X; https://doaj.org/toc/2001-0370

Access URL: https://doaj.org/article/f4c84acc36314b4db586c50e40e901aa

Association between endometriosis, infertility and autoimmune antiplatelet glycoprotein VI antibodies in two patients

Authors: Stéphane Loyau, Anne Bauters, Nathalie Trillot, Cédric Garcia, Pierre Cougoul, Hélène Pol, Camille Paris, Geoffroy Robin, Chrystèle Rubod, Bernard Payrastre, Martine Jandrot-Perrus, Sophie Voisin, Annabelle Dupont

Source: Platelets, Vol 34, Iss 1 (2023)

Subject Terms: autoantibodies, auto-immune diseases, endometriosis, glycoprotein vi, infertility, platelets, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/0953-7104; https://doaj.org/toc/1369-1635

Access URL: https://doaj.org/article/3c671dfb1a434f2f9fcfea74a4988996

Restrained glycoprotein VI-induced platelet signaling by tyrosine protein phosphatases independent of phospholipase Cγ2

Authors: Jingnan Huang, Delia I. Fernández, Jinmi Zou, Xueqing Wang, Johan W.M. Heemskerk, Ángel García

Source: Bleeding, Thrombosis and Vascular Biology, Vol 2, Iss 3 (2023)

Subject Terms: Glycoprotein VI, tyrosine kinase, platelet signaling, tyrosine phosphatase, hemostasis, Diseases of the circulatory (Cardiovascular) system, RC666-701

File Description: electronic resource

Relation: https://btvb.org/btvb/article/view/93; https://doaj.org/toc/2785-5309

Access URL: https://doaj.org/article/980a26f87a6e4e26afb6e9b5ee35830f

Agitation-dependent biomechanical forces modulate GPVI receptor expression and platelet adhesion capacity during storage

Authors: Ehteramolsadat Hosseini, Amin Solouki, Masood Haghshenas, Mehran Ghasemzadeh, Simone M. Schoenwaelder

Source: Thrombosis Journal, Vol 20, Iss 1, Pp 1-14 (2022)

Subject Terms: Agitation, Glycoprotein VI (GPVI), Platelet, Shedding, Shear stress, Src-kinases, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/1477-9560

Access URL: https://doaj.org/article/aec5dd5ebb1c4adca48a38e731dfa3ee

Sinomenium acutum Modulates Platelet Aggregation and Thrombus Formation by Regulating the Glycoprotein VI-Mediated Signalosome in Mice

Authors: Yeon-Ji Kim, Tae In Kim, Ami Lee, Kyungho Kim, Youn-Hwan Hwang

Source: Pharmaceuticals, Vol 17, Iss 1, p 6 (2023)

Subject Terms: Sinomenium acutum, antiplatelet, thrombosis, collagen, glycoprotein VI, Medicine, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1424-8247/17/1/6; https://doaj.org/toc/1424-8247

Access URL: https://doaj.org/article/227466bea7bb4900a8091cd6bbe59ea3

Comparison of inhibitory effects of irreversible and reversible Btk inhibitors on platelet function

Authors: Bibian M.E. Tullemans, Mieke F.A. Karel, Valentine Léopold, Marieke S. ten Brink, Constance C.F.M.J. Baaten, Sanne L. Maas, Alex F. deVos, Johannes A. Eble, Marten R. Nijziel, Emiel P.C. van derVorst, Judith M.E.M. Cosemans, Johan W.M. Heemskerk, Theodora A.M. Claushuis, Marijke J.E. Kuijpers

Source: eJHaem, Vol 2, Iss 4, Pp 685-699 (2021)

Subject Terms: bleeding, Bruton tyrosine kinase, CLEC‐2, glycoprotein VI, platelets, von Willebrand Factor, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/2688-6146

Access URL: https://doaj.org/article/44007a92296c4e6e8eb464bf7bca834a

Platelet calcium signaling by G-protein coupled and ITAM-linked receptors regulating anoctamin-6 and procoagulant activity

Authors: Delia I. Fernández, Marijke J. E. Kuijpers, Johan W. M. Heemskerk

Source: Platelets, Vol 32, Iss 7, Pp 863-871 (2021)

