Genomic consequences of intensive inbreeding in miniature inbred pigs.

Authors: Chen, Hong-Man^1,2,3 (AUTHOR), Zhao, Heng^1,3 (AUTHOR), Zhu, Qun-Yao^1,2 (AUTHOR), Yan, Chen⁴ (AUTHOR), Liu, Ya-Qi⁵ (AUTHOR), Si, Si⁴ (AUTHOR), Jamal, Muhammad Ameen^1,4 (AUTHOR), Xu, Kai-Xiang^1,3 (AUTHOR), Jiao, De-Ling^1,3 (AUTHOR), Lv, Min-Juan^1,2 (AUTHOR), Wang, Wen⁵ (AUTHOR), Zhao, Hong-Ye^1,3 (AUTHOR), Chen, Lei⁵ (AUTHOR) chen_lei@nwpu.edu.cn, Wang, Ming-Shan^4,6 (AUTHOR) wangmingshan@mail.kiz.ac.cn, Wei, Hong-Jiang^1,2,3,4 (AUTHOR) hongjiangwei@126.com

Source: BMC Genomics. 2/17/2025, Vol. 26 Issue 1, p1-13. 13p.

Subject Terms: *GENETIC load, *DOMESTIC animals, *GENETIC variation, *CONSERVATION biology, *INBREEDING, *LIFE sciences

Predictive value of dendritic cell-related genes for prognosis and immunotherapy response in lung adenocarcinoma.

Authors: Sun, Zihao^1,2 (AUTHOR) sunzh158@outlook.com, Hu, Mengfei³ (AUTHOR) hmeng202208@163.com, Huang, Xiaoning^1,2 (AUTHOR) 2112142161@gdpu.edu.cn, Song, Minghan^1,2 (AUTHOR) smh_1997@163.com, Chen, Xiujing^1,2 (AUTHOR) 2112042020@gdpu.edu.cn, Bei, Jiaxin^1,2 (AUTHOR) beijiaxinya@163.com, Lin, Yiguang^1,4 (AUTHOR) yiguang.lin@hotmail.com, Chen, Size^1,2,5,6 (AUTHOR) chensize@gdpu.edu.cn

Source: Cancer Cell International. 1/14/2025, Vol. 25 Issue 1, p1-20. 20p.

Subject Terms: *GENETIC load, *MEDICAL sciences, *PROGNOSTIC models, *TREATMENT effectiveness, *MACHINE learning

Integrated singlecell and bulk RNA-seq analysis identifies a prognostic signature related to inflammation in colorectal cancer.

Authors: Yin, Wen¹ (AUTHOR), Ao, Yanting¹ (AUTHOR), Jia, Qian¹ (AUTHOR), Zhang, Chao¹ (AUTHOR), Yuan, Liping¹ (AUTHOR), Liu, Sha¹ (AUTHOR), Xiao, Wanmeng¹ (AUTHOR), Luo, Gang¹ (AUTHOR), Shi, Xiaomin¹ (AUTHOR), Xin, Chen¹ (AUTHOR), Chen, Maolin² (AUTHOR), Lü, Muhan^3,4 (AUTHOR) lvmuhan@swmu.edu.cn, Yu, Zehui⁵ (AUTHOR) yuzehui_swmu@outlook.com

Source: Scientific Reports. 1/6/2025, Vol. 14 Issue 1, p1-18. 18p.

Subject Terms: *DISEASE risk factors, *GENETIC load, *MEDICAL sciences, *GENE expression, *IMMUNE checkpoint proteins

Defects in the Mitochondrial Genome of Dogs with Recurrent Tumours.

Authors: Kowal, Krzysztof¹ (AUTHOR) krzysztof.kowal@up.lublin.pl, Ziółkowska-Twarowska, Kaja¹ (AUTHOR) kaja.ziolkowska@up.lublin.pl, Tkaczyk-Wlizło, Angelika¹ (AUTHOR) angelika.tkaczyk@up.lublin.pl, Grzybowska-Szatkowska, Ludmiła² (AUTHOR) ludmila.grzybowska-szatkowska@umlub.pl, Ślaska, Brygida¹ (AUTHOR) brygida.slaska@up.lublin.pl

Source: International Journal of Molecular Sciences. Dec2024, Vol. 25 Issue 24, p13414. 12p.

