A phosphodiesterase-4 inhibitor reduces lung inflammation and fibrosis in a hamster model of SARS-CoV-2 infection

Authors: Afsal Kolloli, Santhamani Ramasamy, Ranjeet Kumar, Annuurun Nisa, Gilla Kaplan, Selvakumar Subbian

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: COVID-19, inflammation, cytokine storm, host-directed therapy, lung function, fibrosis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1270414/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/7df68d239c564577bed46aaadc37938e

Aggregation state of Mycobacterium tuberculosis impacts host immunity and augments pulmonary disease pathology

Authors: Afsal Kolloli, Ranjeet Kumar, Pooja Singh, Anshika Narang, Gilla Kaplan, Alex Sigal, Selvakumar Subbian

Source: Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/9200d11ffb0243f6a25ca20a4c43df58

Aggregated Mycobacterium tuberculosis Enhances the Inflammatory Response

Authors: Hylton E. Rodel, Isabella A. T. M. Ferreira, Carly G. K. Ziegler, Yashica Ganga, Mallory Bernstein, Shi-Hsia Hwa, Kievershen Nargan, Gila Lustig, Gilla Kaplan, Mahdad Noursadeghi, Alex K. Shalek, Adrie J. C. Steyn, Alex Sigal

Source: Frontiers in Microbiology, Vol 12 (2021)

Subject Terms: Mycobacterium tuberculosis, TB pathogenesis, aggregation, inflammation, TNF-alpha, phagocytosis, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2021.757134/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/2c87105ebf6a454b849cec67673a9715

Capture and visualization of live Mycobacterium tuberculosis bacilli from tuberculosis patient bioaerosols.

Authors: Ryan Dinkele, Sophia Gessner, Andrea McKerry, Bryan Leonard, Ronnett Seldon, Anastasia S Koch, Carl Morrow, Melitta Gqada, Mireille Kamariza, Carolyn R Bertozzi, Brian Smith, Courtney McLoud, Andrew Kamholz, Wayne Bryden, Charles Call, Gilla Kaplan, Valerie Mizrahi, Robin Wood, Digby F Warner

Source: PLoS Pathogens, Vol 17, Iss 2, p e1009262 (2021)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/46d95117fb0e4fe0858db1757adc7738

The wide utility of rabbits as models of human diseases

Authors: Pedro J. Esteves, Joana Abrantes, Hanna-Mari Baldauf, Lbachir BenMohamed, Yuxing Chen, Neil Christensen, Javier González-Gallego, Lorenzo Giacani, Jiafen Hu, Gilla Kaplan, Oliver T. Keppler, Katherine L. Knight, Xiang-Peng Kong, Dennis K. Lanning, Jacques Le Pendu, Ana Lemos de Matos, Jia Liu, Shuying Liu, Ana M. Lopes, Shan Lu, Sheila Lukehart, Yukari C. Manabe, Fabiana Neves, Grant McFadden, Ruimin Pan, Xuwen Peng, Patricia de Sousa-Pereira, Ana Pinheiro, Masmudur Rahman, Natalie Ruvoën-Clouet, Selvakumar Subbian, Maria Jesús Tuñón, Wessel van der Loo, Michael Vaine, Laura E. Via, Shixia Wang, Rose Mage

Source: Experimental and Molecular Medicine, Vol 50, Iss 5, Pp 1-10 (2018)

Subject Terms: Medicine, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1226-3613; https://doaj.org/toc/2092-6413

Access URL: https://doaj.org/article/291d4ead9ccb4771a09c51a1a83754c4

Thalidomide and Phosphodiesterase 4 Inhibitors as Host Directed Therapeutics for Tuberculous Meningitis: Insights From the Rabbit Model

Authors: Ranjeet Kumar, Afsal Kolloli, Pooja Singh, Christopher Vinnard, Gilla Kaplan, Selvakumar Subbian

Source: Frontiers in Cellular and Infection Microbiology, Vol 9 (2020)

Subject Terms: tuberculosis, mycobacterium, cerebrospinal fluid, phosphodiesterase-4 inhibitors, inflammation, corticosteroid, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fcimb.2019.00450/full; https://doaj.org/toc/2235-2988

Access URL: https://doaj.org/article/187e48c31f8d43eca3657a8cfd55f56c

Frequency of Circulating CD4+Ki67+HLA-DR− T Regulatory Cells Prior to Treatment for Multidrug Resistant Tuberculosis Can Differentiate the Severity of Disease and Predict Time to Culture Conversion

