Phase II Randomized Study of Maintenance Atezolizumab Versus Atezolizumab Plus Talazoparib in Patients With SLFN11 Positive Extensive-Stage SCLC: S1929

Authors: Karim, Nagla Abdel ^{a, b, ∗}, Miao, Jieling ^{c, d}, Reckamp, Karen L. ^{e, f}, Gay, Carl M. ^g, Byers, Lauren A. ^g, Zhao, Ying-Qi ^{c, d}, Redman, Mary W. ^{c, d}, Carrizosa, Daniel R. ^h, Wang, Wei-Lien ⁱ, Petty, William J. ^j, Mehta, Kathan ^k, Faller, Bryan A. ^l, Agamah, Edem S. ^m, Kasbari, Samer S. ⁿ, Malisetti, Rajini K. ^o, Kumar, Atul ^p, Schallenkamp, John ^q, Alluri, Krishna C. ^r, Gray, Jhanelle E. ^s, Kelly, Karen ^t

Source: In Journal of Thoracic Oncology March 2025 20(3):383-394

Comprehensive analysis of transcription factor-based molecular subtypes and their correlation to clinical outcomes in small-cell lung cancer

Authors: Park, Sehhoon, Hong, Tae Hee, Hwang, Soohyun, Heeke, Simon, Gay, Carl M., Kim, Jiyeon, Jung, Hyun-Ae, Sun, Jong-Mu, Ahn, Jin Seok, Ahn, Myung-Ju, Cho, Jong Ho, Choi, Yong Soo, Kim, Jhingook, Shim, Young Mog, Kim, Hong Kwan, Byers, Lauren Averett, Heymach, John V., Choi, Yoon-La, Lee, Se-Hoon, Park, Keunchil

Source: In eBioMedicine April 2024 102

Survival outcomes and toxicity of adjuvant immunotherapy after definitive concurrent chemotherapy with proton beam radiation therapy for patients with inoperable locally advanced non-small cell lung carcinoma

Authors: Corrigan, Kelsey L., Xu, Ting, Sasaki, Yuki, Lin, Ruitao, Chen, Aileen B., Welsh, James W., Lin, Steven H., Chang, Joe Y., Ning, Matthew S., Gandhi, Saumil, O'Reilly, Michael S., Gay, Carl M., Altan, Mehmet, Lu, Charles, Cascone, Tina, Koutroumpakis, Efstratios, Sheshadri, Ajay, Zhang, Xiaodong, Liao, Li, Zhu, X. Ronald, Heymach, John V., Nguyen, Quynh-Nhu, Liao, Zhongxing

Source: In Radiotherapy and Oncology April 2024 193

Immune heterogeneity in small-cell lung cancer and vulnerability to immune checkpoint blockade

Authors: Nabet, Barzin Y., Hamidi, Habib, Lee, Myung Chang, Banchereau, Romain, Morris, Stefanie, Adler, Leah, Gayevskiy, Velimir, Elhossiny, Ahmed M., Srivastava, Minu K., Patil, Namrata S., Smith, Kiandra A., Jesudason, Rajiv, Chan, Caleb, Chang, Patrick S., Fernandez, Matthew, Rost, Sandra, McGinnis, Lisa M., Koeppen, Hartmut, Gay, Carl M., Minna, John D., Heymach, John V., Chan, Joseph M., Rudin, Charles M., Byers, Lauren A., Liu, Stephen V., Reck, Martin, Shames, David S.

Source: In Cancer Cell 11 March 2024 42(3):429-443

Tumor- and circulating-free DNA methylation identifies clinically relevant small cell lung cancer subtypes

Authors: Heeke, Simon, Gay, Carl M., Estecio, Marcos R., Tran, Hai, Morris, Benjamin B., Zhang, Bingnan, Tang, Ximing, Raso, Maria Gabriela, Rocha, Pedro, Lai, Siqi, Arriola, Edurne, Hofman, Paul, Hofman, Veronique, Kopparapu, Prasad, Lovly, Christine M., Concannon, Kyle, De Sousa, Luana Guimaraes, Lewis, Whitney Elisabeth, Kondo, Kimie, Hu, Xin, Tanimoto, Azusa, Vokes, Natalie I., Nilsson, Monique B., Stewart, Allison, Jansen, Maarten, Horváth, Ildikó, Gaga, Mina, Panagoulias, Vasileios, Raviv, Yael, Frumkin, Danny, Wasserstrom, Adam, Shuali, Aharona, Schnabel, Catherine A., Xi, Yuanxin, Diao, Lixia, Wang, Qi, Zhang, Jianjun, Van Loo, Peter, Wang, Jing, Wistuba, Ignacio I., Byers, Lauren A., Heymach, John V.