Subject Terms: *GENETIC load, *DNA analysis, *REACTIVE oxygen species, *GENETIC transcription, *CARCINOGENESIS, *MITOCHONDRIAL DNA

Dietary acid load adopts the effect of ApoB ins/del genetic variant (rs11279109) on obesity trait, cardiovascular markers, lipid profile, and serum leptin level among patients with diabetes: a cross-sectional study.

Authors: Esmaeily, Zahra¹ (AUTHOR), Abaj, Faezeh² (AUTHOR), Naeini, Zeinab³ (AUTHOR), Alvandi, Ehsan⁴ (AUTHOR), Rafiee, Masoumeh⁵ (AUTHOR) masomeh.rafiei@gmail.com, Koohdani, Fariba³ (AUTHOR) fkoohdan@tums.ac.ir

Source: Scientific Reports. 10/27/2024, Vol. 14 Issue 1, p1-13. 13p.

Subject Terms: *LDL cholesterol, *GENETIC load, *TYPE 2 diabetes, *DIETARY patterns, *GENETIC variation

The genetic consequences of population marginality: A case study in maritime pine.

Authors: Theraroz, Adélaïde¹ (AUTHOR), Guadaño‐Peyrot, Carlos² (AUTHOR), Archambeau, Juliette^1,3 (AUTHOR), Pinosio, Sara⁴ (AUTHOR), Bagnoli, Francesca⁴ (AUTHOR), Piotti, Andrea⁴ (AUTHOR), Avanzi, Camilla⁴ (AUTHOR), Vendramin, Giovanni G.⁴ (AUTHOR), Alía, Ricardo² (AUTHOR), Grivet, Delphine² (AUTHOR), Westergren, Marjana⁵ (AUTHOR), González‐Martínez, Santiago C.¹ (AUTHOR) santiago.gonzalez‐martinez@inrae.fr

Source: Diversity & Distributions. Oct2024, Vol. 30 Issue 10, p1-15. 15p.

Subject Terms: *GENETIC load, *GERMPLASM conservation, *GENETIC variation, *GENETIC models, *CLUSTER pine

Constraining models of dominance for nonsynonymous mutations in the human genome.

Authors: Kyriazis, Christopher C.¹ (AUTHOR) ckyriazis@g.ucla.edu, Lohmueller, Kirk E.^1,2,3 (AUTHOR) klohmueller@ucla.edu

Source: PLoS Genetics. 9/20/2024, Vol. 20 Issue 9, p1-25. 25p.

Subject Terms: *GENETIC load, *MOLECULAR genetics, *POPULATION genetics, *NATURAL selection, *GENETIC variation, *INBREEDING

Concurrent analysis of genome and transcriptome in one single cell.

Authors: Heid, Johanna^1,2 (AUTHOR) johanna.heid@nyulangone.org, Cutler, Ronald¹ (AUTHOR), Lee, Moonsook¹ (AUTHOR), Vijg, Jan^1,3 (AUTHOR), Maslov, Alexander Y.^1,4 (AUTHOR) alex.maslov@einsteinmed.edu

Source: BMC Research Notes. 9/16/2024, Vol. 17 Issue 1, p1-6. 6p.

Subject Terms: *GENETIC load, *DNA analysis, *GENE expression, *GENETIC regulation, *CELL analysis, *IMMOBILIZED cells

Pangenome Identification and Analysis of Terpene Synthase Gene Family Members in Gossypium.

Authors: Song, Yueqin¹ (AUTHOR) songyueqin6@163.com, Han, Shengjie^1,2 (AUTHOR) hanshengjie1029@163.com, Wang, Mengting² (AUTHOR) xueqini@163.com, Ni, Xueqi² (AUTHOR), Huang, Xinzheng² (AUTHOR) huangxinzheng@cau.edu.cn, Zhang, Yongjun³ (AUTHOR) huangxinzheng@cau.edu.cn

Source: International Journal of Molecular Sciences. Sep2024, Vol. 25 Issue 17, p9677. 17p.

Subject Terms: *GENETIC load, *GENE families, *HELICOVERPA armigera, *PAN-genome, *GENE regulatory networks

Association of polygenic scores for autism with volumetric MRI phenotypes in cerebellum and brainstem in adults.

