Neoplastic and immune single-cell transcriptomics define subgroup-specific intra-tumoral heterogeneity of childhood medulloblastoma

Authors: Riemondy, Kent A, Venkataraman, Sujatha, Willard, Nicholas, Nellan, Anandani, Sanford, Bridget, Griesinger, Andrea M, Amani, Vladimir, Mitra, Siddhartha, Hankinson, Todd C, Handler, Michael H, Sill, Martin, Ocasio, Jennifer, Weir, Seth J, Malawsky, Daniel S, Gershon, Timothy R, Garancher, Alexandra, Wechsler-Reya, Robert J, Hesselberth, Jay R, Foreman, Nicholas K, Donson, Andrew M, Vibhakar, Rajeev

Source: Neuro-oncology. 24(2):273-286

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Zika Virus Targets Glioblastoma Stem Cells through a SOX2-Integrin αvβ5 Axis

Authors: Zhu, Zhe, Mesci, Pinar, Bernatchez, Jean A., Gimple, Ryan C., Wang, Xiuxing, Schafer, Simon T., Wettersten, Hiromi I., Beck, Sungjun, Clark, Alex E., Wu, Qiulian, Prager, Briana C., Kim, Leo J.Y., Dhanwani, Rekha, Sharma, Sonia, Garancher, Alexandra, Weis, Sara M., Mack, Stephen C., Negraes, Priscilla D., Trujillo, Cleber A., Penalva, Luiz O., Feng, Jing, Lan, Zhou, Zhang, Rong, Wessel, Alex W., Dhawan, Sanjay, Diamond, Michael S., Chen, Clark C., Wechsler-Reya, Robert J., Gage, Fred H., Hu, Hongzhen, Siqueira-Neto, Jair L., Muotri, Alysson R., Cheresh, David A., Rich, Jeremy N.

Source: In Cell Stem Cell 6 February 2020 26(2):187-204

Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy

Authors: Čančer, Matko, Hutter, Sonja, Holmberg, Karl O., Rosén, Gabriela, Sundström, Anders, Tailor, Jignesh, Bergström, Tobias, Garancher, Alexandra, Essand, Magnus, Wechsler-Reya, Robert J., Falk, Anna, Weishaupt, Holger, Swartling, Fredrik J.

Source: In Cell Stem Cell 5 December 2019 25(6):855-870

NRL and CRX Define Photoreceptor Identity and Reveal Subgroup-Specific Dependencies in Medulloblastoma

Authors: Garancher, Alexandra, Lin, Charles Y., Morabito, Morgane, Richer, Wilfrid, Rocques, Nathalie, Larcher, Magalie, Bihannic, Laure, Smith, Kyle, Miquel, Catherine, Leboucher, Sophie, Herath, Nirmitha I., Dupuy, Fanny, Varlet, Pascale, Haberler, Christine, Walczak, Christine, El Tayara, Nadine, Volk, Andreas, Puget, Stéphanie, Doz, François, Delattre, Olivier, Druillennec, Sabine, Ayrault, Olivier, Wechsler-Reya, Robert J., Eychène, Alain, Bourdeaut, Franck, Northcott, Paul A., Pouponnot, Celio

Source: In Cancer Cell 12 March 2018 33(3):435-449

A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases

Authors: Garzia, Livia, Kijima, Noriyuki, Morrissy, A. Sorana, De Antonellis, Pasqualino, Guerreiro-Stucklin, Ana, Holgado, Borja L., Wu, Xiaochong, Wang, Xin, Parsons, Michael, Zayne, Kory, Manno, Alex, Kuzan-Fischer, Claudia, Nor, Carolina, Donovan, Laura K., Liu, Jessica, Qin, Lei, Garancher, Alexandra, Liu, Kun-Wei, Mansouri, Sheila, Luu, Betty, Thompson, Yuan Yao, Ramaswamy, Vijay, Peacock, John, Farooq, Hamza, Skowron, Patryk, Shih, David J.H., Li, Angela, Ensan, Sherine, Robbins, Clinton S., Cybulsky, Myron, Mitra, Siddhartha, Ma, Yussanne, Moore, Richard, Mungall, Andy, Cho, Yoon-Jae, Weiss, William A., Chan, Jennifer A., Hawkins, Cynthia E., Massimino, Maura, Jabado, Nada, Zapotocky, Michal, Sumerauer, David, Bouffet, Eric, Dirks, Peter, Tabori, Uri, Sorensen, Poul H.B., Brastianos, Priscilla K., Aldape, Kenneth, Jones, Steven J.M., Marra, Marco A., Woodgett, James R., Wechsler-Reya, Robert J., Fults, Daniel W., Taylor, Michael D.

