Drug Efficacy Recommendation System of Glioblastoma (GBM) Using Deep Learning

Authors: Naveed, S., Husnain, M., Samad, A., Ikram, A., Afreen, H., Gilanie, G., Alsubaie, N.

Source: IEEE Access Access, IEEE. 13:10398-10411 2025

Brain Tumor Microenvironment

Contributors: Mangiola, Annunziato, Trevisi, Gianluca

Subject Terms: volume regulation, transportome, phlorizin, brainstem glioma, MR spectroscopy, immunotherapy, pediatric brain tumor, vaccine therapy, myo-inositol, creatine, choline, brain tumor prediction, healthcare, deep convolutional features, ensemble learning, glioblastoma, extracellular matrix, cancer, tumor microenvironment, medulloblastoma, extracellular vesicles, exosomes, MMP-2, EMMPRIN, metastasis, stem cell, hypoxia, niche, autophagy, therapy, organoids, slice culture, tumormicroenvironment, classification, survival, glioma-associated microglia, glioma-associated stromal cells, immune infiltrate, microenvironment, peritumoral brain area, peritumor, tumor-infiltrating lymphocytes, glioblastoma (GBM), heterogeneity, tumour microenvironment (TME), myeloid cells, microglia, tumour associated macrophages (TAMs), therapeutic targeting, Medicine and Nursing, Neurosciences

File Description: application/octet-stream

Access URL: https://directory.doabooks.org/handle/20.500.12854/153127
https://mdpi.com/books/pdfview/book/10451

Prostaglandin F2 receptor negative regulator as a potential target for chimeric antigen receptor-T cell therapy for glioblastoma

Authors: Hideki Kuroda, Noriyuki Kijima, Tetsuro Tachi, Shunya Ikeda, Koki Murakami, Tomoyoshi Nakagawa, Moto Yaga, Kanji Nakagawa, Reina Utsugi, Ryuichi Hirayama, Yoshiko Okita, Naoki Kagawa, Naoki Hosen, Haruhiko Kishima

Source: Cancer Immunology, Immunotherapy, Vol 74, Iss 4, Pp 1-12 (2025)

Subject Terms: CAR-T cell therapy, Glioblastoma (GBM), PTGFRN, Expression cloning, Monoclonal antibodies, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1432-0851

Access URL: https://doaj.org/article/5d61d2b9dc584250ac64a81d2b020d9e

Functional loss of ERBB receptor feedback inhibitor 1 (MIG6) promotes glioblastoma tumorigenesis by aberrant activation of epidermal growth factor receptor (EGFR)

Authors: Sang Ah Yi, Daseul Cho, Sujin Kim, Hyunjin Kim, Myung Kyung Choi, Hee Seong Choi, Sukjin Shin, Sujin Yun, Ahjin Lim, Jae Kyun Jeong, Da Eun Yoon, Hye Ji Cha, Kyoungmi Kim, Jeung‐Whan Han, Hyun‐Soo Cho, Jeonghee Cho

Source: Molecular Oncology, Vol 19, Iss 3, Pp 937-953 (2025)

Subject Terms: biomarker, EGFR, glioblastoma (GBM), MIG6, targeted cancer therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1574-7891; https://doaj.org/toc/1878-0261

Access URL: https://doaj.org/article/353d65813dc845fc80f4e6e59fe536a2

Sophocarpine inhibits the proliferation and induces apoptosis of glioblastoma cells through regulating the miR-21/PTEN/PI3K/AKT axis

Authors: Feng Si, Qian Wang, Fei Chen, Xiangdong Lu

Source: Discover Oncology, Vol 16, Iss 1, Pp 1-11 (2025)

Subject Terms: Sophocarpine (SC), Proliferation, Apoptosis, miR-21, PTEN/PI3K/AKT axis, Glioblastoma (GBM), Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2730-6011

Access URL: https://doaj.org/article/914f0211d6654468a9ea2fc30ac41156

Editorial: New insights into intracellular pathways and therapeutic targets in CNS diseases

