Outcomes of haploidentical transplants with PT-CY vs 10/10 MUD transplants with ATG in Germany

Authors: Aysenur Arslan, Svenja Labuhn, Elisa Sala, Mark Ringhoffer, Johannes Schetelig, Thomas Schröder, Gesine Bug, Georg-Nikolaus Franke, Matthias Stelljes, Peter Dreger, Robert Zeiser, Daniel Teschner, Wolfgang Bethge, Matthias Eder, Matthias Edinger, Elisa Maria Amann, Christine Neuchel, Amelie Schmid-Möglich, Sandra Schmeller, Jan Beyersmann, Hubert Schrezenmeier, Joannis Mytilineos, Nicolaus Kröger, Daniel Fürst, Thomas Schroeder, Uwe Platzbecker, Ahmet Elmaagacli, Inken Hilgendorf, Andreas Burchert, Friedrich Stölzel, Mareike Verbeek, Johanna Tischer, Arne Brecht, Martin Kaufmann, Christoph Kimmich, Jörg Thomas Bittenbring, Gerald Wulf, Igor Wolfgang Blau, Julia Winkler, Edgar Jost, Tobias Holderried, Mareike Dürholt, Christof Scheid, Eva Wagner-Drouet, Denise Wolleschak, Michael Kiehl, Friederike Wortmann, Guido Kobbe, Roland Schroers, Angela Krackhardt, Stefan Klein, Lutz P. Müller, Christoph Schmid, Stephan Kaun, Ute Wieschermann, Tobias Bartscht, Ralf Georg Meyer, Matthias Wölfl, Peter Bader, Judith Niederland, Jakob Maucher, Christine Mauz-Körholz, Birgit Burkhardt, Karim Kentouche, Jakob Passweg, Karoline Ehlert

Source: Blood Advances, Vol 8, Iss 23, Pp 6104-6113 (2024)

Subject Terms: Specialties of internal medicine, RC581-951

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2473952924005895; https://doaj.org/toc/2473-9529

Access URL: https://doaj.org/article/1a7d43dbb4804252a15b226d822dc730

Impact of inhibitory KIR ligand mismatch and other variables on outcomes following myeloablative posttransplant cyclophosphamide-based T-cell-replete haploidentical bone marrow transplantation

Authors: Sarah Kayser, Emilia Salzmann-Manrique, Hubert Serve, Peter Bader, Jan-Henning Klusmann, Christian Seidl, Joachim Schwäble, Gesine Bug, Evelyn Ullrich

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: hematopoietic cell transplantation (HCT), T-cell-repleted haploidentical bone marrow transplantation (BMT), posttransplant cyclophosphamide (PTCy), hematological malignancies, inhibitory KIR ligand mismatch, recipient and donor variables, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1413927/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/0889d2ce43f248dda02d077347701039

GVHD after CAR T-cell therapy post allogeneic hematopoietic cell transplantation — successfully treated by extracorporeal photopheresis

Authors: Kiavasch Mohammad Nejad Farid, Gesine Bug, Anita Schmitt, Fabian Lang, Maria-Luisa Schubert, Uwe Haberkorn, Carsten Müller-Tidow, Peter Dreger, Michael Schmitt

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: graft-versus-host disease, CAR T-cell therapy, extracorporeal photopheresis, acute lymphoblastic leukemia, T-cell alloreactivity, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1500177/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/a3081d0d3e2a495586fae7c45402fb2f

Real-world data suggest effectiveness of the allogeneic mesenchymal stromal cells preparation MSC-FFM in ruxolitinib-refractory acute graft-versus-host disease

Authors: Halvard Bonig, Mareike Verbeek, Peter Herhaus, Krischan Braitsch, Gernot Beutel, Christoph Schmid, Nadine Müller, Gesine Bug, Michaela Döring, Arend von Stackelberg, Johanna Tischer, Francis Ayuk, Gerald Wulf, Udo Holtick, Lisa-Marie Pfeffermann, Bernd Jahrsdörfer, Hubert Schrezenmeier, Selim Kuci, Zyrafete Kuci, Anke Zens, Michael Tribanek, Robert Zeiser, Sabine Huenecke, Peter Bader

