2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer

Authors: Arnaud Blomme, Catriona A. Ford, Ernest Mui, Rachana Patel, Chara Ntala, Lauren E. Jamieson, Mélanie Planque, Grace H. McGregor, Paul Peixoto, Eric Hervouet, Colin Nixon, Mark Salji, Luke Gaughan, Elke Markert, Peter Repiscak, David Sumpton, Giovanny Rodriguez Blanco, Sergio Lilla, Jurre J. Kamphorst, Duncan Graham, Karen Faulds, Gillian M. MacKay, Sarah-Maria Fendt, Sara Zanivan, Hing Y. Leung

Source: Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/2a468699bc1a4fa682a39a1ff7c055bc

Stratification of cancer and diabetes based on circulating levels of formate and glucose

Authors: Matthias Pietzke, Salvador Fernandez Arroyo, David Sumpton, Gillian M. Mackay, Begoña Martin-Castillo, Jordi Camps, Jorge Joven, Javier A. Menendez, Alexei Vazquez, On behalf of the METTEN study group

Source: Cancer & Metabolism, Vol 7, Iss 1, Pp 1-11 (2019)

Subject Terms: Cancer, Obesity, Biomarker, Serum metabolomics, Formate, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40170-019-0195-x; https://doaj.org/toc/2049-3002

Access URL: https://doaj.org/article/22428ceb5f4d4fe69c3782cb5800a37f

Increased formate overflow is a hallmark of oxidative cancer

Authors: Johannes Meiser, Anne Schuster, Matthias Pietzke, Johan Vande Voorde, Dimitris Athineos, Kristell Oizel, Guillermo Burgos-Barragan, Niek Wit, Sandeep Dhayade, Jennifer P. Morton, Emmanuel Dornier, David Sumpton, Gillian M. Mackay, Karen Blyth, Ketan J. Patel, Simone P. Niclou, Alexei Vazquez

Source: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/3791b6fce2b1446482c02c147ec6dfd2

Methylglyoxal Scavengers Resensitize KRAS-Mutated Colorectal Tumors to Cetuximab

Authors: Justine Bellier, Marie-Julie Nokin, Maurine Caprasse, Assia Tiamiou, Arnaud Blomme, Jean L. Scheijen, Benjamin Koopmansch, Gillian M. MacKay, Barbara Chiavarina, Brunella Costanza, Gilles Rademaker, Florence Durieux, Ferman Agirman, Naïma Maloujahmoum, Pino G. Cusumano, Pierre Lovinfosse, Hing Y. Leung, Frédéric Lambert, Vincent Bours, Casper G. Schalkwijk, Roland Hustinx, Olivier Peulen, Vincent Castronovo, Akeila Bellahcène

Source: Cell Reports, Vol 30, Iss 5, Pp 1400-1416.e6 (2020)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124720300218; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/96932a30ac1e4a57b60f7bff8ef7fecf

Serine, but Not Glycine, Supports One-Carbon Metabolism and Proliferation of Cancer Cells

Authors: Christiaan F. Labuschagne, Niels J.F. van den Broek, Gillian M. Mackay, Karen H. Vousden, Oliver D.K. Maddocks

Source: Cell Reports, Vol 7, Iss 4, Pp 1248-1258 (2014)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124714003477; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/370608d8200d45b293c2978a651f7af3

THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer

Authors: Arnaud Blomme, Coralie Peter, Ernest Mui, Giovanny Rodriguez Blanco, Ning An, Louise M Mason, Lauren E Jamieson, Grace H McGregor, Sergio Lilla, Chara Ntala, Rachana Patel, Marc Thiry, Sonia H Y Kung, Marine Leclercq, Catriona A Ford, Linda K Rushworth, David J McGarry, Susan Mason, Peter Repiscak, Colin Nixon, Mark J Salji, Elke Markert, Gillian M MacKay, Jurre J Kamphorst, Duncan Graham, Karen Faulds, Ladan Fazli, Martin E Gleave, Edward Avezov, Joanne Edwards, Huabing Yin, David Sumpton, Karen Blyth, Pierre Close, Daniel J Murphy, Sara Zanivan, Hing Y Leung

Source: EMBO Molecular Medicine, Vol 14, Iss 3, Pp 1-21 (2022)

Subject Terms: ATF4, ER stress, lipid metabolism, prostate cancer, therapy resistance, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/0b32d6de175042e18b789240104f3924

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Self-Generated Chemoattractant Gradients: Attractant Depletion Extends the Range and Robustness of Chemotaxis.

Authors: Luke Tweedy, David A Knecht, Gillian M Mackay, Robert H Insall

Source: PLoS Biology, Vol 14, Iss 3, p e1002404 (2016)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1544-9173; https://doaj.org/toc/1545-7885

Access URL: https://doaj.org/article/524c118d62154f26928e9728b63632c6