IL-4 acts on skin-derived dendritic cells to promote the TH2 response to cutaneous sensitization and the development of allergic skin inflammation

Authors: Leyva-Castillo, Juan Manuel, Das, Mrinmoy, Strakosha, Maria, McGurk, Alex, Artru, Emilie, Kam, Christy, Alasharee, Mohammed, Wesemann, Duane R., Tomura, Michio, Karasuyama, Hajime, Brombacher, Frank, Geha, Raif S.

Source: In The Journal of Allergy and Clinical Immunology December 2024 154(6):1462-1471

Basophils Play a Protective Role in the Recovery of Skin Barrier Function from Mechanical Injury in Mice

Authors: Strakosha, Maria, Vega-Mendoza, Daniela, Kane, Jennifer, Jain, Ashish, Sun, Liang, Rockowitz, Shira, Elkins, Megan, Miyake, Kensuke, Chou, Janet, Karasuyama, Hajime, Geha, Raif S., Leyva-Castillo, Juan-Manuel

Source: In Journal of Investigative Dermatology August 2024 144(8):1784-1797

Regulatory T-cell dysfunction and cutaneous exposure to Staphylococcus aureus underlie eczema in DOCK8 deficiency

Authors: Wilkie, Hazel, Das, Mrinmoy, Pelovitz, Tyler, Bainter, Wayne, Woods, Brian, Alasharee, Mohammed, Sobh, Ali, Baris, Safa, Eltan, Sevgi Bilgic, Al-Herz, Waleed, Barbouche, Mohamed-Ridha, Ben-Mustapha, Imen, Ben-Ali, Meriem, Sallam, Mohamed T.H., Awad, Amany, Lotfy, Sohilla, El Marsafy, Aisha, Ezzelarab, Moushira, Farrar, Michael, Schmidt, Brigitta A.R., NandyMazumdar, Monali, Guttman-Yassky, Emma, Sheets, Anthony, Vidic, Katie Maria, Murphy, George, Schlievert, Patrick M., Chou, Janet, Leyva-Castillo, Juan Manuel, Janssen, Erin, Timilshina, Maheshwor, Geha, Raif S.

Source: In The Journal of Allergy and Clinical Immunology July 2024 154(1):143-156

Basophils are important for development of allergic skin inflammation

Authors: Leyva-Castillo, Juan-Manuel, Vega-Mendoza, Daniela, Strakosha, Maria, Deng, Liwen, Choi, Samantha, Miyake, Kensuke, Karasuyama, Hajime, Chiu, Isaac M., Phipatanakul, Wanda, Geha, Raif S.

Source: In The Journal of Allergy and Clinical Immunology May 2024 153(5):1344-1354

Correction: Adapter proteins SLP-76 and BLNK both are expressed by murine macrophages and are linked to signaling via Fcγ receptors I and II/III

Authors: Bonilla, Francisco A., Fujita, Ross M., Pivniouk, Vadim I., Chan, Andrew C., Geha, Raif S.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2022 May 01. 119(18), 1-1.

Access URL: https://www.jstor.org/stable/27151594

IL-4 receptor alpha blockade dampens allergic inflammation and upregulates IL-17A expression to promote Saureus clearance in antigen sensitized mouse skin

Authors: Leyva-Castillo, Juan-Manuel, McGurk, Alex, Strakosha, Maria, Vega-Mendoza, Daniela, Smith, Sophia E.M., Stafstrom, Kelsey, Elkins, Megan, Chou, Janet, Wang, Yui-Hsi, Geha, Raif S.

Source: In The Journal of Allergy and Clinical Immunology October 2023 152(4):907-915

The IL-4Rα Q576R polymorphism is associated with increased severity of atopic dermatitis and exaggerates allergic skin inflammation in mice

Authors: Yang, Barbara, Wilkie, Hazel, Das, Mrinmoy, Timilshina, Maheshwor, Bainter, Wayne, Woods, Brian, Daya, Michelle, Boorgula, Meher P., Mathias, Rasika A., Lai, Peggy, Petty, Carter R., Weller, Edie, Harb, Hani, Chatila, Talal A., Leung, Donald Y.M., Beck, Lisa A., Simpson, Eric L., Hata, Tissa R., Barnes, Kathleen C., Phipatanakul, Wanda, Leyva-Castillo, Juan-Manuel, Geha, Raif S.

