An atlas of the shared genetic architecture between atopic and gastrointestinal diseases

Authors: Cancan Qi, An Li, Fengyuan Su, Yu Wang, Longyuan Zhou, Ce Tang, Rui Feng, Ren Mao, Minhu Chen, Lianmin Chen, Gerard H. Koppelman, Arno R. Bourgonje, Hongwei Zhou, Shixian Hu

Source: Communications Biology, Vol 7, Iss 1, Pp 1-11 (2024)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2399-3642

Access URL: https://doaj.org/article/c523e4402d0146ef8ce0ae1067ca2d2b

Lung function-associated exposome profile in the era of climate change: Pooled analysis of 8 population-based European cohorts within the EXPANSE project

Authors: Ayoung Jeong, Gianfranco Lovison, Alonso Bussalleu, Marta Cirach, Payam Dadvand, Kees de Hoogh, Claudia Flexeder, Gerard Hoek, Medea Imboden, Stefan Karrasch, Gerard H. Koppelman, Sara Kress, Petter Ljungman, Renata Majewska, Göran Pershagen, Regina Pickford, Youchen Shen, Roel C.H. Vermeulen, Jelle J. Vlaanderen, Megi Vogli, Kathrin Wolf, Zhebin Yu, Erik Melén, Agnieszka Pac, Annette Peters, Tamara Schikowski, Marie Standl, Ulrike Gehring, Nicole Probst-Hensch

Source: Environment International, Vol 196, Iss , Pp 109269- (2025)

Subject Terms: Environmental sciences, GE1-350

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0160412025000200; https://doaj.org/toc/0160-4120

Access URL: https://doaj.org/article/2ff28fa40d61495880327370d823505a

Association of exposure to second-hand smoke during childhood with blood DNA methylation

Authors: Marta Cosin-Tomas, Thanh Hoang, Cancan Qi, Giulietta S. Monasso, Ryan Langdon, Simon Kebede Merid, Lucinda Calas, Paula de Prado-Bert, Rebecca Richmond, Vincent VW Jaddoe, Liesbeth Duijts, John Wright, Isabella Annesi-Maesano, Regina Grazuleviciene, Marianna Karachaliou, Gerard H. Koppelman, Erik Melén, Olena Gruzieva, Martine Vrijheid, Paul Yousefi, Janine F. Felix, Stephanie J. London, Mariona Bustamante

Source: Environment International, Vol 195, Iss , Pp 109204- (2025)

Subject Terms: DNA methylation, Passive smoking, Children, Postnatal exposure, Maternal smoking during pregnancy, blood DNA methylation, Environmental sciences, GE1-350

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0160412024007918; https://doaj.org/toc/0160-4120

Access URL: https://doaj.org/article/3ffb44e60c744d5f8dc28931466b38df

Childhood lung function is associated with adolescent-onset and persistent asthma

Authors: Hans Jacob L. Koefoed, Anhar Ullah, Jenny Hallberg, Simon Kebede Merid, Maura M. Kere, Lesley Lowe, Angela Simpson, Clare S. Murray, Ulrike Gehring, Roel Vermeulen, Inger Kull, Anna Bergström, Judith M. Vonk, Adnan Custovic, Erik Melén, Gerard H. Koppelman

Source: ERJ Open Research, Vol 10, Iss 6 (2024)

Subject Terms: Medicine

File Description: electronic resource

Relation: http://openres.ersjournals.com/content/10/6/00469-2024.full; https://doaj.org/toc/2312-0541

Access URL: https://doaj.org/article/4732a08876ec4447bd8f129c6f83a135

An epithelial gene signature of trans-IL-6 signaling defines a subgroup of type 2-low asthma

Authors: Zaid W. El-Husseini, Dmitry Khalenkow, Andy Lan, Thys van der Molen, Chris Brightling, Alberto Papi, Klaus F. Rabe, Salman Siddiqui, Dave Singh, Monica Kraft, Bianca Beghe, Maarten van den Berge, Djoke van Gosliga, Martijn C. Nawijn, Stefan Rose-John, Gerard H. Koppelman, Reinoud Gosens

Source: Respiratory Research, Vol 24, Iss 1, Pp 1-12 (2023)

