Nanostructured lipid carriers based mRNA vaccine leads to a T cell–inflamed tumour microenvironment favourable for improving PD-1/PD-L1 blocking therapy and long-term immunity in a cold tumour model

Authors: Fournier, Carole ^{a, f, ∗}, Mercey-Ressejac, Marion ^a, Derangère, Valentin ^{c, d, e}, Al Kadi, Amal ^a, Rageot, David ^{c, d, e}, Charrat, Christine ^a, Leroy, Alexis ^a, Vollaire, Julien ^a, Josserand, Véronique ^a, Escudé, Marie ^b, Escaich, Séverine ^b, Ghiringhelli, François ^{c, d, e}, Decaens, Thomas ^{a, f}, Navarro, Fabrice P. ^b, Jouvin-Marche, Evelyne ^a, Marche, Patrice N. ^a

Source: In eBioMedicine February 2025 112

Deep learning uncovers histological patterns of YAP1/TEAD activity related to disease aggressiveness in cancer patients

Authors: Schmauch, Benoit ^{1, 20, ∗}, Cabeli, Vincent ¹, Domingues, Omar Darwiche ¹, Le Douget, Jean-Eudes ¹, Hardy, Alexandra ^{1, ∗∗}, Belbahri, Reda ¹, Maussion, Charles ¹, Romagnoni, Alberto ¹, Eckstein, Markus ², Fuchs, Florian ^{3, 4, 5}, Swalduz, Aurélie ⁶, Lantuejoul, Sylvie ⁷, Crochet, Hugo ⁸, Ghiringhelli, François ⁹, Derangere, Valentin ^{9, 10, 11, 12}, Truntzer, Caroline ^{9, 10, 11, 12}, Pass, Harvey ¹³, Moreira, Andre L. ¹⁴, Chiriboga, Luis ¹⁴, Zheng, Yuanning ¹⁵, Ozawa, Michael ¹⁵, Howitt, Brooke E. ¹⁶, Gevaert, Olivier ¹⁶, Girard, Nicolas ¹⁷, Rexhepaj, Elton ¹⁸, Valtingojer, Iris ¹⁸, Debussche, Laurent ¹⁸, de Rinaldis, Emanuele ¹⁹, Nestle, Frank ¹⁹, Spanakis, Emmanuel ¹⁸, Fantin, Valeria R. ¹⁹, Durand, Eric Y. ¹, Classe, Marion ¹⁸, Von Loga, Katharina ¹, Pronier, Elodie ¹, Cesaroni, Matteo ¹⁸

Source: In iScience 17 January 2025 28(1)

Efficacy and Safety of Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting Transforming Growth Factor-β and Programmed Death-Ligand 1, Plus Chemotherapy in Patients With Stage IV NSCLC

Authors: Rolfo, Christian ^{a, b, ∗}, Greillier, Laurent ^c, Veillon, Remi ^d, Badin, Firas ^e, Ghiringhelli, Francois ^f, Isambert, Nicolas ^g, Paulus, Astrid ^h, Chaudhary, Surendra Pal ⁱ, Vugmeyster, Yulia ⁱ, Sato, Masashi ^j, Hiret, Sandrine ^k

Source: In JTO Clinical and Research Reports January 2025 6(1)

Machine learning evaluation of immune infiltrate through digital tumour score allows prediction of survival outcome in a pooled analysis of three international stage III colon cancer cohorts

Authors: Lecuelle, Julie, Truntzer, Caroline, Basile, Debora, Laghi, Luigi, Greco, Luana, Ilie, Alis, Rageot, David, Emile, Jean-François, Bibeau, Fréderic, Taïeb, Julien, Derangere, Valentin, Lepage, Come, Ghiringhelli, François

Source: In eBioMedicine July 2024 105

Custom scoring based on ecological topology of gut microbiota associated with cancer immunotherapy outcome