Source: In The Journal of Allergy and Clinical Immunology May 2023 151(5):1296-1306

NFKB2 haploinsufficiency identified via screening for IFN-α2 autoantibodies in children and adolescents hospitalized with SARS-CoV-2–related complications

Authors: Kong, Michele, Sanders, Ronald C., Jr., Yates, Masson, Smith, Chelsea, Cvijanovich, Natalie Z., Zinter, MattS., McLaughlin, Gwenn, Tarquinio, Keiko M., Coates, Bria M., Rowan, Courtney M., Randolph, Adrienne G., Newhams, Margaret M., Kucukak, Suden, Novak, Tanya, Moon, Hye Kyung, Kobayashi, Takuma, Melo, Jeni, Young, Cameron, Chen, Sabrina R., Chou, Janet, Flori, Heidi R., Dahmer, Mary K., Levy, Emily R., Behl, Supriya, Drapeau, Noelle M., Schuster, Jennifer E., Cullimore, Melissa L., McCulloh, Russell J., Gertz, Shira J., Schwartz, Stephanie P., Walker, Tracie C., Nofziger, Ryan A., Staat, Mary Allen, Rohlfs, Chelsea C., Fitzgerald, Julie C., Mack, Elizabeth H., Reed, Nelson, Halasa, Natasha B., Loftis, Laura L., Crandall, Hillary, Bodansky, Aaron, Vazquez, Sara E., Al-Musa, Amer, Newhams, Margaret, Zambrano, Laura D., Mitchell, Anthea, Wang, Chung-Yu, Moffitt, Kristin, Irby, Katherine, Staat, Mary A., Zinter, Matt S., Chatani, Brandon, Nofziger, Ryan, Geha, Raif S., DeRisi, Joseph, Campbell, Angela P., Anderson, Mark

Source: In The Journal of Allergy and Clinical Immunology April 2023 151(4):926-930

A homozygous truncating mutation of FGL2 is associated with immune dysregulation

Authors: Janssen, Erin, Alosaimi, Mohammad F., Alazami, Anas M., Alsuliman, Abdullah, Alaiya, Ayodele, Al-Saud, Bandar, Al-Mousa, Hamoud, Al-Zaid, Tariq Jassim, Smith, Emma, Platt, Craig D., Alruwaili, Hibah, Albanyan, Sarah, Al-Mayouf, Sulaiman M., Geha, Raif S.

Source: In The Journal of Allergy and Clinical Immunology February 2023 151(2):572-578

The Middle East and North Africa Diagnosis and Management Guidelines for Inborn Errors of Immunity

Authors: Baris, Safa, Abolhassani, Hassan, Massaad, Michel J., Al-Nesf, Maryam, Chavoshzadeh, Zahra, Keles, Sevgi, Reisli, Ismail, Tahiat, Azzeddine, Shendi, Hiba Mohammad, Elaziz, Dalia Abd, Belaid, Brahim, Al Dhaheri, Fatima, Haskologlu, Sule, Dogu, Figen, Ben-Mustapha, Imen, Sobh, Ali, Galal, Nermeen, Meshaal, Safa, Elhawary, Rabab, El-marsafy, Aisha, Alroqi, Fayhan J., Al-Saud, Bandar, Al-Ahmad, Mona, Al Farsi, Tariq, AL Sukaiti, Nashat, Al-Tamemi, Salem, Mehawej, Cybel, Dbaibo, Ghassan, ElGhazali, Gehad, Kilic, Sara Sebnem, Genel, Ferah, Kiykim, Ayca, Musabak, Ugur, Artac, Hasibe, Guner, Sukru Nail, Boukari, Rachida, Djidjik, Reda, Kechout, Nadia, Cagdas, Deniz, El-Sayed, Zeinab Awad, Karakoc-Aydiner, Elif, Alzyoud, Raed, Barbouche, Mohamed Ridha, Adeli, Mehdi, Wakim, Rima Hanna, Reda, Shereen M., Ikinciogullari, Aydan, Ozen, Ahmet, Bousfiha, Aziz, Al-Mousa, Hamoud, Rezaei, Nima, Al-Herz, Waleed, Geha, Raif S.

