Characteristic roadmap of linker governs the rational design of PROTACs

Authors: Yawen Dong, Tingting Ma, Ting Xu, Zhangyan Feng, Yonggui Li, Lingling Song, Xiaojun Yao, Charles R. Ashby, Jr, Ge-Fei Hao

Source: Acta Pharmaceutica Sinica B, Vol 14, Iss 10, Pp 4266-4295 (2024)

Subject Terms: PROTAC, PROTAC linker, Linker characteristics, Rational design, Biodegradation efficiency, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211383524001357; https://doaj.org/toc/2211-3835

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Stabilization of dimeric PYR/PYL/RCAR family members relieves abscisic acid-induced inhibition of seed germination

Authors: Zhi-Zheng Wang, Min-Jie Cao, Junjie Yan, Jin Dong, Mo-Xian Chen, Jing-Fang Yang, Jian-Hong Li, Rui-Ning Ying, Yang-Yang Gao, Li Li, Ya-Nan Leng, Yuan Tian, Kamalani Achala H. Hewage, Rong-Jie Pei, Zhi-You Huang, Ping Yin, Jian-Kang Zhu, Ge-Fei Hao, Guang-Fu Yang

Source: Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/d1de552eff3843fab64b84cefd7eb071

A novel ABA structural analogues enhanced plant resistance by inducing the plant immunity and inactivating ABA signaling pathway

Authors: Yanke Jiang, Yingzhe Yue, Zhaoxu Wang, Chongchong Lu, Zhizheng Wang, Ziyi Yin, Yang Li, Ge-Fei Hao, Xinhua Ding

Source: Advanced Agrochem, Vol 3, Iss 1, Pp 64-73 (2024)

Subject Terms: Abscisic acid, Structural analogues, Plant immunity, PYR1/PYL receptors, Agriculture (General), S1-972, Biochemistry, QD415-436, Chemistry, QD1-999

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Relation: http://www.sciencedirect.com/science/article/pii/S2773237123000618; https://doaj.org/toc/2773-2371

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Molecular interaction network of plant-herbivorous insects

Authors: Chao Hu, Yu-Ting Li, Yu-Xi Liu, Ge-Fei Hao, Xue-Qing Yang

Source: Advanced Agrochem, Vol 3, Iss 1, Pp 74-82 (2024)

Subject Terms: Plant-herbivorous insect interactions, Plant hormone, Plant defense, Counter-defenses, Adaptation, Agriculture (General), S1-972, Biochemistry, QD415-436, Chemistry, QD1-999

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Relation: http://www.sciencedirect.com/science/article/pii/S2773237123000758; https://doaj.org/toc/2773-2371

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Research and development trends in plant growth regulators

Authors: Xue Wu, Daohong Gong, Kejun Zhao, Dongyu Chen, Yawen Dong, Yangyang Gao, Qi Wang, Ge-Fei Hao

Source: Advanced Agrochem, Vol 3, Iss 1, Pp 99-106 (2024)

Subject Terms: PGRs, Innovation, Development, Trends, Market, Agriculture (General), S1-972, Biochemistry, QD415-436, Chemistry, QD1-999

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2773237123000989; https://doaj.org/toc/2773-2371

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Breaking ground: ABLs and TMKs as co-receptors to perceive extracellular auxin

Authors: Guan-Zhu Wang, Xue Wu, Ge-Fei Hao

Source: Advanced Agrochem, Vol 3, Iss 1, Pp 6-8 (2024)

Subject Terms: Agriculture (General), S1-972, Biochemistry, QD415-436, Chemistry, QD1-999

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2773237124000108; https://doaj.org/toc/2773-2371

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Pesticide informatics expands the opportunity for structure-based molecular design and optimization

Authors: Wei Zhao, Yuan-qin Huang, Ge-Fei Hao

Source: Advanced Agrochem, Vol 1, Iss 2, Pp 139-147 (2022)