Authors: Derosa, Lisa, Iebba, Valerio, Silva, Carolina Alves Costa, Piccinno, Gianmarco, Wu, Guojun, Lordello, Leonardo, Routy, Bertrand, Zhao, Naisi, Thelemaque, Cassandra, Birebent, Roxanne, Marmorino, Federica, Fidelle, Marine, Messaoudene, Meriem, Thomas, Andrew Maltez, Zalcman, Gerard, Friard, Sylvie, Mazieres, Julien, Audigier-Valette, Clarisse, Sibilot, Denis Moro, Goldwasser, François, Scherpereel, Arnaud, Pegliasco, Hervé, Ghiringhelli, François, Bouchard, Nicole, Sow, Cissé, Darik, Ines, Zoppi, Silvia, Ly, Pierre, Reni, Anna, Daillère, Romain, Deutsch, Eric, Lee, Karla A., Bolte, Laura A., Björk, Johannes R., Weersma, Rinse K., Barlesi, Fabrice, Padilha, Lucas, Finzel, Ana, Isaksen, Morten L., Escudier, Bernard, Albiges, Laurence, Planchard, David, André, Fabrice, Cremolini, Chiara, Martinez, Stéphanie, Besse, Benjamin, Zhao, Liping, Segata, Nicola, Wojcik, Jérôme, Kroemer, Guido, Zitvogel, Laurence

Source: In Cell 20 June 2024 187(13):3373-3389

Evaluation of immune infiltrate according to the HER2 status in colorectal cancer

Authors: Molimard, Chloé, Dor, Fanny, Overs, Alexis, Monnien, Franck, Gessain, Grégoire, Kedochim, Loïs, D'Angelo, Flavia, Abad, Marine, Heberle, Morgane, Derangère, Valentin, Ghiringhelli, François, Vuitton, Lucine, Valmary-Degano, Séverine, Borg, Christophe, Lakkis, Zaher, Bibeau, Fréderic

Source: In Digestive and Liver Disease May 2024 56(5):853-860

Atezolizumab plus modified docetaxel, cisplatin, and fluorouracil as first-line treatment for advanced anal cancer (SCARCE C17-02 PRODIGE 60): a randomised, non-comparative, phase 2 study

Authors: Kim, Stefano ^*, Ghiringhelli, Francois, de la Fouchardière, Christelle, Evesque, Ludovic, Smith, Denis, Badet, Nicolas, Samalin, Emmanuelle, Lopez-Trabada Ataz, Daniel, Parzy, Aurelie, Desramé, Jérôme, Baba Hamed, Nabil, Buecher, Bruno, Tougeron, David, Bouché, Olivier, Dahan, Laetitia, Chibaudel, Benoist, El Hajbi, Farid, Mineur, Laurent, Dubreuil, Olivier, Ben Abdelghani, Meher, Pecout, Solange, Bibeau, Frederic, Herfs, Michael, Garcia, Marie-Line, Meurisse, Aurelia, Vernerey, Dewi, Taïeb, Julien, Borg, Christophe

Source: In The Lancet Oncology April 2024 25(4):518-528

Fruquintinib versus placebo in patients with refractory metastatic colorectal cancer (FRESCO-2): an international, multicentre, randomised, double-blind, phase 3 study

Authors: Dasari, Arvind ^{*, *}, Lonardi, Sara ^*, Garcia-Carbonero, Rocio, Elez, Elena, Yoshino, Takayuki, Sobrero, Alberto, Yao, James, García-Alfonso, Pilar, Kocsis, Judit, Cubillo Gracian, Antonio, Sartore-Bianchi, Andrea, Satoh, Taroh, Randrian, Violaine, Tomasek, Jiri, Chong, Geoff, Paulson, Andrew Scott, Masuishi, Toshiki, Jones, Jeremy, Csőszi, Tibor, Cremolini, Chiara, Ghiringhelli, Francois, Shergill, Ardaman, Hochster, Howard S, Krauss, John, Bassam, Ali, Ducreux, Michel, Elme, Anneli, Faugeras, Laurence, Kasper, Stefan, Van Cutsem, Eric, Arnold, Dirk, Nanda, Shivani, Yang, Zhao, Schelman, William R, Kania, Marek, Tabernero, Josep, Eng, Cathy

Source: In The Lancet 1-7 July 2023 402(10395):41-53

Immunoscore immune checkpoint using spatial quantitative analysis of CD8 and PD-L1 markers is predictive of the efficacy of anti- PD1/PD-L1 immunotherapy in non-small cell lung cancer

