Cannabinoid regulation of angiotensin II-induced calcium signaling in striatal neurons

Authors: Rafael Rivas-Santisteban, Ana Muñoz, Jaume Lillo, Iu Raïch, Ana I. Rodríguez-Pérez, Gemma Navarro, José L. Labandeira-García, Rafael Franco

Source: npj Parkinson's Disease, Vol 10, Iss 1, Pp 1-14 (2024)

Subject Terms: Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2373-8057

Access URL: https://doaj.org/article/13cd6a6a7aa44df2aecc5b45a642df9e

Homodimerization of CB2 cannabinoid receptor triggered by a bivalent ligand enhances cellular signaling

Authors: Gemma Navarro, Marc Gómez-Autet, Paula Morales, Joan Biel Rebassa, Claudia Llinas del Torrent, Nadine Jagerovic, Leonardo Pardo, Rafael Franco

Source: Pharmacological Research, Vol 208, Iss , Pp 107363- (2024)

Subject Terms: GPCR, cannabinoid CB2 receptor, homobivalent ligand, molecular dynamics, cAMP, arrestin, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1043661824003086; https://doaj.org/toc/1096-1186

Access URL: https://doaj.org/article/0e0661cb783749e1bee2b5a8648b5e8e

Future Perspectives of NMDAR in CNS Disorders

Authors: Toni Capó, Joan Biel Rebassa, Iu Raïch, Jaume Lillo, Pau Badia, Gemma Navarro, Irene Reyes-Resina

Source: Molecules, Vol 30, Iss 4, p 877 (2025)

Subject Terms: NMDA receptors, Alzheimer’s disease, Parkinson’s disease, ischemic stroke, schizophrenia, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/30/4/877; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/7ccb6ccfbc6b4119b5020512581a6198

A metabolomics study in aqueous humor discloses altered arginine metabolism in Parkinson’s disease

Authors: Joan Serrano-Marín, Silvia Marin, David Bernal-Casas, Alejandro Lillo, Marc González-Subías, Gemma Navarro, Marta Cascante, Juan Sánchez-Navés, Rafael Franco

Source: Fluids and Barriers of the CNS, Vol 20, Iss 1, Pp 1-13 (2023)

Subject Terms: Levodopa, Putrescine, Linear discrimination, Sensitivity, Biogenic amines, Carnitine, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/2045-8118

Access URL: https://doaj.org/article/769e14cb8b1047628b6f5e8952cce789

ASTROGLIAL CB1R-A1R AND CB1R-A2AR HETEROMERS INFLUENCE MPFC SYNAPTIC FUNCTION

Authors: Joana Gonçalves-Ribeiro, Oksana Savchak, Sara Costa-Pinto, Rafael Sebastian, Alejandro Lillo, Gemma Navarro-Brugal, Rafael Franco, Ana Sebastião, Sandra H. Vaz

Source: IBRO Neuroscience Reports, Vol 15, Iss , Pp S228-S229 (2023)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2667242123004359; https://doaj.org/toc/2667-2421

Access URL: https://doaj.org/article/5cb08a8d6b2b4d3ca8280ec3ae126804

THE ANGIOTENSIN-TYPE-2 RECEPTORS ARE INVOLVED IN AGE-RELATED CHANGES AND NEUROINFLAMMATION IN THE SUBSTANTIA NIGRA

Authors: Pablo Garrido-Gil, Ana Isabel Rodríguez Pérez, María A Pedrosa, María García-Garrote, Rita Valenzuela, Gemma Navarro-Brugal, Rafael Franco, José Luis Labandeira-García

Source: IBRO Neuroscience Reports, Vol 15, Iss , Pp S412-S413 (2023)

Subject Terms: Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2667242123008497; https://doaj.org/toc/2667-2421

Access URL: https://doaj.org/article/bc420270d24c44c9bab4aac7660d9031

Expanding HIV clinical monitoring: the role of CD4, CD8, and CD4/CD8 ratio in predicting non-AIDS eventsResearch in context

