An engineered chimeric toxin that cleaves activated mutant and wild-type RAS inhibits tumor growth

Authors: Vidimar, Vania, Beilhartz, Greg L., Park, Minyoung, Biancucci, Marco, Kieffer, Matthew B., Gius, David R., Melnyk, Roman A., Satchell, Karla J. F.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2020 Jul . 117(29), 16938-16948.

Access URL: https://www.jstor.org/stable/26935396

Regulation of KLF4 by posttranslational modification circuitry in endocrine resistance

Authors: Zhou, Zhuan, Song, Xinxin, Chi, Junlong (Jack), Gius, David R., Huang, Yi, Cristofanilli, Massimo, Wan, Yong

Source: In Cellular Signalling June 2020 70

SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer

Authors: He, Chenxia, Danes, Jeanne M., Hart, Peter C., Zhu, Yueming, Huang, Yunping, deAbreu, Andre Luelsdorf, O’Brien, Joseph, Mathison, Angela J., Tang, Binwu, Frasor, Jonna M., Wakefield, Lalage M., Ganini, Douglas, Stauder, Erich, Zielonka, Jacek, Gantner, Benjamin N., Urrutia, Raul A., Gius, David, Bonini, Marcelo G.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2019 Nov . 116(47), 23534-23541.

Access URL: https://www.jstor.org/stable/26861938

Mitochondrial ACSS1-K635 acetylation knock-in mice exhibit altered liver lipid metabolism on a ketogenic diet

Authors: Xu, Guogang ^{a, b}, Schell, Joseph ^{a, b}, Quan, Songhua ^c, Gao, Yucheng ^c, Wei, Sung-Jen ^{a, b}, Pan, Meixia ^b, Han, Xianlin ^b, Li, Guiming ^d, Zhou, Daohong ^d, Jiang, Haiyan ^{a, b}, Dong, Felix F. ^{a, b}, Munkácsy, Erin ^{a, b}, Horikoshi, Nobuo ^{a, b}, Gius, David ^{a, b, ⁎}

Source: In Free Radical Biology and Medicine May 2025 232:260-268

MnSOD non-acetylation mimic knock-in mice exhibit dilated cardiomyopathy

Authors: Schell, Joseph R. ^{a, b}, Wei, Sung-Jen ^{a, b}, Zhang, Jun ^b, Trevino, Rolando, Jr. ^{a, b}, Chen, Wan Hsi ^{a, b}, Aguilar, Leonardo ^c, Qian, Wei ^{d, e}, Corbett, Cole W. ^f, Jiang, Haiyan ^{a, b}, Dong, Felix F. ^{a, b}, Chocron, E. Sandra ^{a, b}, Nazarullah, Alia ^{a, g}, Chang, Jenny ^{d, e}, Flanagan, Margaret E. ^{f, g}, Glatt, Vaida ^{b, c}, Dikalov, Sergey ^h, Munkácsy, Erin ^{a, b}, Horikoshi, Nobuo ^{a, b}, Gius, David ^{a, ⁎}

Source: In Free Radical Biology and Medicine 1 March 2025 229:58-67

Efferocytosis Fuels Requirements of Fatty Acid Oxidation and the Electron Transport Chain to Polarize Macrophages for Tissue Repair

Authors: Zhang, Shuang, Weinberg, Samuel, DeBerge, Matthew, Gainullina, Anastasiia, Schipma, Matthew, Kinchen, Jason M., Ben-Sahra, Issam, Gius, David R., Yvan-Charvet, Laurent, Chandel, Navdeep S., Schumacker, Paul T., Thorp, Edward B.

Source: In Cell Metabolism 5 February 2019 29(2):443-456

Sirtuin 2–mediated deacetylation of cyclin-dependent kinase 9 promotes STAT1 signaling in type I interferon responses

Authors: Kosciuczuk, Ewa M., Mehrotra, Swarna, Saleiro, Diana, Kroczynska, Barbara, Majchrzak-Kita, Beata ^**, Lisowski, Pawel, Driehaus, Caroline, Rogalska, Anna, Turner, Acara, Lienhoop, Thomas, Gius, David, Fish, Eleanor N. ^**, Vassilopoulos, Athanassios, Platanias, Leonidas C.

Source: In Journal of Biological Chemistry 18 January 2019 294(3):827-837

Loss of Nrf2 promotes alveolar type 2 cell loss in irradiated, fibrotic lung

Authors: Traver, Geri, Mont, Stacey, Gius, David, Lawson, William E., Ding, George X., Sekhar, Konjeti R., Freeman, Michael L.

Source: In Free Radical Biology and Medicine November 2017 112:578-586

Prolonged fasting suppresses mitochondrial NLRP3 inflammasome assembly and activation via SIRT3-mediated activation of superoxide dismutase 2

Authors: Traba, Javier, Geiger, Sarah S., Kwarteng-Siaw, Miriam, Han, Kim, Ra, One Hyuk, Siegel, Richard M., Gius, David, Sack, Michael N.

Source: In Journal of Biological Chemistry 21 July 2017 292(29):12153-12164

Hypo-Phosphorylation of the Retinoblastoma Protein (pRb) by Cyclin D:Cdk4/6 Complexes Results in Active pRb

Authors: Ezhevsky, Sergei A., Nagahara, Hikaru, Vocero-Akbani, Adita M., Gius, David R., Wei, Michael C., Dowdy, Steven F.

