Evaluation of prognostic scores in patients with HCC undergoing first-line immunotherapy with atezolizumab and bevacizumab

Authors: Gairing, Simon Johannes ¹, Mildenberger, Philipp ², Gile, Jennifer ³, Artusa, Fabian ⁴, Scheiner, Bernhard ⁵, Leyh, Catherine ⁶, Lieb, Sabine ⁷, Sinner, Friedrich ⁸, Jörg, Vincent ⁹, Fruendt, Thorben ⁹, Himmelsbach, Vera ¹⁰, Abedin, Nada ¹⁰, Sahin, Cennet ¹¹, Böttcher, Katrin ¹², Schuhbaur, Jasmin ¹³, Labuhn, Simon ¹⁴, Korolewicz, James ¹⁵, Fulgenzi, Claudia A.M. ¹⁵, D'Alessio, Antonio ¹⁵, Zanuso, Valentina ^{16, 17}, Hucke, Florian ¹⁸, Röhlen, Natascha ¹⁹, Ben Khaled, Najib ²⁰, Ramadori, Eleonora ²¹, Müller, Lukas ²², Weinmann, Arndt ¹, Kloeckner, Roman ²³, Galle, Peter Robert ¹, Tran, Nguyen H. ³, Venkatesh, Sudhakar K. ²⁴, Teufel, Andreas ^{25, 26}, Ebert, Matthias ^{26, 27}, De Toni, Enrico N. ²⁰, Waldschmidt, Dirk-Thomas ²¹, Marquardt, Jens U. ²⁸, Bettinger, Dominik ¹⁹, Peck-Radosavljevic, Markus ¹⁸, Geier, Andreas ²⁹, Reiter, Florian P. ²⁹, Rimassa, Lorenza ^{16, 17}, Pinato, David J. ^{15, 30}, Roderburg, Christoph ¹⁴, Ettrich, Thomas ¹³, Bitzer, Michael ³¹, Scheble, Veit ³¹, Ehmer, Ursula ¹², Berres, Marie-Luise ¹¹, Finkelmeier, Fabian ¹⁰, Gonzalez-Carmona, Maria Angeles ³², von Felden, Johann ⁹, Schulze, Kornelius ⁹, Venerito, Marino ⁸, van Bömmel, Florian ⁷, Jochheim, Leonie S. ⁶, Pinter, Matthias ⁵, Mohr, Raphael ⁴, Ilyas, Sumera I. ³³, Schmidtmann, Irene ², Foerster, Friedrich ^{1, ⁎}

Source: In JHEP Reports March 2025 7(3)

Hypomagnesemia in lymphoma patients receiving CAR T therapy correlates with immune dysfunction and decreased survival.

Authors: Gile, Jennifer J.¹ (AUTHOR) Gile.Jennifer@mayo.edu, Mondello, Patrizia¹ (AUTHOR) Mondello.Patrizia@Mayo.edu, Wang, Zixing² (AUTHOR) zwang2@kitepharma.com, Li, Ying¹ (AUTHOR) Li.Ying@mayo.edu, Bansal, Radhika¹ (AUTHOR) Bansal.Radhika@mayo.edu, Gandhi, Sangeetha¹ (AUTHOR) gandhi.sangeetha@mayo.edu, Zhang, Henan¹ (AUTHOR) Zhang.Henan@mayo.edu, Babadi, Elham¹ (AUTHOR) babadi.elham@mayo.edu, Martinez, Kodi¹ (AUTHOR) Martinez.Kodi@mayo.edu, McCoy, Gabrielle³ (AUTHOR) mccoy.gabrielle@mayo.edu, Shao, Zuoyi¹ (AUTHOR) Shao.Zuoyi@mayo.edu, Regan, Kevin¹ (AUTHOR) regan.kevin@mayo.edu, Hathcock, Matthew A.¹ (AUTHOR) Hathcock.Matthew@mayo.edu, Wang, Panwen³ (AUTHOR) wang.panwen@mayo.edu, Wang, Junwen³ (AUTHOR) wang.junwen@mayo.edu, Al Saleh, Abdullah S.¹ (AUTHOR) alsaleh.abdulla@mayo.edu, Ruan, Gordon¹ (AUTHOR) Ruan.Gordon@Mayo.edu, Ansell, Stephen M.¹ (AUTHOR) Ansell.stephen@mayo.edu, Bennani, N. Nora¹ (AUTHOR) Bennani.Nora@mayo.edu, Johnston, Patrick B.¹ (AUTHOR) johnston.patrick@mayo.edu

Source: Experimental Hematology & Oncology. 4/30/2025, Vol. 14 Issue 1, p1-13. 13p.