Subject Terms: Diseases of the respiratory system, RC705-779

File Description: electronic resource

Relation: https://doaj.org/toc/1465-993X

Access URL: https://doaj.org/article/e4d93162eadc447d86daca4b0d26e0df

Distinction between rhinitis alone and rhinitis with asthma using interactomics

Authors: Daniel Aguilar, Nathanaël Lemonnier, Erik Melén, Mariona Bustamante, Olena Gruzieva, Stefano Guerra, Thomas Keil, Gerard H. Koppelman, Juan C. Celedón, Josep M. Antó, Jean Bousquet

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/c58c66e4654f449b80a63b2c58eabe0f

Comprehensive evaluation of smoking exposures and their interactions on DNA methylationResearch in context

Authors: Thanh T. Hoang, Yunsung Lee, Daniel L. McCartney, Elin T.G. Kersten, Christian M. Page, Paige M. Hulls, Mikyeong Lee, Rosie M. Walker, Charles E. Breeze, Brian D. Bennett, Adam B. Burkholder, James Ward, Anne Lise Brantsæter, Ida H. Caspersen, Alison A. Motsinger-Reif, Marie Richards, Julie D. White, Shanshan Zhao, Rebecca C. Richmond, Maria C. Magnus, Gerard H. Koppelman, Kathryn L. Evans, Riccardo E. Marioni, Siri E. Håberg, Stephanie J. London, Bastiaan Heijmans, Peter ’t Hoen, Joyce van Meurs, Rick Jansen, Lude Franke, Dorret Boomsma, René Pool, Jenny van Dongen, Jouke Hottenga, Marleen van Greevenbroek, Coen Stehouwer, Carla van der Kallen, Casper Schalkwijk, Cisca Wijmenga, Sasha Zhernakova, Ettje Tigchelaar, P. Eline Slagboom, Marian Beekman, Joris Deelen, Diana Van Heemst, Jan Veldink, Leonard van den Berg, Cornelia van Duijn, Bert Hofman, Aaron Isaacs, André Uitterlinden, P. Mila Jhamai, Michael Verbiest, H. Eka Suchiman, Marijn Verkerk, Ruud van der Breggen, Jeroen van Rooij, Nico Lakenberg, Hailiang Mei, Maarten van Iterson, Michiel van Galen, Jan Bot, Dasha Zhernakova, Peter van ‘t Hof, Patrick Deelen, Irene Nooren, Matthijs Moed, Martijn Vermaat, René Luijk, Marc Bonder, Freerk van Dijk, Wibowo Arindrarto, Szymon Kielbasa, Morris Swertz, Erik van Zwet

Source: EBioMedicine, Vol 100, Iss , Pp 104956- (2024)

Subject Terms: Illumina EPIC array, Epigenomics, Secondhand smoke exposure, Dietary intake, Sex difference, Smoking cessation, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396423005224; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/3985b627485b4ff999b2ec073dfaf4e4

The ADEM2 project: early pathogenic mechanisms of preschool wheeze and a randomised controlled trial assessing the gain in health and cost-effectiveness by application of the breath test for the diagnosis of asthma in wheezing preschool children

Authors: Sophie Kienhorst, Moniek H. D. van Aarle, Quirijn Jöbsis, Michiel A. G. E. Bannier, Elin T. G. Kersten, Jan Damoiseaux, Onno C. P. van Schayck, Peter J. F. M. Merkus, Gerard H. Koppelman, Frederik-Jan van Schooten, ADEM2 Consortium, Agnieszka Smolinska, Edward Dompeling

Source: BMC Public Health, Vol 23, Iss 1, Pp 1-20 (2023)

Subject Terms: Asthma, Preschool, Wheeze, Diagnosis, Exhaled VOC, Breath test, Public aspects of medicine, RA1-1270

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2458

Access URL: https://doaj.org/article/16e3fb5172d64d0b88f64060fca3fe75

Oxygen saturation targets for children with respiratory distress: a systematic review

Authors: Sam Louman, Karlijn J. van Stralen, Mariëlle W.H. Pijnenburg, Gerard H. Koppelman, Annemie L.M. Boehmer

Source: ERJ Open Research, Vol 9, Iss 5 (2023)

Subject Terms: Medicine

File Description: electronic resource

Relation: http://openres.ersjournals.com/content/9/5/00256-2023.full; https://doaj.org/toc/2312-0541

