Effect of a 2-week interruption in methotrexate treatment on COVID-19 vaccine response in people with immune-mediated inflammatory diseases (VROOM study): a randomised, open label, superiority trial

Authors: Pande, Ira, Tang, Ting Seng, Tran, Gui, Layton, Alison, Price, Elizabeth, Whittam, Lindsay, Venkatachalam, Srinivasan, Huws, Gwenan, Pratt, Arthur, Reynolds, Nick J, Youngstein, Taryn, Walsh, David A, Joseph, Theresa, Mathew, Rengi, Oikonomou, Stamatios, Gwynne, Catherine, Crowder, Rory, Saravanan, Vadivelu, Mustafa, Alaa, Tacu, Cristina, George, Emmanuel, Batty, Thomas, Soni, Anushka, Horton, Sarah, Gaffney, Karl, Gullick, Nicola, Lapin, Agnieszka, Bingham, Sarah, Madan, Ayesha, Holroyd, Chris, Lwin, May, Khalid, Salema, Green, Mike, Hunt, Laura, Alcorn, Nicola, Ellis, Rob, Hider, Samantha, Hassan, Ala, Douglas, Karen, Ho, Gen Nen, Levasseur, Kirsty, Pradeep, John, Rhys-Dillon, Ceril, Jones, Catrin, Abhishek, Abhishek ^*, Peckham, Nicholas, Pade, Corinna ^*, Gibbons, Joseph M ^*, Cureton, Lucy, Francis, Anne, Barber, Vicki, Williams, Jennifer A E, Appelbe, Duncan, Eldridge, Lucy, Julier, Patrick, Altmann, Daniel M, Bluett, James, Brooks, Tim, Coates, Laura C, Rombach, Ines, Semper, Amanda, Otter, Ashley, Valdes, Ana M, Nguyen-Van-Tam, Jonathan S, Williams, Hywel C, Boyton, Rosemary J ^†, McKnight, Áine ^†, Cook, Jonathan A ^†

Source: In The Lancet Rheumatology February 2024 6(2):e92-e104

Curbside particulate matter and susceptibility to SARS–CoV-2 infection

Authors: Miyashita, Lisa, Foley, Gary, Semple, Sean, Gibbons, Joseph M., Pade, Corinna, McKnight, Áine, Grigg, Jonathan

Source: In Journal of Allergy and Clinical Immunology: Global November 2023 2(4)

Large clones of pre-existing T cells drive early immunity against SARS-COV-2 and LCMV infection

Authors: Milighetti, Martina, Peng, Yanchun, Tan, Cedric, Mark, Michal, Nageswaran, Gayathri, Byrne, Suzanne, Ronel, Tahel, Peacock, Tom, Mayer, Andreas, Chandran, Aneesh, Rosenheim, Joshua, Whelan, Matthew, Yao, Xuan, Liu, Guihai, Felce, Suet Ling, Dong, Tao, Mentzer, Alexander J., Knight, Julian C., Balloux, Francois, Greenstein, Erez, Reich-Zeliger, Shlomit, Pade, Corinna, Gibbons, Joseph M., Semper, Amanda, Brooks, Tim, Otter, Ashley, Altmann, Daniel M., Boyton, Rosemary J., Maini, Mala K., McKnight, Aine, Manisty, Charlotte, Treibel, Thomas A., Moon, James C., Noursadeghi, Mahdad, Chain, Benny

Source: In iScience 16 June 2023 26(6)

Plasma proteomic signature predicts who will get persistent symptoms following SARS-CoV-2 infection

Authors: Captur, Gabriella, Moon, James C., Topriceanu, Constantin-Cristian, Joy, George, Swadling, Leo, Hallqvist, Jenny, Doykov, Ivan, Patel, Nina, Spiewak, Justyna, Baldwin, Tomas, Hamblin, Matt, Menacho, Katia, Fontana, Marianna, Treibel, Thomas A., Manisty, Charlotte, O'Brien, Ben, Gibbons, Joseph M., Pade, Corrina, Brooks, Tim, Altmann, Daniel M., Boyton, Rosemary J., McKnight, Áine, Maini, Mala K., Noursadeghi, Mahdad, Mills, Kevin, Heywood, Wendy E.