Authors: Javier Martínez-Sanz, Jorge Díaz-Álvarez, Marta Rosas, Raquel Ron, José Antonio Iribarren, Enrique Bernal, Félix Gutiérrez, Andrés Ruiz Sancho, Noemi Cabello, Julián Olalla, Santiago Moreno, Sergio Serrano-Villar, Inma Jarrín, David Dalmau, M. Luisa Navarro, M. Isabel González, Federico Garcia, Eva Poveda, Jose Antonio Iribarren, Rafael Rubio, Francesc Vidal, Juan Berenguer, Juan González, M. Ángeles Muñoz-Fernández, Inmaculada Jarrín, Cristina Moreno, Marta Rava, Rebeca Izquierdo, Elba Mauleón, Joaquín Portilla, Irene Portilla, Esperanza Merino, Gema García, Iván Agea, José Sánchez-Payá, Juan Carlos Rodríguez, Livia Giner, Sergio Reus, Vicente Boix, Diego Torrus, Verónica Pérez, Julia Portilla, Juan Luís Gómez, Jehovana Hernández, Ana López Lirola, Dácil García, Felicitas Díaz-Flores, M. Mar Alonso, Ricardo Pelazas, M. Remedios Alemán, Víctor Asensi, María Eugenia Rivas Carmenado, Tomás Suarez-Zarracina, Federico Pulido, Otilia Bisbal, M. Asunción Hernando, David Rial, María de Lagarde, Octavio Arce, Adriana Pinto, Laura Bermejo, Mireia Santacreu, Roser Navarro, Candela Gonzalez, M. José Aramburu, Xabier Camino, Miguel Ángel von Wichmann, Miguel Ángel Goenaga, M. Jesús Bustinduy, Harkaitz Azkune, Maialen Ibarguren, Xabier Kortajarena, Ignacio Álvarez-Rodriguez, Leire Gil, Lourdes Martínez, Catalina Robledano, Mar Masiá, Sergio Padilla, Araceli Adsuar, Rafael Pascual, Marta Fernández, Antonio Galiana, José Alberto García, Xavier Barber, Vanessa Agullo, Javier Garcia Abellán, Reyes Pascual, Guillermo Telenti, Lucia Guillén, Ángela Botella, Roberto Muga, Arantza Sanvisens, Daniel Fuster, Isabel Gutierrez, Juan Carlos López, Margarita Ramírez, Belén Padilla, Paloma Gijón, Teresa Aldamiz-Echevarría, Francisco Tejerina, Cristina Diez, Leire Pérez, Chiara Fanciulli, Saray Corral, Anna Martí, Joaquín Peraire, Consuelo Viladés, Montserrat Vargas, Montserrat Olona, Anna Rull, Verónica Alba, Elena Yeregui, Jenifer Masip, Graciano García-Pardo, Frederic Gómez Bertomeu, Sonia Espineira, Marta Montero, Sandra Cuéllar, Marino Blanes, María Tasias, Eva Calabuig, Miguel Salavert, Juan Fernández, Inmaculada Segarra, Juan González-García, Ana Delgado, Francisco Arnalich, José Ramón Arribas, Jose Ignacio Bernardino, Juan Miguel Castro, Luis Escosa, Pedro Herranz, Victor Hontañón, Silvia García-Bujalance, Milagros García, Alicia González-Baeza, M. Luz Martín-Carbonero, Mario Mayoral, M. Jose Mellado, Rafael Esteban, Rocío Montejano, M. Luisa Montes, Victoria Moreno, Ignacio Pérez-Valero, Berta Rodés, Guadalupe Rúa, Talía Sainz, Elena Sendagorta, Eulalia Valencia, Carmen Busca, Joanna Cano, Julen Cardiñanos, Rosa de Miguel, Jose Ramón Blanco, Laura Pérez-Martínez, José Antonio Oteo, Valvanera Ibarra, Luis Metola, Mercedes Sanz, Piedad Arazo, Gloria Sampériz, Marina Martinez, Angels Jaén, Montse Sanmartí, Mireia Cairó, Javier Martinez-Lacasa, Pablo Velli, Roser Font, Mariona Xercavins, Noemí Alonso, Francesco Aiello, María Rivero, Beatriz Piérola, Maider Goikoetxea, María Gracia, Carlos Ibero, Estela Moreno, Jesús Repáraz, Gemma Navarro, Manel Cervantes Garcia, Sonia Calzado Isbert, Marta Navarro Vilasaro, Belen Lopez Garcia, Ignacio de