Authors: Ghiringhelli, François, Bibeau, Frederic, Greillier, Laurent, Fumet, Jean-David, Ilie, Alis, Monville, Florence, Laugé, Caroline, Catteau, Aurélie, Boquet, Isabelle, Majdi, Amine, Morgand, Erwan, Oulkhouir, Youssef, Brandone, Nicolas, Adam, Julien, Sbarrato, Thomas, Kassambara, Alboukadel, Fieschi, Jacques, Garcia, Stéphane, Lepage, Anne Laure, Tomasini, Pascale, Galon, Jérôme

Source: In eBioMedicine June 2023 92

Biliary tract cancers have distinct epidemiological patterns and clinical characteristics according to tumour site

Authors: Ghiringhelli, François, Jooste, Valérie, Manfredi, Sylvain, Hennequin, Audrey, Lepage, Côme, Bouvier, Anne-Marie

Source: In HPB June 2023 25(6):693-703

Immunotherapy in MSI/dMMR tumors in the perioperative setting: The IMHOTEP trial

Authors: Coutzac, Clélia, Bibeau, Frederic, Ben Abdelghani, Meher, Aparicio, Thomas, Cohen, Romain, Coquan, Elodie, Dubreuil, Olivier, Evesque, Ludovic, Ghiringhelli, François, Kim, Stefano, Lesourd, Samuel, Neuzillet, Cindy, Phelip, Jean-Marc, Piessen, Guillaume, Rochigneux, Philippe, Samalin, Emmanuelle, Soularue, Emilie, Touchefeu, Yann, Tougeron, David, Zaanan, Aziz, de la Fouchardière, Christelle

Source: In Digestive and Liver Disease October 2022 54(10):1335-1341

Immunologically active phenotype by gene expression profiling is associated with clinical benefit from PD-1/PD-L1 inhibitors in real-world head and neck and lung cancer patients

Authors: Foy, Jean-Philippe, Karabajakian, Andy, Ortiz-Cuaran, Sandra, Boussageon, Maxime, Michon, Lucas, Bouaoud, Jebrane, Fekiri, Dorssafe, Robert, Marie, Baffert, Kim-Arthur, Hervé, Geneviève, Quilhot, Pauline, Attignon, Valéry, Girod, Angélique, Chaine, André, Benassarou, Mourad, Zrounba, Philippe, Caux, Christophe, Ghiringhelli, François, Lantuejoul, Sylvie, Crozes, Carole, Brochériou, Isabelle, Pérol, Maurice, Fayette, Jérôme, Bertolus, Chloé, Saintigny, Pierre

Source: In European Journal of Cancer October 2022 174:287-298

Combination of CDX2 H-score quantitative analysis with CD3 AI-guided analysis identifies patients with a good prognosis only in stage III colon cancer

Authors: Derangère, Valentin, Lecuelle, Julie, Lepage, Come, Aoulad-Ben Salem, Oumaima, Allatessem, Ben M., Ilie, Alis, Bouché, Olivier, Phelip, Jean-Marc, Baconnier, Mathieu, Pezet, Denis, Sebbagh, Virginie, Terrebonne, Eric, Bouard, Gauthier, Jooste, Valérie, Bouvier, Anne-Marie, Molimard, Chloé, Monnien, Franck, Gonzalez, Daniel, Le Malicot, Karine, Rageot, David, Truntzer, Caroline, Bibeau, Fréderic, Ghiringhelli, Francois

Source: In European Journal of Cancer September 2022 172:221-230

NIR-II aza-BODIPY Platform for the Development of a Fluorescent Antibody Drug Conjugate.

Authors: Chazeau, Elisa, Pipier, Angélique, Wegner, K. David, Ghiringhelli, François, Sancey, Lucie, Paul, Catherine, Goze, Christine

Source: Journal of Medicinal Chemistry; 4/10/2025, Vol. 68 Issue 7, p7232-7242, 11p

Rationale and Design of the COPERNIC Trial: A Study of On-treatment ctDNA Changes in Chemo-refractory Colorectal Cancer Patients.