Authors: Lisa Gherardini

Source: Frontiers in Cellular Neuroscience, Vol 19 (2025)

Subject Terms: glioblastoma (GBM), Alzheimer's, epilepsy, neurodegeneration, microenvironment, drug repurposing, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fncel.2025.1559821/full; https://doaj.org/toc/1662-5102

Access URL: https://doaj.org/article/570cd779154347a9be5d2ea4913a32d2

Early characterization and prediction of glioblastoma and brain metastasis treatment efficacy using medical imaging-based radiomics and artificial intelligence algorithms

Authors: Noémie N. Moreau, Samuel Valable, Cyril Jaudet, Loïse Dessoude, Leleu Thomas, Romain Hérault, Romain Modzelewski, Dinu Stefan, Juliette Thariat, Alexis Lechervy, Aurélien Corroyer-Dulmont

Source: Frontiers in Oncology, Vol 15 (2025)

Subject Terms: Glioblastoma (GBM), machine learning (ML), brain tumors, artificial intelligence, treatment efficacy, medical imaging, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2025.1497195/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/1bc0ba21b5134b61bed0d7f2e6e885e6

Discovery of mutated oncodriver genes associated with glioblastoma originated from stem cells of subventricular zone through whole exome sequence profile analysis, and drug repurposing

Authors: Arnob Sarker, Burhan Uddin, Reaz Ahmmed, Sabkat Mahmud, Alvira Ajadee, Md. Al Amin Pappu, Md. Abdul Aziz, Md. Nurul Haque Mollah

Source: Heliyon, Vol 11, Iss 2, Pp e42052- (2025)

Subject Terms: Glioblastoma (GBM), Whole exome Sequence (WES) profile, Somatic mutation, Oncodriver genes, Drug repurposing, Integrated bioinformatics analysis, Science (General), Q1-390, Social sciences (General), H1-99

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405844025004323; https://doaj.org/toc/2405-8440

Access URL: https://doaj.org/article/db97678e9664421f9d18664d354950d4

Radiosynthesis and preclinical evaluation of a 68Ga-labeled tetrahydroisoquinoline-based ligand for PET imaging of C-X-C chemokine receptor type 4 in an animal model of glioblastoma

Authors: Piyapan Suwattananuruk, Sukanya Yaset, Chanisa Chotipanich, Angel Moldes-Anaya, Rune Sundset, Rodrigo Berzaghi, Stine Figenschau, Sandra Claes, Dominique Schols, Pornchai Rojsitthisak, Mathias Kranz, Opa Vajragupta

Source: EJNMMI Radiopharmacy and Chemistry, Vol 9, Iss 1, Pp 1-19 (2024)

Subject Terms: CXCR4 receptor, Glioblastoma (GBM), 68Ga, Bifunctional chelator (BFC), Positron emission tomography, PET tracer, Medical physics. Medical radiology. Nuclear medicine, R895-920, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2365-421X

Access URL: https://doaj.org/article/c3db7fc51fd5432a9dad7507f7eb9509

Hemoglobin, albumin, lymphocytes and platelets (HALP) score as a predictor of survival in patients with glioblastoma (GBM)

Authors: Ozden Demir, Guzin Demirag, Furkan Cakmak, Demet Işık Bayraktar, Leman Tokmak

Source: BMC Neurology, Vol 24, Iss 1, Pp 1-10 (2024)

Subject Terms: Glioblastoma (GBM), HALP, Prognostic factor, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2377

