Structural coordination of polymerization and crosslinking by a SEDS–bPBP peptidoglycan synthase complex

Authors: Sjodt, Megan, Rohs, Patricia D. A., Gilman, Morgan S. A., Erlandson, Sarah C., Zheng, Sanduo, Green, Anna G., Brock, Kelly P., Taguchi, Atsushi, Kahne, Daniel, Walker, Suzanne, Marks, Debora S., Rudner, David Z., Bernhardt, Thomas G., Kruse, Andrew C.

Source: Nature microbiology. 5(6):813-820

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174418910.0x000001&indx=1&recIds=ETOCvdc_100174418910.0x000001

Structure-Based Vaccine Antigen Design

Authors: Graham, Barney S., Gilman, Morgan S. A., McLellan, Jason S.

Source: Annual review of medicine. 70:91-104

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN619368847&indx=1&recIds=ETOCRN619368847

A new antibiotic traps lipopolysaccharide in its intermembrane transporter.

Authors: Pahil, Karanbir S., Gilman, Morgan S. A., Baidin, Vadim, Clairfeuille, Thomas, Mattei, Patrizio, Bieniossek, Christoph, Dey, Fabian, Muri, Dieter, Baettig, Remo, Lobritz, Michael, Bradley, Kenneth, Kruse, Andrew C., Kahne, Daniel

Source: Nature; Jan2024, Vol. 625 Issue 7995, p572-577, 6p

Structural and molecular basis for Ebola virus neutralization by protective human antibodies

Authors: Misasi, John, Gilman, Morgan S. A., Kanekiyo, Masaru, Gui, Miao, Cagigi, Alberto, Mulangu, Sabue, Corti, Davide, Ledgerwood, Julie E., Lanzavecchia, Antonio, Cunningham, James, Muyembe-Tamfun, Jean Jacques, Baxa, Ulrich, Graham, Barney S., Xiang, Ye, Sullivan, Nancy J., McLellan, Jason S.

Source: Science, 2016 Mar . 351(6279), 1343-1346.

Access URL: http://www.jstor.org/stable/24742404

Antibodies expand the scope of angiotensin receptor pharmacology

Authors: Skiba, Meredith A., Sterling, Sarah M., Rawson, Shaun, Zhang, Shuhao, Xu, Huixin, Jiang, Haoran, Nemeth, Genevieve R., Gilman, Morgan S. A., Hurley, Joseph D., Shen, Pengxiang, Staus, Dean P., Kim, Jihee, McMahon, Conor, Lehtinen, Maria K., Rockman, Howard A., Barth, Patrick, Wingler, Laura M., Kruse, Andrew C.

Source: Nature Chemical Biology; 20240101, Issue: Preprints p1-9, 9p

Transient opening of trimeric prefusion RSV F proteins

Authors: Gilman, Morgan S. A., Furmanova-Hollenstein, Polina, Pascual, Gabriel, B. van 't Wout, Angélique, Langedijk, Johannes P. M., McLellan, Jason S.

Source: Nature communications. 10(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131061569.0x000001&indx=1&recIds=ETOCvdc_100131061569.0x000001

Allosteric activation of cell wall synthesis during bacterial growth.

Authors: Shlosman, Irina, Fivenson, Elayne M., Gilman, Morgan S. A., Sisley, Tyler A., Walker, Suzanne, Bernhardt, Thomas G., Kruse, Andrew C., Loparo, Joseph J.

Source: Nature Communications; 6/10/2023, Vol. 14 Issue 1, p1-14, 14p

Subject Terms: MICROBIOLOGICAL synthesis, BACTERIAL growth, BACTERIAL cell walls, CROSSLINKING (Polymerization), CELL morphology, STRUCTURAL dynamics

Characterization of a Prefusion-Specific Antibody That Recognizes a Quaternary, Cleavage-Dependent Epitope on the RSV Fusion Glycoprotein.

Authors: Gilman, Morgan S. A.¹, Moin, Syed M.², Mas, Vicente³, Chen, Man², Patel, Nita K.⁴, Kramer, Kari⁴, Zhu, Qing⁴, Kabeche, Stephanie C.¹, Kumar, Azad², Palomo, Concepción³, Beaumont, Tim⁵, Baxa, Ulrich⁶, Ulbrandt, Nancy D.⁴, Melero, José A.³, Graham, Barney S.², McLellan, Jason S.¹ Jason.S.McLellan@Dartmouth.edu

Source: PLoS Pathogens. 7/10/2015, Vol. 11 Issue 7, p1-17. 17p.