Authors: Mohammad, Salahuddin¹ (AUTHOR), Gentreau, Mélissa¹ (AUTHOR), Dubol, Manon² (AUTHOR), Rukh, Gull¹ (AUTHOR), Mwinyi, Jessica¹ (AUTHOR), Schiöth, Helgi B.¹ (AUTHOR) helgi.schioth@uu.se

Source: Molecular Autism. 8/7/2024, Vol. 15 Issue 1, p1-12. 12p.

Subject Terms: *GENETIC risk score, *GENETIC load, *AUTISM spectrum disorders, *WHITE matter (Nerve tissue), *GENOME-wide association studies

Unnatural selection.

Authors: Regalado, Antonio (AUTHOR)

Source: MIT Technology Review. Sep/Oct2024, Vol. 127 Issue 5, p34-41. 8p. 3 Cartoon or Caricatures.

Subject Terms: Human genetics, Genetic load, Gene expression, Genetic engineering, Natural selection, Erythropoietin receptors, Fetus

Dynamic reconfiguration of the distribution systems with load duration curve (LDC) model for reducing the losses and improving the voltage profile.

Authors: Sadeghi, Sana¹, Jahangiri, Alireza¹ a.jahangiri@iauh.ac.ir, Shamim, Ahmad Ghaderi¹

Source: Majlesi Journal of Electrical Engineering. Jun2024, Vol. 18 Issue 2, p1-20. 20p.

Subject Terms: *OHMIC resistance, *GENETIC load, *GENETIC algorithms, *ELECTRIC power distribution grids, *GENETIC software

High germline mutation rates, but not extreme population outbreaks, influence genetic diversity in a keystone coral predator.

Authors: Popovic, Iva¹ (AUTHOR) iva.popovic@uq.net.au, Bergeron, Lucie A.² (AUTHOR), Bozec, Yves-Marie¹ (AUTHOR), Waldvogel, Ann-Marie³ (AUTHOR), Howitt, Samantha M.¹ (AUTHOR), Damjanovic, Katarina⁴ (AUTHOR), Patel, Frances⁴ (AUTHOR), Cabrera, Maria G.⁴ (AUTHOR), Wörheide, Gert^5,6,7 (AUTHOR), Uthicke, Sven⁴ (AUTHOR), Riginos, Cynthia¹ (AUTHOR)

Source: PLoS Genetics. 2/12/2024, Vol. 20 Issue 2, p1-22. 22p.

Subject Terms: *GENETIC variation, *GENETIC load, *GENETIC drift, *WHOLE genome sequencing, *MARINE invertebrates, *PREDATION, *NUCLEOTIDE sequencing, *CORAL bleaching

Geographic Terms: GREAT Barrier Reef, AUSTRALIA

Combination of mutations in genes controlling DNA repair and high mutational load plays a prognostic role in pancreatic ductal adenocarcinoma (PDAC): a retrospective real-life study in Sardinian population.

Authors: Sini, Maria Cristina¹ (AUTHOR), Doro, Maria Grazia¹ (AUTHOR), Frogheri, Laura¹ (AUTHOR), Zinellu, Angelo² (AUTHOR), Paliogiannis, Panagiotis³ (AUTHOR), Porcu, Alberto³ (AUTHOR), Scognamillo, Fabrizio³ (AUTHOR), Delogu, Daniele³ (AUTHOR), Santeufemia, Davide Adriano⁴ (AUTHOR), Persico, Ivana¹ (AUTHOR), Palomba, Grazia¹ (AUTHOR), Maestrale, Giovanni Battista¹ (AUTHOR), Cossu, Antonio³ (AUTHOR), Palmieri, Giuseppe^1,5 (AUTHOR) gpalmieri@yahoo.com

Source: Journal of Translational Medicine. 1/27/2024, Vol. 22 Issue 1, p1-13. 13p.

Subject Terms: *GENETIC load, *PANCREATIC duct, *DNA repair, *DNA mismatch repair, *GENETIC mutation, *VON Hippel-Lindau disease

Geographic Terms: SARDINIA (Italy)

Evolutionary dynamics of the LTR-retrotransposon crapaud in the Podospora anserina species complex and the interaction with repeat-induced point mutations.

Authors: Westerberg, Ivar¹ (AUTHOR), Ament-Velásquez, S. Lorena² (AUTHOR), Vogan, Aaron A.³ (AUTHOR) aaron.vogan@ebc.uu.se, Johannesson, Hanna^1,4 (AUTHOR) hanna.johannesson@su.se

Source: Mobile DNA. 1/13/2024, Vol. 15 Issue 1, p1-16. 16p.

