HER2-positive breast-cancer cell lines are sensitive to KDM5 inhibition: definition of a gene-expression model for the selection of sensitive cases

Authors: Paroni, Gabriela, Bolis, Marco, Zanetti, Adriana, Ubezio, Paolo, Helin, Kristian, Staller, Peter, Gerlach, Lars Ole, Fratelli, Maddalena, Neve, Richard M., Terao, Mineko, Garattini, Enrico

Source: Oncogene. 38(15):2675-2689

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193269518.0x000001&indx=1&recIds=ETOCvdc_100193269518.0x000001

Kappa opioid receptor agonists

Molecular Mechanism of Action of Monocyclam Versus Bicyclam Non-peptide Antagonists in the CXCR4 Chemokine Receptor

Authors: Rosenkilde, Mette M., Gerlach, Lars-Ole, Hatse, Sigrid, Skerlj, Renato T., Schols, Dominique, Bridger, Gary J., Schwartz, Thue W.

Source: In Journal of Biological Chemistry 14 September 2007 282(37):27354-27365

INTESTINAL TREATMENT

Y4 selective receptor agonists for therapeutic interventions

Y-RECEPTOR AGONISTS

Y4 SELECTIVE RECEPTOR AGONISTS FOR THERAPEUTIC INTERVENTIONS

Metal Ion Site Engineering Indicates a Global Toggle Switch Model for Seven-transmembrane Receptor Activation

Authors: Elling, Christian E., Frimurer, Thomas M., Gerlach, Lars-Ole, Jorgensen, Rasmus, Holst, Birgitte, Schwartz, Thue W.

Source: In Journal of Biological Chemistry 23 June 2006 281(25):17337-17346

Identification of Indole Derivatives Exclusively Interfering with a G Protein-Independent Signaling Pathway of the Prostaglandin D2 Receptor CRTH2

Authors: Mathiesen, Jesper Mosolff, Ulven, Trond, Martini, Lene ¹, Gerlach, Lars Ole, Heinemann, Akos, Kostenis, Evi ^*

Source: In Molecular Pharmacology August 2005 68(2):393-402

Metal Ion Enhanced Binding of AMD3100 to Asp262 in the CXCR4 Receptor.

Authors: Gerlach, Lars Ole, Jakobsen, Janus S., Jensen, Kasper P.

Source: Biochemistry; January 28 2003, Vol. 42 Issue 3, p710-717, 8p

Molecular Mechanism of AMD3100 Antagonism in the CXCR4 Receptor: TRANSFER OF BINDING SITE TO THE CXCR3 RECEPTOR

Authors: Rosenkilde, Mette M. ^{‡, §}, Gerlach, Lars-Ole ^{‡, ¶}, Jakobsen, Janus S. ^‡, Skerlj, Renato T. ^∥, Bridger, Gary J. ^{§, ∥}, Schwartz, Thue W. ^{‡, §, ¶}

Source: In Journal of Biological Chemistry 23 January 2004 279(4):3033-3041

Mutations at the CXCR4 interaction sites for AMD3100 influence anti-CXCR4 antibody binding and HIV-1 entry

Authors: Hatse, Sigrid, Princen, Katrien, Vermeire, Kurt, Gerlach, Lars-Ole, Rosenkilde, Mette M., Schwartz, Thue W., Bridger, Gary, De Clercq, Erik, Schols, Dominique

Source: In FEBS Letters 2003 546(2):300-306

Molecular Interactions of Cyclam and Bicyclam Non-peptide Antagonists with the CXCR4 Chemokine Receptor

Authors: Gerlach, Lars Ole ^‡, Skerlj, Renato T. ^§, Bridger, Gary J. ^§, Schwartz, Thue W. ^{‡, ¶, ‖}

Source: In Journal of Biological Chemistry 27 April 2001 276(17):14153-14160

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Model-Based Discovery of Synthetic Agonists for the Zn²⁺-Sensing G-Protein-Coupled Receptor 39 (GPR39) Reveals Novel Biological Functions.

Authors: Frimurer, Thomas M., Mende, Franziska, Graae, Anne-Sofie, Engelstoft, Maja S., Egerod, Kristoffer L., Nygaard, Rie, Gerlach, Lars-Ole, Hansen, Jakob Bondo, Schwartz, Thue W., Holst, Birgitte

Source: Journal of Medicinal Chemistry; Feb2017, Vol. 60 Issue 3, p886-898, 13p

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Arylamide derivatives as allosteric inhibitors of the integrin α2β1/type I collagen interaction

Authors: Yin, Hang, Gerlach, Lars Ole, Miller, Meredith W., Moore, David T., Liu, Dahui, Vilaire, Gaston, Bennett, Joel S., DeGrado, William F.

Source: In Bioorganic & Medicinal Chemistry Letters 1 July 2006 16(13):3380-3382

Expression of Chemokines in Escherichia coli.

Authors: Walker, John M., Proudfoot, Amanda E. I., Wells, Timothy N. C., Power, Christine A., Edgerton, Michael D., Gerlach, Lars-Ole, Boesen, Thomas P., Allet, Bernard

Source: Chemokine Protocols; 2000, p33-40, 8p

A physicogenetic method to assign ligand-binding relationships between 7TM receptors

Authors: Frimurer, Thomas M., Ulven, Trond, Elling, Christian E., Gerlach, Lars-Ole, Kostenis, Evi, Högberg, Thomas

Source: In Bioorganic & Medicinal Chemistry Letters 2005 15(16):3707-3712

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