los Santos, Alejandro de los Santos, Jesús Sanz, Lucio García-Fraile, Enrique Martín, Ildefonso Sánchez-Cerrillo, Marta Calvet, Ana Barrios, Azucena Bautista, Carmen Sáez, Marianela Ciudad, Ángela Gutiérrez, Santos del Campo, José Luis Casado, Fernando Dronda, Ana Moreno, M. Jesús Pérez, Sergio Serrano, Ma Jesús Vivancos, Alejandro Vallejo, Matilde Sanchez, Jose Antonio Pérez-Molina, José Manuel Hermida, Antonia Alcaraz, Joaquín Bravo, Ángeles Muñoz, Cristina Tomás, Mónica Martínez, M. Carmen Villalba, Federico García, Clara Martínez, José Hernández, Leopoldo Muñoz Medina, Marta Álvarez, Natalia Chueca, David Vinuesa, Adolfo de Salazar, Ana Fuentes, Emilio Guirao, Laura Viñuela, Andrés Ruiz-Sancho, Francisco Anguita, Jorge Del Romero, Montserrat Raposo, Carmen Rodríguez, Teresa Puerta, Juan Carlos Carrió, Mar Vera, Juan Ballesteros, Oskar Ayerdi, Begoña Baza, Eva Orviz, Antonio Antela, Elena Losada, Melchor Riera, María Peñaranda, M. Angels Ribas, Antoni A. Campins, Mercedes Garcia-Gazalla, Francisco J. Fanjul, Javier Murillas, Francisco Homar, Helem H. Vilchez, Luisa Martin, Antoni Payeras, Jesús Santos, María López, Crisitina Gómez, Isabel Viciana, Rosario Palacios, Luis Fernando López-Cortés, Nuria Espinosa, Cristina Roca, Silvia Llaves, Juan Manuel Tiraboschi, Arkaitz Imaz, Ana Karina Silva, María Saumoy, Sofía Catalina Scévola, Adrián Curran, Vicenç Falcó, Jordi Navarro, Joaquin Burgos, Paula Suanzes, Jorge García, Vicente Descalzo, Patricia Álvarez, Bibiana Planas, Marta Sanchiz, Lucía Rodríguez, M José Sánchez, Javier Pérez, Alfonso del Arco, Javier de la Torre, José Luis Prada, Onofre Juan Martínez, Lorena Martinez, Francisco Jesús Vera, Josefina García, Begoña Alcaraz, Antonio Jesús Sánchez Guirao, Alvaro Mena, Angeles Castro, Berta Pernas, Pilar Vázquez, Soledad López, Sofía Ibarra, Guillermo García, Josu Mirena, Oscar Luis Ferrero, Josefina López, M. Mar Cámara, Mireia de la Peña, Miriam Lopez, Iñigo Lopez, Itxaso Lombide, Victor Polo, Joana de Miguel, Carlos Galera, Marian Fernández, Helena Albendin, Antonia Castillo, Asunción Iborra, Antonio Moreno, M. Angustias Merlos, Asunción Vidal, Concha Amador, Francisco Pasquau, Concepcion Gil, Jose Tomás Algado, Inés Suarez-García, Eduardo Malmierca, Patricia González-Ruano, M. Pilar Ruiz, José Francisco Pascual, Elena Sáez, Luz Balsalobre, M. Villa López, Mohamed Omar, Carmen Herrero, M. Amparo Gómez, Miguel Alberto de Zarraga, Desiré Pérez, Vicente Estrada, Nieves Sanz, Noemí Cabello, Jorge Vergas García, Maria Jose Núñez, Iñigo Sagastagoitia, Miguel Górgolas, Alfonso Cabello, Beatriz Álvarez, Laura Prieto, Irene Carrillo, José Sanz, Alberto Arranz, Cristina Hernández, María Novella, M. José Galindo, Ana Ferrer, Antonio Rivero Román, Inma Ruíz, Antonio Rivero Juárez, Pedro López, Isabel Machuca, Mario Frias, Ángela Camacho, Ignacio Pérez, Diana Corona, Miguel Cervero, Rafael Torres, Juan Antonio Pineda, Pilar Rincón, Juan Macías, Luis Miguel Real, Anais Corma, Alejandro Gonzalez-Serna, Alexandre Pérez, Luis Morano, Celia Miralles, Antonio Ocampo, Guillermo Pousada, Lucía Patiño, Carlos Dueñas, Sara Gutiérrez, Elena Tapia, Cristina Novoa, Xjoylin Egües, Pablo Telleria