Source: In eBioMedicine November 2022 85

HLA‐DR polymorphism in SARS‐CoV‐2 infection and susceptibility to symptomatic COVID‐19

Authors: Astbury, Stuart, Reynolds, Catherine J., Butler, David K., Muñoz‐Sandoval, Diana C., Lin, Kai‐Min, Pieper, Franziska P., Otter, Ashley, Kouraki, Afroditi, Cusin, Lola, Nightingale, Jessica, Vijay, Amrita, Craxford, Simon, Aithal, Guruprasad P., Tighe, Patrick J., Gibbons, Joseph M., Pade, Corinna, Joy, George, Maini, Mala, Chain, Benny, Semper, Amanda, Brooks, Timothy, Ollivere, Benjamin J., McKnight, Áine, Noursadeghi, Mahdad, Treibel, Thomas A., Manisty, Charlotte, Moon, James C., Valdes, Ana M., Boyton, Rosemary J., Altmann, Daniel M., Abbass, Hakam, Abiodun, Aderonke, Alfarih, Mashael, Alldis, Zoe, Amin, Oliver E., Andiapen, Mervyn, Artico, Jessica, Augusto, João B., Baca, Georgiana L., Bailey, Sasha N. L., Bhuva, Anish N., Boulter, Alex, Bowles, Ruth, Bracken, Olivia V., O'Brien, Ben, Brooks, Tim, Bullock, Natalie, Captur, Gabriella, Champion, Nicola, Chan, Carmen, Chandran, Aneesh, Collier, David, Sousa, Jorge Couto, Couto‐Parada, Xose, Cutino‐Moguel, Teresa, Davies, Rhodri H., Douglas, Brooke, Genova, Cecilia, Dieobi‐Anene, Keenan, Diniz, Mariana O., Ellis, Anaya, Feehan, Karen, Finlay, Malcolm, Fontana, Marianna, Forooghi, Nasim, Gaier, Celia, Gilroy, Derek, Hamblin, Matt, Harker, Gabrielle, Hewson, Jacqueline, Hickling, Lauren M., Hingorani, Aroon D., Howes, Lee, Hughes, Alun, Hughes, Gemma, Hughes, Rebecca, Itua, Ivie, Jardim, Victor, Lee, Wing‐Yiu Jason, Jensen, Melaniepetra, Jones, Jessica, Jones, Meleri, Kapil, Vikas, Kurdi, Hibba, Lambourne, Jonathan, Louth, Sarah, Maini, Mala K., Mandadapu, Vineela, Menacho, Katia, Mfuko, Celina, Mitchelmore, Oliver, Moon, Christopher, Murray, Sam M., Palma, Susana, Parker, Ruth, Patel, Kush, Pawarova, Babita, Petersen, Steffen E., Piniera, Brian, Pope, Daniel, Prossora, Mary, Rannigan, Lisa, Rapala, Alicja, Richards, Amy, Robathan, Matthew, Rosenheim, Joshua, Sambile, Genine, Schmidt, Nathalie M., Seraphim, Andreas, Simion, Mihaela, Smit, Angelique, Sugimoto, Michelle, Swadling, Leo, Taylor, Stephen, Temperton, Nigel, Thomas, Stephen, Thornton, George D., Tucker, Art, Veerapen, Jessry, Vijayakumar, Mohit, Welch, Sophie, Wodehouse, Theresa, Wynne, Lucinda, Zahedi, Dan, Altmann, Daniel M, Chain, Benjamin, Ashraf, Waheed, Ball, Jonathan K., Chappell, Joseph G., Cusin, Lola M. L., Duncan, Joshua D., Ikram, Adeel, Irving, William L., Jackson, Hannah J., Kelly, Anthony, Lingaya, Melanie, Marson, Ben A., Newham, Jayne, Norrish, Alan, Nowicka, Barbara, Tarr, Alexander W., Tsoleridis, Theocharis, Urbanowicz, Richard A.

