ctDNA whole exome sequencing in pancreatic ductal adenocarcinoma unveils organ-dependent metastatic mechanisms and identifies actionable alterations in fast progressing patients

Authors: Huerta, Marisol, Martín-Arana, Jorge, Gimeno-Valiente, Francisco, Carbonell-Asins, Juan Antonio, García-Micó, Blanca, Martínez-Castedo, Belén, Robledo-Yagüe, Fabián, Camblor, Daniel G., Fleitas, Tania, García Bartolomé, Miguel, Alfaro-Cervelló, Clara, Garcés-Albir, Marina, Dorcaratto, Dimitri, Muñoz-Forner, Elena, Seguí, Víctor, Mora-Oliver, Isabel, Gambardella, Valentina, Roselló, Susana, Sabater, Luis, Roda, Desamparados, Cervantes, Andrés, Tarazona, Noelia

Source: In Translational Research September 2024 271:105-115

Targeting HER2-mutant metastatic cervical cancer with neratinib: Final results from the phase 2 SUMMIT basket trial

Authors: Friedman, Claire F., D'Souza, Anishka, Bello Roufai, Diana, Tinker, Anna V., de Miguel, Maria, Gambardella, Valentina, Goldman, Jonathan, Loi, Sherene, Melisko, Michelle E., Oaknin, Ana, Spanggaard, Iben, Shapiro, Geoffrey I., ElNaggar, Adam C., Panni, Stefano, Ravichandran, Vignesh, Frazier, Aimee L., DiPrimeo, Daniel, Eli, Lisa D., Solit, David B.

Source: In Gynecologic Oncology February 2024 181:162-169

Phase I trial of the DLL3/CD3 bispecific T-cell engager BI 764532 in DLL3-positive small-cell lung cancer and neuroendocrine carcinomas

Authors: Wermke, Martin, Felip, Enriqueta, Gambardella, Valentina, Kuboki, Yasutoshi, Morgensztern, Daniel, Hamed, Zohra Oum', Liu, Meiruo, Studeny, Matus, Owonikoko, Taofeek K

Source: Future oncology. 18(24):2639-2649

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100191695466.0x000001&indx=1&recIds=ETOCvdc_100191695466.0x000001

Decoding chromosomal instability insights in CRC by integrating omics and patient-derived organoids.

Authors: Papaccio, Federica, Cabeza-Segura, Manuel, García-Micó, Blanca, Gimeno-Valiente, Francisco, Zúñiga-Trejos, Sheila, Gambardella, Valentina, Gutiérrez‐Bravo, María Fernanda, Martinez‐Ciarpaglini, Carolina, Rentero‐Garrido, Pilar, Fleitas, Tania, Roselló, Susana, Carbonell-Asins, Juan Antonio, Huerta, Marisol, Moro-Valdezate, David, Roda, Desamparados, Tarazona, Noelia, Sánchez del Pino, Manuel M., Cervantes, Andrés, Castillo, Josefa

Source: Journal of Experimental & Clinical Cancer Research (17569966); 2/28/2025, Vol. 44 Issue 1, p1-21, 21p

Subject Terms: PEARSON correlation (Statistics), LIFE sciences, MULTIOMICS, EPITHELIAL-mesenchymal transition, COLORECTAL cancer

Open-label, phase Ia study of STING agonist BI 1703880 plus ezabenlimab for patients with advanced solid tumors.

Authors: Harrington, Kevin, Kitano, Shigehisa, Gambardella, Valentina, Parkes, Eileen E., Moreno, Irene, Alonso, Guzman, Doi, Toshihiko, Berz, David, Gutierrez, Martin E., Fernandez, Natalia, Schmohl, Michael, Barrueco, José, LoRusso, Patricia

Source: Future Oncology; Jan2025, Vol. 21 Issue 2, p195-200, 6p

Tucatinib and trastuzumab in HER2-mutated metastatic breast cancer: a phase 2 basket trial