Source: In The Journal of Allergy and Clinical Immunology: In Practice January 2023 11(1):158-180

Clinical, immunological, molecular and therapeutic findings in monogenic immune dysregulation diseases: Middle East and North Africa registry

Authors: Rasouli, Seyed Erfan, Esmaeili, Marzie, Yazdani, Reza, Delavari, Samaneh, Tavakol, Marzieh, Sadri, Homa, Karimi, Abdollah, Shiari, Reza, Alavi, Samin, Babaie, Delara, Eshghi, Peyman, Armin, Shahnaz, Vosughimotlagh, Ahmad, Eltan, Sevgi Bilgic, Babayeva, Royala, Sefer, Asena Pinar, Kolukisa, Burcu, Gungoren, Ezgi Yalcin, Altunbas, Melek Yorgun, Mammadova, Vafa, Jamee, Mahnaz, Azizi, Gholamreza, Baris, Safa, Karakoc-Aydiner, Elif, Ozen, Ahmet, Kiliç, Sara Ş., Kose, Hulya, Chavoshzadeh, Zahra, Mahdaviani, Seyed Alireza, Momen, Tooba, Shamsian, Bibi Shahin, Fallahi, Mazdak, Sharafian, Samin, Gülez, Nesrin, Aygun, Ayşe, Karaca, Neslihan Edeer, Kutukculer, Necil, Al Sukait, Nashat, Al Farsi, Tariq, Al-Tamemi, Salem, Khalifa, Nisreen, Shereen, Reda, El-Ghoneimy, Dalia, El-Owaidy, Rasha, Radwan, Nesrine, Alzyoud, Raed, Barbouche, Mohamed-Ridha, Ben-Mustapha, Imen, Mekki, Najla, Rais, Afef, Boukari, Rachida, Belbouab, Reda, Djenouhat, Kamel, Tahiat, Azzeddine, Touri, Souad, Elghazali, Gehad, Al-Hammadi, Suleiman, Shendi, Hiba Mohammed, Alkuwaiti, Amna, Belaid, Brahim, Djidjik, Reda, Artac, Hasibe, Adeli, Mehdi, Sobh, Ali, Elnagdy, Marwa H., Bahgat, Sara A., Nasrullayeva, Gulnara, Chou, Janet, Rezaei, Nima, Al-Herz, Waleed, Geha, Raif S., Abolhassani, Hassan

Source: In Clinical Immunology November 2022 244

Single-cell transcriptome profile of mouse skin undergoing antigen-driven allergic inflammation recapitulates findings in atopic dermatitis skin lesions

Authors: Leyva-Castillo, Juan Manuel, Sun, Liang, Wu, Shih-Ying, Rockowitz, Shira, Sliz, Piotr, Geha, Raif S.

Source: In The Journal of Allergy and Clinical Immunology August 2022 150(2):373-384

Mechanisms underlying genetic susceptibility to multisystem inflammatory syndrome in children (MIS-C)

Authors: Almutairi, Abduarahman, Jaber, Faris, Banzon, Tina, Roberts, Jordan, Halyabar, Olha, Lo, Mindy, Kahn, Stacy, Henderson, Lauren A., Lee, Pui Y., Son, Mary Beth, Cheng, Leah, Chou, Janet ^∗, Platt, Craig D. ^∗, Habiballah, Saddiq, Nguyen, Alan A., Elkins, Megan, Weeks, Sabrina, Peters, Zachary, Day-Lewis, Megan, Novak, Tanya, Armant, Myriam, Williams, Lucinda, Rockowitz, Shira, Sliz, Piotr, Williams, David A., Randolph, Adrienne G., Geha, Raif S.

