From Inflammasomes to Pyroptosis: Molecular Mechanisms in Chronic Intestinal Diseases — Opportunity or Challenge?

Authors: Fang J, Zhu W, Yu D, Zhu L, Zha H, Tang J, Li Y, Zhu X, Zhao T, Zhang W

Source: Journal of Inflammation Research, Vol Volume 18, Pp 3349-3360 (2025)

Subject Terms: pyroptosis, chronic intestinal diseases, inflammasomes, gasdermin proteins, cell death, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.dovepress.com/from-inflammasomes-to-pyroptosis-molecular-mechanisms-in-chronic-intes-peer-reviewed-fulltext-article-JIR; https://doaj.org/toc/1178-7031

Access URL: https://doaj.org/article/69e50e45fbd44d70bb6721b9024b7494

Nanomaterials evoke pyroptosis boosting cancer immunotherapy

Authors: Zhenhua Li, Ziyue Xi, Chuanyong Fan, Xinran Xi, Yao Zhou, Ming Zhao, Lu Xu

Source: Acta Pharmaceutica Sinica B, Vol 15, Iss 2, Pp 852-875 (2025)

Subject Terms: Pyroptosis, Nanomaterials, Gasdermin family, Mechanism, Induction, Cancer immunotherapy, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211383524004453; https://doaj.org/toc/2211-3835

Access URL: https://doaj.org/article/bbd45cffafbb44d09a4328253fe0f5b5

Pyroptosis-Mediator GSDMD in Plasma: A Promising Biomarker for Early Diagnosis of Type 2 Diabetes

Authors: Huo L, Liu X, Ding N, Zhang H, Hou S, He J, Zhao B

Source: Diabetes, Metabolic Syndrome and Obesity, Vol Volume 18, Pp 453-464 (2025)

Subject Terms: biomarker discovery, gasdermin d, early diagnosis, type 2 diabetes mellitus, plasma biomarker, prediabetes, Specialties of internal medicine, RC581-951

File Description: electronic resource

Relation: https://www.dovepress.com/pyroptosis-mediator-gsdmd-in-plasma-a-promising-biomarker-for-early-di-peer-reviewed-fulltext-article-DMSO; https://doaj.org/toc/1178-7007

Access URL: https://doaj.org/article/bd400b2ed34b4e8c9fa3eb30ada14ffb

Identification of the expression, prognostic value and cancer immunity of Gasdermin E based on multi-omics data, machine learning and gene ontology

Authors: Qiu, Shizheng, Zhang, Ying, Hu, Yang

Source: 2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM) Bioinformatics and Biomedicine (BIBM), 2022 IEEE International Conference on. :2418-2423 Dec, 2022

Relation: 2022 IEEE International Conference on Bioinformatics and Biomedicine (BIBM)

Dapagliflozin attenuates skeletal muscle atrophy in diabetic nephropathy mice through suppressing Gasdermin D-mediated pyroptosis

Authors: Zhang, Shuo ^{a, b, 1}, Guo, Shuang ^{c, 1}, Wang, Pengyu ^{a, b}, Song, Yan ^{a, b}, Yang, Leiming ^{a, b}, Sun, Qiyu ^{a, b}, Huang, Qi ^{a, b, ⁎}, Zhang, Youzhi ^{a, b, c, ⁎}

Source: In International Immunopharmacology 20 February 2025 148

Biological and pharmacological roles of pyroptosis in pulmonary inflammation and fibrosis: recent advances and future directions

Authors: Ya Liu, Danxia Wang, Xiang Liu, Haibin Yuan, Dan Liu, Yixiang Hu, Shipeng Ning

Source: Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-17 (2024)

Subject Terms: Pulmonary fibrosis, Pyroptosis, Inflammation, Gasdermin, Inflammasome, Medicine, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1478-811X

Access URL: https://doaj.org/article/5147afcd5eca4a04a8118c81df4ebb43

GSDMB Gene Polymorphisms and Their Association with Asthma Susceptibility: A Systematic Review and Meta-Analysis of Case–Control Studies

Authors: Maria E. Ramos-Nino, Prakash V. A. K. Ramdass

Source: Journal of Respiration, Vol 4, Iss 4, Pp 198-209 (2024)

Subject Terms: asthma, gasdermin B, rs7216389, polymorphism, Internal medicine, RC31-1245, Medicine (General), R5-920

File Description: electronic resource

Relation: https://www.mdpi.com/2673-527X/4/4/18; https://doaj.org/toc/2673-527X

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Estimation of noncanonical pyroptosis biomarkers gasdermin D and caspase 4 in gingiva of periodontitis and diabetes patients: An observational cross-sectional study