Access URL: https://doaj.org/article/b7b3080138f041bdb1944f3eb96ac2d0

Nasal DNA methylation at three CpG sites predicts childhood allergic disease

Authors: Merlijn van Breugel, Cancan Qi, Zhongli Xu, Casper-Emil T. Pedersen, Ilya Petoukhov, Judith M. Vonk, Ulrike Gehring, Marijn Berg, Marnix Bügel, Orestes A. Carpaij, Erick Forno, Andréanne Morin, Anders U. Eliasen, Yale Jiang, Maarten van den Berge, Martijn C. Nawijn, Yang Li, Wei Chen, Louis J. Bont, Klaus Bønnelykke, Juan C. Celedón, Gerard H. Koppelman, Cheng-Jian Xu

Source: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/c100626637b74ab19f631fe608beaa08

Eradication of Burkholderia cepacia complex in cystic fibrosis patients with inhalation of amiloride and tobramycin combined with oral cotrimoxazole

Authors: Anne M. Akkerman-Nijland, Bart L. Rottier, Joanne Holstein, Rik L.J. Winter, Daniel J. Touw, Onno W. Akkerman, Gerard H. Koppelman

Source: ERJ Open Research, Vol 9, Iss 3 (2023)

Subject Terms: Medicine

File Description: electronic resource

Relation: http://openres.ersjournals.com/content/9/3/00055-2023.full; https://doaj.org/toc/2312-0541

Access URL: https://doaj.org/article/b15a6c801768479ba6a3fdfb4dd2d323

Definitions of non-response and response to biological therapy for severe asthma: a systematic review

Authors: Ekaterina Khaleva, Anna Rattu, Chris Brightling, Andrew Bush, Arnaud Bourdin, Apostolos Bossios, Kian Fan Chung, Rekha Chaudhuri, Courtney Coleman, Ratko Djukanovic, Sven-Erik Dahlén, Andrew Exley, Louise Fleming, Stephen J. Fowler, Atul Gupta, Eckard Hamelmann, Gerard H. Koppelman, Erik Melén, Vera Mahler, Paul Seddon, Florian Singer, Celeste Porsbjerg, Valeria Ramiconi, Franca Rusconi, Valentyna Yasinska, Graham Roberts

Source: ERJ Open Research, Vol 9, Iss 3 (2023)

Subject Terms: Medicine

File Description: electronic resource

Relation: http://openres.ersjournals.com/content/9/3/00444-2022.full; https://doaj.org/toc/2312-0541

Access URL: https://doaj.org/article/c9344bc69fde4a8d913ebd3dd5f62d8b

Association of asthma genetic variants with asthma‐associated traits reveals molecular pathways of eosinophilic asthma

Authors: Zaid W. El‐Husseini, Judith M. Vonk, Maarten van denBerge, Reinoud Gosens, Gerard H. Koppelman

Source: Clinical and Translational Allergy, Vol 13, Iss 4, Pp n/a-n/a (2023)

Subject Terms: asthma heterogeneity, endotype, genome wide association, phenotype, single nucleotide polymorphism, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/2045-7022

Access URL: https://doaj.org/article/0e8cd52efa0443b49dbf35e43a6d9863

Rare variant analysis in eczema identifies exonic variants in DUSP1, NOTCH4 and SLC9A4

Authors: Sarah Grosche, Ingo Marenholz, Jorge Esparza-Gordillo, Aleix Arnau-Soler, Erola Pairo-Castineira, Franz Rüschendorf, Tarunveer S. Ahluwalia, Catarina Almqvist, Andreas Arnold, Australian Asthma Genetics Consortium (AAGC), Hansjörg Baurecht, Hans Bisgaard, Klaus Bønnelykke, Sara J. Brown, Mariona Bustamante, John A. Curtin, Adnan Custovic, Shyamali C. Dharmage, Ana Esplugues, Mario Falchi, Dietmar Fernandez-Orth, Manuel A. R. Ferreira, Andre Franke, Sascha Gerdes, Christian Gieger, Hakon Hakonarson, Patrick G. Holt, Georg Homuth, Norbert Hubner, Pirro G. Hysi, Marjo-Riitta Jarvelin, Robert Karlsson, Gerard H. Koppelman, Susanne Lau, Manuel Lutz, Patrik K. E. Magnusson, Guy B. Marks, Martina Müller-Nurasyid, Markus M. Nöthen, Lavinia Paternoster, Craig E. Pennell, Annette Peters, Konrad Rawlik, Colin F. Robertson, Elke Rodriguez, Sylvain Sebert, Angela Simpson, Patrick M. A. Sleiman, Marie Standl, Dora Stölzl, Konstantin Strauch, Agnieszka Szwajda, Albert Tenesa, Philip J. Thompson, Vilhelmina Ullemar, Alessia Visconti, Judith M. Vonk, Carol A. Wang, Stephan Weidinger, Matthias Wielscher, Catherine L. Worth, Chen-Jian Xu, Young-Ae Lee

