Heightened expression of type I interferon signaling genes in CD4⁺ T cells from acutely HIV-1–infected women is associated with lower viral loads.

Authors: El-Badry, Elina, Chen, Luxiao, Ghneim, Khader, Li, Ziyi, Brooks, Kelsie, Rhodes, Jake, Sekaly, Rafick, Kilembe, William, Allen, Susan, Wu, Hao, Hunter, Eric

Source: Frontiers in Immunology; 2025, p1-12, 12p

Subject Terms: TYPE I interferons, GENE expression, HIV infections, T cells, VIRAL load

Acquisition of optimal TFH cell function is defined by specific molecular, positional, and TCR dynamic signatures

Authors: Padhan, Kartika, Moysi, Eirini, Noto, Alessandra, Chassiakos, Alexander, Ghneim, Khader, Perra, Maria Maddalena, Shah, Sanjana, Papaioannou, Vasilis, Fabozzi, Giulia, Ambrozak, David R., Poultsidi, Antigoni, Ioannou, Maria, Fenwick, Craig, Darko, Samuel, Douek, Daniel C., Sekaly, Rafick-Pierre, Pantaleo, Giuseppe, Koup, Richard A., Petrovas, Constantinos

Source: Proceedings of the National Academy of Sciences of the United States of America, 2021 May 01. 118(18), 1-11.

Access URL: https://www.jstor.org/stable/27040349

Passive Transfer of Vaccine-Elicited Antibodies Protects against SIV in Rhesus Macaques

Authors: Alter, Galit, Yu, Wen-Han, Chandrashekar, Abishek, Borducchi, Erica N., Ghneim, Khader, Sharma, Ashish, Nedellec, Rebecca, McKenney, Katherine R., Linde, Caitlyn, Broge, Thomas, Suscovich, Todd J., Linnekin, Tom, Abbink, Peter, Mercado, Noe B., Nkolola, Joseph P., McMahan, Katherine, Bondzie, Esther A., Hamza, Venous, Peter, Lauren, Kordana, Nicole, Mahrokhian, Shant, Seaman, Michael S., Li, Wenjun, Lewis, Mark G., Lauffenburger, Douglas A., Hangartner, Lars, Sekaly, Rafick-Pierre, Barouch, Dan H.

Source: In Cell 1 October 2020 183(1):185-196

Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption

Authors: Pereira Ribeiro, Susan, Strongin, Zachary, Soudeyns, Hugo, ten-Caten, Felipe, Ghneim, Khader, Pacheco Sanchez, Gabriela, Xavier de Medeiros, Giuliana, Del Rio Estrada, Perla Mariana, Pelletier, Adam-Nicolas, Hoang, Timothy, Nguyen, Kevin, Harper, Justin, Jean, Sherrie, Wallace, Chelsea, Balderas, Robert, Lifson, Jeffrey D., Raghunathan, Gopalan, Rimmer, Eric, Pastuskovas, Cinthia V., Wu, Guoxin, Micci, Luca, Ribeiro, Ruy M., Chan, Chi Ngai, Estes, Jacob D., Silvestri, Guido, Gorman, Daniel M., Howell, Bonnie J., Hazuda, Daria J., Paiardini, Mirko, Sekaly, Rafick P.

Source: Nature Immunology; October 2024, Vol. 25 Issue: 10 p1900-1912, 13p

Initiation of Antiviral B Cell Immunity Relies on Innate Signals from Spatially Positioned NKT Cells

Authors: Gaya, Mauro, Barral, Patricia, Burbage, Marianne, Aggarwal, Shweta, Montaner, Beatriz, Warren Navia, Andrew, Aid, Malika, Tsui, Carlson, Maldonado, Paula, Nair, Usha, Ghneim, Khader, Fallon, Padraic G., Sekaly, Rafick-Pierre, Barouch, Dan H., Shalek, Alex K., Bruckbauer, Andreas, Strid, Jessica, Batista, Facundo D.