Authors: Assaf, Irene, Bregni, Giacomo, Anthoine, Geraldine, Aparicio, Thomas, Artru, Pascal, Abdelghani, Meher Ben, Buyse, Marc, Chibaudel, Benoist, Coart, Elisabeth, Diaz, Marie, Evrard, Camille, Geboes, Karen, Ghiringhelli, François, Puleo, Francesco, Raimbourg, Judith, Vandamme, Timon, Van den Eynde, Marc, Hendlisz, Alain, Sclafani, Francesco

Source: Clinical Colorectal Cancer; Mar2025, Vol. 24 Issue 1, p101-105, 5p

Targeting Immune Checkpoint Inhibitors for Non-Small-Cell Lung Cancer: Beyond PD-1/PD-L1 Monoclonal Antibodies.

Authors: Roussot, Nicolas, Kaderbhai, Courèche, Ghiringhelli, François

Source: Cancers; Mar2025, Vol. 17 Issue 5, p906, 43p

Subject Terms: THERAPEUTIC use of antineoplastic agents, THERAPEUTIC use of monoclonal antibodies, IMMUNOTHERAPY, PROGRAMMED death-ligand 1, TREATMENT effectiveness, IMMUNE checkpoint inhibitors, PHARMACY information services, DRUG efficacy, LUNG cancer, T-cell exhaustion, IMMUNITY, IPILIMUMAB

Biomarkers of response in patients with gastric/gastroesophageal junction adenocarcinoma (GEA) treated with telisotuzumab adizutecan.

Authors: Strickler, John H, Raimbourg, Judith, Ghiringhelli, François, Cohen, Jonathan, Kitagawa, Chiyoe, Sharma, Manish R, Lee, Ki Hyeong, Saada-Bouzid, Esma, O'Neil, Bert, Rudra-Ganguly, Nandini, Luo, Xizhi, Roberts-Rapp, Lisa, Predoiu, Raluca, Zhao, Weilong, Li, Rui, Hunter, Zoe, Burns, Michael Charles, Blaney, Martha Elizabeth, Kuboki, Yasutoshi

Source: Journal of Clinical Oncology; 2025 Supplement 4, Vol. 43, p490-490, 188p

Genomic alterations in circulating tumor DNA (ctDNA) and response to telisotuzumab adizutecan (ABBV-400) treatment in patients (pts) with colorectal cancer (CRC).

Authors: Cecchini, Michael, Sharma, Manish R, Kuboki, Yasutoshi, Perets, Ruth, Cohen, Jonathan, Raimbourg, Judith, Nakajima, Takako Eguchi, Cruz-Correa, Marcia, Ghiringhelli, François, Raghav, Kanwal Pratap Singh, Vasilopoulos, Athanasios, Luo, Xizhi, Neagu Aristide, Martha Raluca, Morrison Thiele, Gladys, Hunter, Zoe, Burns, Michael Charles, Roberts-Rapp, Lisa, Strickler, John H

Source: Journal of Clinical Oncology; 2025 Supplement 4, Vol. 43, p258-258, 307p

Fruquintinib plus best supportive care for patients with metastatic colorectal cancer: Characterization of patients who had an overall survival of ≥10 months in the FRESCO-2 study.

Authors: Kasper, Stefan, Sartore-Bianchi, Andrea, Randrian, Violaine, Cremolini, Chiara, Arnold, Dirk, Dasari, Arvind, Eng, Cathy, Lonardi, Sara, Elez, Elena, Yoshino, Takayuki, Sobrero, Alberto F., Yao, James C., Hochster, Howard S., Van Cutsem, Eric, Tougeron, David, Yu, Ziji, Dong, Cynthia, Schelman, William R., Ghiringhelli, François

Source: Journal of Clinical Oncology; 2025 Supplement 4, Vol. 43, p142-142, 307p

Health-Related Quality of Life Analysis in Metastatic Colorectal Cancer Patients Treated by Second-Line Chemotherapy, Associated With Either Cetuximab or Bevacizumab: The PRODIGE 18 Randomized Phase II Study

Authors: Bertaut, Aurelie, Touchefeu, Yann, Blanc, Julie, Bouché, Olivier, François, Eric, Conroy, Thierry, Artru, Pascal, Adenis, Antoine, Gobbo, Jessica, Borg, Christophe, Ghiringhelli, François, Bennouna, Jaafar

Source: In Clinical Colorectal Cancer June 2022 21(2):e49-e61