Source: In Cell 22 February 2018 172(5):1050-1062

Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma

Authors: Lee, Catherine, Rudneva, Vasilisa, Erkek, Serap, Zapatka, Marc, Chau, Lianne, Tacheva-Grigorova, Silvia, Garancher, Alexandra, Rusert, Jessica, Aksoy, Ozlem, Lea, Robin, Mohammad, Helai, Wang, Jianxun, Weiss, William, Grimes, H., Pfister, Stefan, Northcott, Paul, Wechsler-Reya, Robert

Source: Nature communications. 10(1):1-13

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Medulloblastoma: From Molecular Subgroups to Molecular Targeted Therapies

Authors: Wang, Jun, Garancher, Alexandra, Ramaswamy, Vijay, Wechsler-Reya, Robert J.

Source: Annual review of neuroscience. 41:207-232

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HDAC and PI3K Antagonists Cooperate to Inhibit Growth of MYC-Driven Medulloblastoma

Authors: Pei, Yanxin, Liu, Kun-Wei, Wang, Jun, Garancher, Alexandra, Tao, Ran, Esparza, Lourdes A., Maier, Donna L., Udaka, Yoko T., Murad, Najiba, Morrissy, Sorana, Seker-Cin, Huriye, Brabetz, Sebastian, Qi, Lin, Kogiso, Mari, Schubert, Simone, Olson, James M., Cho, Yoon-Jae, Li, Xiao-Nan, Crawford, John R., Levy, Michael L., Kool, Marcel, Pfister, Stefan M., Taylor, Michael D., Wechsler-Reya, Robert J.

Source: In Cancer Cell 14 March 2016 29(3):311-323

EMBR-27. NEOPLASTIC AND IMMUNE SINGLE CELL TRANSCRIPTOMICS DEFINE SUBGROUP-SPECIFIC INTRA-TUMORAL HETEROGENEITY OF CHILDHOOD MEDULLOBLASTOMA

Authors: Donson, Andrew, Riemondy, Kent, Venkataraman, Sujatha, Willard, Nicholas, Nellan, Anandani, Sanford, Bridget, Griesinger, Andrea, Amani, Vladimir, Mitra, Siddhartha, Hankinson, Todd, Handler, Michael, Sill, Martin, Ocasio, Jennifer, Weir, Seth, Malawsky, Daniel, Gershon, Timothy, Garancher, Alexandra, Wechsler-Reya, Robert, Hesselberg, Jay, Foreman, Nicholas, Vibhakar, Rajeev

Source: Neuro-oncology. 23(Supplement 1):i11-i12

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125173645.0x000001&indx=1&recIds=ETOCvdc_100125173645.0x000001

An autocrine ActivinB mechanism drives TGFβ/Activin signaling in Group 3 medulloblastoma

Authors: Morabito, Morgane, Larcher, Magalie, Cavalli, Florence MG, Foray, Chloé, Forget, Antoine, Mirabal‐Ortega, Liliana, Andrianteranagna, Mamy, Druillennec, Sabine, Garancher, Alexandra, Masliah‐Planchon, Julien, Leboucher, Sophie, Debalkew, Abel, Raso, Alessandro, Delattre, Olivier, Puget, Stéphanie, Doz, François, Taylor, Michael D, Ayrault, Olivier, Bourdeaut, Franck, Eychène, Alain, Pouponnot, Celio

