Classification and functional characterization of regulators of intracellular STING trafficking identified by genome-wide optical pooled screening

Authors: Gentili, Matteo, Carlson, Rebecca J., Liu, Bingxu, Hellier, Quentin, Andrews, Jocelyn, Qin, Yue, Blainey, Paul C., Hacohen, Nir

Source: In Cell Systems 18 December 2024 15(12):1264-1277

The HLA-II immunopeptidome of SARS-CoV-2

Authors: Weingarten-Gabbay, Shira, Chen, Da-Yuan, Sarkizova, Siranush, Taylor, Hannah B., Gentili, Matteo, Hernandez, Gabrielle M., Pearlman, Leah R., Bauer, Matthew R., Rice, Charles M., Clauser, Karl R., Hacohen, Nir, Carr, Steven A., Abelin, Jennifer G., Saeed, Mohsan, Sabeti, Pardis C.

Source: In Cell Reports 23 January 2024 43(1)

Compromised nuclear envelope integrity drives TREX1-dependent DNA damage and tumor cell invasion

Authors: Nader, Guilherme Pedreira de Freitas, Agüera-Gonzalez, Sonia, Routet, Fiona, Gratia, Matthieu, Maurin, Mathieu, Cancila, Valeria, Cadart, Clotilde, Palamidessi, Andrea, Ramos, Rodrigo Nalio, San Roman, Mabel, Gentili, Matteo, Yamada, Ayako, Williart, Alice, Lodillinsky, Catalina, Lagoutte, Emilie, Villard, Catherine, Viovy, Jean-Louis, Tripodo, Claudio, Galon, Jérôme, Scita, Giorgio, Manel, Nicolas, Chavrier, Philippe, Piel, Matthieu

Source: In Cell 30 September 2021 184(20):5230-5246

Profiling SARS-CoV-2 HLA-I peptidome reveals T cell epitopes from out-of-frame ORFs

Authors: Lavin-Parsons, Kendall, Parry, Blair, Lilley, Brendan, Lodenstein, Carl, McKaig, Brenna, Charland, Nicole, Khanna, Hargun, Margolin, Justin, Gonye, Anna, Gushterova, Irena, Lasalle, Tom, Sharma, Nihaarika, Russo, Brian C., Rojas-Lopez, Maricarmen, Sade-Feldman, Moshe, Manakongtreecheep, Kasidet, Tantivit, Jessica, Fisher Thomas, Molly, Weingarten-Gabbay, Shira, Klaeger, Susan, Sarkizova, Siranush, Pearlman, Leah R., Chen, Da-Yuan, Gallagher, Kathleen M.E., Bauer, Matthew R., Taylor, Hannah B., Dunn, W. Augustine, Tarr, Christina, Sidney, John, Rachimi, Suzanna, Conway, Hasahn L., Katsis, Katelin, Wang, Yuntong, Leistritz-Edwards, Del, Durkin, Melissa R., Tomkins-Tinch, Christopher H., Finkel, Yaara, Nachshon, Aharon, Gentili, Matteo, Rivera, Keith D., Carulli, Isabel P., Chea, Vipheaviny A., Chandrashekar, Abishek, Bozkus, Cansu Cimen, Carrington, Mary, Bhardwaj, Nina, Barouch, Dan H., Sette, Alessandro, Maus, Marcela V., Rice, Charles M., Clauser, Karl R., Keskin, Derin B., Pregibon, Daniel C., Hacohen, Nir, Carr, Steven A., Abelin, Jennifer G., Saeed, Mohsan, Sabeti, Pardis C.

Source: In Cell 22 July 2021 184(15):3962-3980

Chromosome mis-segregation triggers cell cycle arrest through a mechanosensitive nuclear envelope checkpoint

Authors: Hervé, Solène, Scelfo, Andrea, Bersano Marchisio, Gabriele, Grison, Marine, Vaidžiulytė, Kotryna, Dumont, Marie, Angrisani, Annapaola, Keikhosravi, Adib, Pegoraro, Gianluca, Deygas, Mathieu, P. F. Nader, Guilherme, Macé, Anne-Sophie, Gentili, Matteo, Williart, Alice, Manel, Nicolas, Piel, Matthieu, Miroshnikova, Yekaterina A., Fachinetti, Daniele