Access URL: https://doaj.org/article/f229fdf0af3c436799709f84f49cfe92

Molecular and Cellular Mechanisms of Cancers

Contributors: Castresana, Javier S., Meléndez, Bárbara

Subject Terms: oxidative stress, chaperone mediated autophagy (CMA), mitochondrial scavenger, drug resistance, reactive oxygen species (ROS), cell motility, gliomas, protein synthesis, translation, cap-dependent, IRES, astrocytoma, glioblastoma, serum proteins, Protein Antibody Array, decision tree, survival, glioblastoma stem cells (GSCs), epithelial-to-mesenchymal transition (EMT) markers, GSC invasiveness, transforming growth factor beta, BzATP, P2X7 receptor splice variants A and B, tumor microenvironment, exosomes, microvesicles, glioma stem cells, immunotherapy, resistance mechanisms, programme death-1, immune checkpoint blockade, glioblastoma (GBM), proteomics, GBM cell-states, recurrence, tumour heterogeneity, therapeutic targets, WNK2, glioblastoma cell line, autophagy, inhibition, autophagic flux, glioma, 5’-methylthioadenosine phosphorylase (MTAP), immunohistochemistry, tumor biology, proliferation, migration, invasion, cancer stem cells, M2 muscarinic receptors, EGFR, Notch, cell cycle, apoptosis, radiotherapy, membrane Hsp70, dose- and time-kinetics, NK cell-based therapy, non-coding RNA, noncoding RNA BC200/miR-218-5p signaling circuit, glioblastoma stem cells, temozolomide resistance, epithelial–mesenchymal transition (EMT), glioblastoma multiforme (GBM), 17β-estradiol (E2), estrogen receptors (ERs), adhesion, arginine deprivation, canavanine, cancer, cytoskeleton, ER stress, unfolded protein response, IDH, ADD3, high throughout techniques, precision, cerebral organoids, nanomedicines, astrocytes, microglia, lipocalin-2, inflammation, glioblastomas, hippo signaling pathway, MST1/2, LATS1/2, YAP/TAZ, TEADs, energy metabolism, glycolysis, oxidative phosphorylation, therapeutics, gene expression profiling, tumor model, stem cell, organoid, heterogeneity, immunosuppression, microenvironment, IDH1-mutation, Medicine and Nursing, Epidemiology and Medical statistics

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Access URL: https://directory.doabooks.org/handle/20.500.12854/153132
https://mdpi.com/books/pdfview/book/10385

Nonthermal plasma boosted dichloroacetate induces metabolic shifts to combat glioblastoma CSCs via oxidative stress

Authors: Jaiswal, Apurva ^{a, 1}, Kaushik, Neha ^{b, 1}, Patel, Paritosh ^a, Acharya, Tirtha Raj ^a, Mukherjee, Subhadip ^a, Choi, Eun Ha ^{a, ⁎⁎}, Kaushik, Nagendra Kumar ^{a, ⁎}

Source: In Free Radical Biology and Medicine 1 March 2025 229:264-275

Unlocking the code: The role of molecular and genetic profiling in revolutionizing glioblastoma treatment

Authors: Mansour, Moustafa A. ^{a, b, c, ⁎}, Kamer-Eldawla, Ahmed M. ^{a, d}, Malaeb, Reem W. ^e, Aboelhassan, Rasha ^f, Nabawi, Dina H. ^g, Aziz, Mohamed M. ^{a, h}, Mostafa, Hamdi Nabawi ^{a, i}

Source: In Cancer Treatment and Research Communications 2025 43

Synergistic antitumor effects of Phlorizin and Temozolomide in glioblastoma: Mechanistic insights and molecular targeting

Authors: Hou, Junzhi ^{a, b}, Xing, Zhaobin ^b, Li, Ang ^b, Wu, Hongjiao ^b, Jin, Ye ^c, Song, Qinqin ^a, Ji, Shanshan ^a, Zhang, Zhi ^{a, ⁎⁎}, Zhang, Xuemei ^{b, d, ⁎}

Source: In Fitoterapia January 2025 180

IN VIVO INOCULATION OF GBM CELLS IN RATS AND TREATMENT WITH RUXOLITINIB

Authors: Ioan-Alexandru Florian, Valeriu-Sergiu Susman, Bodoki Ede, Olga Soritau, Petru-Cosmin Pestean, Bogdan-Cezar Iacob, Alexandra-Iulia Baraian, Andrei Buruiana, Ioan-Stefan Florian