Authors: Lalitha Tanjore Arunachalam, Snophia Suresh, Vamsi Lavu, Shankarram Vedamanickam, John Ebinezer, Bhavishya Balachandran

Source: Journal of Indian Society of Periodontology, Vol 28, Iss 3, Pp 297-303 (2024)

Subject Terms: caspase 4, diabetes, gasdermin d, periodontitis, pyroptosis, Dentistry, RK1-715

File Description: electronic resource

Relation: https://journals.lww.com/10.4103/jisp.jisp_92_24; https://doaj.org/toc/0972-124X; https://doaj.org/toc/0975-1580

Access URL: https://doaj.org/article/665585e3d67a4a63ae8b29a39458a9c2

Identification of gasdermin B function in the progression of renal clear cell carcinoma by a pan-cancer analysis

Authors: Xiangyuan Tan, Zhanzhan Li, Yanyan Li

Source: Discover Oncology, Vol 15, Iss 1, Pp 1-19 (2024)

Subject Terms: Pan-cancer, Gasdermin, Prognosis, Progression, Kidney renal clear cell carcinoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2730-6011

Access URL: https://doaj.org/article/3625b1c9e3b645c485ba6a8c90c632ed

The role of pyroptosis in cancer: key components and therapeutic potential

Authors: Zixi Liu, Simiao Xu, Lin Chen, Jun Gong, Min Wang

Source: Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-23 (2024)

Subject Terms: Pyroptosis, Inflammasome, Gasdermin, Targeted therapy, Medicine, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1478-811X

Access URL: https://doaj.org/article/9f0542963cc74c91b16b898b1935ff47

GSDMD Mediates Ang II-Induced Hypertensive Nephropathy by Regulating the GATA2/AQP4 Signaling Pathway

Authors: Fan X, Zhang W, Zheng R, Zhang Y, Lai X, Han J, Fang Z, Han B, Huang W, Ye B, Dai S

Source: Journal of Inflammation Research, Vol Volume 17, Pp 8241-8259 (2024)

Subject Terms: gasdermin d, hypertensive nephropathy, pyroptosis, angiotensin ii, aquaporin 4, gata2, Pathology, RB1-214, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://www.dovepress.com/gsdmd-mediates-ang-ii-induced-hypertensive-nephropathy-by-regulating-t-peer-reviewed-fulltext-article-JIR; https://doaj.org/toc/1178-7031

Access URL: https://doaj.org/article/8fd829b22812414eacc68fd29063619a

Intestinal epithelial Gasdermin C is induced by IL-4R/STAT6 signaling but is dispensable for gut immune homeostasis

Authors: Reyes Gámez-Belmonte, Yara Wagner, Mousumi Mahapatro, Ru Wang, Lena Erkert, Miguel González-Acera, Roodline Cineus, Saskia Hainbuch, Jay V. Patankar, David Voehringer, Ahmed N. Hegazy, Markus F. Neurath, Stefan Wirtz, Christoph Becker

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)

Subject Terms: Intestinal homeostasis, Gut pathology, Gasdermin, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/b1384b9584bd49dc96d572989f1a8151

Pyroptosis: Induction and inhibition strategies for immunotherapy of diseases

Authors: Junjun Wu, Hong Wang, Pu Gao, Songying Ouyang

Source: Acta Pharmaceutica Sinica B, Vol 14, Iss 10, Pp 4195-4227 (2024)

Subject Terms: Pyroptosis, Gasdermin, Induction, Inhibition, Immunotherapy, Cell death, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211383524002569; https://doaj.org/toc/2211-3835

Access URL: https://doaj.org/article/9ed0f6315fc747a380cbf650aa304cf8

The novel GSDMD inhibitor GI‐Y2 exerts antipyroptotic effects to reduce atherosclerosis

Authors: Xiaoxi Fan, Zhenfeng Cheng, Ruiyin Shao, Keke Ye, Xudong Chen, Xueli Cai, Shanshan Dai, Zhixuan Tang, Si Shi, Wenyuan Zheng, Weijian Huang, Jibo Han, Bozhi Ye

Source: Clinical and Translational Medicine, Vol 15, Iss 3, Pp n/a-n/a (2025)

Subject Terms: atherosclerosis, gasdermin D, macrophage, pyroptosis, Medicine (General), R5-920

File Description: electronic resource

Relation: https://doaj.org/toc/2001-1326

Access URL: https://doaj.org/article/4fa189396eef4f25a3a4bc334736b9aa

Understanding the mechanisms of hypoxia-induced tissue damage in fish: The role of GasderminEa/b in Larimichthys crocea