Source: Journal of Translational Medicine, Vol 21, Iss 1, Pp 1-11 (2023)

Subject Terms: MSC-FFM, Mesenchymal stromal cells, Steroid-refractory, Ruxolitinib-refractory, Allogeneic haematopoietic stem cell transplantation, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/1942e01c115d422bbf46c4611ede54dd

Treatment of adult ALL patients with third-generation CD19-directed CAR T cells: results of a pivotal trial

Authors: Maria-Luisa Schubert, Anita Schmitt, Angela Hückelhoven-Krauss, Brigitte Neuber, Alexander Kunz, Philip Waldhoff, Dominik Vonficht, Schayan Yousefian, Lea Jopp-Saile, Lei Wang, Felix Korell, Anna Keib, Birgit Michels, Dominik Haas, Tim Sauer, Patrick Derigs, Andreas Kulozik, Joachim Kunz, Petra Pavel, Sascha Laier, Patrick Wuchter, Johann Schmier, Gesine Bug, Fabian Lang, Nicola Gökbuget, Jochen Casper, Martin Görner, Jürgen Finke, Andreas Neubauer, Mark Ringhoffer, Denise Wolleschak, Monika Brüggemann, Simon Haas, Anthony D. Ho, Carsten Müller-Tidow, Peter Dreger, Michael Schmitt

Source: Journal of Hematology & Oncology, Vol 16, Iss 1, Pp 1-17 (2023)

Subject Terms: Acute lymphoblastic leukemia (ALL), Third-generation chimeric antigen receptor (CAR) T cells, Investigator-initiated trial (IIT), CART-associated toxicities, Cytokine release syndrome (CRS), Cytopenia, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/26e8df351a78481d84b79ca3e21d57c8

Correction: Real‑world data suggest effectiveness of the allogeneic mesenchymal stromal cells preparation MSC‑FFM in ruxolitinib‑refractory acute graft‑versus‑host disease

Authors: Halvard Bonig, Mareike Verbeek, Peter Herhaus, Krischan Braitsch, Gernot Beutel, Christoph Schmid, Nadine Müller, Gesine Bug, Michaela Döring, Arend von Stackelberg, Johanna Tischer, Francis Ayuk, Gerald Wulf, Udo Holtick, Lisa‑Marie Pfeffermann, Bernd Jahrsdörfer, Hubert Schrezenmeier, Selim Kuci, Zyrafete Kuci, Anke Zens, Michael Tribanek, Robert Zeiser, Sabine Huenecke, Peter Bader

Source: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-2 (2024)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/b531e2a3fa18414fbe6b2e7f1a58550c

Thiotepa-busulfan-fludarabine Compared to Treosulfan-based Conditioning for Haploidentical Transplant With Posttransplant Cyclophosphamide in Patients With Acute Myeloid Leukemia in Remission: A Study From the Acute Leukemia Working Party of the EBMT

Authors: Francesco Saraceni, Myriam Labopin, Anna M. Raiola, Didier Blaise, Péter Reményi, Federica Sorà, Jiri Pavlu, Stefania Bramanti, Alessandro Busca, Ana Berceanu, Giorgia Battipaglia, Giuseppe Visani, Gerard Sociè, Gesine Bug, Caterina Micò, Giorgio La Nasa, Maurizio Musso, Attilio Olivieri, Alexandros Spyridonidis, Bipin Savani, Fabio Ciceri, Arnon Nagler, Mohamad Mohty, on behalf of the Acute Leukemia Working Party (ALWP) of the European Society for Blood and Marrow Transplantation (EBMT)

Source: HemaSphere, Vol 7, Iss 10, p e952 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/HS9.0000000000000952; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/43bceaa88620409183d75baac3c88d12