Source: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/d54f293b9f924ec89242fe90b53feed8

The association of pure fruit juice, sugar-sweetened beverages and fruit consumption with asthma prevalence in adolescents growing up from 11 to 20 years: The PIAMA birth cohort study

Authors: Floor R. Scheffers, Jolanda M.A. Boer, Ulrike Gehring, Gerard H. Koppelman, Judith Vonk, Henriëtte A. Smit, W.M. Monique Verschuren, Alet H. Wijga

Source: Preventive Medicine Reports, Vol 28, Iss , Pp 101877- (2022)

Subject Terms: Asthma, Pure fruit juice, Sugar-sweetened beverages, Fruit, Sugars, Fructose, Medicine

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S221133552200184X; https://doaj.org/toc/2211-3355

Access URL: https://doaj.org/article/797c97747def4e90a55932564ee89953

Association of bronchial steroid inducible methylation quantitative trait loci with asthma and chronic obstructive pulmonary disease treatment response

Authors: Elise M. A. Slob, Alen Faiz, Jos vanNijnatten, Susanne J. H. Vijverberg, Cristina Longo, Merve Kutlu, Fook Tim Chew, Yang Yie Sio, Esther Herrera‐Luis, Antonio Espuela‐Ortiz, Javier Perez‐Garcia, Maria Pino‐Yanes, Esteban G. Burchard, Uroš Potočnik, Mario Gorenjak, Colin Palmer, Cyrielle Maroteau, Steve Turner, Katia Verhamme, Leila Karimi, Somnath Mukhopadhyay, Wim Timens, Pieter S. Hiemstra, Mariëlle W. Pijnenburg, Margaret Neighbors, Michele A. Grimbaldeston, Gaik W. Tew, Corry A. Brandsma, Vojko Berce, Hananeh Aliee, Fabian Theis, Don D. Sin, Xuan Li, Maarten van denBerge, Anke H. Maitland‐van der Zee, Gerard H. Koppelman

Source: Clinical and Translational Allergy, Vol 12, Iss 8, Pp n/a-n/a (2022)

Subject Terms: children, exacerbations, inhaled corticosteroids, methylation quantitative trait loci (meQTL), pharmacogenetics, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://doaj.org/toc/2045-7022

Access URL: https://doaj.org/article/aad33376d38744ce9d92723e7fc44c1d

Spirometric phenotypes from early childhood to young adulthood: a Chronic Airway Disease Early Stratification study

Authors: Gang Wang, Jenny Hallberg, Dimitrios Charalampopoulos, Maribel Casas Sanahuja, Robab Breyer-Kohansal, Arnulf Langhammer, Raquel Granell, Judith M. Vonk, Annemiek Mian, Núria Olvera, Lisbeth Mølgaard Laustsen, Eva Rönmark, Alicia Abellan, Alvar Agusti, Syed Hasan Arshad, Anna Bergström, H. Marike Boezen, Marie-Kathrin Breyer, Otto Burghuber, Anneli Clea Bolund, Adnan Custovic, Graham Devereux, Gavin C. Donaldson, Liesbeth Duijts, Ana Esplugues, Rosa Faner, Ferran Ballester, Judith Garcia-Aymerich, Ulrike Gehring, Sadia Haider, Sylvia Hartl, Helena Backman, John W. Holloway, Gerard H. Koppelman, Aitana Lertxundi, Turid Lingaas Holmen, Lesley Lowe, Sara M. Mensink-Bout, Clare S. Murray, Graham Roberts, Linnea Hedman, Vivi Schlünssen, Torben Sigsgaard, Angela Simpson, Jordi Sunyer, Maties Torrent, Stephen Turner, Maarten Van den Berge, Roel C.H. Vermeulen, Sigrid Anna Aalberg Vikjord, Jadwiga A. Wedzicha, Anke H. Maitland van der Zee, Erik Melén

