Mass Balance, Metabolic Pathways, Absolute Bioavailability, and Pharmacokinetics of Giredestrant in Healthy Subjects

Authors: Kshirsagar, Smita ¹, Chen, Ya-Chi ¹, Yu, Jiajie ¹, Gates, Mary R. ³, Kawakatsu, Sonoko ¹, Khojasteh, S Cyrus ², Ma, Shuguang ², Musib, Luna ¹, Malhi, Vikram ¹, Osaghae, Uyi ⁴, Wang, Jing ², Cho, Sungjoon ², Tang, Yang (Thomas) ², Zhang, Donglu ², Zhao, Weiping ^{2, **}, De Bruyn, Tom ^{2, *}

Source: In Drug Metabolism and Disposition August 2024 52(8):847-857

Phase Ib study of the MEK inhibitor cobimetinib (GDC-0973) in combination with the PI3K inhibitor pictilisib (GDC-0941) in patients with advanced solid tumors

Authors: Shapiro, Geoffrey I., LoRusso, Patricia, Kwak, Eunice, Pandya, Susan, Rudin, Charles M., Kurkjian, Carla, Cleary, James M., Pilat, Mary Jo, Jones, Suzanne, de Crespigny, Alex, Fredrickson, Jill, Musib, Luna, Yan, Yibing, Wongchenko, Matthew, Hsieh, Hsin-Ju, Gates, Mary R., Chan, Iris T., Bendell, Johanna

Source: Investigational new drugs. 38(2):419-432

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164277044.0x000001&indx=1&recIds=ETOCvdc_100164277044.0x000001

Effect of OATP1B1/1B3 Inhibitor GDC‐0810 on the Pharmacokinetics of Pravastatin and Coproporphyrin I/III in Healthy Female Subjects

Authors: Liu, Lichuan, Cheeti, Sravanthi, Yoshida, Kenta, Choo, Edna, Chen, Eugene, Chen, Buyun, Gates, Mary, Singel, Stina, Morley, Roland, Ware, Joseph, Sahasranaman, Srikumar

Source: Journal of clinical pharmacology. 58(11):1427-1435

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100152440097.0x000001&indx=1&recIds=ETOCvdc_100152440097.0x000001

Absorption, Metabolism, Excretion, and the Contribution of Intestinal Metabolism to the Oral Disposition of [14C]Cobimetinib, a MEK Inhibitor, in Humans

Authors: Takahashi, Ryan H ^*, Choo, Edna F, Ma, Shuguang, Wong, Susan, Halladay, Jason ¹, Deng, Yuzhong, Rooney, Isabelle, Gates, Mary, Hop, Cornelis E.C.A, Khojasteh, S. Cyrus, Dresser, Mark J ², Musib, Luna

Source: In Drug Metabolism and Disposition January 2016 44(1):28-39

Changing role of women in voluntarism.

Alternate Title: address, February 27, 1981

Authors: GATES, Mary M.

Source: Vital Speeches of the Day; May 1 1981, Vol. 47, p436-439, 4p

Somatosensory evoked potentials can be recorded on the midline of the skull with subdermal electrodes in non-sedated rats elicited by magnetic stimulation of the tibial nerve

Authors: Zhang, Shu-xin, Huang, Fengfa, Gates, Mary, Holmberg, Eric G.

Source: In Journal of Neuroscience Methods 15 July 2012 208(2):114-118

Tail nerve electrical stimulation combined with scar ablation and neural transplantation promotes locomotor recovery in rats with chronically contused spinal cord

Authors: Zhang, Shu-xin, Huang, Fengfa, Gates, Mary, Holmberg, Eric G.

Source: In Brain Research 25 May 2012 1456:22-35

Scar ablation combined with LP/OEC transplantation promotes anatomical recovery and P0-positive myelination in chronically contused spinal cord of rats

Authors: Zhang, Shu-xin, Huang, Fengfa, Gates, Mary, Holmberg, Eric G.

Source: In Brain Research 2011 1399:1-14

The Changing Role of Women In Voluntarism.

Authors: Gates, Mary M.

Source: Vital Speeches of the Day. 5/1/81, Vol. 47 Issue 14, p436. 4p.

Subjects: GATES, Mary, VOLUNTEER service, WOMEN volunteers in social services, WOMEN in community development

Extensive scarring induced by chronic intrathecal tubing augmented cord tissue damage and worsened functional recovery after rat spinal cord injury

Authors: Zhang, Shu-xin, Huang, Fengfa, Gates, Mary, White, Jason, Holmberg, Eric G.

Source: In Journal of Neuroscience Methods 2010 191(2):201-207

Tail nerve electrical stimulation induces body weight-supported stepping in rats with spinal cord injury

Authors: Zhang, Shu-xin, Huang, Fengfa, Gates, Mary, White, Jason, Holmberg, Eric G.

Source: In Journal of Neuroscience Methods 2010 187(2):183-189

The oral selective estrogen receptor degrader GDC-0810 (ARN-810) in postmenopausal women with hormone receptor-positive HER2-negative (HR + /HER2 −) advanced/metastatic breast cancer.

