Hepatocyte-specific O-GlcNAc transferase downregulation ameliorates nonalcoholic steatohepatitis by improving mitochondrial function

Authors: Maria J. Gonzalez-Rellan, Tamara Parracho, Violeta Heras, Amaia Rodriguez, Marcos F. Fondevila, Eva Novoa, Natalia Lima, Marta Varela-Rey, Ana Senra, Maria D.P. Chantada-Vazquez, Cristina Ameneiro, Ganeko Bernardo, David Fernandez-Ramos, Fernando Lopitz-Otsoa, Jon Bilbao, Diana Guallar, Miguel Fidalgo, Susana Bravo, Carlos Dieguez, Maria L. Martinez-Chantar, Oscar Millet, Jose M. Mato, Markus Schwaninger, Vincent Prevot, Javier Crespo, Gema Frühbeck, Paula Iruzubieta, Ruben Nogueiras

Source: Molecular Metabolism, Vol 75, Iss , Pp 101776- (2023)

Subject Terms: O-GlcNAcylation, Mitochondrial dysfunction, NAFLD, Internal medicine, RC31-1245

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2212877823001102; https://doaj.org/toc/2212-8778

Access URL: https://doaj.org/article/534b9501b49e4a008f0846e144ff4da3

Redox regulation of KV7 channels through EF3 hand of calmodulin

Authors: Eider Nuñez, Frederick Jones, Arantza Muguruza-Montero, Janire Urrutia, Alejandra Aguado, Covadonga Malo, Ganeko Bernardo-Seisdedos, Carmen Domene, Oscar Millet, Nikita Gamper, Alvaro Villarroel

Source: eLife, Vol 12 (2023)

Subject Terms: KCNQ, calmodulin, redox, calcium, EF-hand, signal transduction, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/81961; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/0bd7d7f107f1445e8d187383cd53a107

O-GlcNAcylated p53 in the liver modulates hepatic glucose production

Authors: Maria J. Gonzalez-Rellan, Marcos F. Fondevila, Uxia Fernandez, Amaia Rodríguez, Marta Varela-Rey, Christelle Veyrat-Durebex, Samuel Seoane, Ganeko Bernardo, Fernando Lopitz-Otsoa, David Fernández-Ramos, Jon Bilbao, Cristina Iglesias, Eva Novoa, Cristina Ameneiro, Ana Senra, Daniel Beiroa, Juan Cuñarro, Maria DP Chantada-Vazquez, Maria Garcia-Vence, Susana B. Bravo, Natalia Da Silva Lima, Begoña Porteiro, Carmen Carneiro, Anxo Vidal, Sulay Tovar, Timo D. Müller, Johan Ferno, Diana Guallar, Miguel Fidalgo, Guadalupe Sabio, Stephan Herzig, Won Ho Yang, Jin Won Cho, Maria Luz Martinez-Chantar, Roman Perez-Fernandez, Miguel López, Carlos Dieguez, Jose M. Mato, Oscar Millet, Roberto Coppari, Ashwin Woodhoo, Gema Fruhbeck, Ruben Nogueiras

Source: Nature Communications, Vol 12, Iss 1, Pp 1-21 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/9769f87dfa1c4d5b90bfa5688f97fb4c

An Epoxide Intermediate in Glycosidase Catalysis

Authors: Lukasz F. Sobala, Gaetano Speciale, Sha Zhu, Lluı́s Raich, Natalia Sannikova, Andrew J. Thompson, Zalihe Hakki, Dan Lu, Saeideh Shamsi Kazem Abadi, Andrew R. Lewis, Vı́ctor Rojas-Cervellera, Ganeko Bernardo-Seisdedos, Yongmin Zhang, Oscar Millet, Jesús Jiménez-Barbero, Andrew J. Bennet, Matthieu Sollogoub, Carme Rovira, Gideon J. Davies, Spencer J. Williams

Source: ACS Central Science, Vol 6, Iss 5, Pp 760-770 (2020)

Subject Terms: Chemistry, QD1-999

File Description: electronic resource

Relation: https://doaj.org/toc/2374-7951

Access URL: https://doaj.org/article/74e7b245be3a4006a0bd9ec45aa0acd6

Protoporphyrin IX Binds to Iron(II)-Loaded and to Zinc-Loaded Human Frataxin

Authors: Ganeko Bernardo-Seisdedos, Andreas Schedlbauer, Tania Pereira-Ortuzar, José M. Mato, Oscar Millet

Source: Life, Vol 13, Iss 1, p 222 (2023)

Subject Terms: frataxin, iron metabolism, heme biosynthesis, iron-sulfur clusters, ferrochelatase, Friedreich’s ataxia, Science

File Description: electronic resource

Relation: https://www.mdpi.com/2075-1729/13/1/222; https://doaj.org/toc/2075-1729

Access URL: https://doaj.org/article/6f9fe83059b2488b9ea48156a3cb7829

Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor

Authors: Albert Escobedo, Busra Topal, Micha B. A. Kunze, Juan Aranda, Giulio Chiesa, Daniele Mungianu, Ganeko Bernardo-Seisdedos, Bahareh Eftekharzadeh, Margarida Gairí, Roberta Pierattelli, Isabella C. Felli, Tammo Diercks, Oscar Millet, Jesús García, Modesto Orozco, Ramon Crehuet, Kresten Lindorff-Larsen, Xavier Salvatella

Source: Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/1f190bc76aba4d9fb248940a644fa9a9

Identification of novel UROS mutations in a patient with congenital erythropoietic porphyria and efficient treatment by phlebotomy

Authors: Jean-Marc Blouin, Cécile Ged, Ganeko Bernardo-Seisdedos, Txomin Cabantous, Benoît Pinson, Antoine Poli, Hervé Puy, Oscar Millet, Laurent Gouya, Fanny Morice-Picard, Emmanuel Richard

Source: Molecular Genetics and Metabolism Reports, Vol 27, Iss , Pp 100722- (2021)

Subject Terms: Congenital erythropoietic porphyria, Iron deficiency, ALAS2, Therapeutic phlebotomy, UROS, Heme synthesis, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2214426921000161; https://doaj.org/toc/2214-4269

Access URL: https://doaj.org/article/d94966ec4ecb4b5b89626f93d399b2b2

SARS-CoV-2 Infection Dysregulates the Metabolomic and Lipidomic Profiles of Serum

Authors: Chiara Bruzzone, Maider Bizkarguenaga, Rubén Gil-Redondo, Tammo Diercks, Eunate Arana, Aitor García de Vicuña, Marisa Seco, Alexandre Bosch, Asís Palazón, Itxaso San Juan, Ana Laín, Jon Gil-Martínez, Ganeko Bernardo-Seisdedos, David Fernández-Ramos, Fernando Lopitz-Otsoa, Nieves Embade, Shelly Lu, José M. Mato, Oscar Millet

Source: iScience, Vol 23, Iss 10, Pp 101645- (2020)

Subject Terms: Human Metabolism, Virology, Metabolomics, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004220308373; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/6c94517cdfc74dbc8bca49abed3a345f

Pivoting between calmodulin lobes triggered by calcium in the Kv7.2/calmodulin complex.

Authors: Alessandro Alaimo, Araitz Alberdi, Carolina Gomis-Perez, Juncal Fernández-Orth, Ganeko Bernardo-Seisdedos, Covadonga Malo, Oscar Millet, Pilar Areso, Alvaro Villarroel

Source: PLoS ONE, Vol 9, Iss 1, p e86711 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24489773/pdf/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/dca1fc06521041f5b0972c7720bcbb4a