Subject Terms: Web resources, Hit compounds identification, Scaffold optimization, Pesticide-likeness, Agriculture (General), S1-972, Biochemistry, QD415-436, Chemistry, QD1-999

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2773237122000272; https://doaj.org/toc/2773-2371

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Systematic characterization of the branch point binding protein, splicing factor 1, gene family in plant development and stress responses

Authors: Kai-Lu Zhang, Zhen Feng, Jing-Fang Yang, Feng Yang, Tian Yuan, Di Zhang, Ge-Fei Hao, Yan-Ming Fang, Jianhua Zhang, Caie Wu, Mo-Xian Chen, Fu-Yuan Zhu

Source: BMC Plant Biology, Vol 20, Iss 1, Pp 1-20 (2020)

Subject Terms: Alternative splicing, Expression profile, Phylogenetics, Plants, Promoter, Splicing factor, Botany, QK1-989

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12870-020-02570-6; https://doaj.org/toc/1471-2229

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ACID: a free tool for drug repurposing using consensus inverse docking strategy

Authors: Fan Wang, Feng-Xu Wu, Cheng-Zhang Li, Chen-Yang Jia, Sun-Wen Su, Ge-Fei Hao, Guang-Fu Yang

Source: Journal of Cheminformatics, Vol 11, Iss 1, Pp 1-11 (2019)

Subject Terms: ACID, Web server, Drug repurposing, Consensus inverse docking, Information technology, T58.5-58.64, Chemistry, QD1-999

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13321-019-0394-z; https://doaj.org/toc/1758-2946

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Phylogenetic Comparison and Splicing Analysis of the U1 snRNP-specific Protein U1C in Eukaryotes

Authors: Kai-Lu Zhang, Jian-Li Zhou, Jing-Fang Yang, Yu-Zhen Zhao, Debatosh Das, Ge-Fei Hao, Caie Wu, Jianhua Zhang, Fu-Yuan Zhu, Mo-Xian Chen, Shao-Ming Zhou

Source: Frontiers in Molecular Biosciences, Vol 8 (2021)

Subject Terms: alternative splicing, phylogenetics, gene expression, splice site, U1-snRNP, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmolb.2021.696319/full; https://doaj.org/toc/2296-889X

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Ecology and Evolution of Marine Fungi With Their Adaptation to Climate Change

Authors: Vinit Kumar, V. Venkateswara Sarma, Kasun M. Thambugala, Jun-Jie Huang, Xiang-Yang Li, Ge-Fei Hao

Source: Frontiers in Microbiology, Vol 12 (2021)

Subject Terms: Aspergillus terreus, ecology, eDNA, evolution, Hortaea werneckii, next-generation sequencing, Microbiology, QR1-502

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fmicb.2021.719000/full; https://doaj.org/toc/1664-302X

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Chemical Manipulation of Abscisic Acid Signaling: A New Approach to Abiotic and Biotic Stress Management in Agriculture

Authors: Kamalani Achala H. Hewage, Jing‐Fang Yang, Di Wang, Ge‐Fei Hao, Guang‐Fu Yang, Jian‐Kang Zhu

Source: Advanced Science, Vol 7, Iss 18, Pp n/a-n/a (2020)

Subject Terms: ABA signaling, agonists, antagonists, chemical manipulation, plant stress, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2198-3844

Access URL: https://doaj.org/article/4373247ebb874469bc05a3e1c7c9d1d9

Molecular Determinants Elucidate the Selectivity in Abscisic Acid Receptor and HAB1 Protein Interactions

Authors: Jing-Fang Yang, Chun-Yan Yin, Di Wang, Chen-Yang Jia, Ge-Fei Hao, Guang-Fu Yang

Source: Frontiers in Chemistry, Vol 8 (2020)

Subject Terms: abscisic acid, PYR/PYL/RCARs, pyrabactin, selectivity, molecular dynamics, Chemistry, QD1-999

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fchem.2020.00425/full; https://doaj.org/toc/2296-2646

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Introducing a Toxicological Perspective to View Chemicals: A Web-Based Class for Educating Green Molecular Design

Authors: Xing-Xing Shi, Jing-Yi Li, Fan Wang (ORCID 0000-0003-2664-9214), Qiong Chen, Yu-Liang Wang, Ge-Fei Hao (ORCID 0000-0003-4090-8411), Guang-Fu Yang (ORCID 0000-0003-4384-2593)

Source: Journal of Chemical Education. 2024 101(4):1514-1525.