Source: Immunology. 166(1):68-77

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100152437830.0x000001&indx=1&recIds=ETOCvdc_100152437830.0x000001

Quantitative, multiplexed, targeted proteomics for ascertaining variant specific SARS-CoV-2 antibody response

Authors: Abbass, Hakam, Abiodun, Aderonke, Alfarih, Mashael, Alldis, Zoe, Altmann, Daniel M., Amin, Oliver E., Andiapen, Mervyn, Artico, Jessica, Augusto, João B., Baca, Georgina L., Bailey, Sasha N.L., Bhuva, Anish N., Boulter, Alex, Bowles, Ruth, Boyton, Rosemary J., Bracken, Olivia V., O’Brien, Ben, Brooks, Tim, Bullock, Natalie, Butler, David K., Captur, Gabriella, Carr, Olivia, Champion, Nicola, Chan, Carmen, Chandran, Aneesh, Coleman, Tom, Couto de Sousa, Jorge, Couto-Parada, Xose, Cross, Eleanor, Cutino-Moguel, Teresa, D’Arcangelo, Silvia, Davies, Rhodri H., Douglas, Brooke, Di Genova, Cecilia, Dieobi-Anene, Keenan, Diniz, Mariana O., Ellis, Anaya, Feehan, Karen, Finlay, Malcolm, Fontana, Marianna, Forooghi, Nasim, Francis, Sasha, Gibbons, Joseph M., Gillespie, David, Gilroy, Derek, Hamblin, Matt, Harker, Gabrielle, Hemingway, Georgia, Hewson, Jacqueline, Heywood, Wendy, Hickling, Lauren M., Hicks, Bethany, Hingorani, Aroon D., Howes, Lee, Itua, Ivie, Jardim, Victor, Lee, Wing-Yiu Jason, Jensen, Melaniepetra, Jones, Jessica, Jones, Meleri, Joy, George, Kapil, Vikas, Kelly, Caoimhe, Kurdi, Hibba, Lambourne, Jonathan, Lin, Kai-Min, Liu, Siyi, Lloyd, Aaron, Louth, Sarah, Maini, Mala K., Mandadapu, Vineela, Manisty, Charlotte, McKnight, Áine, Menacho, Katia, Mfuko, Celina, Mills, Kevin, Millward, Sebastian, Mitchelmore, Oliver, Moon, Christopher, Moon, James, Sandoval, Diana Muñoz, Murray, Sam M., Noursadeghi, Mahdad, Otter, Ashley, Pade, Corinna, Palma, Susana, Parker, Ruth, Patel, Kush, Pawarova, Mihaela, Petersen, Steffen E., Piniera, Brian, Pieper, Franziska P., Rannigan, Lisa, Rapala, Alicja, Reynolds, Catherine J., Richards, Amy, Robathan, Matthew, Rosenheim, Joshua, Rowe, Cathy, Royds, Matthew, West, Jane Sackville, Sambile, Genine, Schmidt, Nathalie M., Selman, Hannah, Semper, Amanda, Seraphim, Andreas, Simion, Mihaela, Smit, Angelique, Sugimoto, Michelle, Swadling, Leo, Taylor, Stephen, Temperton, Nigel, Thomas, Stephen, Thornton, George D., Treibel, Thomas A., Tucker, Art, Varghese, Ann, Veerapen, Jessry, Vijayakumar, Mohit, Warner, Tim, Welch, Sophie, White, Hannah, Wodehouse, Theresa, Wynne, Lucinda, Zahedi, Dan, Doykov, Ivan, Baldwin, Tomas, Spiewak, Justyna, Gilmour, Kimberly C., Áine McKnight, Treibel, Thomas, Moon, James C., Kevin Mills, Heywood, Wendy E.