Subject Terms: *HYPOMAGNESEMIA, *SURVIVAL rate, *LYMPHOMAS, *IMMUNOLOGIC diseases, *BIOMARKERS, *PROGNOSIS, *CHIMERIC antigen receptors, *CYTOKINES

Outcomes of Patients with Advanced Hepatocellular Carcinoma Receiving Lenvatinib following Immunotherapy: A Real World Evidence Study.

Authors: Palmer, Mathias E.¹ (AUTHOR) palmer.mathias@mayo.edu, Gile, Jennifer J.² (AUTHOR) gile.jennifer@mayo.edu, Storandt, Michael H.¹ (AUTHOR) storandt.michael@mayo.edu, Jin, Zhaohui² (AUTHOR) jin.zhaohui@mayo.edu, Zemla, Tyler J.³ (AUTHOR) zemla.tyler@mayo.edu, Tran, Nguyen H.² (AUTHOR) tran.nguyen@mayo.edu, Mahipal, Amit^2,4 (AUTHOR) amit.mahipal@uhhospitals.org

Source: Cancers. Oct2023, Vol. 15 Issue 19, p4867. 12p.

Subject Terms: *THERAPEUTIC use of antineoplastic agents, *DRUG efficacy, *DISEASE progression, *RESEARCH, *TIME, *MULTIVARIATE analysis, *RETROSPECTIVE studies, *RACE, *METASTASIS, *SEX distribution, *RESEARCH funding, *PROGRESSION-free survival, *BODY mass index, *HEPATOCELLULAR carcinoma, *IMMUNOTHERAPY, *OVERALL survival

Low magnesium levels and prognosis in newly diagnosed diffuse large B-cell lymphoma.

Authors: Gile, Jennifer J, Maurer, Matthew, Ruan, Gordon J, Abeykoon, Jithma P, Heimgartner, Joy R, Baumann, Nikola A, McMahon, Molly, Lin, Yi, Witzig, Thomas E

Source: Oncologist; Dec2024, Vol. 29 Issue 12, pe1779-e1782, 4p

Subject Terms: HEMATOPOIETIC stem cell transplantation, REFERENCE values, MAGNESIUM, RESEARCH funding, MAGNESIUM compounds, CANCER patients, TREATMENT effectiveness, DESCRIPTIVE statistics, SURVIVAL analysis (Biometry), TUMOR classification, DATA analysis software, B cell lymphoma

Magnesium: The overlooked electrolyte in blood cancers?

Authors: Gile, Jennifer, Ruan, Gordon, Abeykoon, Jithma, McMahon, M. Molly, Witzig, Thomas

Source: In Blood Reviews November 2020 44

37-Year-Old Woman With Bilateral Lower Extremity Edema, Proteinuria, and Microscopic Hematuria

Authors: Gile, Jennifer J., Satterfield, Benjamin A., Leasure, Emily L.

Source: In Mayo Clinic Proceedings August 2020 95(8):e81-e86

Efficacy of first‐line checkpoint inhibitors in combination with chemotherapy in high‐grade extrapulmonary metastatic neuroendocrine carcinomas.

Authors: Gile, Jennifer J.¹ (AUTHOR), McGarrah, Patrick W.¹ (AUTHOR), Leventakos, Konstantinos¹ (AUTHOR), Sonbol, Mohamad B.² (AUTHOR), Starr, Jason S.³ (AUTHOR), Eiring, Rachel A.¹ (AUTHOR), Hobday, Timothy J.¹ (AUTHOR), Halfdanarson, Thorvardur R.¹ (AUTHOR) halfdanarson.thorvardur@mayo.edu

Source: Journal of Neuroendocrinology. May2023, Vol. 35 Issue 5, p1-4. 4p.