Authors: Bardia, Aditya, Mayer, Ingrid, Winer, Eric, Linden, Hannah M., Ma, Cynthia X., Parker, Barbara A., Bellet, Meritxell, Arteaga, Carlos L., Cheeti, Sravanthi, Gates, Mary, Chang, Ching-Wei, Fredrickson, Jill, Spoerke, Jill M., Moore, Heather M., Giltnane, Jennifer, Friedman, Lori S., Chow Maneval, Edna, Chan, Iris, Jhaveri, Komal

Source: Breast Cancer Research & Treatment; Jan2023, Vol. 197 Issue 2, p319-331, 13p

Application of a Novel 'Make and Test in Parallel' Strategy to Investigate the Effect of Formulation on the Pharmacokinetics of GDC-0810 in Healthy Subjects

Authors: Cheeti, Sravanthi, Hou, Hao Helen, Nelson, Eric, Walker, Helen, Chen, Buyun, Morley, Roland, Gates, Mary, Musib, Luna, Girish, Sandhya, Sahasranaman, Srikumar, Liu, Lichuan

Source: PHARMACEUTICAL RESEARCH. 35(12)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100127725338.0x000001&indx=1&recIds=ETOCvdc_100127725338.0x000001

Correction to: Application of a Novel 'Make and Test in Parallel' Strategy to Investigate the Effect of Formulation on the Pharmacokinetics of GDC-0810 in Healthy Subjects

Authors: Cheeti, Sravanthi, Hou, Hao Helen, Nelson, Eric, Walker, Helen, Chen, Buyun, Morley, Roland, Gates, Mary, Musib, Luna, Girish, Sandhya, Sahasranaman, Srikumar, Liu, Lichuan

Source: PHARMACEUTICAL RESEARCH. 35(12)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100127725313.0x000001&indx=1&recIds=ETOCvdc_100127725313.0x000001

Safety and activity of single-agent giredestrant (GDC-9545) from a phase Ia/b study in patients (pts) with estrogen receptor-positive (ER+), HER2-negative locally advanced/metastatic breast cancer (LA/mBC).

Authors: Jhaveri, Komal L., Boni, Valentina, Sohn, Joohyuk, Villanueva-Vásquez, Rafael, Bardia, Aditya, Schmid, Peter, Lim, Elgene, Patel, Jaymin M., Perez-Fidalgo, Jose Alejandro, Loi, Sherene, Im, Seock-Ah, Kshirsagar, Smita, Gates, Mary R., Bond, John, Eng-Wong, Jennifer, Chang, Ching-Wei, Turner, Nicholas C., Lopez Miranda, Elena, García-Estévez, Laura, Bellet, Meritxell

Source: Journal of clinical oncology. 39(15 suppl):1017-1017

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100173178492.0x000001&indx=1&recIds=ETOCvdc_100173178492.0x000001

Evaluation of pharmacodynamic (PD) and biologic activity in a preoperative window-of-opportunity (WOO) study of giredestrant (GDC-9545) in postmenopausal patients (pts) with estrogen receptor-positive, HER2-negative (ER+/HER2–) operable breast cancer (BC).

Authors: Moore, Heather M., Boni, Valentina, Bellet, Meritxell, Bermejo De Las Heras, Begoña, Gión Cortés, Maria, Oakman, Catherine, Schmid, Peter, Trinh, Xuan Bich, Wheatley, Duncan, Jhaveri, Komal L., Kabos, Peter, Lim, Elgene, Velu, Thierry, Metcalfe, Ciara, Gates, Mary R., Chang, Ching-Wei, Bond, John, Goldstein, Leonard D, Lauchle, Jennifer O'Hara, Bardia, Aditya

Source: Journal of clinical oncology. 39(15 suppl):577-577

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Pharmacological Characterization of the Competitive GLUK5 Receptor Antagonist Decahydroisoquinoline LY466195 in Vitro and in Vivo

Authors: Weiss, Brianne, Alt, Andrew, Ogden, Ann Marie, Gates, Mary, Dieckman, Donna K., Clemens-Smith, Amy, Ho, Ken H., Jarvie, Keith, Rizkalla, Geihan, Wright, Rebecca A., Calligaro, David O., Schoepp, Darryle, Mattiuz, Edward L., Stratford, Robert E., Johnson, Bryan, Salhoff, Craig, Katofiasc, Mary, Phebus, Lee A., Schenck, Kathryn, Cohen, Marlene, Filla, Sandra A., Ornstein, Paul L., Johnson, Kirk W., Bleakman, David ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics August 2006 318(2):772-781

Giredestrant reverses progesterone hypersensitivity driven by estrogen receptor mutations in breast cancer.

Authors: Liang, Jackson, Ingalla, Ellen Rei, Yao, Xiaosai, Wang, Bu-Er, Tai, Lisa, Giltnane, Jennifer, Liang, Yuxin, Daemen, Anneleen, Moore, Heather M., Aimi, Junko, Chang, Ching-Wei, Gates, Mary R., Eng-Wong, Jennifer, Tam, Lucinda, Bacarro, Natasha, Roose-Girma, Merone, Bellet, Meritxell, Hafner, Marc, Metcalfe, Ciara

Source: Science Translational Medicine; 9/21/2022, Vol. 14 Issue 663, p1-12, 12p

Subject Terms: ESTROGEN receptors, PROGESTERONE, BREAST cancer, PROGESTERONE receptors, MAMMARY glands, TISSUE remodeling

Title: Out of this nettle

Authors: Gates, Mary

Publisher: Crowell

Publication Year: 1937

Pages: 315p.

Document Type: Book

Library of Congress Control Number: 37-1117

Reviews: Reviews of this Title

Accession Number: 67904792

Conditioned behavior of isolated and grouped cockroaches on a simple maze.

Authors: GATES, Mary Frances, Allee, W. C.

Source: Journal of Comparative Psychology; April 1933, Vol. 15, p331-358, 28p