Authors: Okines, Alicia F. C., Curigliano, Giuseppe, Mizuno, Nobumasa, Oh, Do-Youn, Rorive, Andree, Soliman, Hatem, Takahashi, Shunji, Bekaii-Saab, Tanios, Burkard, Mark E., Chung, Ki Y., Debruyne, Philip R., Fox, Jenny R., Gambardella, Valentina, Gil-Martin, Marta, Hamilton, Erika P., Monk, Bradley J., Nakamura, Yoshiaki, Nguyen, Danny, O’Malley, David M., Olawaiye, Alexander B., Pothuri, Bhavana, Reck, Martin, Sudo, Kazuki, Sunakawa, Yu, Van Marcke, Cedric, Yu, Evan Y., Ramos, Jorge, Tan, Sherry, Bieda, Mark, Stinchcombe, Thomas E., Pohlmann, Paula R.

Source: Nature Medicine; March 2025, Vol. 31 Issue: 3 p909-916, 8p

Phase I/Ib Trial of Inavolisib Plus Palbociclib and Endocrine Therapy for PIK3CA -Mutated, Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Advanced or Metastatic Breast Cancer.

Authors: Jhaveri, Komal L., Accordino, Melissa K., Bedard, Philippe L., Cervantes, Andrés, Gambardella, Valentina, Hamilton, Erika, Italiano, Antoine, Kalinsky, Kevin, Krop, Ian E., Oliveira, Mafalda, Schmid, Peter, Saura, Cristina, Turner, Nicholas C., Varga, Andrea, Cheeti, Sravanthi, Hilz, Stephanie, Hutchinson, Katherine E., Jin, Yanling, Royer-Joo, Stephanie, Peters, Ubong

Source: Journal of Clinical Oncology; 11/20/2024, Vol. 42 Issue 33, p3947-3956, 16p

Neoadjuvant treatment for locally advanced unresectable and borderline resectable pancreatic cancer: oncological outcomes at a single academic centre

Authors: Roselló, Susana, Pizzo, Claudio, Huerta, Marisol, Muñoz, Elena, Aliaga, Roberto, Vera, Almudena, Alfaro-Cervelló, Clara, Jordá, Esther, Garcés-Albir, Marina, Roda, Desamparados, Dorcaratto, Dimitri, Tarazona, Noelia, Torondel, Sergio, Guijarro, Jorge, Sánchiz, Vicente, Gambardella, Valentina, Fleitas-Kanonnikoff, Tania, Lluch, Paloma, Pascual, Isabel, Ferrández, Antonio, Sabater, Luis, Cervantes, Andrés

Source: In ESMO Open 2020 5(6)

Detection of postoperative plasma circulating tumour DNA and lack of CDX2 expression as markers of recurrence in patients with localised colon cancer

Authors: Tarazona, Noelia, Gimeno-Valiente, Francisco, Gambardella, Valentina, Huerta, Marisol, Roselló, Susana, Zuniga, Sheila, Calon, Alexandre, Carbonell-Asins, Juan Antonio, Fontana, Elisa, Martinez-Ciarpaglini, Carolina, Eason, Katherine, Rentero-Garrido, Pilar, Fleitas, Tania, Papaccio, Federica, Moro-Valdezate, David, Nyamundanda, Gift, Castillo, Josefa, Espí, Alejandro, Sadanandam, Anguraj, Roda, Desamparados, Cervantes, Andrés

Source: In ESMO Open 2020 5(5)

Aurora kinases in ovarian cancer

Authors: Pérez-Fidalgo, J. Alejandro, Gambardella, Valentina, Pineda, Begoña, Burgues, Octavio, Piñero, Oscar, Cervantes, Andrés

Source: In ESMO Open 2020 5(5)

In the literature: February 2019

Authors: Insa, Amelia, Gambardella, Valentina, Cervantes, Andrés

Source: In ESMO Open 2019 4(1)

Assessing molecular subtypes of gastric cancer: microsatellite unstable and Epstein-Barr virus subtypes. Methods for detection and clinical and pathological implications

Authors: Martinez-Ciarpaglini, Carolina, Fleitas-Kanonnikoff, Tania, Gambardella, Valentina, Llorca, Marta, Mongort, Cristina, Mengual, Regina, Nieto, Gema, Navarro, Lara, Huerta, Marisol, Rosello, Susana, Roda, Desamparados, Tarazona, Noelia, Navarro, Samuel, Ribas, Gloria, Cervantes, Andrés

