ADAMTS13 Improves Endothelial Function and Reduces Inflammation in Diabetic Retinopathy

Authors: Ahmed M. Abu El-Asrar, Mohd I. Nawaz, Ajmal Ahmad, Mairaj Siddiquei, Eef Allegaert, Lowie Adyns, Lotte Vanbrabant, Priscilla W. Gikandi, Gert De Hertogh, Sofie Struyf, Ghislain Opdenakker

Source: Cells, Vol 14, Iss 2, p 85 (2025)

Subject Terms: diabetic retinopathy, ADAMTS13, inflammation, blood–retinal barrier, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/14/2/85; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/4abbda263a4e4c33bfc4c52e808c615b

Protection of stromal cell-derived factor-1 SDF-1/CXCL12 against proteases yields improved skin wound healing

Authors: Rafaela Vaz Sousa Pereira, Mostafa EzEldeen, Estefania Ugarte-Berzal, Jennifer Vandooren, Erik Martens, Mieke Gouwy, Eva Ganseman, Jo Van Damme, Patrick Matthys, Jan Jeroen Vranckx, Paul Proost, Ghislain Opdenakker

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: SDF-1, CXCL12, proteolysis, chemokine, COAM, wound healing, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1359497/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/a3beb009fdca434c94d95233677ef312

Physiological fibrin hydrogel modulates immune cells and molecules and accelerates mouse skin wound healing

Authors: Rafaela Vaz Sousa Pereira, Mostafa EzEldeen, Estefania Ugarte-Berzal, Erik Martens, Bert Malengier-Devlies, Jennifer Vandooren, Jan Jeroen Vranckx, Patrick Matthys, Ghislain Opdenakker

Source: Frontiers in Immunology, Vol 14 (2023)

Subject Terms: wound healing, fibrin, leukocytes, macrophages, inflammation, hydrogel, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1170153/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/9a6150249c7b408392914a097751c5d7

How to place the duality of specific MMP-9 inhibition for treatment of inflammatory bowel diseases into clinical opportunities?

Authors: Ghislain Opdenakker, Séverine Vermeire, Ahmed Abu El-Asrar

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: matrix metalloprotease, tissue inhibitors of metalloproteases, ulcerative colitis, Crohn’s disease, diabetic retinopathy, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.983964/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/a23e5814f8164408b69c19f405f615a5

Chlorite oxidized oxyamylose differentially influences the microstructure of fibrin and self assembling peptide hydrogels as well as dental pulp stem cell behavior

Authors: Mostafa EzEldeen, Burak Toprakhisar, Denise Murgia, Nick Smisdom, Olivier Deschaume, Carmen Bartic, Hans Van Oosterwyck, Rafaela Vaz Sousa Pereira, Ghislain Opdenakker, Ivo Lambrichts, Annelies Bronckaers, Reinhilde Jacobs, Jennifer Patterson

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/28aa3ba4bf784093af58d527a792cfcc

STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

Authors: Robbert Boudewijns, Hendrik Jan Thibaut, Suzanne J. F. Kaptein, Rong Li, Valentijn Vergote, Laura Seldeslachts, Johan Van Weyenbergh, Carolien De Keyzer, Lindsey Bervoets, Sapna Sharma, Laurens Liesenborghs, Ji Ma, Sander Jansen, Dominique Van Looveren, Thomas Vercruysse, Xinyu Wang, Dirk Jochmans, Erik Martens, Kenny Roose, Dorien De Vlieger, Bert Schepens, Tina Van Buyten, Sofie Jacobs, Yanan Liu, Joan Martí-Carreras, Bert Vanmechelen, Tony Wawina-Bokalanga, Leen Delang, Joana Rocha-Pereira, Lotte Coelmont, Winston Chiu, Pieter Leyssen, Elisabeth Heylen, Dominique Schols, Lanjiao Wang, Lila Close, Jelle Matthijnssens, Marc Van Ranst, Veerle Compernolle, Georg Schramm, Koen Van Laere, Xavier Saelens, Nico Callewaert, Ghislain Opdenakker, Piet Maes, Birgit Weynand, Christopher Cawthorne, Greetje Vande Velde, Zhongde Wang, Johan Neyts, Kai Dallmeier

Source: Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4bd55434a94243038b030da67ad476bb

Corrigendum: CCR2 Is Dispensable for Disease Resolution but Required for the Restoration of Leukocyte Homeostasis Upon Experimental Malaria-Associated Acute Respiratory Distress Syndrome

Authors: Emilie Pollenus, Thao-Thy Pham, Leen Vandermosten, Queeny Robalo, Hendrik Possemiers, Sofie Knoops, Ghislain Opdenakker, Philippe E. Van den Steen

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: malaria, inflammation, resolution, monocytes, immunology, parasitology, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.926032/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/9e8f05a97a714ddc8017ea849cd4f0a5

