Urine steroid metabolomics as a diagnostic tool in primary aldosteronism

Authors: Prete, Alessandro, Lang, Katharina, Pavlov, David, Rhayem, Yara, Sitch, Alice J., Franke, Anna S., Gilligan, Lorna C., Shackleton, Cedric H.L., Hahner, Stefanie, Quinkler, Marcus, Dekkers, Tanja, Deinum, Jaap, Reincke, Martin, Beuschlein, Felix, Biehl, Michael, Arlt, Wiebke ^°

Source: In Journal of Steroid Biochemistry and Molecular Biology March 2024 237

Multi-steroid profiling by UHPLC-MS/MS with post-column infusion of ammonium fluoride

Authors: Schiffer, Lina, Shaheen, Fozia, Gilligan, Lorna C., Storbeck, Karl-Heinz, Hawley, James M., Keevil, Brian G., Arlt, Wiebke, Taylor, Angela E.

Source: In Journal of Chromatography B 15 October 2022 1209

Insights from the genetic characterization of central precocious puberty associated with multiple anomalies

Authors: Canton, Ana Pinheiro Machado, Krepischi, Ana Cristina Victorino, Montenegro, Luciana Ribeiro, Costa, Silvia, Rosenberg, Carla, Steunou, Virginie, Sobrier, Marie-Laure, Santana, Lucas, Honjo, Rachel Sayuri, Kim, Chong Ae, de Zegher, Francis, Idkowiak, Jan, Gilligan, Lorna C, Arlt, Wiebke, Funari, Mariana Ferreira de Assis, Jorge, Alexander Augusto de Lima, Mendonca, Berenice Bilharinho, Netchine, Irène, Brito, Vinicius Nahime, Latronico, Ana Claudia

Source: Human reproduction. 36(2):506-518

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100128204583.0x000001&indx=1&recIds=ETOCvdc_100128204583.0x000001

Urine steroid metabolomics for the differential diagnosis of adrenal incidentalomas in the EURINE-ACT study: a prospective test validation study

Authors: Glöckner, Stephan, Sinnott, Richard O., Stell, Anthony, Fragoso, Maria C., Kastelan, Darko, Pupovac, Ivana D., Simunov, Bojana, Cazenave, Sarah, Haissaguerre, Magalie, Tabarin, Antoine, Bertherat, Jérôme, Libé, Rossella, Kienitz, Tina, Quinkler, Marcus, Langton, Katharina, Eisenhofer, Graeme, Beuschlein, Felix, Brugger, Christina, Reincke, Martin, Riester, Anna, Spyroglou, Ariadni, Burger-Stritt, Stephanie, Deutschbein, Timo, Fassnacht, Martin, Hahner, Stefanie, Kroiss, Matthias, Ronchi, Cristina L., Palimeri, Sotiria, Tsagarakis, Stylianos, Tsirou, Ioanna, Vassiliadi, Dimitra A., Basile, Vittoria, Ingargiola, Elisa, Reimondo, Giuseppe, Terzolo, Massimo, Canu, Letizia, Mannelli, Massimo, Ettaieb, Hester, Haak, Harm R., Kerkhofs, Thomas M., Biehl, Michael, Feelders, Richard A., Hofland, Johannes, Hofland, Leo J., Grytaas, Marianne A., Husebye, Eystein S., Ueland, Grethe A., Ambroziak, Urszula, Bednarczuk, Tomasz, Kondracka, Agnieszka, Macech, Magdalena, Zawierucha, Malgorzata, Paiva, Isabel, Dennedy, M. Conall, Sajwani, Ahmed, Sherlock, Mark, Crowley, Rachel K., Ivovic, Miomira, Marina, Ljiljana, Deeks, Jonathan J., Sitch, Alice J., Arlt, Wiebke, Bancos, Irina, Chortis, Vasileios, Giligan, Lorna C., Hughes, Beverly A., Lang, Katharina, Ivison, Hannah E., Jenkinson, Carl, Manolopoulos, Konstantinos, O'Neil, Donna M., O'Reilly, Michael W., Papathomas, Thomas G., Prete, Alessandro, Shackleton, Cedric H.L., Taylor, Angela E., Asia, Miriam, Sutcliffe, Robert P., Guest, Peter, Skordilis, Kassiani, Bancos, Cristian, Chang, Alice, Davidge-Pitts, Caroline J., Delivanis, Danae A., Erickson, Dana, Natt, Neena, Nippoldt, Todd B., Thomas, Melinda, Young Jr., William F., Taylor, Angela E ^*, Sitch, Alice J, Davidge-Pitts, Caroline J, Pupovac, Ivana D, Papathomas, Thomas G, Gilligan, Lorna C, Grytaas, Marianne A, Ivison, Hannah E, Shackleton, Cedric H L, Ronchi, Cristina L, Delivanis, Danae A, Sutcliffe, Robert P, Feelders, Richard A, Haak, Harm R, Dennedy, M Conall, Ueland, Grethe A, Vassiliadi, Dimitra A, O'Reilly, Michael W, Young, William F, Jr, Deeks, Jonathan J