Source: In Cell Reports Methods 19 September 2022 2(9)

Blood transcriptional biomarkers of acute viral infection for detection of pre-symptomatic SARS-CoV-2 infection: a nested, case-control diagnostic accuracy study

Authors: Abbass, Hakam, Abiodun, Aderonke, Alfarih, Mashael, Alldis, Zoe, Altmann, Daniel M, Amin, Oliver E, Andiapen, Mervyn, Artico, Jessica, Augusto, João B, Baca, Georgiana L, Bailey, Sasha NL, Bhuva, Anish N, Boulter, Alex, Bowles, Ruth, Boyton, Rosemary J, Bracken, Olivia V, O'Brien, Ben, Brooks, Tim, Bullock, Natalie, Butler, David K, Captur, Gabriella, Champion, Nicola, Chan, Carmen, Chandran, Aneesh, Collier, David, Couto de Sousa, Jorge, Couto-Parada, Xose, Cutino-Moguel, Teresa, Davies, Rhodri H, Douglas, Brooke, Di Genova, Cecilia, Dieobi-Anene, Keenan, Diniz, Mariana O, Ellis, Anaya, Feehan, Karen, Finlay, Malcolm, Fontana, Marianna, Forooghi, Nasim, Gaier, Celia, Gibbons, Joseph M, Gilroy, Derek, Hamblin, Matt, Harker, Gabrielle, Hewson, Jacqueline, Hickling, Lauren M, Hingorani, Aroon D, Howes, Lee, Hughes, Alun, Hughes, Gemma, Hughes, Rebecca, Itua, Ivie, Jardim, Victor, Lee, Wing-Yiu Jason, Jensen, Melaniepetra, Jones, Jessica, Jones, Meleri, Joy, George, Kapil, Vikas, Kurdi, Hibba, Lambourne, Jonathan, Lin, Kai-Min, Louth, Sarah, Maini, Mala K, Mandadapu, Vineela, Manisty, Charlotte, McKnight, Áine, Menacho, Katia, Mfuko, Celina, Mitchelmore, Oliver, Moon, Christopher, Moon, James C, Munoz Sandoval, Diana, Murray, Sam M, Noursadeghi, Mahdad, Otter, Ashley, Pade, Corinna, Palma, Susana, Parker, Ruth, Patel, Kush, Pawarova, Babita, Petersen, Steffen E, Piniera, Brian, Pieper, Franziska P, Pope, Daniel, Prossora, Maria, Rannigan, Lisa, Rapala, Alicja, Reynolds, Catherine J, Richards, Amy, Robathan, Matthew, Rosenheim, Joshua, Sambile, Genine, Schmidt, Nathalie M, Semper, Amanda, Seraphim, Andreas, Simion, Mihaela, Smit, Angelique, Sugimoto, Michelle, Swadling, Leo, Taylor, Stephen, Temperton, Nigel, Thomas, Stephen, Thornton, George D, Treibel, Thomas A, Tucker, Art, Veerapen, Jessry, Vijayakumar, Mohit, Welch, Sophie, Wodehouse, Theresa, Wynne, Lucinda, Zahedi, Dan, Gupta, Rishi K ^*, Bell, Lucy C ^*, Guerra-Assuncao, Jose A, Pollara, Gabriele, Whelan, Matthew, McKnight, Aine, Chain, Benjamin M

Source: In The Lancet Microbe October 2021 2(10):e508-e517

Influence of individuals' determinants including vaccine type on cellular and humoral responses to SARS-CoV-2 vaccination.

Authors: Chambers, Emma S., Cai, Weigang, Vivaldi, Giulia, Jolliffe, David A., Perdek, Natalia, Li, Wenhao, Faustini, Sian E., Gibbons, Joseph M., Pade, Corinna, Richter, Alex G., Coussens, Anna K., Martineau, Adrian R.

Source: NPJ Vaccines; 5/22/2024, Vol. 9 Issue 1, p1-9, 9p

Subject Terms: HUMORAL immunity, BODY mass index, VACCINE immunogenicity, T cells, VACCINATION, SARS-CoV-2, VACCINE effectiveness

Geographic Terms: UNITED Kingdom

Company/Entity: UNIVERSITY of Oxford, ASTRAZENECA PLC

Persistent symptoms after COVID-19 are not associated with differential SARS-CoV-2 antibody or T cell immunity.

Authors: Altmann, Daniel M., Reynolds, Catherine J., Joy, George, Otter, Ashley D., Gibbons, Joseph M., Pade, Corinna, Swadling, Leo, Maini, Mala K., Brooks, Tim, Semper, Amanda, McKnight, Áine, Noursadeghi, Mahdad, Manisty, Charlotte, Treibel, Thomas A., Moon, James C., Boyton, Rosemary J.