Source: EMBO molecular medicine. 11(8)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100087230175.0x000001&indx=1&recIds=ETOCvdc_100087230175.0x000001

OMIC-01. THE LANDSCAPE OF EXTRACHROMOSOMAL CIRCULAR DNA IN MEDULLOBLASTOMA SUBGROUPS

Authors: Chapman, Owen, Luebeck, Jens, Wang, Shanqing, Garancher, Alexandra, Larson, Jon, Lange, Joshua, Wong, Ivy Tsz Lo, Crawford, John, Pomeroy, Scott, Mischel, Paul, Fraenkel, Ernest, Wechsler-Reya, Robert, Bafna, Vineet, Mesirov, Jill, Chavez, Lukas

Source: Neuro-oncology. 23(Supplement 1):i37-i37

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125174423.0x000001&indx=1&recIds=ETOCvdc_100125174423.0x000001

Le facteur de transcription Mafa, en l’absence de phosphorylation par GSK3, induit des apnées obstructives chez le souriceau

Authors: Lecoin, Laure, Dempsey, Bowen, Garancher, Alexandra, Bourane, Steeve, Morin-Surun, Marie-Pierre, Rocques, Nathalie, Eychene, Alain, Pouponnot, Celio, Fortin, Gilles, Champagnat, Jean

Source: In Médecine du Sommeil March 2023 20(1):45-45

Mafa-dependent GABAergic activity promotes mouse neonatal apneas.

Authors: Lecoin, Laure, Dempsey, Bowen, Garancher, Alexandra, Bourane, Steeve, Ruffault, Pierre-Louis, Morin-Surun, Marie-Pierre, Rocques, Nathalie, Goulding, Martyn, Eychène, Alain, Pouponnot, Celio, Fortin, Gilles, Champagnat, Jean

Source: Nature Communications; 6/7/2022, Vol. 13 Issue 1, p1-15, 15p

Neoplastic and immune single-cell transcriptomics define subgroup-specific intra-tumoral heterogeneity of childhood medulloblastoma.

Authors: Riemondy, Kent A, Venkataraman, Sujatha, Willard, Nicholas, Nellan, Anandani, Sanford, Bridget, Griesinger, Andrea M, Amani, Vladimir, Mitra, Siddhartha, Hankinson, Todd C, Handler, Michael H, Sill, Martin, Ocasio, Jennifer, Weir, Seth J, Malawsky, Daniel S, Gershon, Timothy R, Garancher, Alexandra, Wechsler-Reya, Robert J, Hesselberth, Jay R, Foreman, Nicholas K, Donson, Andrew M

Source: Neuro-Oncology; Feb2022, Vol. 24 Issue 2, p273-286, 14p

MBRS-10. QUIESCENT SOX9-POSITIVE CELLS BEHIND MYC DRIVEN MEDULLOBLASTOMA RECURRENCE

Authors: Bolin, Sara, Savov, Vasil, Borgenvik, Anna, Rosén, Gabriela, Olausson, Karl Holmberg, Zhao, Miao, Garancher, Alexandra, Rahmanto, Aldwin Suryo, Hutter, Sonja, Mainwaring, Oliver, Rusert, Jessica, Sundstrom, Anders, Richardson, Stacey, Fotaki, Grammatiki, Hill, Rebecca M, Dubuc, Adrian M, Kalushkova, Antonia, Remke, Marc, Čančer, Matko, Jernberg-Wiklund, Helena, Ramaswamy, Vijay, Chen, Xingqi, Taylor, Michael D, Sangfelt, Olle, Schüller, Ulrich, Clifford, Steve C, Wechsler-Reya, Robert J, Weishaupt, Holger, Swartling, Fredrik J

Source: Neuro-oncology. 22(Supplement 3):iii400-iii400

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112162601.0x000001&indx=1&recIds=ETOCvdc_100112162601.0x000001