Source: In Cancer Cell 12 February 2024 42(2):225-237

Receptor Tyrosine Kinase Fusion-Mediated Resistance to EGFR TKI in EGFR-Mutant NSCLC: A Multi-Center Analysis and Literature Review

Authors: Xia, Yang ^a, Wang, Kaiwen ^b, Zhao, Jing ^c, Arter, Zhaohui ^d, Zhang, Yongchang ^e, Zhou, Jiaqi ^a, Lu, Yuefei ^a, Zeng, Liang ^e, Du, Robyn ^f, Owens, Jennifer A. ^f, Elamin, Yasir Y. ^f, Gay, Carl M. ^f, Skoulidis, Ferdinandos ^f, Tsao, Anne S. ^f, Lu, Charles ^f, Cascone, Tina ^f, Gibbons, Don L. ^f, Zhang, Jianjun ^f, Chen, Olivia ^g, Mok, Kevin K.S. ^g, Nagasaka, Misako ^d, Li, Wen ^a, Heymach, John V. ^f, Ignatius Ou, Sai-Hong ^d, Li, Molly ^h, Le, Xiuning ^{f, ∗}

Source: In Journal of Thoracic Oncology November 2024

Combining targeted DNA repair inhibition and immune-oncology approaches for enhanced tumor control

Authors: Concannon, Kyle, Morris, Benjamin B., Gay, Carl M., Byers, Lauren A.

Source: Molecular cell. 83(5):660-680

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184721850.0x000001&indx=1&recIds=ETOCvdc_100184721850.0x000001

Neoadjuvant immunotherapy for advanced, resectable non–small cell lung cancer: A systematic review and meta‐analysis

Authors: Wu, Yajing, Verma, Vivek, Gay, Carl M., Chen, Yujia, Liang, Fei, Lin, Qiang, Wang, Jianing, Zhang, Wei, Hui, Zhouguang, Zhao, Min, Wang, Jun, Chang, Joe Y.

Source: Cancer. 129(13):1969-1985

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184987377.0x000001&indx=1&recIds=ETOCvdc_100184987377.0x000001

Clinical and molecular characterization of long-term survivors with extensive-stage small cell lung cancer treated with first-line atezolizumab plus carboplatin and etoposide

Authors: Liu, Stephen V., Mok, Tony S.K., Nabet, Barzin Y., Mansfield, Aaron S., De Boer, Richard, Losonczy, György, Sugawara, Shunichi, Dziadziuszko, Rafal, Krzakowski, Maciej, Smolin, Alexey, Hochmair, Maximilian J., Garassino, Marina C., Gay, Carl M., Heymach, John V., Byers, Lauren A., Lam, Sivuonthanh, Cardona, Andrés, Morris, Stefanie, Adler, Leah, Shames, David S., Reck, Martin

Source: In Lung Cancer December 2023 186

Stereotactic ablative radiotherapy with or without immunotherapy for early-stage or isolated lung parenchymal recurrent node-negative non-small-cell lung cancer: an open-label, randomised, phase 2 trial

Authors: Chang, Joe Y ^*, Lin, Steven H, Dong, Wenli, Liao, Zhongxing, Gandhi, Saumil J, Gay, Carl M, Zhang, Jianjun, Chun, Stephen G, Elamin, Yasir Y, Fossella, Frank V, Blumenschein, George, Cascone, Tina, Le, Xiuning, Pozadzides, Jenny V, Tsao, Anne, Verma, Vivek, Welsh, James W, Chen, Aileen B, Altan, Mehmet, Mehran, Reza J, Vaporciyan, Ara A, Swisher, Stephen G, Balter, Peter A, Fujimoto, Junya, Wistuba, Ignacio I, Feng, Lei, Lee, J Jack, Heymach, John V

Source: In The Lancet 9-15 September 2023 402(10405):871-881

Predicting benefit from immune checkpoint inhibitors in patients with non-small-cell lung cancer by CT-based ensemble deep learning: a retrospective study