Source: In The Journal of Allergy and Clinical Immunology September 2021 148(3):732-738

Mast cell–derived IL-13 downregulates IL-12 production by skin dendritic cells to inhibit the TH1 cell response to cutaneous antigen exposure

Authors: Leyva-Castillo, Juan Manuel, Das, Mrinmoy, Artru, Emilie, Yoon, Juhan ^∗, Galand, Claire, Geha, Raif S.

Source: In The Journal of Allergy and Clinical Immunology June 2021 147(6):2305-2315

DOCK8 Expression in Regulatory T Cells Maintains their Stability and Limits Contact Hypersensitivity

Authors: Wilkie, Hazel, Janssen, Erin, Leyva-Castillo, Juan Manuel, Geha, Raif S.

Source: In Journal of Investigative Dermatology June 2021 141(6):1503-1511

Hematopoietic Stem Cell Transplantation Is a Curative Therapy for Transferrin Receptor 1 (TFRC) Deficiency

Authors: Whangbo, Jennifer S., Chou, Janet, Al-Dhekri, Hasan, Harris, Marian, Geha, Raif S., Pai, Sung-Yun, Al-Herz, Waleed

Source: In The Journal of Allergy and Clinical Immunology: In Practice February 2021 9(2):753-759

Efficacy and economics of targeted panel versus whole-exome sequencing in 878 patients with suspected primary immunodeficiency

Authors: Platt, Craig D., Zaman, Fatima, Bainter, Wayne, Stafstrom, Kelsey, Almutairi, Abuarahman, Reigle, Margot, Weeks, Sabrina, Geha, Raif S., Chou, Janet

Source: In The Journal of Allergy and Clinical Immunology February 2021 147(2):723-726

Acetaminophen Inhibits the Neutrophil Oxidative Burst: Implications for Diagnostic Testing

Authors: Almutairi, Abduarahman, Zaman, Fatima, Day-Lewis, Megan, Tsitsikov, Erdyni, Reiter, Amanda, Xue, Kanyun, Geha, Raif S., Chou, Janet, Yee, Christina S.K.

Source: In The Journal of Allergy and Clinical Immunology: In Practice November-December 2020 8(10):3543-3548

Immune dysregulation and multisystem inflammatory syndrome in children (MIS-C) in individuals with haploinsufficiency of SOCS1

Authors: Lee, Pui Y., Platt, Craig D., Weeks, Sabrina, Grace, Rachael F., Maher, George, Gauthier, Kasey, Devana, Sridevi, Vitali, Sally, Randolph, Adrienne G., McDonald, Douglas R., Geha, Raif S., Chou, Janet

Source: In The Journal of Allergy and Clinical Immunology November 2020 146(5):1194-1200

Cutaneous barrier leakage and gut inflammation drive skin disease in Omenn syndrome

Authors: Rigoni, Rosita ^∗, Fontana, Elena ^∗, Dobbs, Kerry, Marrella, Veronica, Taverniti, Valentina, Maina, Virginia, Facoetti, Amanda, D’Amico, Giovanna, Al-Herz, Waleed, Cruz-Munoz, Mario Ernesto, Schuetz, Catharina, Gennery, Andrew R., Garabedian, Elizabeth K., Giliani, Silvia, Draper, Deborah, Dbaibo, Ghassan, Geha, Raif S., Meyts, Isabelle, Tousseyn, Thomas, Neven, Benedicte, Moshous, Despina, Fischer, Alain, Schulz, Ansgar, Finocchi, Andrea, Kuhns, Douglas B., Fink, Danielle L., Lionakis, Michail S., Swamydas, Muthulekha, Guglielmetti, Simone, Alejo, Julie, Myles, Ian A., Pittaluga, Stefania, Notarangelo, Luigi D., Villa, Anna, Cassani, Barbara

Source: In The Journal of Allergy and Clinical Immunology November 2020 146(5):1165-1179