Authors: Lin Wang, Shuaiyu Chen, Yongyang Wang, Weini Zhang, Yinnan Mu, Yudong Jia, Changtao Guan, Meng Xue, Xinhua Chen

Source: Water Biology and Security, Vol 4, Iss 1, Pp 100322- (2025)

Subject Terms: Hypoxia stress, Larimichthys crocea, Pyroptosis, Gasdermin, Tissue damage, Environmental sciences, GE1-350, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2772735124000945; https://doaj.org/toc/2772-7351

Access URL: https://doaj.org/article/68f7252570474addb1a2678ec509eea8

Exploiting gasdermin-mediated pyroptosis for enhanced antimicrobial activity of phage endolysin against Pseudomonas aeruginosa

Authors: Dorota Kuc-Ciepluch, Karol Ciepluch, Daria Augustyniak, Grzegorz Guła, Barbara Maciejewska, Artur Kowalik, Ewelina Jop, Zuzanna Drulis-Kawa, Michał Arabski

Source: mSystems, Vol 10, Iss 1 (2025)

Subject Terms: Pseudomonas aeruginosa LPS, pyroptosis, gasdermin D, endolysin, outer membrane permeabilization, Microbiology, QR1-502

File Description: electronic resource

Relation: https://doaj.org/toc/2379-5077

Access URL: https://doaj.org/article/066fda5f197a470c9748ae75adc0096c

Comprehensive analyses reveal the promising value of gasdermins as prognostic biomarkers and immunotherapeutic targets in head and neck squamous cell carcinoma

Authors: Huageng Huang, Jingjing Ge, Shunzhen Lu, Xinyi Deng, Ying Tian, He Huang, Zhao Wang, Yuyi Yao, Huangming Hong, Tongyu Lin

Source: Heliyon, Vol 11, Iss 1, Pp e41213- (2025)

Subject Terms: Antitumor immunity, Gasdermin, Head and neck squamous cell carcinoma, Prognosis, Pyroptosis, Science (General), Q1-390, Social sciences (General), H1-99

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405844024172441; https://doaj.org/toc/2405-8440

Access URL: https://doaj.org/article/f27d73c949604fa09bdd8494a82aaac6

Enhanced pyroptosis induction with pore-forming gene delivery for osteosarcoma microenvironment reshaping

Authors: Jing-Jun Nie, Bowen Zhang, Peng Luo, Maoguo Luo, Yuwen Luo, Jingjing Cao, Honggang Wang, Jianping Mao, Yonggang Xing, Weifeng Liu, Yuning Cheng, Renxian Wang, Yajun Liu, Xinbao Wu, Xieyuan Jiang, Xiaoguang Cheng, Chi Zhang, Da-Fu Chen

Source: Bioactive Materials, Vol 38, Iss , Pp 455-471 (2024)

Subject Terms: Osteosarcoma, Pyroptosis, Gasdermin, Gene delivery, Immune microenvironment reshaping, Materials of engineering and construction. Mechanics of materials, TA401-492, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2452199X24001750; https://doaj.org/toc/2452-199X

Access URL: https://doaj.org/article/edb31512544f4ad5a181b63aa3200040

Comprehensive analysis, diagnosis, prognosis, and cordycepin (CD) regulations for GSDME expressions in pan-cancers

Authors: Jiewen Fu, Dabing Li, Lianmei Zhang, Mazaher Maghsoudloo, Jingliang Cheng, Junjiang Fu

Source: Cancer Cell International, Vol 24, Iss 1, Pp 1-14 (2024)

Subject Terms: The Gasdermin E gene, Pan-cancers, Diagnosis, Prognostics, Therapeutics, Cordycepin (CD), Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/1475-2867

Access URL: https://doaj.org/article/f98d018f76594807a8d9411c00548cfe

Nanoparticle-mediated cell pyroptosis: a new therapeutic strategy for inflammatory diseases and cancer

Authors: Lin Zhao, Haipeng Cheng, Zhongyi Tong, Jing Cai

Source: Journal of Nanobiotechnology, Vol 22, Iss 1, Pp 1-24 (2024)

Subject Terms: Pyroptosis, Nanoparticle, Tumor immunotherapy, Nano-delivery system, Nanodrugs, Gasdermin, Biotechnology, TP248.13-248.65, Medical technology, R855-855.5

File Description: electronic resource

Relation: https://doaj.org/toc/1477-3155

Access URL: https://doaj.org/article/f7ee28baaeb9468c8963b375e2e5ae15