Source: EBioMedicine, Vol 95, Iss , Pp 104773- (2023)

Subject Terms: HIV, Non-AIDS events, Neoplasia, Cardiovascular event, CD4/CD8 ratio, Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396423003390; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/58776bce09a046cdb96584187ca1fd3d

Neuroprotection afforded by targeting G protein-coupled receptors in heteromers and by heteromer-selective drugs

Authors: Rafael Franco, Gemma Navarro

Source: Frontiers in Pharmacology, Vol 14 (2023)

Subject Terms: heteromer imprint, heteromer selective drug, GPCR, neuronal death, neurodegeneration, drug discovery, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1222158/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/7847545410574e75901f17681d08f50b

The olfactory Olfr-78/51E2 receptor interacts with the adenosine A2A receptor. Effect of menthol and 1,8-cineole on A2A receptor-mediated signaling

Authors: Jaume Lillo, Irene García-Pérez, Alejandro Lillo, Joan Serrano-Marín, Eva Martínez-Pinilla, Gemma Navarro, Rafael Franco

Source: Frontiers in Pharmacology, Vol 14 (2023)

Subject Terms: G protein-coupled receptor, heteromer, receptor-receptor interactions, signaling, adenosine receptor, olfactory receptor, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2023.1108617/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/97de8941c7574105bca05a609f938cc7

A Robust and Efficient FRET-Based Assay for Cannabinoid Receptor Ligands Discovery

Authors: Gemma Navarro, Eddy Sotelo, Iu Raïch, María Isabel Loza, Jose Brea, Maria Majellaro

Source: Molecules, Vol 28, Iss 24, p 8107 (2023)

Subject Terms: CB1R, CB2R, HTRF, binding, HTS, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/28/24/8107; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/b984db540fcc45b38c1ff849fd3cbb3b

The NADPH Link between the Renin Angiotensin System and the Antioxidant Mechanisms in Dopaminergic Neurons

Authors: Rafael Franco, Joan Serrano-Marín, Gemma Navarro, Rafael Rivas-Santisteban

Source: Antioxidants, Vol 12, Iss 10, p 1869 (2023)

Subject Terms: Parkinson’s disease, glucose-6-phosphate dehydrogenase, NADPH, substantia nigra, brain, angiotensin receptors, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.mdpi.com/2076-3921/12/10/1869; https://doaj.org/toc/2076-3921

Access URL: https://doaj.org/article/4bb0e28e1c8e4640a8120cfe94714dfd

N-Methyl-D-aspartate (NMDA) and cannabinoid CB2 receptors form functional complexes in cells of the central nervous system: insights into the therapeutic potential of neuronal and microglial NMDA receptors

Authors: Rafael Rivas-Santisteban, Alejandro Lillo, Jaume Lillo, Joan-Biel Rebassa, Joan S. Contestí, Carlos A. Saura, Rafael Franco, Gemma Navarro

Source: Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-15 (2021)

Subject Terms: Alzheimer’s disease, Neuroprotection, G-protein-coupled receptors, Excitotoxicity, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://doaj.org/toc/1758-9193

Access URL: https://doaj.org/article/0254e2d26c33408e83ebdd64aef88946

Cholesterol in autism spectrum disorders

Authors: Rafael Franco, Rafael Rivas-Santisteban, Gemma Navarro, Irene Reyes-Resina

Source: Exploration of Neuroprotective Therapy, Vol 1, Iss 1, Pp 10-18 (2021)

Subject Terms: autism spectrum disorder, asperger syndrome, cholesterol, cholesterol dyshomeostasis, rett syndrome, smith-lemli-opitz syndrome, blood brain barrier, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://www.explorationpub.com/Journals/ent/Article/10043; https://doaj.org/toc/2769-6510

Access URL: https://doaj.org/article/16b064d5a9c5466b9af1a2b7edfaf39a

Antioxidant Supplements versus Health Benefits of Brief/Intermittent Exposure to Potentially Toxic Physical or Chemical Agents

Authors: Rafael Franco, Berta Casanovas, Jordi Camps, Gemma Navarro, Eva Martínez-Pinilla

Source: Current Issues in Molecular Biology, Vol 43, Iss 2, Pp 650-664 (2021)

Subject Terms: diet, hormesis, antioxidant, innate mechanisms, oxidative stress, redox, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/1467-3045/43/2/47; https://doaj.org/toc/1467-3037; https://doaj.org/toc/1467-3045

Access URL: https://doaj.org/article/ba83ebc382c24c9e8023dc78fc62660b

Differential Gene Expression in Activated Microglia Treated with Adenosine A2A Receptor Antagonists Highlights Olfactory Receptor 56 and T-Cell Activation GTPase-Activating Protein 1 as Potential Biomarkers of the Polarization of Activated Microglia