Subject Terms: *NEUROENDOCRINE tumors, *COMBINATION drug therapy, *SMALL cell carcinoma, *CANCER chemotherapy, *TUMOR growth, *IPILIMUMAB, *PEMETREXED

Atezolizumab plus bevacizumab as first-line systemic therapy for hepatocellular carcinoma: a multi-institutional cohort study.

Authors: Storandt, Michael H, Zemla, Tyler J, Patell, Kanchi, Naleid, Nikolas, Gile, Jennifer J, Tran, Nguyen H, Chakrabarti, Sakti, Jin, Zhaohui, Borad, Mitesh, Mahipal, Amit

Source: Oncologist; Nov2024, Vol. 29 Issue 11, p986-996, 11p

Subject Terms: THERAPEUTIC use of antineoplastic agents, THERAPEUTIC use of monoclonal antibodies, PREDICTIVE tests, BEVACIZUMAB, TREATMENT effectiveness, MULTIVARIATE analysis, DESCRIPTIVE statistics, FUNCTIONAL status, RETROSPECTIVE studies, LONGITUDINAL method, KAPLAN-Meier estimator, RESEARCH, HEPATITIS B, CANCER patient psychology, HEPATOCELLULAR carcinoma, LIVER function tests, OVERALL survival, PROPORTIONAL hazards models

Geographic Terms: UNITED States

Outcomes of Invasive Fungal Infections Treated with Isavuconazole: A Retrospective Review.

Authors: Gow-Lee, Vanessa, Abu Saleh, Omar M., Harris, Courtney E., Gile, Jennifer J., Akhiyat, Nadia, Chesdachai, Supavit

Source: Pathogens; Oct2024, Vol. 13 Issue 10, p886, 7p

Subject Terms: CENTRAL nervous system infections, PULMONARY aspergillosis, MYCOSES, SALVAGE therapy, CENTRAL nervous system

Cabozantinib Following Immunotherapy in Patients with Advanced Hepatocellular Carcinoma.

Authors: Storandt, Michael H.¹ (AUTHOR), Gile, Jennifer J.² (AUTHOR), Palmer, Mathias E.¹ (AUTHOR), Zemla, Tyler J.³ (AUTHOR), Ahn, Daniel H.⁴ (AUTHOR), Bekaii-Saab, Tanios S.⁴ (AUTHOR), Jin, Zhaohui² (AUTHOR), Tran, Nguyen H.² (AUTHOR), Mahipal, Amit^2,5 (AUTHOR) amit.mahipal@uhhospitals.org

Source: Cancers. Nov2022, Vol. 14 Issue 21, p5173. 10p.

Subject Terms: *THERAPEUTIC use of antineoplastic agents, *RESEARCH, *DISEASE progression, *CONFIDENCE intervals, *RETROSPECTIVE studies, *TREATMENT effectiveness, *SURVIVAL analysis (Biometry), *KAPLAN-Meier estimator, *DESCRIPTIVE statistics, *PROGRESSION-free survival, *HEPATOCELLULAR carcinoma, *IMMUNOTHERAPY

Geographic Terms: FLORIDA, ARIZONA

Multiinstitutional cohort study of patient outcomes in Child-Pugh (CP) B liver function treated with atezolizumab plus bevacizumab (A+B) for hepatocellular carcinoma (HCC).

Authors: Mahipal, Amit¹ (AUTHOR), Zemla, Tyler J.² (AUTHOR), Patell, Kanchi³ (AUTHOR), Naleid, Nikolas⁴ (AUTHOR), Gile, Jennifer² (AUTHOR), Jin, Zhaohui⁵ (AUTHOR), Tran, Nguyen H.⁵ (AUTHOR), Borad, Mitesh⁶ (AUTHOR), Chakrabarti, Sakti⁷ (AUTHOR), Storandt, Michael H.² (AUTHOR)

Source: Journal of Clinical Oncology. 2024 Supplement, Vol. 42, p50-50. 48p.

Sleep impairment and reduced interneuron excitability in a mouse model of Dravet Syndrome

Authors: Kalume, Franck, Oakley, John C., Westenbroek, Ruth E., Gile, Jennifer, de la Iglesia, Horacio O., Scheuer, Todd, Catterall, William A.