Source: Nature Communications; 8/23/2023, Vol. 14 Issue 1, p1-9, 9p

Subject Terms: MEDICAL personnel, T cells, POST-acute COVID-19 syndrome, SARS-CoV-2, COVID-19, IMMUNOGLOBULINS, VIRAL antibodies

Correlation Between Postvaccination Anti-Spike Antibody Titers and Protection Against Breakthrough Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Population-Based Longitudinal Study.

Authors: Vivaldi, Giulia, Jolliffe, David A, Faustini, Sian, Shields, Adrian M, Holt, Hayley, Perdek, Natalia, Talaei, Mohammad, Tydeman, Florence, Chambers, Emma S, Cai, Weigang, Li, Wenhao, Gibbons, Joseph M, Pade, Corinna, McKnight, Áine, Shaheen, Seif O, Richter, Alex G, Martineau, Adrian R

Source: Journal of Infectious Diseases; 12/1/2022, Vol. 226 Issue 11, p1903-1908, 6p

Subject Terms: COVID-19, SARS-CoV-2, ANTIBODY titer, BREAKTHROUGH infections

Vitamin D Supplementation Does Not Influence SARS-CoV-2 Vaccine Efficacy or Immunogenicity: Sub-Studies Nested within the CORONAVIT Randomised Controlled Trial.

Authors: Jolliffe, David A., Vivaldi, Giulia, Chambers, Emma S., Cai, Weigang, Li, Wenhao, Faustini, Sian E., Gibbons, Joseph M., Pade, Corinna, Coussens, Anna K., Richter, Alex G., McKnight, Áine, Martineau, Adrian R.

Source: Nutrients; Sep2022, Vol. 14 Issue 18, pN.PAG-N.PAG, 16p

Heterologous infection and vaccination shapes immunity against SARS-CoV-2 variants.

Authors: Reynolds, Catherine J., Gibbons, Joseph M., Pade, Corinna, Lin, Kai-Min, Sandoval, Diana Muñoz, Pieper, Franziska, Butler, David K., Liu, Siyi, Otter, Ashley D., Joy, George, Menacho, Katia, Fontana, Marianna, Smit, Angelique, Kele, Beatrix, Cutino-Moguel, Teresa, Maini, Mala K., Noursadeghi, Mahdad, Brooks, Tim, Semper, Amanda, Manisty, Charlotte

Source: Science. 1/14/2022, Vol. 375 Issue 6577, p183-192. 10p. 4 Graphs.

Subject Terms: *VACCINATION, *VIRAL vaccines, *CORONAVIRUSES, *IMMUNITY, *VIRAL variation

Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2.

Authors: Swadling, Leo, Diniz, Mariana O., Schmidt, Nathalie M., Amin, Oliver E., Chandran, Aneesh, Shaw, Emily, Pade, Corinna, Gibbons, Joseph M., Le Bert, Nina, Tan, Anthony T., Jeffery-Smith, Anna, Tan, Cedric C. S., Tham, Christine Y. L., Kucykowicz, Stephanie, Aidoo-Micah, Gloryanne, Rosenheim, Joshua, Davies, Jessica, Johnson, Marina, Jensen, Melanie P., Joy, George

Source: Nature; 1/6/2022, Vol. 601 Issue 7891, p110-117, 8p

Generation of Novel Severe Acute Respiratory Syndrome Coronavirus 2 Variants on the B.1.1.7 Lineage in 3 Patients With Advanced Human Immunodeficiency Virus-1 Disease.