Authors: Alejandro Lillo, Joan Serrano-Marín, Jaume Lillo, Iu Raïch, Gemma Navarro, Rafael Franco

Source: Cells, Vol 12, Iss 18, p 2213 (2023)

Subject Terms: adenosine A3 receptor, Alzheimer’s disease, microglia, neurodegeneration, neuroinflammation, Parkinson’s disease, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/12/18/2213; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/f1c7bcee2d05449a8fe89ae1de79bdc5

Targeted Metabolomics Shows That the Level of Glutamine, Kynurenine, Acyl-Carnitines and Lysophosphatidylcholines Is Significantly Increased in the Aqueous Humor of Glaucoma Patients

Authors: Alejandro Lillo, Silvia Marin, Joan Serrano-Marín, Nicolas Binetti, Gemma Navarro, Marta Cascante, Juan Sánchez-Navés, Rafael Franco

Source: Frontiers in Medicine, Vol 9 (2022)

Subject Terms: lipidomics, glutamine, eye disease, mass spectrometry, biomarker, glaucoma, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmed.2022.935084/full; https://doaj.org/toc/2296-858X

Access URL: https://doaj.org/article/fb804306dada4773bb145e8ebef4fcaa

The Heteromeric Complex Formed by Dopamine Receptor D5 and CCR9 Leads the Gut Homing of CD4+ T Cells Upon InflammationSummary

Authors: Francisco Osorio-Barrios, Gemma Navarro, Javier Campos, Valentina Ugalde, Carolina Prado, Iu Raïch, Francisco Contreras, Ernesto López, Alexandra Espinoza, Alvaro Lladser, Rafael Franco, Rodrigo Pacheco

Source: Cellular and Molecular Gastroenterology and Hepatology, Vol 12, Iss 2, Pp 489-506 (2021)

Subject Terms: Dopaminergic Regulation, Chemokine Receptors, G Protein–Coupled Receptors Heteromers, T Cell Migration, Gut Tropism, Inflammatory Colitis, Diseases of the digestive system. Gastroenterology, RC799-869

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352345X21000771; https://doaj.org/toc/2352-345X

Access URL: https://doaj.org/article/80b96c1220db41d58f4765c6e2d56f9a

Angiotensin AT1 and AT2 receptor heteromer expression in the hemilesioned rat model of Parkinson’s disease that increases with levodopa-induced dyskinesia

Authors: Rafael Rivas-Santisteban, Ana I. Rodriguez-Perez, Ana Muñoz, Irene Reyes-Resina, José Luis Labandeira-García, Gemma Navarro, Rafael Franco

Source: Journal of Neuroinflammation, Vol 17, Iss 1, Pp 1-16 (2020)

Subject Terms: Neuroinflammation, Heteromer, G-protein-coupled receptor (GPCR), Dyskinesia, Levodopa, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12974-020-01908-z; https://doaj.org/toc/1742-2094

Access URL: https://doaj.org/article/5b12098c13c3447c81a4afd49f51dce7

The Binding Mode to Orthosteric Sites and/or Exosites Underlies the Therapeutic Potential of Drugs Targeting Cannabinoid CB2 Receptors

Authors: Rafael Franco, Paula Morales, Gemma Navarro, Nadine Jagerovic, Irene Reyes-Resina

Source: Frontiers in Pharmacology, Vol 13 (2022)

Subject Terms: biased agonism, heteromer, health benefits, therapy, functional selectivity, cannabinoid receptor, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fphar.2022.852631/full; https://doaj.org/toc/1663-9812

Access URL: https://doaj.org/article/afbbc5a71e5e4873b7b89ddbc373f385

The Expression of Cellular Prion Protein, PrPC, Favors pTau Propagation and Blocks NMDAR Signaling in Primary Cortical Neurons

Authors: Rafael Rivas-Santisteban, Iu Raïch, David Aguinaga, Carlos A. Saura, Rafael Franco, Gemma Navarro

Source: Cells, Vol 12, Iss 2, p 283 (2023)

Subject Terms: Alzheimer’s disease, NMDA, prion protein, Tau protein, pTau protein, axonal transport, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/12/2/283; https://doaj.org/toc/2073-4409

Access URL: https://doaj.org/article/e07c90400a1a4638b70861446deb8c03