Source: In Neurobiology of Disease May 2015 77:141-154

Evolving treatment patterns and improved outcomes in relapsed/refractory mantle cell lymphoma: a prospective cohort study.

Authors: Bock, Allison M., Gile, Jennifer J., Larson, Melissa C., Poonsombudlert, Kittika, Tawfiq, Reema K., Maliske, Seth, Maurer, Matthew J., Kabat, Brian F., Paludo, Jonas, Inwards, David J., Ayyappan, Sabarish, Link, Brian K., Ansell, Stephen M., Habermann, Thomas M., Witzig, Thomas E., Nowakowski, Grzegorz S., Cerhan, James R., Farooq, Umar, Wang, Yucai

Source: Blood Cancer Journal; 11/13/2023, Vol. 13 Issue 1, p1-9, 9p

Subject Terms: COHORT analysis, LONGITUDINAL method, SURVIVAL rate

Clinical Outcomes in Patients with Mantle Cell Lymphoma Who Received Autologous Stem Cell Transplant in the Second Line Setting

Authors: Gile, Jennifer Jane, Bock, Allison M., Tawfiq, Reema K. ^*, Larson, Melissa C. ^*, Poonsombudlert, Kittika, Maliske, Seth M., Maurer, Matthew J., Cerhan, James R., Kabat, Brian ^*, Gysbers, Brianna ^*, Smith, Katherine ^*, Hwang, Steven R, Inwards, David J., Paludo, Jonas, Ansell, Stephen M., Habermann, Thomas M., Ayyappan, Sabarish, Witzig, Thomas E., Nowakowski, Grzegorz S., Farooq, Umar, Wang, Yucai

Source: In Blood 15 November 2022 140 Supplement 1:6517-6519

Treatment Patterns and Outcomes in Relapsed/Refractory Mantle Cell Lymphoma

Authors: Tawfiq, Reema K. ^*, Larson, Melissa C. ^*, Gile, Jennifer Jane, Bock, Allison M., Poonsombudlert, Kittika, Maliske, Seth M., Maurer, Matthew J., Cerhan, James R., Kabat, Brian ^*, Smith, Katherine ^*, Godby, Richard Curtis, Paludo, Jonas, Inwards, David J., Ayyappan, Sabarish, Ansell, Stephen M., Habermann, Thomas M., Witzig, Thomas E., Nowakowski, Grzegorz S., Farooq, Umar, Wang, Yucai

Source: In Blood 15 November 2022 140 Supplement 1:6489-6491

OS-079-YI Development and validation of the CABLE score to estimate individual prognosis of patients with hepatocellular carcinoma treated with 1L atezolizumab and bevacizumab

Authors: Gairing, Simon Johannes, Mildenberger, Philipp, Gile, Jennifer, Artusa, Fabian, Scheiner, Bernhard, Leyh, Catherine, Lieb, Sabine, Sinner, Friedrich, Jörg, Vincent, Fruendt, Thorben, Himmelsbach, Vera, Abedin, Nada, Sahin, Cennet, Boettcher, Katrin, Schuhbaur, Jasmin, Labuhn, Simon, Korolewicz, James, Fulgenzi, Claudia, D'Alessio, Antonio, Zanuso, Valentina, Hucke, Florian, Röhlen, Natascha, Khaled, Najib Ben, Ramadori, Eleonora, Müller, Lukas, Weinmann, Arndt, Kloeckner, Roman, Galle, Peter R., Tran, Nguyen H., Venkatesh, Sudhakar, Teufel, Andreas, de Toni, Enrico, Waldschmidt, Dirk-Thomas, Marquardt, Jens U., Bettinger, Dominik, Peck-Radosavljevic, Markus, Geier, Andreas, Reiter, Florian P, Rimassa, Lorenza, Pinato, David J., Roderburg, Christoph, Ettrich, Thomas, Bitzer, Michael, Scheble, Veit, Ehmer, Ursula, Berres, Marie-Luise, Finkelmeier, Fabian, Gonzalez-Carmona, Maria Angeles, von Felden, Johann, Schulze, Kornelius, Venerito, Marino, van Bömmel, Florian, Jochheim, Leonie, Pinter, Matthias, Mohr, Raphael, Ilyas, Sumera I., Schmidtmann, Irene, Foerster, Friedrich

Source: In Journal of Hepatology June 2024 80 Supplement 1:S52-S52

Hypomagnesemia is associated with an increased risk of early clinical failure in patients with Burkitt lymphoma.