Source: Nature Cell Biology; 20250101, Issue: Preprints p1-14, 14p

Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions

Authors: Filbin, Michael R., Mehta, Arnav, Schneider, Alexis M., Kays, Kyle R., Guess, Jamey R., Gentili, Matteo, Fenyves, Bánk G., Charland, Nicole C., Gonye, Anna L.K., Gushterova, Irena, Khanna, Hargun K., LaSalle, Thomas J., Lavin-Parsons, Kendall M., Lilley, Brendan M., Lodenstein, Carl L., Manakongtreecheep, Kasidet, Margolin, Justin D., McKaig, Brenna N., Rojas-Lopez, Maricarmen, Russo, Brian C., Sharma, Nihaarika, Tantivit, Jessica, Thomas, Molly F., Gerszten, Robert E., Heimberg, Graham S., Hoover, Paul J., Lieb, David J., Lin, Brian, Ngo, Debby, Pelka, Karin, Reyes, Miguel, Smillie, Christopher S., Waghray, Avinash, Wood, Thomas E., Zajac, Amanda S., Jennings, Lori L., Grundberg, Ida, Bhattacharyya, Roby P., Parry, Blair Alden, Villani, Alexandra-Chloé, Sade-Feldman, Moshe, Hacohen, Nir, Goldberg, Marcia B.

Source: In Cell Reports Medicine 18 May 2021 2(5)

The Photocatalyzed Thiol‐ene reaction: A New Tag to Yield Fast, Selective and reversible Paramagnetic Tagging of Proteins

Authors: Denis, Maxime, Softley, Charlotte, Giuntini, Stefano, Gentili, Matteo, Ravera, Enrico, Parigi, Giacomo, Fragai, Marco, Popowicz, Grzegorz, Sattler, Michael, Luchinat, Claudio, Cerofolini, Linda, Nativi, Cristina

Source: Chemphyschem. 21(9):863-869

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100107085740.0x000001&indx=1&recIds=ETOCvdc_100107085740.0x000001

The N-Terminal Domain of cGAS Determines Preferential Association with Centromeric DNA and Innate Immune Activation in the Nucleus

Authors: Gentili, Matteo, Lahaye, Xavier, Nadalin, Francesca, Nader, Guilherme P.F., Puig Lombardi, Emilia, Herve, Solène, De Silva, Nilushi S., Rookhuizen, Derek C., Zueva, Elina, Goudot, Christel, Maurin, Mathieu, Bochnakian, Aurore, Amigorena, Sebastian, Piel, Matthieu, Fachinetti, Daniele, Londoño-Vallejo, Arturo, Manel, Nicolas

Source: In Cell Reports 26 February 2019 26(9):2377-2393

NONO Detects the Nuclear HIV Capsid to Promote cGAS-Mediated Innate Immune Activation

Authors: Lahaye, Xavier, Gentili, Matteo, Silvin, Aymeric, Conrad, Cécile, Picard, Léa, Jouve, Mabel, Zueva, Elina, Maurin, Mathieu, Nadalin, Francesca, Knott, Gavin J., Zhao, Baoyu, Du, Fenglei, Rio, Marlène, Amiel, Jeanne, Fox, Archa H., Li, Pingwei, Etienne, Lucie, Bond, Charles S., Colleaux, Laurence, Manel, Nicolas

Source: In Cell 4 October 2018 175(2):488-501

Nuclear Envelope Protein SUN2 Promotes Cyclophilin-A-Dependent Steps of HIV Replication

Authors: Lahaye, Xavier, Satoh, Takeshi, Gentili, Matteo, Cerboni, Silvia, Silvin, Aymeric, Conrad, Cécile, Ahmed-Belkacem, Abdelhakim, Rodriguez, Elisa C., Guichou, Jean-François, Bosquet, Nathalie, Piel, Matthieu, Le Grand, Roger, King, Megan C., Pawlotsky, Jean-Michel, Manel, Nicolas

Source: In Cell Reports 26 April 2016 15(4):879-892

Profiling SARS-CoV-2 HLA-I peptidome reveals T cell epitopes from out-of-frame ORFs

Authors: Weingarten-Gabbay, Shira, Klaeger, Susan, Sarkizova, Siranush, Pearlman, Leah R., Chen, Da-Yuan, Gallagher, Kathleen M.E., Bauer, Matthew R., Taylor, Hannah B., Dunn, W. Augustine, Tarr, Christina, Sidney, John, Rachimi, Suzanna, Conway, Hasahn L., Katsis, Katelin, Wang, Yuntong, Leistritz-Edwards, Del, Durkin, Melissa R., Tomkins-Tinch, Christopher H., Finkel, Yaara, Nachshon, Aharon, Gentili, Matteo, Rivera, Keith D., Carulli, Isabel P., Chea, Vipheaviny A., Chandrashekar, Abishek, Bozkus, Cansu Cimen, Carrington, Mary, Bhardwaj, Nina, Barouch, Dan H., Sette, Alessandro, Maus, Marcela V., Rice, Charles M., Clauser, Karl R., Keskin, Derin B., Pregibon, Daniel C., Hacohen, Nir, Carr, Steven A., Abelin, Jennifer G., Saeed, Mohsan, Sabeti, Pardis C.