Authors: Saad, Maliazurina B ^*, Hong, Lingzhi ^*, Aminu, Muhammad ^*, Vokes, Natalie I ^*, Chen, Pingjun, Salehjahromi, Morteza, Qin, Kang, Sujit, Sheeba J, Lu, Xuetao, Young, Elliana, Al-Tashi, Qasem, Qureshi, Rizwan, Wu, Carol C, Carter, Brett W, Lin, Steven H, Lee, Percy P, Gandhi, Saumil, Chang, Joe Y, Li, Ruijiang, Gensheimer, Michael F, Wakelee, Heather A, Neal, Joel W, Lee, Hyun-Sung, Cheng, Chao, Velcheti, Vamsidhar, Lou, Yanyan, Petranovic, Milena, Rinsurongkawong, Waree, Le, Xiuning, Rinsurongkawong, Vadeerat, Spelman, Amy, Elamin, Yasir Y, Negrao, Marcelo V, Skoulidis, Ferdinandos, Gay, Carl M, Cascone, Tina, Antonoff, Mara B, Sepesi, Boris, Lewis, Jeff, Wistuba, Ignacio I, Hazle, John D, Chung, Caroline, Jaffray, David, Gibbons, Don L, Vaporciyan, Ara, Lee, J Jack, Heymach, John V ^***, Zhang, Jianjun ^**, Wu, Jia ^*

Source: In The Lancet Digital Health July 2023 5(7):e404-e420

A Multicenter Open-Label Randomized Phase II Study of Osimertinib With and Without Ramucirumab in Tyrosine Kinase Inhibitor–Naïve EGFR -Mutant Metastatic Non–Small Cell Lung Cancer (RAMOSE trial).

Authors: Le, Xiuning, Patel, Jyoti D., Shum, Elaine, Baik, Christina, Sanborn, Rachel E., Shu, Catherine A., Kim, Chul, Fidler, Mary Jo, Hall, Richard, Elamin, Yasir Y., Tu, Janet, Blumenschein, George, Zhang, Jianjun, Gibbons, Don, Gay, Carl, Mohindra, Nisha A., Chae, Young, Boumber, Yanis, Sabari, Joshua, Santana-Davila, Rafael

Source: Journal of Clinical Oncology; 2/1/2025, Vol. 43 Issue 4, p403-411, 16p

Lung Cancer Models Reveal Severe Acute Respiratory Syndrome Coronavirus 2–Induced Epithelial-to-Mesenchymal Transition Contributes to Coronavirus Disease 2019 Pathophysiology

Authors: Stewart, C. Allison, Gay, Carl M., Ramkumar, Kavya, Cargill, Kasey R., Cardnell, Robert J., Nilsson, Monique B., Heeke, Simon, Park, Elizabeth M., Kundu, Samrat T., Diao, Lixia, Wang, Qi, Shen, Li, Xi, Yuanxin, Zhang, Bingnan, Della Corte, Carminia Maria, Fan, Youhong, Kundu, Kiran, Gao, Boning, Avila, Kimberley, Pickering, Curtis R., Johnson, Faye M., Zhang, Jianjun, Kadara, Humam, Minna, John D., Gibbons, Don L., Wang, Jing, Heymach, John V., Byers, Lauren Averett

Source: In Journal of Thoracic Oncology November 2021 16(11):1821-1839

Patterns of transcription factor programs and immune pathway activation define four major subtypes of SCLC with distinct therapeutic vulnerabilities

Authors: Gay, Carl M., Stewart, C. Allison, Park, Elizabeth M., Diao, Lixia, Groves, Sarah M., Heeke, Simon, Nabet, Barzin Y., Fujimoto, Junya, Solis, Luisa M., Lu, Wei, Xi, Yuanxin, Cardnell, Robert J., Wang, Qi, Fabbri, Giulia, Cargill, Kasey R., Vokes, Natalie I., Ramkumar, Kavya, Zhang, Bingnan, Della Corte, Carminia M., Robson, Paul, Swisher, Stephen G., Roth, Jack A., Glisson, Bonnie S., Shames, David S., Wistuba, Ignacio I., Wang, Jing, Quaranta, Vito, Minna, John, Heymach, John V., Byers, Lauren Averett

Source: In Cancer Cell 8 March 2021 39(3):346-360

Predictors of survival following surgical resection of limited-stage small cell lung cancer

Authors: Mitchell, Kyle G., Corsini, Erin M., Antonoff, Mara B., Hofstetter, Wayne L., Mehran, Reza J., Rice, David C., Swisher, Stephen G., Vaporciyan, Ara A., Walsh, Garrett L., Huynh, Caroline, Fiset, Pierre-Olivier, Chun, Stephen G., Gay, Carl M., Zhou, Nicolas, Bott, Matthew, Park, Bernard J., Vallières, Eric, Wilshire, Candice L., Yasufuku, Kazuhiro, Spicer, Jonathan D., Jones, David R., Sepesi, Boris

