TGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24− cancer cells

Authors: Debjani Pal, Anja Pertot, Nitin H Shirole, Zhan Yao, Naishitha Anaparthy, Tyler Garvin, Hilary Cox, Kenneth Chang, Fred Rollins, Jude Kendall, Leyla Edwards, Vijay A Singh, Gary C Stone, Michael C Schatz, James Hicks, Gregory J Hannon, Raffaella Sordella

Source: eLife, Vol 6 (2017)

Subject Terms: genetic diversity, drug adaptability, intra-tumor heterogeneity, tumor evolution, tumor fitness, copy number alteration, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/21615; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/b7f989bbb5ea4d239de1e7c89e4b0fc4