Source: ERJ Open Research, Vol 7, Iss 4 (2021)

Subject Terms: Medicine

File Description: electronic resource

Relation: http://openres.ersjournals.com/content/7/4/00457-2021.full; https://doaj.org/toc/2312-0541

Access URL: https://doaj.org/article/308270070678456684381c04b9a9f6b6

Ultrafine particles, particle components and lung function at age 16 years: The PIAMA birth cohort study

Authors: Zhebin Yu, Gerard H. Koppelman, Gerard Hoek, Jules Kerckhoffs, Judith M. Vonk, Roel Vermeulen, Ulrike Gehring

Source: Environment International, Vol 157, Iss , Pp 106792- (2021)

Subject Terms: Ultrafine particles, Particulate matter, Elemental composition, Lung function, Adolescence, Environmental sciences, GE1-350

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0160412021004177; https://doaj.org/toc/0160-4120

Access URL: https://doaj.org/article/28fe576d7e1644999002b65009c56988

Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age

Authors: Simon Kebede Merid, Alexei Novoloaca, Gemma C. Sharp, Leanne K. Küpers, Alvin T. Kho, Ritu Roy, Lu Gao, Isabella Annesi-Maesano, Pooja Jain, Michelle Plusquin, Manolis Kogevinas, Catherine Allard, Florianne O. Vehmeijer, Nabila Kazmi, Lucas A. Salas, Faisal I. Rezwan, Hongmei Zhang, Sylvain Sebert, Darina Czamara, Sheryl L. Rifas-Shiman, Phillip E. Melton, Debbie A. Lawlor, Göran Pershagen, Carrie V. Breton, Karen Huen, Nour Baiz, Luigi Gagliardi, Tim S. Nawrot, Eva Corpeleijn, Patrice Perron, Liesbeth Duijts, Ellen Aagaard Nohr, Mariona Bustamante, Susan L. Ewart, Wilfried Karmaus, Shanshan Zhao, Christian M. Page, Zdenko Herceg, Marjo-Riitta Jarvelin, Jari Lahti, Andrea A. Baccarelli, Denise Anderson, Priyadarshini Kachroo, Caroline L. Relton, Anna Bergström, Brenda Eskenazi, Munawar Hussain Soomro, Paolo Vineis, Harold Snieder, Luigi Bouchard, Vincent W. Jaddoe, Thorkild I. A. Sørensen, Martine Vrijheid, S. Hasan Arshad, John W. Holloway, Siri E. Håberg, Per Magnus, Terence Dwyer, Elisabeth B. Binder, Dawn L. DeMeo, Judith M. Vonk, John Newnham, Kelan G. Tantisira, Inger Kull, Joseph L. Wiemels, Barbara Heude, Jordi Sunyer, Wenche Nystad, Monica C. Munthe-Kaas, Katri Räikkönen, Emily Oken, Rae-Chi Huang, Scott T. Weiss, Josep Maria Antó, Jean Bousquet, Ashish Kumar, Cilla Söderhäll, Catarina Almqvist, Andres Cardenas, Olena Gruzieva, Cheng-Jian Xu, Sarah E. Reese, Juha Kere, Petter Brodin, Olivia Solomon, Matthias Wielscher, Nina Holland, Akram Ghantous, Marie-France Hivert, Janine F. Felix, Gerard H. Koppelman, Stephanie J. London, Erik Melén

Source: Genome Medicine, Vol 12, Iss 1, Pp 1-17 (2020)

Subject Terms: Development, Epigenetics, Gestational age, Preterm birth, Transcriptomics, Medicine, Genetics, QH426-470

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13073-020-0716-9; https://doaj.org/toc/1756-994X

Access URL: https://doaj.org/article/63a99804af224399a4a483c0037dd871

Use of cleaning agents at home and respiratory and allergic symptoms in adolescents: The PIAMA birth cohort study

Authors: Joseph S. Bukalasa, Bert Brunekreef, Gerard H. Koppelman, Judith M. Vonk, Ulrike Gehring

Source: Environment International, Vol 128, Iss , Pp 63-69 (2019)

Subject Terms: Environmental sciences, GE1-350

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S016041201833023X; https://doaj.org/toc/0160-4120

Access URL: https://doaj.org/article/75b60f6679754c10aa95ff9cf6dcf753