Source: Cell. 184(15):3962-3980.e17

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100144078623.0x000001&indx=1&recIds=ETOCvdc_100144078623.0x000001

Transmission of innate immune signaling by packaging of cGAMP in viral particles

Authors: Gentili, Matteo, Kowal, Joanna, Tkach, Mercedes, Satoh, Takeshi, Lahaye, Xavier, Conrad, Cécile, Boyron, Marilyn, Lombard, Bérangère, Durand, Sylvère, Kroemer, Guido, Loew, Damarys, Dalod, Marc, Théry, Clotilde, Manel, Nicolas

Source: Science, 2015 Sep 01. 349(6253), 1232-1236.

Access URL: http://www.jstor.org/stable/24749387

Intrinsic antiproliferative activity of the innate sensor STING in T lymphocytes

Authors: Cerboni, Silvia, Jeremiah, Nadia, Gentili, Matteo, Gehrmann, Ulf, Conrad, Cécile, Stolzenberg, Marie-Claude, Picard, Capucine, Neven, Bénédicte, Fischer, Alain, Amigorena, Sébastian

Source: Journal of experimental medicine. 214(6):1769-1786

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN611581073&indx=1&recIds=ETOCRN611581073

The Capsids of HIV-1 and HIV-2 Determine Immune Detection of the Viral cDNA by the Innate Sensor cGAS in Dendritic Cells

Authors: Lahaye, Xavier, Satoh, Takeshi, Gentili, Matteo, Cerboni, Silvia, Conrad, Cécile, Hurbain, Ilse, El Marjou, Ahmed, Lacabaratz, Christine, Lelièvre, Jean-Daniel, Manel, Nicolas

Source: In Immunity 12 December 2013 39(6):1132-1142

Human STING is a proton channel.

Authors: Liu, Bingxu^1,2,3, bggscientific@gmail.com, Carlson, Rebecca J.^1,4, Pires, Ivan S.³, Gentili, Matteo¹, Feng, Ellie^1,5, Hellier, Quentin¹, Schwartz, Marc A.^1,6,7,8, Blainey, Paul C.^1,3,5, Irvine, Darrell J.³, djirvine@mit.edu, Hacohen, Nir^1,9, hacohen@mgh.harvard.edu

Source: Science; 8/4/2023, Vol. 381 Issue 6657, p508-514, 7p, 4 Color Photographs

ESCRT-dependent STING degradation inhibits steady-state and cGAMP-induced signalling.

Authors: Gentili, Matteo, Liu, Bingxu, Papanastasiou, Malvina, Dele-Oni, Deborah, Schwartz, Marc A., Carlson, Rebecca J., Al'Khafaji, Aziz M., Krug, Karsten, Brown, Adam, Doench, John G., Carr, Steven A., Hacohen, Nir

Source: Nature Communications; 2/4/2023, Vol. 14 Issue 1, p1-22, 22p

Subject Terms: FAMILIAL spastic paraplegia, TYPE I interferons, GENETIC testing, SIGNALS & signaling, LYSOSOMES, CD14 antigen, DENDRITIC cells

Niosomes Functionalized with a Synthetic Carbohydrate Binding Agent for Mannose-Targeted Doxorubicin Delivery.

Authors: Burrini, Nastassja, D'Ambrosio, Mario, Gentili, Matteo, Giaquinto, Roberta, Settimelli, Veronica, Luceri, Cristina, Cirri, Marzia, Francesconi, Oscar

Source: Pharmaceutics; Jan2023, Vol. 15 Issue 1, p235, 19p

Subject Terms: DOXORUBICIN, BINDING agents, GLYCANS, CARBOHYDRATES, TARGETED drug delivery, DRUG delivery systems, CANCER cells

Diversity of Pathogen Sensors in Dendritic Cells

Authors: Cerboni, Silvia, Gentili, Matteo, Manel, Nicolas

Source: Advances in Immunology: Advances in Immunology Development and Function of Myeloid Subsets. 2013, v. 120, p211-238.

Wide-aperture no-moving-parts optical beam profiler using liquid-crystal displays.

Authors: Gentili, Matteo, Riza, Nabeel A.

Source: Applied Optics; February 1 2007, Vol. 46 Issue 4, p506-512, 7p

Cover Feature: The Photocatalyzed Thiol‐ene reaction: A New Tag to Yield Fast, Selective and reversible Paramagnetic Tagging of Proteins (ChemPhysChem 9/2020)

Authors: Denis, Maxime, Softley, Charlotte, Giuntini, Stefano, Gentili, Matteo, Ravera, Enrico, Parigi, Giacomo, Fragai, Marco, Popowicz, Grzegorz, Sattler, Michael, Luchinat, Claudio, Cerofolini, Linda, Nativi, Cristina

Source: Chemphyschem. 21(9):823-823

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100107085831.0x000001&indx=1&recIds=ETOCvdc_100107085831.0x000001