Authors: Selena Ferrian, Melinda Ross, Francesca Conradie, Shaheed Vally Omar, Nazir Ismail, Francesca Little, Gilla Kaplan, Dorothy Fallows, Clive M. Gray

Source: Frontiers in Immunology, Vol 9 (2018)

Subject Terms: Treg cells, Mycobacteria tuberculosis, multi-drug resistant tuberculosis, lung cavities, sputum culture, smear grades, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2018.02438/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/280e6224004b4412b0fa398e8953f7ab

Adjunctive Phosphodiesterase-4 Inhibitor Therapy Improves Antibiotic Response to Pulmonary Tuberculosis in a Rabbit Model

Authors: Selvakumar Subbian, Liana Tsenova, Jennifer Holloway, Blas Peixoto, Paul O'Brien, Véronique Dartois, Vikram Khetani, Jerome B. Zeldis, Gilla Kaplan

Source: EBioMedicine, Vol 4, Iss C, Pp 104-114 (2016)

Subject Terms: Pulmonary tuberculosis, Immune modulation, Phosphodiesterase inhibitor, Lung fibrosis, Inflammation, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396416300111; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/f6df5ed8b2964f1d815adcb0d25e25ee

A combination of baseline plasma immune markers can predict therapeutic response in multidrug resistant tuberculosis.

Authors: Selena Ferrian, Claudia Manca, Sugnet Lubbe, Francesca Conradie, Nazir Ismail, Gilla Kaplan, Clive M Gray, Dorothy Fallows

Source: PLoS ONE, Vol 12, Iss 5, p e0176660 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5413057?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/0b574b0aeef14094ad2f1804e0d6eded

Correlation of rpoB mutations with minimal inhibitory concentration of Rifampin and Rifabutin in Mycobacterium tuberculosis in an HIV/AIDS endemic setting, South Africa

Authors: Ivy - Rukasha, Halima Mohammed Said, Shaheed Vally Omar, Hendrik - Koornhoof, Andries W Dreyer, Alfred - Musekiwa, Harry Moultrie, Anwar A Hoosen, Gilla Kaplan, Dorothy Fallows, Nazir Ismail

Source: Frontiers in Microbiology, Vol 7 (2016)

Subject Terms: Mycobacterium tuberculosis, Point Mutation, Rifabutin, South Africa, rifampicin, hiv/aids, Microbiology, QR1-502

File Description: electronic resource

Relation: http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01947/full; https://doaj.org/toc/1664-302X

Access URL: https://doaj.org/article/bd88654063d447439ecf05c202046c71

‘ZS-MDR-TB’ versus ‘ZR-MDR-TB’: improving treatment of MDR-TB by identifying pyrazinamide susceptibility

Authors: Ying Zhang, Kwok Chiu Chang, Chi-Chiu Leung, Wing Wai Yew, Brigitte Gicquel, Dorothy Fallows, Gilla Kaplan, Richard E Chaisson, Wenhong Zhang

Source: Emerging Microbes and Infections, Vol 1, Iss 1, Pp 1-4 (2012)

Subject Terms: MDR-TB, pncA, pyrazinamide, susceptibility testing, therapy, tuberculosis, Infectious and parasitic diseases, RC109-216, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2222-1751

Access URL: https://doaj.org/article/dd3a953ee56a4f929c38f9f3556a62f4

Translational Research for Tuberculosis Elimination: Priorities, Challenges, and Actions.

Authors: Christian Lienhardt, Knut Lönnroth, Dick Menzies, Manica Balasegaram, Jeremiah Chakaya, Frank Cobelens, Jennifer Cohn, Claudia M Denkinger, Thomas G Evans, Gunilla Källenius, Gilla Kaplan, Ajay M V Kumar, Line Matthiessen, Charles S Mgone, Valerie Mizrahi, Ya-Diul Mukadi, Viet Nhung Nguyen, Anders Nordström, Christine F Sizemore, Melvin Spigelman, S Bertel Squire, Soumya Swaminathan, Paul D Van Helden, Alimuddin Zumla, Karin Weyer, Diana Weil, Mario Raviglione

Source: PLoS Medicine, Vol 13, Iss 3, p e1001965 (2016)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1549-1277; https://doaj.org/toc/1549-1676

Access URL: https://doaj.org/article/56795b672f764a11bdfbae85e33b193f

A Novel Molecular Strategy for Surveillance of Multidrug Resistant Tuberculosis in High Burden Settings.