Source: In ESMO Open 2019 4(3)

Breast cancer in pregnant patients: A review of the literature

Authors: Martínez, María Teresa, Bermejo, Begoña, Hernando, Cristina, Gambardella, Valentina, Cejalvo, Juan Miguel, Lluch, Ana

Source: In European Journal of Obstetrics and Gynecology November 2018 230:222-227

In the literature: October 2018

Authors: Roda, Desamparados, Gambardella, Valentina, Cervantes, Andrés

Source: In ESMO Open 2018 3(6)

In the literature: August 2018

Authors: Gambardella, Valentina, Martin-Martorell, Paloma, Cervantes, Andrés

Source: In ESMO Open 2018 3(6)

In the literature: December 2018

Authors: Gambardella, Valentina, Fleitas, Tania, Cervantes, Andrés

Source: In ESMO Open 2018 3(7)

ZNF518B gene up-regulation promotes dissemination of tumour cells and is governed by epigenetic mechanisms in colorectal cancer

Authors: Gimeno-Valiente, Francisco, Riffo-Campos, Ángela, Vallet-Sánchez, Azahara, Siscar-Lewin, Sofía, Gambardella, Valentina, Tarazona, Noelia, Cervantes, Andrés, Franco, Luis, Castillo, Josefa, López-Rodas, Gerardo

Source: Scientific reports. 9(1):1-12

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182783219.0x000001&indx=1&recIds=ETOCvdc_100182783219.0x000001

Phase 1, first-in-human study of TYRP1-TCB (RO7293583), a novel TYRP1-targeting CD3 T-cell engager, in metastatic melanoma: active drug monitoring to assess the impact of immune response on drug exposure.

Authors: Spreafico, Anna, Couselo, Eva Muñoz, Irmisch, Anja, Bessa, Juliana, Au-Yeung, George, Bechter, Oliver, Svane, Inge Marie, Sanmamed, Miguel F., Gambardella, Valentina, McKean, Meredith, Callahan, Margaret, Dummer, Reinhard, Klein, Christian, Umaña, Pablo, Justies, Nicole, Heil, Florian, Fahrni, Linda, Opolka-Hoffmann, Eugenia, Waldhauer, Inja, Bleul, Conrad

Source: Frontiers in Oncology; 2024, p1-16, 16p

Subject Terms: MICROPHTHALMIA-associated transcription factor, DRUG monitoring, IMMUNE response, TUMOR necrosis factors, CYTOKINE release syndrome, T cells, UVEA cancer, UVEAL diseases

Clinical pharmacokinetics and pharmacodynamics of ramucirumab in the treatment of colorectal cancer

Authors: Gambardella, Valentina, Tarazona, Noelia, Cejalvo, Juan Miguel, Roselló, Susana, Cervantes, Andrés

Source: Expert opinion on drug metabolism and toxicology. 12(4):449-456

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100106459424.0x000001&indx=1&recIds=ETOCvdc_100106459424.0x000001

"Proteotranscriptomic analysis of advanced colorectal cancer patient derived organoids for drug sensitivity prediction".

Authors: Papaccio, Federica, García-Mico, Blanca, Gimeno-Valiente, Francisco, Cabeza-Segura, Manuel, Gambardella, Valentina, Gutiérrez-Bravo, María Fernanda, Alfaro-Cervelló, Clara, Martinez-Ciarpaglini, Carolina, Rentero-Garrido, Pilar, Zúñiga-Trejos, Sheila, Carbonell-Asins, Juan Antonio, Fleitas, Tania, Roselló, Susana, Huerta, Marisol, Sánchez del Pino, Manuel M., Sabater, Luís, Roda, Desamparados, Tarazona, Noelia, Cervantes, Andrés, Castillo, Josefa

Source: Journal of Experimental & Clinical Cancer Research (17569966); 1/7/2023, Vol. 42 Issue 1, p1-22, 22p

Subject Terms: CANCER patients, GENE expression profiling, PROTEIN expression, ORGANOIDS, LIVER metastasis