Sex- and age-specific regulation of ACE2: Insights into severe COVID-19 susceptibility

Authors: Viveiros, Anissa, Gheblawi, Mahmoud, Aujla, Preetinder K., Sosnowski, Deanna K., Seubert, John M., Kassiri, Zamaneh, Oudit, Gavin Y.

Source: Journal of molecular and cellular cardiology. 164:13-16

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Dysregulation of ACE (Angiotensin-Converting Enzyme)-2 and Renin-Angiotensin Peptides in SARS-CoV-2 Mediated Mortality and End-Organ Injuries

Authors: Wang, Kaiming, Gheblawi, Mahmoud, Nikhanj, Anish, Munan, Matt, MacIntyre, Erika, O'Neil, Conar, Poglitsch, Marko, Colombo, Daniele, Del Nonno, Franca, Kassiri, Zamaneh, Sligl, Wendy, Oudit, Gavin Y.

Source: Hypertension. 79(2):365-378

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100146365978.0x000001&indx=1&recIds=ETOCvdc_100146365978.0x000001

Metabolically stable apelin-analogues, incorporating cyclohexylalanine and homoarginine, as potent apelin receptor activatorsElectronic supplementary information (ESI) available. See DOI: 10.1039/d1md00120e

Authors: Fernandez, Kleinberg X., Fischer, Conrad, Vu, Jennie, Gheblawi, Mahmoud, Wang, Wang, Gottschalk, Samantha, Iturrioz, Xavier, Llorens-Cortés, Catherine, Oudit, Gavin Y., Vederas, John C.

Source: RSC medicinal chemistry. 12(8):1402-1413

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An advanced endothelial murine HFpEF model: eNOS is critical for angiotensin 1–7 rescue of the diabetic phenotype

Authors: Gheblawi, Mahmoud, de Oliveira, Amanda A., Williams, Vanessa R., John, Rohan, Grant, Maria B., Scholey, James W., Oudit, Gavin Y.

Source: Journal of molecular and cellular cardiology. 169:10-12

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Plasma taurine level is linked to symptom burden and clinical outcomes in post-COVID condition.

Authors: Khoramjoo, Mobin, Wang, Kaiming, Srinivasan, Karthik, Gheblawi, Mahmoud, Mandal, Rupasri, Rousseau, Simon, Wishart, David, Prasad, Vinay, Richer, Lawrence, Cheung, Angela M., Oudit, Gavin Y.

Source: PLoS ONE; 6/5/2024, Vol. 19 Issue 6, p1-16, 16p

Subject Terms: SYMPTOM burden, TAURINE, COVID-19 pandemic, COVID-19, TREATMENT effectiveness

Angiotensin Converting Enzyme 2

Authors: Wang, Kaiming, Gheblawi, Mahmoud, Oudit, Gavin Y.

Source: Circulation. 142(5):426-428

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100188866944.0x000001&indx=1&recIds=ETOCvdc_100188866944.0x000001

Urinary angiotensin-converting enzyme 2 and metabolomics in COVID-19-mediated kidney injury.

Authors: Vergara, Ander, Wang, Kaiming, Colombo, Daniele, Gheblawi, Mahmoud, Rasmuson, Jaslyn, Mandal, Rupasri, Nonno, Franca Del, Chiu, Brian, Scholey, James W, Soler, María José, Wishart, David S, Oudit, Gavin Y

Source: Clinical Kidney Journal; Feb2023, Vol. 16 Issue 2, p272-284, 13p

Subject Terms: SARS-CoV-2, ANGIOTENSIN converting enzyme, COVID-19, ESSENTIAL amino acids, LIPOCALIN-2

Response by Gheblawi et al to Letter Regarding Article, 'Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2'

Authors: Gheblawi, Mahmoud, Wang, Kaiming, Viveiros, Anissa, Nguyen, Quynh, Zhong, Jiu-Chang, Turner, Anthony J., Raizada, Mohan K., Grant, Maria B., Oudit, Gavin Y.

Source: Circulation research. 127(2):e46-e47

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190134858.0x000001&indx=1&recIds=ETOCvdc_100190134858.0x000001

ACE2 (Angiotensin-Converting Enzyme 2)-Mediated Protection From Pulmonary Hypertension

Authors: Gheblawi, Mahmoud, Wang, Kaiming, Oudit, Gavin Y.

Source: Hypertension. 76(1):28-29

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100176815926.0x000001&indx=1&recIds=ETOCvdc_100176815926.0x000001

SARS-CoV-2 infection downregulates myocardial ACE2 and potentiates cardiac inflammation in humans and hamsters.

Authors: Viveiros, Anissa, Noyce, Ryan S., Gheblawi, Mahmoud, Colombo, Daniele, Bilawchuk, Leanne M., Clemente-Casares, Xavier, Marchant, David J., Kassiri, Zamaneh, Del Nonno, Franca, Evans, David H., Oudit, Gavin Y.

Source: American Journal of Physiology: Heart & Circulatory Physiology; Dec2022, Vol. 323 Issue 6, pH1262-H1269, 8p

Subject Terms: ANGIOTENSIN converting enzyme, COVID-19, SARS-CoV-2 Delta variant, HAMSTERS, SARS-CoV-2

Optimizing PEG-Extended Apelin Analogues as Cardioprotective Drug Leads: Importance of the KFRR Motif and Aromatic Head Group for Improved Physiological Activity.

Authors: Fischer, Conrad, Lamer, Tess, Fernandez, Kleinberg, Gheblawi, Mahmoud, Wang, Wang, Pascoe, Cameron, Lambkin, Gareth, Iturrioz, Xavier, Llorens-Cortes, Catherine, Oudit, Gavin Y., Vederas, John C.

Source: Journal of Medicinal Chemistry; 10/22/2020, Vol. 63 Issue 20, p12073-12082, 10p

Angiotensin-Converting Enzyme 2: SARS-CoV-2 Receptor and Regulator of the Renin-Angiotensin System: Celebrating the 20th Anniversary of the Discovery of ACE2.

Authors: Gheblawi, Mahmoud, Wang, Kaiming, Viveiros, Anissa, Nguyen, Quynh, Zhong, Jiu-Chang, Turner, Anthony J., Raizada, Mohan K., Grant, Maria B., Oudit, Gavin Y.

Source: Circulation Research; 5/8/2020, Vol. 126 Issue 10, p1456-1474, 19p

Testosterone and cardiac remodeling: why are older men susceptible to heart disease?

Authors: Zhabyeyev, Pavel¹, Gheblawi, Mahmoud¹, Oudit, Gavin Y.¹ gavin.oudit@ualberta.ca

Source: American Journal of Physiology: Heart & Circulatory Physiology. Apr2019, Vol. 316 Issue 4, pH765-H767. 3p.

Subject Terms: *HEART diseases, *ANDROGEN receptors, *TESTOSTERONE, *OLDER men, *TRP channels

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Interaction between the apelinergic system and ACE2 in the cardiovascular system: therapeutic implications.

Authors: Chatterjee, Paulami^1,2, Gheblawi, Mahmoud^1,2, Kaiming Wang², Jeannie Vu^1,2, Kondaiah, Palsa^1,2, Oudit, Gavin Y.^1,2 gavin.oudit@ualberta.ca

Source: Clinical Science. Sep2020, Vol. 134 Issue 17, p2319-2336. 18p.

Subject Terms: *CARDIOVASCULAR system, *ANGIOTENSIN converting enzyme, *ALTERNATIVE medicine, *RENIN-angiotensin system, *APELIN

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