P1278: MEASURABLE RESIDUAL DISEASE ASSESSMENT IN THE PROSPECTIVE HAPLOMUD STUDY

Authors: Isabell Arnhardt, Arnold Kloos, Nadine Kattre, Razif Gabdoulline, Alina Lasch, Yasmine Alwie, Nicolaus Kröger, Rudolf Trenschel, Matthias Stelljes, Matthias Eder, Wolfgang Bethge, Gesine Bug, Carlos Solano Vercet, Jaime Sanz, Fermin Sanchez-Guijo, Alessandro Rambaldi, Francesca Bonifazi, Francesca Patriarca, Marketa Šťastná Marková, Philipp Wohlfarth, Hildegard Greinix, Adrian Schwarzer, Michael Heuser

Source: HemaSphere, Vol 7, p e51143d7 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000972000.51143.d7; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/61dee36027b14ff2a410af8e1b0fcd18

P1319: TREATMENT WITH MIDOSTAURIN AND OTHER FLT3 TARGETING INHIBITORS IS ASSOCIATED WITH AN INCREASED RISK OF CARDIOVASCULAR ADVERSE EVENTS IN PATIENTS WITH FLT3 MUTATED AML WHO UNDERWENT ALLOGENEIC HCT

Authors: Anjali Cremer, Julius C. Enssle, Saskia Pfaff, Khouloud Kouidri, Fabian Lang, Christian Brandts, Andreas Zeiher, Sebastian Cremer, Björn Steffen, Hubert Serve, Gesine Bug

Source: HemaSphere, Vol 7, p e39454e5 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/01.HS9.0000972164.39454.e5; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/65baba4e5f9f4af5aba2c776759d836b

Impact of IDH1 and IDH2 mutational subgroups in AML patients after allogeneic stem cell transplantation

Authors: Desiree Kunadt, Sebastian Stasik, Klaus H. Metzeler, Christoph Röllig, Christoph Schliemann, Philipp A. Greif, Karsten Spiekermann, Maja Rothenberg-Thurley, Utz Krug, Jan Braess, Alwin Krämer, Andreas Hochhaus, Sebastian Scholl, Inken Hilgendorf, Tim H. Brümmendorf, Edgar Jost, Björn Steffen, Gesine Bug, Hermann Einsele, Dennis Görlich, Cristina Sauerland, Kerstin Schäfer-Eckart, Stefan W. Krause, Mathias Hänel, Maher Hanoun, Martin Kaufmann, Bernhard Wörmann, Michael Kramer, Katja Sockel, Katharina Egger-Heidrich, Tobias Herold, Gerhard Ehninger, Andreas Burchert, Uwe Platzbecker, Wolfgang E. Berdel, Carsten Müller-Tidow, Wolfgang Hiddemann, Hubert Serve, Matthias Stelljes, Claudia D. Baldus, Andreas Neubauer, Johannes Schetelig, Christian Thiede, Martin Bornhäuser, Jan M. Middeke, Friedrich Stölzel, the A. M. L. Cooperative Group (AMLCG), Study Alliance Leukemia (SAL)

Source: Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-15 (2022)

Subject Terms: Acute myeloid leukemia, IDH mutations, Allogeneic hematopoietic cell transplantation, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1756-8722

Access URL: https://doaj.org/article/1665eacc6b1a46028a7f2723eae46d4a

Reduced 8-Gray Compared to Standard 12-Gray Total Body Irradiation for Allogeneic Transplantation in First Remission Acute Lymphoblastic Leukemia: A Study of the Acute Leukemia Working Party of the EBMT

Authors: Alexandros Spyridonidis, Myriam Labopin, Bipin Savani, Sebastian Giebel, Gesine Bug, Stefan Schönland, Nicolaus Kröger, Matthias Stelljes, Thomas Schroeder, Andrew McDonald, Igor-Wolfgang Blau, Martin Bornhäuser, Montse Rovira, Wolfgang Bethge, Andreas Neubauer, Arnold Ganser, Jean Henri Bourhis, Matthias Edinger, Bruno Lioure, Gerald Wulf, Kerstin Schäfer-Eckart, Mutlu Arat, Zinaida Peric, Christoph Schmid, Ali Bazarbachi, Fabio Ciceri, Arnon Nagler, Mohamad Mohty

Source: HemaSphere, Vol 7, Iss 1, p e812 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: http://journals.lww.com/10.1097/HS9.0000000000000812; https://doaj.org/toc/2572-9241