Source: In The Journal of Thoracic and Cardiovascular Surgery March 2021 161(3):760-771

Toxicity and Survival After Intensity-Modulated Proton Therapy Versus Passive Scattering Proton Therapy for NSCLC

Authors: Gjyshi, Olsi, Xu, Ting, Elhammali, Adnan, Boyce-Fappiano, David, Chun, Stephen G., Gandhi, Saumil, Lee, Percy, Chen, Aileen B., Lin, Steven H., Chang, Joe Y., Tsao, Anne, Gay, Carl M., Zhu, X. Ronald, Zhang, Xiaodong, Heymach, John V., Fossella, Frank V., Lu, Charles, Nguyen, Quynh-Nhu, Liao, Zhongxing

Source: In Journal of Thoracic Oncology February 2021 16(2):269-277

Programmed Death-Ligand 1 Heterogeneity and Its Impact on Benefit From Immune Checkpoint Inhibitors in NSCLC

Authors: Hong, Lingzhi, Negrao, Marcelo V., Dibaj, Seyedeh S., Chen, Runzhe, Reuben, Alexandre, Bohac, Jadi M., Liu, Xiaoke, Skoulidis, Ferdinandos, Gay, Carl M., Cascone, Tina, Mitchell, Kyle G., Tran, Hai T., Le, Xiuning, Byers, Lauren A., Sepesi, Boris, Altan, Mehmet, Elamin, Yasir Y., Fossella, Frank V., Kurie, Jonathan M., Lu, Charles, Mott, Frank E., Tsao, Anne S., Rinsurongkawong, Waree, Lewis, Jeff, Gibbons, Don L., Glisson, Bonnie S., Blumenschein, George R., Jr., Roarty, Emily B., Futreal, P. Andrew, Wistuba, Ignacio I., Roth, Jack A., Swisher, Stephen G., Papadimitrakopoulou, Vassiliki A., Heymach, John V., Lee, J. Jack, Simon, George R., Zhang, Jianjun

Source: In Journal of Thoracic Oncology September 2020 15(9):1449-1459

STING Pathway Expression Identifies NSCLC With an Immune-Responsive Phenotype

Authors: Della Corte, Carminia M., Sen, Triparna, Gay, Carl M., Ramkumar, Kavya, Diao, Lixia, Cardnell, Robert J., Rodriguez, Bertha Leticia, Stewart, C. Allison, Papadimitrakopoulou, Vassiliki A., Gibson, Laura, Fradette, Jared J., Wang, Qi, Fan, Youhong, Peng, David H., Negrao, Marcelo V., Wistuba, Ignacio I., Fujimoto, Junya, Solis Soto, Luisa M., Behrens, Carmen, Skoulidis, Ferdinandos, Heymach, John V., Wang, Jing, Gibbons, Don L., Byers, Lauren A.

Source: In Journal of Thoracic Oncology May 2020 15(5):777-791

258 HORIZON-01: a phase I–III platform study evaluating the efficacy and safety of multiple therapies in patients with biomarker-defined locally advanced, unresectable stage III non-small cell lung cancer (NSCLC)

Authors: Popat, Sanjay ^{1, 2}, Januszewski, Adam ³, Cove-Smith, Laura ^{4, 5}, Baijal, Shobhit ⁶, Imseeh, Georgios ⁷, Gay, Carl ⁸, Kerr, Keith ⁹, Kato, Terufumi ¹⁰, Paz-Ares, Luis ¹¹, Zhou, Caicun ¹², Redhead, Karl ¹³, Theogaraj, Elizabeth ¹³, Shagan, Sarah M. ¹⁴, Solomon, Benjamin J. ¹⁵

Source: In Lung Cancer February 2025 200 Supplement 1

Combination Treatment of the Oral CHK1 Inhibitor, SRA737, and Low-Dose Gemcitabine Enhances the Effect of Programmed Death Ligand 1 Blockade by Modulating the Immune Microenvironment in SCLC

Authors: Sen, Triparna, Della Corte, Carminia M., Milutinovic, Snezana, Cardnell, Robert J., Diao, Lixia, Ramkumar, Kavya, Gay, Carl M., Stewart, C. Allison, Fan, Youhong, Shen, Li, Hansen, Ryan J., Strouse, Bryan, Hedrick, Michael P., Hassig, Christian A., Heymach, John V., Wang, Jing, Byers, Lauren A.

Source: In Journal of Thoracic Oncology December 2019 14(12):2152-2163