Source: In The Lancet Diabetes & Endocrinology September 2020 8(9):773-781

The A-ring reduction of 11-ketotestosterone is efficiently catalysed by AKR1D1 and SRD5A2 but not SRD5A1

Authors: Barnard, Lise, Nikolaou, Nikolaos, Louw, Carla, Schiffer, Lina, Gibson, Hylton, Gilligan, Lorna C., Gangitano, Elena, Snoep, Jacky, Arlt, Wiebke, Tomlinson, Jeremy W., Storbeck, Karl-Heinz ^*

Source: In Journal of Steroid Biochemistry and Molecular Biology September 2020 202

Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review

Authors: Schiffer, Lina, Barnard, Lise, Baranowski, Elizabeth S., Gilligan, Lorna C., Taylor, Angela E., Arlt, Wiebke, Shackleton, Cedric H.L., Storbeck, Karl-Heinz

Source: In Journal of Steroid Biochemistry and Molecular Biology November 2019 194

AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells

Authors: Nikolaou, Nikolaos, Gathercole, Laura L., Kirkwood, Lucy, Dunford, James E., Hughes, Beverly A., Gilligan, Lorna C., Oppermann, Udo, Penning, Trevor M., Arlt, Wiebke, Hodson, Leanne, Tomlinson, Jeremy W.

Source: In Journal of Steroid Biochemistry and Molecular Biology May 2019 189:218-227

11βHSD1 Inhibition with AZD4017 Improves Lipid Profiles and Lean Muscle Mass in Idiopathic Intracranial Hypertension

Authors: Hardy, Rowan S, Botfield, Hannah, Markey, Keira, Mitchell, James L, Alimajstorovic, Zerin, Westgate, Connar S J, Sagmeister, Michael, Fairclough, Rebecca J, Ottridge, Ryan S, Yiangou, Andreas, Storbeck, Karl-Heinz H, Taylor, Angela E, Gilligan, Lorna C, Arlt, Wiebke, Stewart, Paul M, Tomlinson, Jeremy W, Mollan, Susan P, Lavery, Gareth G, Sinclair, Alexandra J

Source: Journal of clinical endocrinology & metabolism. 106(1):174-187

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138371737.0x000001&indx=1&recIds=ETOCvdc_100138371737.0x000001

Mapping the Steroid Response to Major Trauma From Injury to Recovery: A Prospective Cohort Study

Authors: Foster, Mark A, Taylor, Angela E, Hill, Neil E, Bentley, Conor, Bishop, Jon, Gilligan, Lorna C, Shaheen, Fozia, Bion, Julian F, Fallowfield, Joanne L, Woods, David R, Bancos, Irina, Midwinter, Mark M, Lord, Janet M, Arlt, Wiebke

Source: Journal of clinical endocrinology & metabolism. 105(3):925-937

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100136537267.0x000001&indx=1&recIds=ETOCvdc_100136537267.0x000001

Natural History of Adrenal Steroidogenesis in Autoimmune Addison's Disease Following Diagnosis and Treatment

Authors: Napier, Catherine, Allinson, Kathleen, Gan, Earn H, Mitchell, Anna L, Gilligan, Lorna C, Taylor, Angela E, Arlt, Wiebke, Pearce, Simon H S

Source: Journal of clinical endocrinology & metabolism. 105(7):2322-2330

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100108983146.0x000001&indx=1&recIds=ETOCvdc_100108983146.0x000001

Altered cortisol metabolism in individuals with HNF1A‐MODY

Authors: Juszczak, Agata, Gilligan, Lorna C., Hughes, Beverly A., Hassan‐Smith, Zaki K., McCarthy, Mark I., Arlt, Wiebke, Tomlinson, Jeremy W., Owen, Katharine R.

