Brain cell-specific origin of circulating microRNA biomarkers in experimental temporal lobe epilepsy

Authors: Elizabeth Brindley, Mona Heiland, Catherine Mooney, Mairead Diviney, Omar Mamad, Thomas D. M. Hill, Yan Yan, Morten T. Venø, Cristina R. Reschke, Aasia Batool, Elena Langa, Amaya Sanz-Rodriguez, Janosch P. Heller, Gareth Morris, Karen Conboy, Jørgen Kjems, Gary P. Brennan, David C. Henshall

Source: Frontiers in Molecular Neuroscience, Vol 16 (2023)

Subject Terms: electroencephalogram, diagnosis, epigenetic, hippocampus, noncoding RNA, point-of-care testing, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnmol.2023.1230942/full; https://doaj.org/toc/1662-5099

Access URL: https://doaj.org/article/5a12b88c05be4334969707b5a82ff1e7

Editorial: The molecular mechanisms of epilepsy and potential therapeutics

Authors: Tobias Engel, Gary P. Brennan, Hermona Soreq

Source: Frontiers in Molecular Neuroscience, Vol 15 (2022)

Subject Terms: epilepsy, epileptogenesis, brain, therapy, anti-seizure medication (ASM), Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnmol.2022.1064121/full; https://doaj.org/toc/1662-5099

Access URL: https://doaj.org/article/947f4670cbc44850b672a4bfb4a143e6

Genetic deletion of microRNA-22 blunts the inflammatory transcriptional response to status epilepticus and exacerbates epilepsy in mice

Authors: Luiz F. Almeida Silva, Cristina R. Reschke, Ngoc T. Nguyen, Elena Langa, Amaya Sanz-Rodriguez, Rogerio R. Gerbatin, Fernanda R. Temp, Mayara L. de Freitas, Ronan M. Conroy, Gary P. Brennan, Tobias Engel, David C. Henshall

Source: Molecular Brain, Vol 13, Iss 1, Pp 1-15 (2020)

Subject Terms: Antagomirs, kainic acid, Hippocampus, microRNA, Oligonucleotide, Temporal lobe epilepsy, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13041-020-00653-x; https://doaj.org/toc/1756-6606

Access URL: https://doaj.org/article/437cebdae0ed4f06ac210951c4c7a083

MicroRNA Profiling Shows a Time-Dependent Regulation within the First 2 Months Post-Birth and after Mild Neonatal Hypoxia in the Hippocampus from Mice

Authors: Aisling Leavy, Gary P. Brennan, Eva M. Jimenez-Mateos

Source: Biomedicines, Vol 10, Iss 11, p 2740 (2022)

Subject Terms: microRNAs1, hippocampus, hypoxia, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/10/11/2740; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/b1913d86414e46739128624709263783

Regulatory Mechanisms of the RNA Modification m6A and Significance in Brain Function in Health and Disease

Authors: Justine Mathoux, David C. Henshall, Gary P. Brennan

Source: Frontiers in Cellular Neuroscience, Vol 15 (2021)

Subject Terms: m6A (N6-methyladenosine), brain function and brain diseases, brain development, epitranscriptomics, METTL3, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fncel.2021.671932/full; https://doaj.org/toc/1662-5102

Access URL: https://doaj.org/article/2c0ea216f3444ef39c07d55702d50734

Multiple Disruptions of Glial-Neuronal Networks in Epileptogenesis That Follows Prolonged Febrile Seizures

Authors: Gary P. Brennan, Megan M. Garcia-Curran, Katelin P. Patterson, Renhao Luo, Tallie Z. Baram

Source: Frontiers in Neurology, Vol 12 (2021)

Subject Terms: epilepsy, microRNA, microglia, astrocyte, cytokines, neuroinflammation, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fneur.2021.615802/full; https://doaj.org/toc/1664-2295

Access URL: https://doaj.org/article/f4fa7057264b4718a44a40eeeb6815e5

Epigenetic principles underlying epileptogenesis and epilepsy syndromes

Authors: Karen Conboy, David C. Henshall, Gary P. Brennan

Source: Neurobiology of Disease, Vol 148, Iss , Pp 105179- (2021)

Subject Terms: Anti-epileptogenesis, Drug-resistant epilepsy, Gene expression, Hippocampus, Seizure, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S096999612030454X; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/ed02a26beb67452b8271e1e373d985cd

Genome-wide microRNA profiling of plasma from three different animal models identifies biomarkers of temporal lobe epilepsy