Peer Reviewed: Y

Page Count: 12

Descriptors: Chemistry, Conservation (Environment), Hazardous Materials, Social Justice, Toxicology, Graduate Students, Educational Technology, Technology Uses in Education, Molecular Structure, Program Effectiveness, Student Attitudes

Computational and experimental insights into the mechanism of substrate recognition and feedback inhibition of protoporphyrinogen oxidase.

Authors: Ge-Fei Hao, Ying Tan, Sheng-Gang Yang, Zhi-Fang Wang, Chang-Guo Zhan, Zhen Xi, Guang-Fu Yang

Source: PLoS ONE, Vol 8, Iss 7, p e69198 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3720618?pdf=render; https://doaj.org/toc/1932-6203

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Protoporphyrinogen Oxidase Inhibitor: An Ideal Target for Herbicide Discovery

Authors: Ge-Fei Hao, Yang Zuo, Sheng-Gang Yang, Guang-Fu Yang

Source: CHIMIA, Vol 65, Iss 12 (2011)

Subject Terms: Herbicide, Inhibitor, Molecular design, Protoporphyrinogen oxidase, Qsar, Chemistry, QD1-999

File Description: electronic resource

Relation: https://www.chimia.ch/chimia/article/view/5139; https://doaj.org/toc/0009-4293; https://doaj.org/toc/2673-2424

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The role of Phe82 and Phe351 in auxin-induced substrate perception by TIR1 ubiquitin ligase: a novel insight from molecular dynamics simulations.

Authors: Ge-Fei Hao, Guang-Fu Yang

Source: PLoS ONE, Vol 5, Iss 5, p e10742 (2010)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2873998?pdf=render; https://doaj.org/toc/1932-6203

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Design and synthesis of 1-(benzothiazol-5-yl)-1H-1,2,4-triazol-5-ones as protoporphyrinogen oxidase inhibitors

Authors: Yang, Zuo, Sheng-Gang, Yang, Yan-Ping, Luo, Ying, Tan, Ge-Fei, Hao, Qiong-You, Wu, Zhen, Xi, Guang-Fu, Yang

Source: In Bioorganic & Medicinal Chemistry 1 June 2013 21(11):3245-3255

Discovery of Next-Generation Tropomyosin Receptor Kinase Inhibitors for Combating Multiple Resistance Associated with Protein Mutation.

Authors: Lin-Sheng Zhuo, Ming-Shu Wang, Feng-Xu Wu, Hong-Chuang Xu, Yi Gong, Zhi-Cheng Yu, Yan-Guang Tian, Chao Pang, Ge-Fei Hao, Wei Huang, Guang-Fu Yang

Source: Journal of Medicinal Chemistry; 10/28/2021, Vol. 64 Issue 20, p15503-15514, 12p

Structure-activity relationships of diphenyl-ether as protoporphyrinogen oxidase inhibitors: insights from computational simulations.

Authors: Ge-Fei Hao¹, Ying Tan¹, Ning-Xi Yu¹, Guang-Fu Yang¹ gfyang@mail.ccnu.edu.cn

Source: Journal of Computer-Aided Molecular Design. Mar2011, Vol. 25 Issue 3, p213-222. 10p. 3 Diagrams, 3 Charts, 3 Graphs.

Subject Terms: *OXIDASES, *CHEMICAL structure, *HERBICIDES, *CHLOROPHYLL, *PHOTOCHEMOTHERAPY, *HEME, *CANCER treatment, *HYDROGEN bonding