Validation of CRISPR targeting for proliferation and cytarabine resistance control genes in the acute myeloid leukemia cell line MOLM-13

Authors: Prajapati, Subhash C, Dunham, Nicholas, Fan, Hao, Garrett-Bakelman, Francine E

Source: Biotechniques. 72(3):81-84

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187072846.0x000001&indx=1&recIds=ETOCvdc_100187072846.0x000001

Harnessing the power of sphingolipids: Prospects for acute myeloid leukemia

Authors: Ung, Johnson, Tan, Su-Fern, Fox, Todd E., Shaw, Jeremy J.P., Vass, Luke R., Costa-Pinheiro, Pedro, Garrett-Bakelman, Francine E., Keng, Michael K., Sharma, Arati, Claxton, David F., Levine, Ross L., Tallman, Martin S., Cabot, Myles C., Kester, Mark, Feith, David J., Loughran, Thomas P., Jr

Source: In Blood Reviews September 2022 55

Frequent somatic TET2 mutations in chronic NK-LGL leukemia with distinct patterns of cytopenias

Authors: Olson, Thomas L., Cheon, HeeJin, Xing, Jeffrey C., Olson, Kristine C., Paila, Umadevi, Hamele, Cait E., Neelamraju, Yaseswini, Shemo, Bryna C., Schmachtenberg, Matt, Sundararaman, Shriram K., Toro, Mariella F., Keller, Cheryl A., Farber, Emily A., Onengut-Gumuscu, Suna, Garrett-Bakelman, Francine E., Hardison, Ross C., Feith, David J., Ratan, Aakrosh, Loughran, Thomas P., Jr ^*

Source: In Blood 26 August 2021 138(8):662-673

Genomic and evolutionary portraits of disease relapse in acute myeloid leukemia

Authors: Rapaport, Franck, Neelamraju, Yaseswini, Baslan, Timour, Hassane, Duane, Gruszczynska, Agata, Robert de Massy, Marc, Farnoud, Noushin, Haddox, Samuel, Lee, Tak, Medina-Martinez, Juan, Sheridan, Caroline, Thurmond, Alexis, Becker, Michael, Bekiranov, Stefan, Carroll, Martin, Moses Murdock, Heardly, Valk, Peter J. M., Bullinger, Lars, D'Andrea, Richard, Lowe, Scott W., Neuberg, Donna, Levine, Ross L., Melnick, Ari, Garrett-Bakelman, Francine E.

Source: Leukemia. 35(9):2688-2692

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193006110.0x000001&indx=1&recIds=ETOCvdc_100193006110.0x000001

Cell-free DNA (cfDNA) and Exosome Profiling from a Year-Long Human Spaceflight Reveals Circulating Biomarkers

Authors: Bezdan, Daniela, Grigorev, Kirill, Meydan, Cem, Pelissier Vatter, Fanny A., Cioffi, Michele, Rao, Varsha, MacKay, Matthew, Nakahira, Kiichi, Burnham, Philip, Afshinnekoo, Ebrahim, Westover, Craig, Butler, Daniel, Mozsary, Chris, Donahoe, Timothy, Foox, Jonathan, Mishra, Tejaswini, Lucotti, Serena, Rana, Brinda K., Melnick, Ari M., Zhang, Haiying, Matei, Irina, Kelsen, David, Yu, Kenneth, Lyden, David C., Taylor, Lynn, Bailey, Susan M., Snyder, Michael P., Garrett-Bakelman, Francine E., Ossowski, Stephan, De Vlaminck, Iwijn, Mason, Christopher E.

Source: In iScience 18 December 2020 23(12)

Temporal Telomere and DNA Damage Responses in the Space Radiation Environment

Authors: Luxton, Jared J., McKenna, Miles J., Taylor, Lynn E., George, Kerry A., Zwart, Sara R., Crucian, Brian E., Drel, Viktor R., Garrett-Bakelman, Francine E., Mackay, Matthew J., Butler, Daniel, Foox, Jonathan, Grigorev, Kirill, Bezdan, Daniela, Meydan, Cem, Smith, Scott M., Sharma, Kumar, Mason, Christopher E., Bailey, Susan M.

Source: In Cell Reports 8 December 2020 33(10)

The NASA Twins Study : A multidimensional analysis of a year-long human spaceflight

Authors: Garrett-Bakelman, Francine E.