Inhibition of renal fibrosis with a human CXCL9‐derived glycosaminoglycan‐binding peptide

Authors: Fariba Poosti, Mohammad Ayodhia Soebadi, Helena Crijns, Alexandra De Zutter, Mieke Metzemaekers, Nele Berghmans, Vincent Vanheule, Maarten Albersen, Ghislain Opdenakker, Jo Van Damme, Ben Sprangers, Paul Proost, Sofie Struyf

Source: Clinical & Translational Immunology, Vol 11, Iss 2, Pp n/a-n/a (2022)

Subject Terms: chemokine‐derived peptides, CXCL9, glycosaminoglycans, inflammation, renal fibrosis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/2050-0068

Access URL: https://doaj.org/article/bd9c21f8f6074be9b98c363f5b2c851e

Atypical response to bacterial coinfection and persistent neutrophilic bronchoalveolar inflammation distinguish critical COVID-19 from influenza

Authors: Seppe Cambier, Mieke Metzemaekers, Ana Carolina de Carvalho, Amber Nooyens, Cato Jacobs, Lore Vanderbeke, Bert Malengier-Devlies, Mieke Gouwy, Elisabeth Heylen, Philippe Meersseman, Greet Hermans, Els Wauters, Alexander Wilmer, the CONTAGIOUS Consortium, Dominique Schols, Patrick Matthys, Ghislain Opdenakker, Rafael Elias Marques, Joost Wauters, Jennifer Vandooren, Paul Proost

Source: JCI Insight, Vol 7, Iss 1 (2022)

Subject Terms: COVID-19, Immunology, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2379-3708

Access URL: https://doaj.org/article/827151a3853f4fa29df87b693838bc11

Tissue Inhibitor of Metalloproteinase-3 Ameliorates Diabetes-Induced Retinal Inflammation

Authors: Ahmed M. Abu El-Asrar, Ajmal Ahmad, Mohd Imtiaz Nawaz, Mohammad Mairaj Siddiquei, Alexandra De Zutter, Lotte Vanbrabant, Priscilla W. Gikandi, Ghislain Opdenakker, Sofie Struyf

Source: Frontiers in Physiology, Vol 12 (2022)

Subject Terms: diabetic retinopathy, tissue inhibitor of metalloproteinase-3, inflammation, angiogenesis, blood-retinal barrier, Physiology, QP1-981

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphys.2021.807747/full; https://doaj.org/toc/1664-042X

Access URL: https://doaj.org/article/b91e370392b74e9eb4f76fbd09edcc25

New Perspectives on the Immunopathogenesis and Treatment of Uveitis Associated With Vogt-Koyanagi-Harada Disease

Authors: Ahmed M. Abu El-Asrar, Jo Van Damme, Sofie Struyf, Ghislain Opdenakker

Source: Frontiers in Medicine, Vol 8 (2021)

Subject Terms: autoimmune disease, B cells, immunomodulatory therapy, therapeutic window of opportunity, remnant epitope, molecular mimicry, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2021.705796/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/e1f4a77998014789aa6f069e7d0c95bd

Proteoform Analysis of Matrix Metalloproteinase-9/Gelatinase B and Discovery of Its Citrullination in Rheumatoid Arthritis Synovial Fluids

Authors: Bernard Grillet, Karen Yu, Estefania Ugarte-Berzal, Rik Janssens, Rafaela Vaz Sousa Pereira, Lise Boon, Erik Martens, Nele Berghmans, Isabelle Ronsse, Ilse Van Aelst, Pierre Fiten, René Conings, Jennifer Vandooren, Patrick Verschueren, Jo Van Damme, Paul Proost, Ghislain Opdenakker

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: matrix metalloproteinase, arthritis, proteoform, proteolysis, citrullination, synovial fluid, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.763832/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/fcdb7e2221a94516bc4d928080b5e8a7

Internal Disulfide Bonding and Glycosylation of Interleukin-7 Protect Against Proteolytic Inactivation by Neutrophil Metalloproteinases and Serine Proteases

Authors: Jennifer Vandooren, Rafaela Vaz Sousa Pereira, Estefania Ugarte-Berzal, Vasily Rybakin, Sam Noppen, Melissa R. Stas, Eline Bernaerts, Eva Ganseman, Mieke Metzemaekers, Dominique Schols, Paul Proost, Ghislain Opdenakker

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: IL-7, matrix metalloproteinase-9, proteolysis, signal transduction, proliferation, neutrophils, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.701739/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/caa802cfe35d4da393ab5bd67065bfda

Differential Expression and Localization of ADAMTS Proteinases in Proliferative Diabetic Retinopathy

Authors: Ahmed M. Abu El-Asrar, Mohd Imtiaz Nawaz, Eef Allegaert, Mohammad Mairaj Siddiquei, Ajmal Ahmad, Priscilla Gikandi, Gert De Hertogh, Ghislain Opdenakker

Source: Molecules, Vol 27, Iss 18, p 5977 (2022)