Source: Clinical endocrinology. 93(3):269-279

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100108096583.0x000001&indx=1&recIds=ETOCvdc_100108096583.0x000001

Urine steroid metabolomics for the differential diagnosis of adrenal incidentalomas in the EURINE-ACT study: a prospective test validation study

Authors: Bancos, Irina, Taylor, Angela E, Chortis, Vasileios, Sitch, Alice J, Jenkinson, Carl, Davidge-Pitts, Caroline J, Lang, Katharina, Tsagarakis, Stylianos, Macech, Magdalena, Riester, Anna, Deutschbein, Timo, Pupovac, Ivana D, Kienitz, Tina, Prete, Alessandro, Papathomas, Thomas G, Gilligan, Lorna C, Bancos, Cristian, Reimondo, Giuseppe, Haissaguerre, Magalie, Marina, Ljiljana, Grytaas, Marianne A, Sajwani, Ahmed, Langton, Katharina, Ivison, Hannah E, Shackleton, Cedric H L, Erickson, Dana, Asia, Miriam, Palimeri, Sotiria, Kondracka, Agnieszka, Spyroglou, Ariadni, Ronchi, Cristina L, Simunov, Bojana, Delivanis, Danae A, Sutcliffe, Robert P, Tsirou, Ioanna, Bednarczuk, Tomasz, Reincke, Martin, Burger-Stritt, Stephanie, Feelders, Richard A, Canu, Letizia, Haak, Harm R, Eisenhofer, Graeme, Dennedy, M Conall, Ueland, Grethe A, Ivovic, Miomira, Tabarin, Antoine, Terzolo, Massimo, Quinkler, Marcus, Kastelan, Darko, Fassnacht, Martin, Beuschlein, Felix, Ambroziak, Urszula, Vassiliadi, Dimitra A, O'Reilly, Michael W, Young, William F, Biehl, Michael, Deeks, Jonathan J, Arlt, Wiebke

Source: Lancet.Diabetes & endocrinology. 8(9):773-781

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183251004.0x000001&indx=1&recIds=ETOCvdc_100183251004.0x000001

Effects of interleukin-1 receptor antagonism in women with polycystic ovary syndrome-- the FertIL trial.

Authors: Wälchli-Popovic, Milica, Monnerat, Sophie, Taylor, Angela E., Gilligan, Lorna C., Schiffer, Lina, Arlt, Wiebke, Vogt, Deborah R., De Geyter, Christian, Hutter, Nina, Donath, Marc Y., Sartorius, Gideon, Christ-Crain, Mirjam

Source: Frontiers in Endocrinology; 2024, p1-13, 13p

Subject Terms: POLYCYSTIC ovary syndrome, TANDEM mass spectrometry, INTERLEUKIN-1 receptors, END of treatment, C-reactive protein

Primary unilateral macronodular adrenal hyperplasia with concomitant glucocorticoid and androgen excess and KDM1A inactivation.

Authors: Elhassan, Yasir S, Appenzeller, Silke, Landwehr, Laura-Sophie, Lippert, Juliane, Popat, Dillon, Gilligan, Lorna C, Abdi, Lida, Goh, Edwina, Diaz-Cano, Salvador, Kircher, Stefan, Gramlich, Susanne, Sutcliffe, Robert P, Thangaratinam, Shakila, Chan, Li F, Fassnacht, Martin, Arlt, Wiebke, Ronchi, Cristina L

Source: European Journal of Endocrinology; Sep2024, Vol. 191 Issue 3, p334-344, 11p

Subject Terms: CUSHING'S syndrome, GENETIC variation, GENE expression, ADRENAL glands, WEIGHT gain, ADRENAL tumors

Urine Steroid Metabolomics as a Novel Tool for Detection of Recurrent Adrenocortical Carcinoma