Source: In Cell 25 January 2018 172(3):517-533

The sooner the better: innate immunity as a path toward the HIV cure

Authors: Tomalka, Jeffrey, Ghneim, Khader, Bhattacharyya, Sanghamitra, Aid, Malika, Barouch, Dan H, Sekaly, Rafick Pierre, Ribeiro, Susan Pereira

Source: In Current Opinion in Virology August 2016 19:85-91

Rapid Inflammasome Activation following Mucosal SIV Infection of Rhesus Monkeys

Authors: Barouch, Dan H., Ghneim, Khader, Bosche, William J., Li, Yuan, Berkemeier, Brian, Hull, Michael, Bhattacharyya, Sanghamitra, Cameron, Mark, Liu, Jinyan, Smith, Kaitlin, Borducchi, Erica, Cabral, Crystal, Peter, Lauren, Brinkman, Amanda, Shetty, Mayuri, Li, Hualin, Gittens, Courtney, Baker, Chantelle, Wagner, Wendeline, Lewis, Mark G., Colantonio, Arnaud, Kang, Hyung-Joo, Li, Wenjun, Lifson, Jeffrey D., Piatak, Michael, Jr., Sekaly, Rafick-Pierre

Source: In Cell 21 April 2016 165(3):656-667

Antibody-mediated protection against SHIV challenge includes systemic clearance of distal virus

Authors: Liu, Jinyan, Ghneim, Khader, Sok, Devin, Bosche, William J., Li, Yuan, Chipriano, Elizabeth, Berkemeier, Brian, Oswald, Kelli, Borducchi, Erica, Cabral, Crystal, Peter, Lauren, Brinkman, Amanda, Shetty, Mayuri, Jimenez, Jessica, Mondesir, Jade, Lee, Benjamin, Giglio, Patricia, Chandrashekar, Abishek, Abbink, Peter, Colantonio, Arnaud, Gittens, Courtney, Baker, Chantelle, Wagner, Wendeline, Lewis, Mark G., Li, Wenjun, Sekaly, Rafick-Pierre, Lifson, Jeffrey D., Burton, Dennis R., Barouch, Dan H.

Source: Science, 2016 Sep 01. 353(6303), 1045-1049.

Access URL: https://www.jstor.org/stable/44710518

Human Monocyte Subsets Are Transcriptionally and Functionally Altered in Aging in Response to Pattern Recognition Receptor Agonists

Authors: Metcalf, Talibah U., Wilkinson, Peter A., Cameron, Mark J., Ghneim, Khader, Chiang, Cindy, Wertheimer, Anne M., Hiscott, John B., Nikolich-Zugich, Janko, Haddad, Elias K.

Source: Journal of immunology. 199(4):1405-1417

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN612420281&indx=1&recIds=ETOCRN612420281

Increased homeostatic cytokines and stability of HIV-infected memory CD4 T-cells identify individuals with suboptimal CD4 T-cell recovery on-ART.

Authors: Pino, Maria¹, Pereira Ribeiro, Susan², Pagliuzza, Amélie³, Ghneim, Khader², Khan, Anum⁴, Ryan, Emily¹, Harper, Justin L.¹, King, Colin T.¹, Welbourn, Sarah⁵, Micci, Luca¹, Aldrete, Sol⁶, Delman, Keith A.⁷, Stuart, Theron⁸, Lowe, Michael⁷, Brenchley, Jason M.⁹, Derdeyn, Cynthia A.^2,5, Easley, Kirk⁴, Sekaly, Rafick P.², Chomont, Nicolas³, Paiardini, Mirko^1,2, mirko.paiardini@emory.edu

Source: PLoS Pathogens; 8/27/2021, Vol. 17 Issue 8, p1-30, 30p

Regulation of Immune Homeostasis, Inflammation, and HIV Persistence by the Microbiome, Short-Chain Fatty Acids, and Bile Acids.

Authors: Enriquez, Ana Beatriz, ten Caten, Felipe, Ghneim, Khader, Sekaly, Rafick-Pierre, Sharma, Ashish Arunkumar

Source: Annual Review of Virology; 2023, Vol. 10 Issue 1, p397-422, 22p

Author Correction: Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption

Authors: Pereira Ribeiro, Susan, Strongin, Zachary, Soudeyns, Hugo, ten-Caten, Felipe, Ghneim, Khader, Pacheco Sanchez, Gabriela, Xavier de Medeiros, Giuliana, Del Rio Estrada, Perla Mariana, Pelletier, Adam-Nicolas, Hoang, Timothy, Nguyen, Kevin, Harper, Justin, Jean, Sherrie, Wallace, Chelsea, Balderas, Robert, Lifson, Jeffrey D., Raghunathan, Gopalan, Rimmer, Eric, Pastuskovas, Cinthia V., Wu, Guoxin, Micci, Luca, Ribeiro, Ruy M., Chan, Chi Ngai, Estes, Jacob D., Silvestri, Guido, Gorman, Daniel M., Howell, Bonnie J., Hazuda, Daria J., Paiardini, Mirko, Sekaly, Rafick P.