Subject Terms: calcium channels, glycoprotein vi, gpcr, thrombin, tmem16f, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/0953-7104; https://doaj.org/toc/1369-1635

Access URL: https://doaj.org/article/74671a565b0947cfad72e0c250d58249

Absence of bleeding upon dual antiplatelet therapy in a patient with a immune GPVI deficiency

Authors: Stéphane Loyau Inserm, Dorothée Faille, Philippe Gautier, Paquita Nurden, Martine Jandrot-Perrus, Nadine Ajzenberg

Source: Platelets, Vol 32, Iss 5, Pp 705-709 (2021)

Subject Terms: glycoprotein vi, immune deficiency, dual antiplatelet therapy, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/0953-7104; https://doaj.org/toc/1369-1635

Access URL: https://doaj.org/article/2cbf19bd53bb46b98c10c5dbbc6f919f

Posttranslational modifications of platelet adhesion receptors

Authors: Shukun Sun, Bao Qiao, Yu Han, Bailu Wang, Shujian Wei, Yuguo Chen

Source: Pharmacological Research, Vol 183, Iss , Pp 106413- (2022)

Subject Terms: Platelets, Adhesion receptors, Glycoprotein Ib-IX-V, Glycoprotein VI, Integrin αIIbβ3, Posttranslational modification, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1043661822003589; https://doaj.org/toc/1096-1186

Access URL: https://doaj.org/article/e309465416f2439ab2dfb3bf14c55f1f

Human milk oligosaccharide, 2′-Fucosyllactose, attenuates platelet activation in arterial thrombosis

Authors: Malk Eun Pak, Yeon-Ji Kim, Yeo Jin Park, Younghoon Go, Chul Soo Shin, Jong-Won Yoon, Seon-min Jeon, Young-Ha Song, Kyungho Kim

Source: Journal of Functional Foods, Vol 94, Iss , Pp 105138- (2022)

Subject Terms: Platelet, Thrombosis, 2′-fucosyllactose, Human milk oligosaccharides, glycoprotein VI, Nutrition. Foods and food supply, TX341-641

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1756464622002080; https://doaj.org/toc/1756-4646

Access URL: https://doaj.org/article/aacf411f397944b7be0d0cc50a8609df

Biophysical targeting of high‐risk cerebral aneurysms

Authors: Mark Epshtein, Moran Levi, Afif M. Kraitem, Hikaia Zidan, Robert M. King, Meinrad Gawaz, Matthew J. Gounis, Netanel Korin

Source: Bioengineering & Translational Medicine, Vol 7, Iss 1, Pp n/a-n/a (2022)

Subject Terms: aneurysm targeting, cerebral aneurysm, glycoprotein VI (GPVI) coating, particle carriers, vascular models, Chemical engineering, TP155-156, Biotechnology, TP248.13-248.65, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2380-6761

Access URL: https://doaj.org/article/9c7033252d124074818211bd705aaa35

Platelet Activation by Antisense Oligonucleotides (ASOs) in the Göttingen Minipig, including an Evaluation of Glycoprotein VI (GPVI) and Platelet Factor 4 (PF4) Ontogeny

Authors: Allan Valenzuela, Miriam Ayuso, Laura Buyssens, Chloé Bars, Chris Van Ginneken, Yann Tessier, Steven Van Cruchten

Source: Pharmaceutics, Vol 15, Iss 4, p 1112 (2023)

Subject Terms: antisense oligonucleotide (ASO), Göttingen minipig, glycoprotein VI (GPVI), platelet factor 4 (PF4), ontogeny, thrombocytopenia, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/15/4/1112; https://doaj.org/toc/1999-4923

Access URL: https://doaj.org/article/a581d311f8d044f28e5dbaac0a1dd2a6

Platelet glycoprotein VI genetic quantitative and qualitative defects

Authors: Martine Jandrot-Perrus, Cedric Hermans, Diego Mezzano

Source: Platelets, Vol 30, Iss 6, Pp 708-713 (2019)

Subject Terms: glycoprotein vi, genetic deficiency, platelet disorder, Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://doaj.org/toc/0953-7104; https://doaj.org/toc/1369-1635

Access URL: https://doaj.org/article/025fa129574f4e269e1a85ff4f209f04