Source: Romanian Neurosurgery, Vol 38, Iss Special Issue (2024)

Subject Terms: glioblastoma (GBM), Ruxolitinib (RUX), molecularly imprinted polymers (MIP), in vivo studies, GlioStat, microscooping, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://journals.lapub.co.uk/index.php/roneurosurgery/article/view/2820; https://doaj.org/toc/1220-8841; https://doaj.org/toc/2344-4959

Access URL: https://doaj.org/article/e0b819d0dcd2401a96b025c2c99fd367

An immune-related gene pair signature predicts the prognosis and immunotherapeutic response in glioblastoma

Authors: Gang Wang, Yingchun Man, Kui Cao, Lihong Zhao, Lixin Lun, Yiyang Chen, Xinyu Zhao, Xueying Wang, Lijie Zhang, Chuncheng Hao

Source: Heliyon, Vol 10, Iss 19, Pp e39025- (2024)

Subject Terms: Glioblastoma (GBM), IRGP, Prognostic model, Immune infiltration, Immune checkpoints, Science (General), Q1-390, Social sciences (General), H1-99

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405844024150566; https://doaj.org/toc/2405-8440

Access URL: https://doaj.org/article/1e01ff20f776440ba92b0a25d0d76682

New insights into targeted therapy of glioblastoma using smart nanoparticles

Authors: Habib Ghaznavi, Reza Afzalipour, Samideh Khoei, Saman Sargazi, Sakine Shirvalilou, Roghayeh Sheervalilou

Source: Cancer Cell International, Vol 24, Iss 1, Pp 1-18 (2024)

Subject Terms: Smart nanoparticles, Glioblastoma (GBM), Therapy, Clinical trials, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2867

Access URL: https://doaj.org/article/d2bde50d70094df9996d4d709bb037e2

LINC00606 promotes glioblastoma progression through sponge miR-486-3p and interaction with ATP11B

Authors: Naijun Dong, Wenxin Qi, Lingling Wu, Jie Li, Xueqi Zhang, Hao Wu, Wen Zhang, Jiawen Jiang, Shibo Zhang, Wenjun Fu, Qian Liu, Guandong Qi, Lukai Wang, Yanyuan Lu, Jingyi Luo, Yanyan Kong, Yihao Liu, Robert Chunhua Zhao, Jiao Wang

Source: Journal of Experimental & Clinical Cancer Research, Vol 43, Iss 1, Pp 1-21 (2024)

Subject Terms: Glioblastoma (GBM), LINC00606, miR-486-3p, TCF12, ATP11B, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-9966

Access URL: https://doaj.org/article/d661b97e11d645a1a7e0243a6e33d39f

Targeting of REST with rationally-designed small molecule compounds exhibits synergetic therapeutic potential in human glioblastoma cells

Authors: Svetlana B. Panina, Joshua V. Schweer, Qian Zhang, Gaurav Raina, Haley A. Hardtke, Seungjin Kim, Wanjie Yang, Dionicio Siegel, Y. Jessie Zhang

Source: BMC Biology, Vol 22, Iss 1, Pp 1-22 (2024)

Subject Terms: Glioblastoma (GBM), Repressor element-1 silencing transcription factor, SCP1 phosphatase, Synergy, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1741-7007

Access URL: https://doaj.org/article/b58d579647434e908a08b19c276417dd

Fusing Multiple Deep Models for In Vivo Human Brain Hyperspectral Image Classification to Identify Glioblastoma Tumor

Authors: Hao, Q., Pei, Y., Zhou, R., Sun, B., Sun, J., Li, S., Kang, X.

Source: IEEE Transactions on Instrumentation and Measurement IEEE Trans. Instrum. Meas. Instrumentation and Measurement, IEEE Transactions on. 70:1-14 2021