Source: Proceedings of the National Academy of Sciences of the United States of America, 1997 Sep . 94(20), 10699-10704.

Access URL: https://www.jstor.org/stable/43401

ATRIP Deacetylation by SIRT2 Drives ATR Checkpoint Activation by Promoting Binding to RPA-ssDNA

Authors: Zhang, Hui, Head, PamelaSara E., Daddacha, Waaqo, Park, Seong-Hoon, Li, Xingzhe, Pan, Yunfeng, Madden, Matthew Z., Duong, Duc M., Xie, Maohua, Yu, Bing, Warren, Matthew D., Liu, Elaine A., Dhere, Vishal R., Li, Chunyang, Pradilla, Ivan, Torres, Mylin A., Wang, Ya, Dynan, William S., Doetsch, Paul W., Deng, Xingming, Seyfried, Nicholas T., Gius, David, Yu, David S.

Source: In Cell Reports 16 February 2016 14(6):1435-1447

Antioxidant inhibition of steady-state reactive oxygen species and cell growth in neuroblastoma

Authors: Zhu, Yueming, Paul, Pritha, Lee, Sora, Craig, Brian T., Rellinger, Eric J., Qiao, Jingbo, Gius, David R., Chung, Dai H.

Source: In Surgery September 2015 158(3):827-836

SIRT3 deacetylates and increases pyruvate dehydrogenase activity in cancer cells

Authors: Ozden, Ozkan, Park, Seong-Hoon, Wagner, Brett A., Yong Song, Ha, Zhu, Yueming, Vassilopoulos, Athanassios, Jung, Barbara, Buettner, Garry R., Gius, David

Source: In Free Radical Biology and Medicine November 2014 76:163-172

Decreased mitochondrial SIRT3 expression is a potential molecular biomarker associated with poor outcome in breast cancer

Authors: Desouki, Mohamed Mokhtar, Doubinskaia, Irina, Gius, David, Abdulkadir, Sarki A.

Source: In Human Pathology May 2014 45(5):1071-1077

Genotype and Tumor Locus Determine Expression Profile of Pseudohypoxic Pheochromocytomas and Paragangliomas

Authors: Shankavaram, Uma, Fliedner, Stephanie M.J., Elkahloun, Abdel G., Barb, Jenifer J., Munson, Peter J., Huynh, Thanh T., Matro, Joey C., Turkova, Hana, Linehan, W. Marston, Timmers, Henri J., Tischler, Arthur S., Powers, James F., de Krijger, Ronald, Baysal, Bora E., Takacova, Martina, Pastorekova, Silvia, Gius, David, Lehnert, Hendrik, Camphausen, Kevin, Pacak, Karel

Source: In Neoplasia April 2013 15(4):435

Circadian Clock NAD⁺ Cycle Drives Mitochondrial Oxidative Metabolism in Mice

Authors: Peek, Clara Bien, Affinati, Alison H., Ramsey, Kathryn Moynihan, Kuo, Hsin-Yu, Yu, Wei, Sena, Laura A., Ilkayeva, Olga, Marcheva, Biliana, Kobayashi, Yumiko, Omura, Chiaki, Levine, Daniel C., Bacsik, David J., Gius, David, Newgard, Christopher B., Goetzman, Eric, Chandel, Navdeep S., Denu, John M., Mrksich, Milan, Bass, Joseph

Source: Science, 2013 Nov 01. 342(6158), 591-591.

Access URL: http://dx.doi.org/10.1126/science.1243417

SIRT2 directs the replication stress response through CDK9 deacetylation

Authors: Zhang, Hui, Park, Seong-Hoon, Pantazides, Brooke G., Karpiuk, Oleksandra, Warren, Matthew D., Hardy, Claire W., Duong, Due M., Park, So-Jeong, Kim, Hyun-Seok, Vassilopoulos, Athanassios, Seyfried, Nicholas T., Johnsen, Steven A., Gius, David, Yu, David S.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2013 Aug . 110(33), 13546-13551.

Access URL: https://www.jstor.org/stable/42712944

Low-Dose Radiation-Induced Enhancement of Thymic Lymphomagenesis in Lck-Bax Mice is Dependent on LET and Gender

Authors: Jacobus, James A., Duda, Chester G., Coleman, Mitchell C., Martin, Sean M., Mapuskar, Kranti, Mao, Gaowei, Smith, Brian J., Aykin-Burns, Nukhet, Guida, Peter, Gius, David, Domann, Frederick E., Knudson, C. Michael, Spitz, Douglas R.

Source: Radiation Research, 2013 Aug 01. 180(2), 156-165.

Access URL: http://dx.doi.org/10.1667/RR3293.1

Exploring the electrostatic repulsion model in the role of Sirt3 in directing MnSOD acetylation status and enzymatic activity

Authors: Zhu, Yueming, Park, Seong-Hoon, Ozden, Ozkan, Kim, Hyun-Seok, Jiang, Haiyan, Vassilopoulos, Athanassios, Spitz, Douglas R., Gius, David

Source: In Free Radical Biology and Medicine 15 August 2012 53(4):828-833

Simultaneous inhibition of glutathione- and thioredoxin-dependent metabolism is necessary to potentiate 17AAG-induced cancer cell killing via oxidative stress

Authors: Scarbrough, Peter M., Mapuskar, Kranti A., Mattson, David M., Gius, David, Watson, Walter H., Spitz, Douglas R.

Source: In Free Radical Biology and Medicine 2012 52(2):436-443