Subject Terms: proliferative diabetic retinopathy, ADAMTS proteinases, MMP-15, versican, biglycan, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/27/18/5977; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/3d704d954d144c0ebf5f5285aea686f3

From ELISA to Immunosorbent Tandem Mass Spectrometry Proteoform Analysis: The Example of CXCL8/Interleukin-8

Authors: Mieke Metzemaekers, Sara Abouelasrar Salama, Jennifer Vandooren, Anneleen Mortier, Rik Janssens, Sofie Vandendriessche, Eva Ganseman, Erik Martens, Mieke Gouwy, Barbara Neerinckx, Patrick Verschueren, Lien De Somer, Carine Wouters, Sofie Struyf, Ghislain Opdenakker, Jo Van Damme, Paul Proost

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: chemokine, CXCL8, neutrophil, ELISA, proteolysis, posttranslational modification, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.644725/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/98eedf5312eb4a159a82972e990bd062

CCR2 Is Dispensable for Disease Resolution but Required for the Restoration of Leukocyte Homeostasis Upon Experimental Malaria-Associated Acute Respiratory Distress Syndrome

Authors: Emilie Pollenus, Thao-Thy Pham, Leen Vandermosten, Queeny Robalo, Hendrik Possemiers, Sofie Knoops, Ghislain Opdenakker, Philippe E. Van den Steen

Source: Frontiers in Immunology, Vol 11 (2021)

Subject Terms: malaria, inflammation, resolution, monocytes, immunology, parasitology, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2020.628643/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/9d65bb7dfae74480b3bf67bdf0fa3ca7

Kinetics of peripheral blood neutrophils in severe coronavirus disease 2019

Authors: Mieke Metzemaekers, Seppe Cambier, Marfa Blanter, Jennifer Vandooren, Ana Carolina deCarvalho, Bert Malengier‐Devlies, Lore Vanderbeke, Cato Jacobs, Sofie Coenen, Erik Martens, Noëmie Pörtner, Lotte Vanbrabant, Pierre Van Mol, Yannick Van Herck, Nathalie Van Aerde, Greet Hermans, Jan Gunst, Alexandre Borin, Bruna Toledo N Pereira, Arilson Bernardo dosSP Gomes, Stéfanie Primon Muraro, Gabriela Fabiano de Souza, Alessandro S Farias, José Luiz Proenca‐Modena, Marco Aurélio R Vinolo, the CONTAGIOUS Consortium, Pedro Elias Marques, Carine Wouters, Els Wauters, Sofie Struyf, Patrick Matthys, Ghislain Opdenakker, Rafael Elias Marques, Joost Wauters, Mieke Gouwy, Paul Proost

Source: Clinical & Translational Immunology, Vol 10, Iss 4, Pp n/a-n/a (2021)

Subject Terms: neutrophil, COVID‐19, chemokine, cytokine, protease, emergency myelopoiesis, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/2050-0068

Access URL: https://doaj.org/article/ba10ccf13bec4842bb4c17c27de42dce

Evaluation of Proteoforms of the Transmembrane Chemokines CXCL16 and CX3CL1, Their Receptors, and Their Processing Metalloproteinases ADAM10 and ADAM17 in Proliferative Diabetic Retinopathy

Authors: Ahmed M. Abu El-Asrar, Mohd Imtiaz Nawaz, Ajmal Ahmad, Alexandra De Zutter, Mohammad Mairaj Siddiquei, Marfa Blanter, Eef Allegaert, Priscilla W. Gikandi, Gert De Hertogh, Jo Van Damme, Ghislain Opdenakker, Sofie Struyf

Source: Frontiers in Immunology, Vol 11 (2021)

Subject Terms: proliferative diabetic retinopathy, chemokines, metalloproteinases, CXCL16, CX3CL1, ADAM10, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2020.601639/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/96070714f230472782f75f5efe1485f3

Adrenal hormones mediate disease tolerance in malaria

Authors: Leen Vandermosten, Thao-Thy Pham, Sofie Knoops, Charlotte De Geest, Natacha Lays, Kristof Van der Molen, Christopher J. Kenyon, Manu Verma, Karen E. Chapman, Frans Schuit, Karolien De Bosscher, Ghislain Opdenakker, Philippe E. Van den Steen

Source: Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4a46f7525e7d4cd28340e26b10d771de

Poxviruses Bearing DNA Polymerase Mutations Show Complex Patterns of Cross-Resistance

Authors: Graciela Andrei, Pierre Fiten, Marcela Krečmerová, Ghislain Opdenakker, Dimitrios Topalis, Robert Snoeck

Source: Biomedicines, Vol 10, Iss 3, p 580 (2022)

Subject Terms: vaccinia virus, DNA polymerase, drug resistance, nucleotide analogues, cidofovir, phosphonoacetic acid, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/10/3/580; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/4b4928b02fcf4374883a31892f6f3596