Source: Science, 2019 Apr 01. 364(6436), 144-144.

Access URL: https://www.jstor.org/stable/26649236

Cooperative Epigenetic Remodeling by TET2 Loss and NRAS Mutation Drives Myeloid Transformation and MEK Inhibitor Sensitivity

Authors: Kunimoto, Hiroyoshi, Meydan, Cem, Nazir, Abbas, Whitfield, Justin, Shank, Kaitlyn, Rapaport, Franck, Maher, Rebecca, Pronier, Elodie, Meyer, Sara C., Garrett-Bakelman, Francine E., Tallman, Martin, Melnick, Ari, Levine, Ross L., Shih, Alan H.

Source: In Cancer Cell 8 January 2018 33(1):44-59

CD97 is a critical regulator of acute myeloid leukemia stem cell function

Authors: Martin, Gaëlle H., Roy, Nainita, Chakraborty, Sohini, Desrichard, Alexis, Chung, Stephen S., Woolthuis, Carolien M., Hu, Wenhuo, Berezniuk, Iryna, Garrett-Bakelman, Francine E., Hamann, Jörg

Source: Journal of experimental medicine. 216(10):2362-2377

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN621816121&indx=1&recIds=ETOCRN621816121

Aid is a key regulator of myeloid/erythroid differentiation and DNA methylation in hematopoietic stem/progenitor cells

Authors: Kunimoto, Hiroyoshi, McKenney, Anna Sophia, Meydan, Cem, Shank, Kaitlyn, Nazir, Abbas, Rapaport, Franck, Durham, Benjamin, Garrett-Bakelman, Francine E., Pronier, Elodie, Shih, Alan H., Melnick, Ari, Chaudhuri, Jayanta, Levine, Ross L.

Source: In Blood 30 March 2017 129(13):1779-1790

Acute myeloid leukemia stratifies as 2 clinically relevant sphingolipidomic subtypes

Authors: Paudel, B. Bishal, Tan, Su-Fern, Fox, Todd E., Ung, Johnson, Golla, Upendarrao, Shaw, Jeremy J. P., Dunton, Wendy, Lee, Irene, Fares, Wisam A., Patel, Satyam, Sharma, Arati, Viny, Aaron D., Barth, Brian M., Tallman, Martin S., Cabot, Myles, Garrett-Bakelman, Francine E., Levine, Ross L., Kester, Mark, Feith, David J., Claxton, David, Janes, Kevin A., Loughran, Thomas P., Jr.

Source: In Blood Advances 12 March 2024 8(5):1137-1142

Mutant IDH: a targetable driver of leukemic phenotypes linking metabolism, epigenetics and transcriptional regulation

Authors: Garrett-Bakelman, Francine E, Melnick, Ari M

Source: Epigenomics. 8(7):945-957

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138517924.0x000001&indx=1&recIds=ETOCvdc_100138517924.0x000001

COCOA: coordinate covariation analysis of epigenetic heterogeneity

Authors: Lawson, John T., Smith, Jason P., Bekiranov, Stefan, Garrett-Bakelman, Francine E., Sheffield, Nathan C.

Source: Genome biology. 21(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100171988518.0x000001&indx=1&recIds=ETOCvdc_100171988518.0x000001

Loss of CCAAT‐Enhancer Binding Protein Delta Promotes Acute Myeloid Leukemia Cell Proliferation and Survival By Upregulating Cyclin D1 Expression

Authors: Prajapati, Subhash, Meydan, Cem, Dillon, Richard, Dunham, Nicholas, Fan, Hao, Gandara, Jorge A, Lee, Tak, Neelamraju, Yaseswini, Sheridan, Caroline, Wang, Zhenjia, Zumbo, Paul, Becker, Michael W., Bullinger, Lars, Carroll, Martin, D'Andrea, Richard J, Levine, Ross L, Mason, Christopher, Melnick, Ari M, Zang, Chongzhi, Bekiranov, Stefan, Garrett-Bakelman, Francine E.