Authors: Halima M Said, Nicole Kushner, Shaheed V Omar, Andries W Dreyer, Hendrik Koornhof, Linda Erasmus, Yasmin Gardee, Ivy Rukasha, Elena Shashkina, Natalie Beylis, Gilla Kaplan, Dorothy Fallows, Nazir A Ismail

Source: PLoS ONE, Vol 11, Iss 1, p e0146106 (2016)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4713439?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/7725a3f2f8a044a2853ebb25af765205

Lesion-Specific Immune Response in Granulomas of Patients with Pulmonary Tuberculosis: A Pilot Study.

Authors: Selvakumar Subbian, Liana Tsenova, Mi-Jeong Kim, Helen C Wainwright, Annalie Visser, Nirmalya Bandyopadhyay, Joel S Bader, Petros C Karakousis, Gabriele B Murrmann, Linda-Gail Bekker, David G Russell, Gilla Kaplan

Source: PLoS ONE, Vol 10, Iss 7, p e0132249 (2015)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4489805?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/16167bfc738a42f19540f6b99a0839c0

A subset of circulating blood mycobacteria-specific CD4 T cells can predict the time to Mycobacterium tuberculosis sputum culture conversion.

Authors: Catherine Riou, Clive M Gray, Masixole Lugongolo, Thabisile Gwala, Agano Kiravu, Pamela Deniso, Lynsey Stewart-Isherwood, Shaheed Vally Omar, Martin P Grobusch, Gerrit Coetzee, Francesca Conradie, Nazir Ismail, Gilla Kaplan, Dorothy Fallows

Source: PLoS ONE, Vol 9, Iss 7, p e102178 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4105550?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/84279f6ecc79469db9d88512e7b3c1eb

Host targeted activity of pyrazinamide in Mycobacterium tuberculosis infection.

Authors: Claudia Manca, Mi-Sun Koo, Blas Peixoto, Dorothy Fallows, Gilla Kaplan, Selvakumar Subbian

Source: PLoS ONE, Vol 8, Iss 8, p e74082 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3755974?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/e867ba0ee92247139904edd78d3e5a4a

Genetic variation in TLR genes in Ugandan and South African populations and comparison with HapMap data.

Authors: Allison R Baker, Feiyou Qiu, April Kaur Randhawa, David J Horne, Mark D Adams, Muki Shey, Jill Barnholtz-Sloan, Harriet Mayanja-Kizza, Gilla Kaplan, Willem A Hanekom, W Henry Boom, Thomas R Hawn, Catherine M Stein, Tuberculosis Research Unit and South African Tuberculosis Vaccine Initiative Team

Source: PLoS ONE, Vol 7, Iss 10, p e47597 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3480404?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/1234d6fa91e74d0c86ff9b89e355e15b

Effect of standard tuberculosis treatment on plasma cytokine levels in patients with active pulmonary tuberculosis.

Authors: Catherine Riou, Blas Perez Peixoto, Lindi Roberts, Katharina Ronacher, Gerhard Walzl, Claudia Manca, Roxana Rustomjee, Thuli Mthiyane, Dorothy Fallows, Clive M Gray, Gilla Kaplan

Source: PLoS ONE, Vol 7, Iss 5, p e36886 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3351475?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/6e697aed8d264995be5897740f472dcf

Phosphodiesterase-4 inhibition alters gene expression and improves isoniazid-mediated clearance of Mycobacterium tuberculosis in rabbit lungs.

Authors: Selvakumar Subbian, Liana Tsenova, Paul O'Brien, Guibin Yang, Mi-Sun Koo, Blas Peixoto, Dorothy Fallows, Veronique Dartois, George Muller, Gilla Kaplan

Source: PLoS Pathogens, Vol 7, Iss 9, p e1002262 (2011)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3174258?pdf=render; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/05f5258dcd2f4fbc8ca0de57d17de563

Association of human TLR1 and TLR6 deficiency with altered immune responses to BCG vaccination in South African infants.

Authors: April Kaur Randhawa, Muki S Shey, Alana Keyser, Blas Peixoto, Richard D Wells, Marwou de Kock, Lesedi Lerumo, Jane Hughes, Gregory Hussey, Anthony Hawkridge, Gilla Kaplan, Willem A Hanekom, Thomas R Hawn, South African Tuberculosis Vaccine Initiative Team

Source: PLoS Pathogens, Vol 7, Iss 8, p e1002174 (2011)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3154845?pdf=render; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/28d80e4872fc46ada9936e6fa622d3e3