Subject Terms: *IMMUNOGLOBULINS, *BLOOD proteins, *EPITOPES, *ANTIGENS, *GLYCOPROTEINS

Author Correction: A new antibiotic traps lipopolysaccharide in its intermembrane transporter.

Authors: Pahil, Karanbir S., Gilman, Morgan S. A., Baidin, Vadim, Clairfeuille, Thomas, Mattei, Patrizio, Bieniossek, Christoph, Dey, Fabian, Muri, Dieter, Baettig, Remo, Lobritz, Michael, Bradley, Kenneth, Kruse, Andrew C., Kahne, Daniel

Source: Nature; Jul2024, Vol. 631 Issue 8022, pE18-E18, 1p

Structural basis for recognition of the central conserved region of RSV G by neutralizing human antibodies.

Authors: Jones, Harrison G.¹, Ritschel, Tina², Pascual, Gabriel³, Brakenhoff, Just P. J.⁴, Keogh, Elissa³, Furmanova-Hollenstein, Polina², Lanckacker, Ellen⁵, Wadia, Jehangir S.⁶, Gilman, Morgan S. A.¹, Williamson, R. Anthony⁷, Roymans, Dirk⁵, van ‘t Wout, Angélique B.⁴, Langedijk, Johannes P.², HLangedi@its.jnj.com, McLellan, Jason S.¹, jmclellan@austin.utexas.edu

Source: PLoS Pathogens; 3/6/2018, Vol. 14 Issue 3, p1-23, 23p

Rapid generation of potent antibodies by autonomous hypermutation in yeast

Authors: Wellner, Alon, McMahon, Conor, Gilman, Morgan S. A., Clements, Jonathan R., Clark, Sarah, Nguyen, Kianna M., Ho, Ming H., Hu, Vincent J., Shin, Jung-Eun, Feldman, Jared, Hauser, Blake M., Caradonna, Timothy M., Wingler, Laura M., Schmidt, Aaron G., Marks, Debora S., Abraham, Jonathan, Kruse, Andrew C., Liu, Chang C.

Source: Nature Chemical Biology; October 2021, Vol. 17 Issue: 10 p1057-1064, 8p

Discovery of Sisunatovir (RV521), an Inhibitor of Respiratory Syncytial Virus Fusion

Authors: Cockerill, G. Stuart, Angell, Richard M., Bedernjak, Alexandre, Chuckowree, Irina, Fraser, Ian, Gascon-Simorte, Jose, Gilman, Morgan S. A., Good, James A. D., Harland, Rachel, Johnson, Sara M., Ludes-Meyers, John H, Littler, Edward, Lumley, James, Lunn, Graham, Mathews, Neil, McLellan, Jason S., Paradowski, Michael, Peeples, Mark E., Scott, Claire, Tait, Dereck, Taylor, Geraldine, Thom, Michelle, Thomas, Elaine, Villalonga Barber, Carol, Ward, Simon E., Watterson, Daniel, Williams, Gareth, Young, Paul, Powell, Kenneth

Source: Journal of Medicinal Chemistry; April 2021, Vol. 64 Issue: 7 p3658-3676, 19p

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Iterative screen optimization maximizes the efficiency of macromolecular crystallization.

Authors: Jones, Harrison G., Wrapp, Daniel, Gilman, Morgan S. A., Battles, Michael B., Wang, Nianshuang, Sacerdote, Sofia, Chuang, Gwo-Yu, Kwong, Peter D., McLellan, Jason S.

Source: Acta Crystallographica: Section F, Structural Biology Communications; Feb2019, Vol. 75 Issue 2, p123-131, 9p

Subject Terms: MATHEMATICAL optimization, MACROMOLECULAR dynamics, CRYSTALLIZATION

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Corrigendum: Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state.

Authors: Rossey, Iebe, Gilman, Morgan S. A., Kabeche, Stephanie C., Sedeyn, Koen, Wrapp, Daniel, Kanekiyo, Masaru, Chen, Man, Mas, Vicente, Spitaels, Jan, Melero, José A., Graham, Barney S., Schepens, Bert, McLellan, Jason S., Saelens, Xavier

Source: Nature Communications; Nov2017, Vol. 8 Issue 11, p16165, 1p