Subject Terms: *PODOSPORA anserina, *GENETIC load, *SPECIES, *RETROTRANSPOSONS, *GENETIC mutation, *TRANSPOSONS

Mitochondrial point heteroplasmy: insights from deep-sequencing of human replicate samples.

Authors: Korolija, Marina¹ (AUTHOR) mkorolija@mup.hr, Sukser, Viktorija¹ (AUTHOR), Vlahoviček, Kristian² (AUTHOR)

Source: BMC Genomics. 1/10/2024, Vol. 25 Issue 1, p1-11. 11p.

Subject Terms: *GENETIC load, *MITOCHONDRIA, *MITOCHONDRIAL DNA, *MOLECULAR evolution, *GENE frequency, *NUCLEOTIDE sequencing

Lipid nanoparticles as nano-Trojan-horses for siRNA delivery and gene-knockdown.

Authors: Sánchez-Arribas, Natalia¹ (AUTHOR), Velasco Rodríguez, Brenda² (AUTHOR), Aicart, Emilio¹ (AUTHOR), Guerrero-Martínez, Andrés¹ (AUTHOR), Junquera, Elena¹ (AUTHOR) junquera@ucm.es, Taboada, Pablo^1,2 (AUTHOR) pablo.taboada@usc.es

Source: Journal of Colloid & Interface Science. Feb2025:Part B, Vol. 679, p975-987. 13p.

Subject Terms: *SMALL interfering RNA, *GENETIC load, *GREEN fluorescent protein, *MESSENGER RNA, *REACTIVE oxygen species

The Genetic Consequences of Range Expansion and Its Influence on Diploidization in Polyploids.

Authors: Booker, William W.¹ (AUTHOR) wbooker14@gmail.com, Schrider, Daniel R.¹ (AUTHOR)

Source: American Naturalist. Feb2025, Vol. 205 Issue 2, p203-223. 21p.

Subject Terms: *GENETIC load, *POPULATION genetics, *PLOIDY, *TREE branches, *POLYPLOIDY

Understanding the Past to Preserve the Future: Genomic Insights Into the Conservation Management of a Critically Endangered Waterbird.

Authors: Chen, Qing^1,2 (AUTHOR), Lin, Hongzhou³ (AUTHOR), Zheng, Chenqing³ (AUTHOR), Mudrik, Elena A.⁴ (AUTHOR), Kashentseva, Tatiana A.⁵ (AUTHOR), Cheng, Yalin⁶ (AUTHOR), Wang, Zhiru⁷ (AUTHOR), Zhou, Haiyan⁸ (AUTHOR), Zhou, Haixiang⁹ (AUTHOR), Wang, Wenjuan^10,11,12 (AUTHOR) wangwj870120@163.com, Liu, Yang² (AUTHOR) liuy353@mail.sysu.edu.cn

Source: Molecular Ecology. Jan2025, Vol. 34 Issue 2, p1-15. 15p.

Subject Terms: *GENETIC load, *OUTCROSSING (Biology), *GENETIC variation, *CRANES (Birds), *WILDLIFE conservation, *INBREEDING, *WATER birds

Targeted Next-Generation Sequencing in Succinate Dehydrogenase–Deficient GI Stromal Tumor Identifies Actionable Alterations in the PI3K/mTOR Pathway.

Authors: Cicala, Carlo María^1,2 (AUTHOR), Matito, Judit³ (AUTHOR), Quindos, María⁴ (AUTHOR), Gómez-Peregrina, David¹ (AUTHOR), Romero-Lozano, Paula⁵ (AUTHOR), Fernández-Suárez, Paula⁶ (AUTHOR), Valverde, Claudia² (AUTHOR), González, Macarena² (AUTHOR), Landolfi, Stefania⁷ (AUTHOR), Pérez-Albert, Paula^8,9 (AUTHOR), Gros, Luis^8,9 (AUTHOR), Vivancos, Ana³ (AUTHOR), Serrano, César^1,2 (AUTHOR) cserrano@vhio.net

Source: JCO Precision Oncology. 1/9/2025, Vol. 9, p1-11. 11p.

Subject Terms: *CELL cycle regulation, *GENETIC load, *SUCCINATE dehydrogenase, *NUCLEOTIDE sequencing, *DNA repair