Authors: Riddell, Anna C, Kele, Beatrix, Harris, Kathryn, Bible, Jon, Murphy, Maurice, Dakshina, Subathira, Storey, Nathaniel, Owoyemi, Dola, Pade, Corinna, Gibbons, Joseph M, Harrington, David, Alexander, Eliza, McKnight, Áine, Cutino-Moguel, Teresa

Source: Clinical Infectious Diseases; Dec2022, Vol. 75 Issue 11, p2016-2018, 3p

Subject Terms: HIV infections, HIV-positive persons, IN vitro studies, SARS-CoV-2, COVID-19, GENETIC mutation, IN vivo studies, IMMUNOCOMPROMISED patients, RISK assessment, CASE studies

COVID-19 vaccine boosted immunity against Omicron in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors

Authors: Milojkovic, Dragana, Reynolds, Catherine J., Sandoval, Diana Mūnoz, Pieper, Franziska P., Liu, Siyi, Pade, Corinna, Gibbons, Joseph M., McKnight, Áine, Loaiza, Sandra, Palanicawander, Renuka, Innes, Andrew J., Claudiani, Simone, Apperley, Jane F., Altmann, Daniel M., Boyton, Rosemary J.

Source: Leukemia; 20220101, Issue: Preprints p1-4, 4p

Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose.

Authors: Reynolds, Catherine J., Pade, Corinna, Gibbons, Joseph M., Butler, David K., Otter, Ashley D., Menacho, Katia, Fontana, Marianna, Smit, Angelique, Sackville-West, Jane E., Cutino-Moguel, Teresa, Maini, Mala K., Chain, Benjamin, Noursadeghi, Mahdad, Brooks, Tim, Semper, Amanda, Manisty, Charlotte, Treibel, Thomas A., Moon, James C., Valdes, Ana M., McKnight, Áine

Source: Science; 6/25/2021, Vol. 372 Issue 6549, p1418-1423, 6p, 3 Diagrams

Discordant neutralizing antibody and T cell responses in asymptomatic and mild SARS-CoV-2 infection.

Authors: Reynolds, Catherine J., Swadling, Leo, Gibbons, Joseph M., Pade, Corinna, Jensen, Melanie P., Diniz, Mariana O., Schmidt, Nathalie M., Butler, David K., Amin, Oliver E., Bailey, Sasha N. L., Murray, Sam M., Pieper, Franziska P., Taylor, Stephen, Jones, Jessica, Jones, Meleri, Lee, Wing-Yiu Jason, Rosenheim, Joshua, Chandran, Aneesh, Joy, George, Di Genova, Cecilia

Source: Science Immunology; 2020, Vol. 5 Issue 54, p1-18, 18p

Pre-existing polymerase-specific T cells expand in abortive seronegative SARS-CoV-2

Authors: Swadling, Leo, Diniz, Mariana O., Schmidt, Nathalie M., Amin, Oliver E., Chandran, Aneesh, Shaw, Emily, Pade, Corinna, Gibbons, Joseph M., Le Bert, Nina, Tan, Anthony T., Jeffery-Smith, Anna, Tan, Cedric C. S., Tham, Christine Y. L., Kucykowicz, Stephanie, Aidoo-Micah, Gloryanne, Rosenheim, Joshua, Davies, Jessica, Johnson, Marina, Jensen, Melanie P., Joy, George, McCoy, Laura E., Valdes, Ana M., Chain, Benjamin M., Goldblatt, David, Altmann, Daniel M., Boyton, Rosemary J., Manisty, Charlotte, Treibel, Thomas A., Moon, James C., van Dorp, Lucy, Balloux, Francois, McKnight, Áine, Noursadeghi, Mahdad, Bertoletti, Antonio, Maini, Mala K.

Source: Nature; 20210101, Issue: Preprints p1-8, 8p

HIV-1 accessory protein Vpr interacts with REAF/RPRD2 to mitigate its antiviral activity.

Authors: Gibbons, Joseph M.¹, Marno, Kelly M.¹, Pike, Rebecca¹, Wing-yiu Jason Lee¹, Jones, Christopher E.¹, Ogunkolade, Babatunji W.¹, Pardieu, Claire¹, Bryan, Alexander², Fu, Rebecca Menhua², Warnes, Gary¹, Rowley, Paul A.³, Sloan, Richard D.^2,4, McKnight, Áine¹ a.mcknight@qmul.ac.uk

Source: Journal of Virology. 2/15/2020, Vol. 94 Issue 4, p1-39. 39p.

Subject Terms: *HIV infections, *HIV, *T cells, *UBIQUITIN ligases, *PROTEINS, *VIRAL replication

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