MBRS-12. A TRANSPOSON MUTAGENESIS SCREEN IDENTIFIES Rreb1 AS A DRIVER FOR GROUP 3 MEDULLOBLASTOMA

Authors: Masihi, Meher Beigi, Lee, Catherine, Furnari, Grace A, Garancher, Alexandra, Wechsler-Reya, Robert J

Source: Neuro-oncology. 22(Supplement 3):iii400-iii400

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112162604.0x000001&indx=1&recIds=ETOCvdc_100112162604.0x000001

MBRS-16. MYC REGULATED LONG NONCODING RNA LNC-HLX-2–7 IS A PUTATIVE MOLECULAR MARKER AND A THERAPEUTIC TARGET FOR GROUP 3 MEDULLOBLASTOMAS IN CHILDREN

Authors: Katsushima, Keisuke, Joshi, Piyush, Stapleton, Stacie, Garancher, Alexandra, Vibhakar, Rajeev, Raabe, Eric, Eberhart, Charles, Wechsler-Reya, Robert, Jallo, George, Perera, Ranjan

Source: Neuro-oncology. 22(Supplement 3):iii401-iii401

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100112162631.0x000001&indx=1&recIds=ETOCvdc_100112162631.0x000001

The long noncoding RNA lnc-HLX-2-7 is oncogenic in Group 3 medulloblastomas.

Authors: Katsushima, Keisuke, Lee, Bongyong, Kunhiraman, Haritha, Zhong, Cuncong, Murad, Rabi, Yin, Jun, Liu, Ben, Garancher, Alexandra, Gonzalez-Gomez, Ignacio, Monforte, Hector L, Stapleton, Stacie, Vibhakar, Rajeev, Bettegowda, Chetan, Wechsler-Reya, Robert J, Jallo, George, Raabe, Eric, Eberhart, Charles G, Perera, Ranjan J

Source: Neuro-Oncology; Apr2021, Vol. 23 Issue 4, p572-585, 14p

TMOD-35. CAN RARE SOX9-POSITIVE CELLS INCITE MYC-DRIVEN MEDULLOBLASTOMA RECURRENCE?

Authors: Bolin, Sara, Savov, Vasil, Borgenvik, Anna, Garancher, Alexandra, Rosén, Gabriela, Rahmanto, Aldwin, Hutter, Sonja, Rusert, Jessica, Garzia, Livia, Fotaki, Grammatiki, Hill, Rebecca M, Dubuc, Adrian M, Remke, Marc, aner, Matko, Ramaswamy, Vijay, Clifford, Steve, Sangfelt, Olle, Schüller, Ulrich, Taylor, Michael, Wechsler-Reya, Robert, Weishaupt, Holger, Swartling, Fredrik

Source: Neuro-oncology. 20(suppl 6):vi276-vi276

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RETRACTED ARTICLE: Tumor necrosis factor overcomes immune evasion in p53-mutant medulloblastoma

Authors: Garancher, Alexandra, Suzuki, Hiromichi, Haricharan, Svasti, Chau, Lianne Q., Masihi, Meher Beigi, Rusert, Jessica M., Norris, Paula S., Carrette, Florent, Romero, Megan M., Morrissy, Sorana A., Skowron, Patryk, Cavalli, Florence M. G., Farooq, Hamza, Ramaswamy, Vijay, Jones, Steven J. M., Moore, Richard A., Mungall, Andrew J., Ma, Yussanne, Thiessen, Nina, Li, Yisu, Morcavallo, Alaide, Qi, Lin, Kogiso, Mari, Du, Yuchen, Baxter, Patricia, Henderson, Jacob J., Crawford, John R., Levy, Michael L., Olson, James M., Cho, Yoon-Jae, Deshpande, Aniruddha J., Li, Xiao-Nan, Chesler, Louis, Marra, Marco A., Wajant, Harald, Becher, Oren J., Bradley, Linda M., Ware, Carl F., Taylor, Michael D., Wechsler-Reya, Robert J.

Source: Nature Neuroscience; July 2020, Vol. 23 Issue: 7 p842-853, 12p