Authors: Gary P. Brennan, Sebastian Bauer, Tobias Engel, Eva M. Jimenez-Mateos, Federico Del Gallo, Thomas D.M. Hill, Niamh M.C. Connolly, Lara S. Costard, Valentin Neubert, Beatrice Salvetti, Amaya Sanz-Rodriguez, Mona Heiland, Omar Mamad, Elizabeth Brindley, Braxton Norwood, Aasia Batool, Rana Raoof, Hany El-Naggar, Cristina R. Reschke, Norman Delanty, Jochen H.M. Prehn, Paolo Fabene, Catherine Mooney, Felix Rosenow, David C. Henshall

Source: Neurobiology of Disease, Vol 144, Iss , Pp 105048- (2020)

Subject Terms: Epilepsy, MicroRNA, Biomarkers, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S0969996120303235; https://doaj.org/toc/1095-953X

Access URL: https://doaj.org/article/072c418aab5a4a749a92db661a9cf3ff

Dual-center, dual-platform microRNA profiling identifies potential plasma biomarkers of adult temporal lobe epilepsyResearch in context

Authors: Rana Raoof, Sebastian Bauer, Hany El Naggar, Niamh M.C. Connolly, Gary P. Brennan, Elizabeth Brindley, Thomas Hill, Hazel McArdle, Elaine Spain, Robert J. Forster, Jochen H.M. Prehn, Hajo Hamer, Norman Delanty, Felix Rosenow, Catherine Mooney, David C. Henshall

Source: EBioMedicine, Vol 38, Iss , Pp 127-141 (2018)

Subject Terms: Medicine, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352396418304894; https://doaj.org/toc/2352-3964

Access URL: https://doaj.org/article/632bc337534f44689d22d27b78ebe8f0

Altered Biogenesis and MicroRNA Content of Hippocampal Exosomes Following Experimental Status Epilepticus

Authors: Aasia Batool, Thomas D. M. Hill, Ngoc T. Nguyen, Elena Langa, Mairéad Diviney, Catherine Mooney, Gary P. Brennan, Niamh M. C. Connolly, Amaya Sanz-Rodriguez, Brenton L. Cavanagh, David C. Henshall

Source: Frontiers in Neuroscience, Vol 13 (2020)

Subject Terms: epileptogenesis, extracellular vesicle, neuroinflammation, non-coding RNA, seizure, temporal lobe epilepsy, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fnins.2019.01404/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/46abeaf665154000a4909c438eaf4e3c

Dual and Opposing Roles of MicroRNA-124 in Epilepsy Are Mediated through Inflammatory and NRSF-Dependent Gene Networks

Authors: Gary P. Brennan, Deblina Dey, Yuncai Chen, Katelin P. Patterson, Eric J. Magnetta, Alicia M. Hall, Celine M. Dube, Yu-Tang Mei, Tallie Z. Baram

Source: Cell Reports, Vol 14, Iss 10, Pp 2402-2412 (2016)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124716301450; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/88446abf8b09460bbe0e2bd94ee45b66

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RNA-sequencing analysis of umbilical cord plasma microRNAs from healthy newborns.

Authors: Gary P Brennan, Dimitrios M Vitsios, Sophie Casey, Ann-Marie Looney, Boubou Hallberg, David C Henshall, Geraldine B Boylan, Deirdre M Murray, Catherine Mooney

Source: PLoS ONE, Vol 13, Iss 12, p e0207952 (2018)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/87e9038b973c475590bb8543188b19b3

The transcription factor NRSF contributes to epileptogenesis by selective repression of a subset of target genes

Authors: Shawn McClelland, Gary P Brennan, Celine Dubé, Seeta Rajpara, Shruti Iyer, Cristina Richichi, Christophe Bernard, Tallie Z Baram

Source: eLife, Vol 3 (2014)

Subject Terms: neuron-restrictive silencing factor, epilepsy, gene set enrichment analysi, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/01267; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/1988140a94ad4323a2aba1f399965d38

Transgenic overexpression of 14-3-3 zeta protects hippocampus against endoplasmic reticulum stress and status epilepticus in vivo.

Authors: Gary P Brennan, Eva M Jimenez-Mateos, Ross C McKiernan, Tobias Engel, Guri Tzivion, David C Henshall

Source: PLoS ONE, Vol 8, Iss 1, p e54491 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23359526/pdf/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/1031131f71fa488ebe16d9680cc5aaa7

Reduced mature microRNA levels in association with dicer loss in human temporal lobe epilepsy with hippocampal sclerosis.

Authors: Ross C McKiernan, Eva M Jimenez-Mateos, Isabella Bray, Tobias Engel, Gary P Brennan, Takanori Sano, Zuzanna Michalak, Catherine Moran, Norman Delanty, Michael Farrell, Donncha O'Brien, Robert Meller, Roger P Simon, Raymond L Stallings, David C Henshall

Source: PLoS ONE, Vol 7, Iss 5, p e35921 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3352899?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/bca703fd974c41699ec6045e74402c1d