Authors: Gile, Jennifer¹ (AUTHOR), Ruan, Gordon¹ (AUTHOR), Abeykoon, Jithma¹ (AUTHOR), McMahon, M. Molly² (AUTHOR), Macon, William R.³ (AUTHOR), Witzig, Thomas E.¹ (AUTHOR) Witzig.Thomas@Mayo.Edu

Source: Leukemia & Lymphoma. Sep2020, Vol. 61 Issue 9, p2274-2276. 3p.

Subject Terms: *GRASS tetany, *BURKITT'S lymphoma, *EPSTEIN-Barr virus diseases

Durvalumab: A PD-L1 Blocking Antibody for the Treatment of Adult Patients with Locally Advanced or Metastatic Biliary Tract Cancer.

Authors: Mahipal, Amit, Palmer, Mathias, Gile, Jennifer, Kim, Richard

Source: touchREVIEWS in Oncology & Haematology; 2023, Vol. 19 Issue 1, p22-26, 5p

Subject Terms: BILIARY tract cancer, GALLBLADDER cancer, CLINICAL trials, PROGRAMMED death-ligand 1, ADULTS, IMMUNE checkpoint inhibitors

Company/Entity: UNITED States. Food & Drug Administration

ABCL-673 Single Cell Analysis Reveals Immune Dysfunction in Large B-Cell Lymphoma (LBCL) Patients With Hypomagnesemia Receiving Axi-Cel: Results from ZUMA-1 Trial and Mayo Clinic Cohort

Authors: Mondello, Patrizia, Gile, Jennifer, Wang, Zixing, Li, Ying, Bansal, Radhika, Gandhi, Sangeetha, Zhang, Henan, Babadi, Elham, Martinez, Kodi, McCoy, Gabrielle, Shao, Zuoyi, Regan, Keven, Hathcock, Matthew, Wang, Panwen, Wang, Wang, Al Saleh, Abdullah, Ruan, Gordon, Yang, Zhi Zhang, Paludo, Jonas, Villasboas, Jose, Khurana, Arushi, Durani, Urshila, Wang, Yucai, Hampel, Paul, Rosenthal, Allison, Munoz, Javier, Moreno, Eider, Castro, Januario, Murthy, Murthy, Kharfan-Dabaja, Mohamed, Kenderian, Saad, Mattie, Mike, Bot, Adrian, Rossi, John, Witzig, Thomas, Lin, Yi

Source: In Clinical Lymphoma, Myeloma and Leukemia September 2023 23 Supplement 1:S445-S446

POSTER: ABCL-673 Single Cell Analysis Reveals Immune Dysfunction in Large B-Cell Lymphoma (LBCL) Patients With Hypomagnesemia Receiving Axi-Cel: Results from ZUMA-1 Trial and Mayo Clinic Cohort

Authors: Mondello, Patrizia, Gile, Jennifer, Wang, Zixing, Li, Ying, Bansal, Radhika, Gandhi, Sangeetha, Zhang, Henan, Babadi, Elham, Martinez, Kodi, McCoy, Gabrielle, Shao, Zuoyi, Regan, Keven, Hathcock, Matthew, Wang, Panwen, Wang, Wang, Al Saleh, Abdullah, Ruan, Gordon, Yang, Zhi Zhang, Paludo, Jonas, Villasboas, Jose, Khurana, Arushi, Durani, Urshila, Wang, Yucai, Hampel, Paul, Rosenthal, Allison, Munoz, Javier, Moreno, Eider, Castro, Januario, Murthy, Murthy, Kharfan-Dabaja, Mohamed, Kenderian, Saad, Mattie, Mike, Bot, Adrian, Rossi, John, Witzig, Thomas, Lin, Yi

Source: In Clinical Lymphoma, Myeloma and Leukemia September 2023 23 Supplement 1:S204-S204