Access URL: https://doaj.org/article/eb30afc7089b40299a7ace1e15bb6dbe

Activity of decitabine combined with all-trans retinoic acid in oligoblastic acute myeloid leukemia: results from a randomized 2x2 phase II trial (DECIDER)

Authors: Christoph Rummelt, Olga Grishina, Claudia Schmoor, Martina Crysandt, Michael Heuser, Katharina S. Götze, Richard F. Schlenk, Konstanze Döhner, Helmut R. Salih, Gerhard Heil, Carsten Müller-Tidow, Wolfram Brugger, Andrea Kündgen, Maike de Wit, Aristoteles Giagounidis, Sebastian Scholl, Andreas Neubauer, Jürgen Krauter, Gesine Bug, Haifa Kathrin Al-Ali, Ralph Wäsch, Heiko Becker, Annette M. May, Justus Duyster, Björn Hackanson, Arnold Ganser, Hartmut Döhner, Michael Lübbert

Source: Haematologica, Vol 108, Iss 8 (2023)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/10930; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/3448ad0c720c4bd583057eb97a440fb5

Allogeneic transplant procurement in the times of COVID-19: Quality report from the central European cryopreservation site

Authors: Eliza Wiercinska, Vera Schlipfenbacher, Gesine Bug, Peter Bader, Mareike Verbeek, Erhard Seifried, Halvard Bonig

Source: Journal of Translational Medicine, Vol 19, Iss 1, Pp 1-10 (2021)

Subject Terms: Hematopoietic stem cell, Stem cell enumeration, CD34+ cell enumeration, Graft, Graft quality, Quality control, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/029ed9362b4642d2a3a345f990382243

Impact of Clostridioides difficile infection on the outcome of patients receiving a hematopoietic stem cell transplantation

Authors: Sarah Weber, Sebastian Scheich, Aaron Magh, Sebastian Wolf, Julius C. Enßle, Uta Brunnberg, Claudia Reinheimer, Thomas A. Wichelhaus, Volkhard A.J. Kempf, Johanna Kessel, Maria J.G.T. Vehreschild, Hubert Serve, Gesine Bug, Björn Steffen, Michael Hogardt

Source: International Journal of Infectious Diseases, Vol 99, Iss , Pp 428-436 (2020)

Subject Terms: Clostridioides difficile, diarrhea, hematopoietic stem cell transplantation, acute myeloid leukemia, lymphoma, Infectious and parasitic diseases, RC109-216

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1201971220306597; https://doaj.org/toc/1201-9712

Access URL: https://doaj.org/article/252fac670d66471eae510bfe1bfc1bc9

A phase I study of a dual PI3-kinase/mTOR inhibitor BEZ235 in adult patients with relapsed or refractory acute leukemia

Authors: Fabian Lang, Lydia Wunderle, Susanne Badura, Eberhard Schleyer, Monika Brüggemann, Hubert Serve, Susanne Schnittger, Nicola Gökbuget, Heike Pfeifer, Sebastian Wagner, Kevin Ashelford, Gesine Bug, Oliver G. Ottmann

Source: BMC Pharmacology and Toxicology, Vol 21, Iss 1, Pp 1-14 (2020)

Subject Terms: Refractory ALL, Refractory AML, PI3K/mTor inhibition, BEZ235, Phase I clinical trial, Therapeutics. Pharmacology, RM1-950, Toxicology. Poisons, RA1190-1270

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s40360-020-00446-x; https://doaj.org/toc/2050-6511

Access URL: https://doaj.org/article/feda2fbc95de41e789dcb412107b0d8e

Monitoring of Circulating CAR T Cells: Validation of a Flow Cytometric Assay, Cellular Kinetics, and Phenotype Analysis Following Tisagenlecleucel

Authors: Andreas Peinelt, Melanie Bremm, Hermann Kreyenberg, Claudia Cappel, Julia Banisharif-Dehkordi, Stephanie Erben, Eva Rettinger, Andrea Jarisch, Roland Meisel, Paul-Gerhardt Schlegel, Olaf Beck, Gesine Bug, Jan-Henning Klusmann, Thomas Klingebiel, Sabine Huenecke, Peter Bader