Source: Nature Immunology; March 2025, Vol. 26 Issue: 3 p524-524, 1p

Multi-omics analyses reveal that HIV-1 alters CD4+T cell immunometabolism to fuel virus replication

Authors: Guo, Haitao, Wang, Qi, Ghneim, Khader, Wang, Li, Rampanelli, Elena, Holley-Guthrie, Elizabeth, Cheng, Liang, Garrido, Carolina, Margolis, David M., Eller, Leigh A., Robb, Merlin L., Sekaly, Rafick-Pierre, Chen, Xian, Su, Lishan, Ting, Jenny P.-Y.

Source: Nature Immunology; 20210101, Issue: Preprints p1-11, 11p

Activation of HIV Transcription with Short-Course Vorinostat in HIV-Infected Patients on Suppressive Antiretroviral Therapy.

Authors: Elliott, Julian H.^1,2, Wightman, Fiona^1,2,3, Solomon, Ajantha^1,2,3, Ghneim, Khader⁴, Ahlers, Jeffrey⁴, Cameron, Mark J.⁴, Smith, Miranda Z.^1,2,3, Spelman, Tim², McMahon, James¹, Velayudham, Pushparaj^1,2, Brown, Gregor¹, Roney, Janine¹, Watson, Jo⁵, Prince, Miles H.^6,7, Hoy, Jennifer F.¹, Chomont, Nicolas⁴, Fromentin, Rémi⁴, Procopio, Francesco A.⁴, Zeidan, Joumana⁴, Palmer, Sarah^8,9

Source: PLoS Pathogens; Nov2014, Vol. 10 Issue 11, p1-19, 19p

Systems Analysis of a RIG-I Agonist Inducing Broad Spectrum Inhibition of Virus Infectivity.

Authors: Goulet, Marie-Line¹, Olagnier, David², Zhengyun Xu^1,3, Paz, Suzanne¹, Belgnaoui, S. Mehdi¹, Lafferty, Erin I.³, Janelle, Valérie⁴, Arguello, Meztli¹, Paquet, Marilene⁵, Ghneim, Khader², Richards, Stephanie², Smith, Andrew², Wilkinson, Peter², Cameron, Mark², Kalinke, Ulrich⁶, Qureshi, Salman³, Lamarre, Alain⁴, Haddad, Elias K.², Sekaly, Rafick Pierre², Peri, Suraj⁷

Source: PLoS Pathogens; Apr2013, Vol. 9 Issue 4, Special section p1-19, 19p, 1 Color Photograph, 2 Black and White Photographs, 2 Diagrams, 1 Chart, 3 Graphs

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SINGLE INFUSION OF STEM LIKE CCR5-MODIFIED CD4 T CELLS PROVIDE LONG-TERM HIV CONTROL.

Authors: Enriquez, Ana B., Sharma, Ashish Arunkumar, Zeidan, Joumana, Lee, Gary, Fourati, Slim, Ghneim, Khader, Sanchez, Gabriela, Procopio, Francesco, Balderas, Robert, Chomont, Nicolas, Ando, Dale, Deeks, Steven G., Sékaly, Rafick P., Fromentin, Rémi

Source: Topics in Antiviral Medicine; Apr2023, Vol. 31 Issue 2, p75-75, 1/3p

ANTI-IL-10/PD-1 IMMUNE MEDIATED CONTROL OF VIRAL REBOUND IN SIV INFECTED MACAQUES.

Authors: Ribeiro, Susan Pereira, Strongin, Zachary, Caten, Felipe Ten, Ghneim, Khader, Hakeem, Mohamed Abdel, Hoang, Timothy N., Nguyen, Kevin, Harper, Justin, Micci, Luca, Lifson, Jeffrey D., Howell, Bonnie, Gorman, Daniel, Hazuda, Daria J., Paiardini, Mirko, Sékaly, Rafick P.

Source: Topics in Antiviral Medicine; Apr2023, Vol. 31 Issue 2, p58-58, 1/2p