Authors: Chortis, Vasileios, Bancos, Irina, Nijman, Thomas, Gilligan, Lorna C, Taylor, Angela E, Ronchi, Cristina L, O'Reilly, Michael W, Schreiner, Jochen, Asia, Miriam, Riester, Anna, Perotti, Paola, Libé, Rosella, Quinkler, Marcus, Canu, Letizia, Paiva, Isabel, Bugalho, Maria J, Kastelan, Darko, Dennedy, M Conall, Sherlock, Mark, Ambroziak, Urszula, Vassiliadi, Dimitra, Bertherat, Jerome, Beuschlein, Felix, Fassnacht, Martin, Deeks, Jonathan J, Biehl, Michael, Arlt, Wiebke

Source: Journal of clinical endocrinology & metabolism. 105(3):e307-e318

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100136536705.0x000001&indx=1&recIds=ETOCvdc_100136536705.0x000001

Inhibition of the glucocorticoid‐activating enzyme 11β‐hydroxysteroid dehydrogenase type 1 drives concurrent 11‐oxygenated androgen excess.

Authors: Schiffer, Lina, Oestlund, Imken, Snoep, Jacky L., Gilligan, Lorna C., Taylor, Angela E., Sinclair, Alexandra J., Singhal, Rishi, Freeman, Adrian, Ajjan, Ramzi, Tiganescu, Ana, Arlt, Wiebke, Storbeck, Karl‐Heinz

Source: FASEB Journal; 4/15/2024, Vol. 38 Issue 7, p1-18, 18p

Gonadal androgens are associated with decreased type I interferon production by plasmacytoid dendritic cells and increased IgG titres to BNT162b2 following co-vaccination with live attenuated influenza vaccine in adolescents.

Authors: Sampson, Oliver L., Jay, Cecilia, Adland, Emily, Csala, Anna, Lim, Nicholas, Ebbrecht, Stella M., Gilligan, Lorna C., Taylor, Angela E., George, Sherley Sherafin, Longet, Stephanie, Jones, Lucy C., Barnes, Ellie, Frater, John, Klenerman, Paul, Dunachie, Susie, Carrol, Miles, Hawley, James, Arlt, Wiebke, Groll, Andreas, Goulder, Philip

Source: Frontiers in Immunology; 2024, p1-12, 12p

Subject Terms: TYPE I interferons, INFLUENZA vaccines, DENDRITIC cells, PATTERN perception receptors, COVID-19 vaccines

Tissue Glucocorticoid Metabolism in Adrenal Insufficiency: A Prospective Study of Dual-release Hydrocortisone Therapy.

Authors: Dineen, Rosemary A., Martin-Grace, Julie, Saeed Ahmed, Khalid Mohamed, Taylor, Angela E., Shaheen, Fozia, Schiffer, Lina, Gilligan, Lorna C., Lavery, Gareth G., Frizelle, Isolda, Gunness, Anjuli, Garrahy, Aoife, Hannon, Anne Marie, Methlie, Paal, Eystein, Sverre Husebye, Stewart, Paul M., Tomlinson, Jeremy W., Hawley, James M., Keevil, Brian G., O'Reilly, Michael W., Smith, Diarmuid

Source: Journal of Clinical Endocrinology & Metabolism; Dec2023, Vol. 108 Issue 12, p3178-3189, 12p

Subject Terms: GLUCOCORTICOIDS, HYDROCORTISONE

The Regulation of Steroid Action by Sulfation and Desulfation

Authors: Mueller, Jonathan W., Gilligan, Lorna C., Idkowiak, Jan, Arlt, Wiebke, Foster, Paul A.

Source: Endocrine reviews. 36(5):526-563

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN603173828&indx=1&recIds=ETOCRN603173828

The ultra-acute steroid response to traumatic injury: a cohort study.

Authors: Bentley, Conor, Hazeldine, Jon, Bravo, Laura, Taylor, Angela E., Gilligan, Lorna C., Shaheen, Fozia, Acharjee, Animesh, Gkoutos, George, Foster, Mark A., Arlt, Wiebke, Lord, Janet M.

Source: European Journal of Endocrinology; Mar2023, Vol. 188 Issue 3, p290-299, 10p