Source: In Blood 2 November 2023 142 Supplement 1:1380-1380

A Pro-Inflammatory Gene Signature Characterizes a Better Risk Aged AML Patient Group in ECOG-ACRIN Cancer Research Group's Clinical Trial E3999

Authors: Neelamraju, Yaseswini, Rapaport, Franck, Gandara, Jorge A, Dunham, Nicholas, Fan, Hao, Lee, Tak, Prajapati, Subhash, Sheridan, Caroline, Wang, Ling, Cripe, Larry D., Dillon, Richard, Kleppe, Maria, Levine, Ross L, Mason, Christopher, Melnick, Ari M, Paietta, Elisabeth, Roboz, Gail J., Sun, Zhuoxin, Tallman, Martin S., Zhang, Yanming, Bekiranov, Stefan, Garrett-Bakelman, Francine E.

Source: In Blood 2 November 2023 142 Supplement 1:4326-4326

DNA methylation landscapes of 1538 breast cancers reveal a replication-linked clock, epigenomic instability and cis-regulation.

Authors: Batra, Rajbir Nath, Lifshitz, Aviezer, Vidakovic, Ana Tufegdzic, Chin, Suet-Feung, Sati-Batra, Ankita, Sammut, Stephen-John, Provenzano, Elena, Ali, H. Raza, Dariush, Ali, Bruna, Alejandra, Murphy, Leigh, Purushotham, Arnie, Ellis, Ian, Green, Andrew, Garrett-Bakelman, Francine E., Mason, Chris, Melnick, Ari, Aparicio, Samuel A. J. R., Rueda, Oscar M., Tanay, Amos

Source: Nature Communications; 9/13/2021, Vol. 12 Issue 1, p1-13, 13p

Subject Terms: DNA methylation, BREAST cancer, DNA analysis, BREAST tumors, LANDSCAPES, EPIGENOMICS, P16 gene

An optimized algorithm for detecting and annotating regional differential methylation.

Authors: Sheng Li^1,2, Garrett-Bakelman, Francine E.³, Akalin, Altuna^1,2, Zumbo, Paul^1,2, Levine, Ross⁴, To, Bik L.⁵, Lewis, Ian D.⁵, Brown, Anna L.⁶, D'Andrea, Richard J.^6,7, Melnick, Ari^3,8, Mason, Christopher E.^1,2 chm2042@med.cornell.edu

Source: BMC Bioinformatics. 2013, Vol. 14 Issue Suppl 5, p1-9. 9p. 1 Diagram, 2 Graphs.

Subject Terms: *METHYLATION, *GENOMES, *GENETICS, *NUCLEIC acids, *ALGORITHMS

Targeted detection and quantitation of histone modifications from 1,000 cells.

Authors: Abshiru, Nebiyu A., Sikora, Jacek W., Camarillo, Jeannie M., Morris, Juliette A., Compton, Philip D., Lee, Tak, Neelamraju, Yaseswini, Haddox, Samuel, Sheridan, Caroline, Carroll, Martin, Cripe, Larry D., Tallman, Martin S., Paietta, Elisabeth M., Melnick, Ari M., Thomas, Paul M., Garrett-Bakelman, Francine E., Kelleher, Neil L.

Source: PLoS ONE; 10/26/2020, Vol. 15 Issue 10, p1-17, 17p

Subject Terms: HUMAN stem cells, ACUTE myeloid leukemia, CELL populations, POST-translational modification, HISTONE acetylation, CENTROMERE, CELL separation

Base-Pair Resolution DNA Methylation Sequencing Reveals Profoundly Divergent Epigenetic Landscapes in Acute Myeloid Leukemia.

Authors: Akalin, Altuna¹, Garrett-Bakelman, Francine E.², Kormaksson, Matthias³, Busuttil, Jennifer², Lu Zhang⁴, Khrebtukova, Irina⁴, Milne, Thomas A.⁵, Huang, Yongsheng⁶, Biswas, Debabrata⁷, Hess, Jay L.⁶, Allis, C. David⁷, Roeder, Robert G.⁸, Valk, Peter J. M.⁹, Löwenberg, Bob⁹, Delwel, Ruud⁹, Fernandez, Hugo F.¹⁰, Paietta, Elisabeth¹¹, Tallman, Martin S.¹², Schroth, Gary P.⁴, Mason, Christopher E.¹ chm2042@med.cornell.edu

Source: PLoS Genetics. Jun2012, Vol. 8 Issue 6, Special section p1-16. 16p. 1 Diagram, 1 Chart, 5 Graphs.

Subject Terms: *DNA methylation, *EPIGENETICS, *LANDSCAPES, *ACUTE myeloid leukemia, *SULFITES

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