Source: Frontiers in Immunology, Vol 13 (2022)

Subject Terms: acute lymphoblastic leukemia, chimeric antigen receptor (CAR), immunotherapy, flow cytometry, immune monitoring, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.830773/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/79daa92e8f4244719dcde74aa8452d48

Efficacy of UVC-treated, pathogen-reduced platelets versus untreated platelets: a randomized controlled non-inferiority trial

Authors: Veronika Brixner, Gesine Bug, Petra Pohler, Doris Krämer, Bernd Metzner, Andreas Voss, Jochen Casper, Ulrich Ritter, Stefan Klein, Nael Alakel, Rudolf Peceny, Hans G. Derigs, Frank Stegelmann, Martin Wolf, Hubert Schrezenmeier, Thomas Thiele, Erhard Seifried, Hans-Hermann Kapels, Andrea Döscher, Eduard K. Petershofen, Thomas H. Müller, Axel Seltsam

Source: Haematologica, Vol 106, Iss 4 (2021)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/10163; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/e2852c63bc044be2b5740649a1c09838

Clinical practice recommendation on hematopoietic stem cell transplantation for acute myeloid leukemia patients with FLT3-internal tandem duplication: a position statement from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation

Authors: Ali Bazarbachi, Gesine Bug, Frederic Baron, Eolia Brissot, Fabio Ciceri, Iman Abou Dalle, Hartmut Döhner, Jordi Esteve, Yngvar Floisand, Sebastian Giebel, Maria Gilleece, Norbert-Claude Gorin, Elias Jabbour, Mahmoud Aljurf, Hagop Kantarjian, Mohamed Kharfan-Dabaja, Myriam Labopin, Francesco Lanza, Florent Malard, Zinaida Peric, Thomas Prebet, Farhad Ravandi, Annalisa Ruggeri, Jaime Sanz, Christoph Schmid, Roni Shouval, Alexandros Spyridonidis, Jurjen Versluis, Norbert Vey, Bipin N Savani, Arnon Nagler, Mohamad Mohty

Source: Haematologica, Vol 105, Iss 6 (2020)

Subject Terms: Diseases of the blood and blood-forming organs, RC633-647.5

File Description: electronic resource

Relation: https://haematologica.org/article/view/9426; https://doaj.org/toc/0390-6078; https://doaj.org/toc/1592-8721

Access URL: https://doaj.org/article/5008f9a4eb4f47229b08281560fa9180

Erythrocyte depletion from bone marrow: performance evaluation after 50 clinical-scale depletions with Spectra Optia BMC

Authors: Soo-Zin Kim-Wanner, Gesine Bug, Juliane Steinmann, Salem Ajib, Nadine Sorg, Carolin Poppe, Milica Bunos, Eva Wingenfeld, Christiane Hümmer, Beate Luxembourg, Erhard Seifried, Halvard Bonig

Source: Journal of Translational Medicine, Vol 15, Iss 1, Pp 1-7 (2017)

Subject Terms: Cell processing, RBC-depletion, Apheresis, Medicine

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12967-017-1277-6; https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/99b056d539b94e3db900708a520d3e05

Functional Dominance of CHIP-Mutated Hematopoietic Stem Cells in Patients Undergoing Autologous Transplantation

Authors: Christina A. Ortmann, Lena Dorsheimer, Khalil Abou-El-Ardat, Jennifer Hoffrichter, Birgit Assmus, Halvard Bonig, Anica Scholz, Heike Pfeifer, Hans Martin, Tobias Schmid, Bernhard Brüne, Sebastian Scheich, Björn Steffen, Julia Riemann, Stella Hermann, Alexandra Dukat, Gesine Bug, Christian H. Brandts, Sebastian Wagner, Hubert Serve, Michael A. Rieger

Source: Cell Reports, Vol 27, Iss 7, Pp 2022-2028.e3 (2019)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124719305376; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/c59b55a4abea4891a6ce2eedd4dfb75b