Three immunizations with Novavax’s protein vaccines increase antibody breadth and provide durable protection from SARS-CoV-2

Authors: Klara Lenart, Rodrigo Arcoverde Cerveira, Fredrika Hellgren, Sebastian Ols, Daniel J. Sheward, Changil Kim, Alberto Cagigi, Matthew Gagne, Brandon Davis, Daritza Germosen, Vicky Roy, Galit Alter, Hélène Letscher, Jérôme Van Wassenhove, Wesley Gros, Anne-Sophie Gallouët, Roger Le Grand, Harry Kleanthous, Mimi Guebre-Xabier, Ben Murrell, Nita Patel, Gregory Glenn, Gale Smith, Karin Loré

Source: npj Vaccines, Vol 9, Iss 1, Pp 1-17 (2024)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/2059-0105

Access URL: https://doaj.org/article/c088a289c59c484090d22680d31eac78

XBB.1.5 spike protein COVID-19 vaccine induces broadly neutralizing and cellular immune responses against EG.5.1 and emerging XBB variants

Authors: Nita Patel, Jessica F. Trost, Mimi Guebre-Xabier, Haixia Zhou, Jim Norton, Desheng Jiang, Zhaohui Cai, Mingzhu Zhu, Anthony M. Marchese, Ann M. Greene, Raburn M. Mallory, Raj Kalkeri, Filip Dubovsky, Gale Smith

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/ad7456950c5a471aa62cd2ee79cad670

Immunogenicity and protection of a variant nanoparticle vaccine that confers broad neutralization against SARS-CoV-2 variants

Authors: James Logue, Robert M. Johnson, Nita Patel, Bin Zhou, Sonia Maciejewski, Bryant Foreman, Haixia Zhou, Alyse D. Portnoff, Jing-Hui Tian, Asma Rehman, Marisa E. McGrath, Robert E. Haupt, Stuart M. Weston, Lauren Baracco, Holly Hammond, Mimi Guebre-Xabier, Carly Dillen, M. Madhangi, Ann M. Greene, Michael J. Massare, Greg M. Glenn, Gale Smith, Matthew B. Frieman

Source: Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/6b9ab71cb4bd4f84b8cc8463a5dfad83

The Matrix-M™ adjuvant: A critical component of vaccines for the 21st century

Authors: Linda Stertman, Anna-Karin E. Palm, Behdad Zarnegar, Berit Carow, Carolina Lunderius Andersson, Sofia E. Magnusson, Cecilia Carnrot, Vivek Shinde, Gale Smith, Gregory Glenn, Louis Fries, Karin Lövgren Bengtsson

Source: Human Vaccines & Immunotherapeutics, Vol 19, Iss 1 (2023)

Subject Terms: matrix-m™ adjuvant, quillaja saponin, vaccine, immunogenicity, safety, mechanism of action, innate immune response, adaptive immune response, sars-cov-2, covid-19, Immunologic diseases. Allergy, RC581-607, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: https://doaj.org/toc/2164-5515; https://doaj.org/toc/2164-554X

Access URL: https://doaj.org/article/f73e86e78de8490f9c7688c046ee0852

Author Correction: Intradermal immunization by Ebola virus GP subunit vaccines using microneedle patches protects mice against lethal EBOV challenge

Authors: Ying Liu, Ling Ye, Fang Lin, Yasmine Gomaa, David Flyer, Ricardo Carrion, Jean L. Patterson, Mark R. Prausnitz, Gale Smith, Gregory Glenn, Hua Wu, Richard W. Compans, Chinglai Yang

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-1 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/ff2b5d4e8873422293eb5e1c62295876

SARS-CoV-2 spike glycoprotein vaccine candidate NVX-CoV2373 immunogenicity in baboons and protection in mice

Authors: Jing-Hui Tian, Nita Patel, Robert Haupt, Haixia Zhou, Stuart Weston, Holly Hammond, James Logue, Alyse D. Portnoff, James Norton, Mimi Guebre-Xabier, Bin Zhou, Kelsey Jacobson, Sonia Maciejewski, Rafia Khatoon, Malgorzata Wisniewska, Will Moffitt, Stefanie Kluepfel-Stahl, Betty Ekechukwu, James Papin, Sarathi Boddapati, C. Jason Wong, Pedro A. Piedra, Matthew B. Frieman, Michael J. Massare, Louis Fries, Karin Lövgren Bengtsson, Linda Stertman, Larry Ellingsworth, Gregory Glenn, Gale Smith

Source: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/4a4e382fc93a4e5c84f3c4b94fc40a65

Influenza A(H7N9) Pandemic Preparedness: Assessment of the Breadth of Heterologous Antibody Responses to Emerging Viruses from Multiple Pre-Pandemic Vaccines and Population Immunity

Authors: Min Z. Levine, Crystal Holiday, Yaohui Bai, Weimin Zhong, Feng Liu, Stacie Jefferson, F. Liaini Gross, Wen-pin Tzeng, Louis Fries, Gale Smith, Philippe Boutet, Damien Friel, Bruce L. Innis, Corey P. Mallett, C. Todd Davis, David E. Wentworth, Ian A. York, James Stevens, Jacqueline M. Katz, Terrence Tumpey

Source: Vaccines, Vol 10, Iss 11, p 1856 (2022)

Subject Terms: A(H7N9) viruses, influenza vaccine, pandemic preparedness, population immunity, heterologous cross-reactivity, hemagglutination inhibition, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-393X/10/11/1856; https://doaj.org/toc/2076-393X

Access URL: https://doaj.org/article/68771ddb6ca74390957381a38314d5b0

Fab and Fc contribute to maximal protection against SARS-CoV-2 following NVX-CoV2373 subunit vaccine with Matrix-M vaccination

Authors: Matthew J. Gorman, Nita Patel, Mimi Guebre-Xabier, Alex L. Zhu, Caroline Atyeo, Krista M. Pullen, Carolin Loos, Yenny Goez-Gazi, Ricardo Carrion, Jr., Jing-Hui Tian, Dansu Yuan, Kathryn A. Bowman, Bin Zhou, Sonia Maciejewski, Marisa E. McGrath, James Logue, Matthew B. Frieman, David Montefiori, Colin Mann, Sharon Schendel, Fatima Amanat, Florian Krammer, Erica Ollmann Saphire, Douglas A. Lauffenburger, Ann M. Greene, Alyse D. Portnoff, Michael J. Massare, Larry Ellingsworth, Gregory Glenn, Gale Smith, Galit Alter

Source: Cell Reports Medicine, Vol 2, Iss 9, Pp 100405- (2021)

Subject Terms: Fc-function, antibodies, COVID-19, Fc-receptors, correlates, vaccination, Medicine (General), R5-920

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666379121002639; https://doaj.org/toc/2666-3791

Access URL: https://doaj.org/article/4986517e15404f80baa1ac1f4714b268

Immune Correlates of Protection from Filovirus Efficacy Studies in Non-Human Primates

Authors: Cheryl A. Triplett, Nancy A. Niemuth, Christopher Cirimotich, Gabriel Meister, Mimi Guebre-Xabier, Nita Patel, Mike Massare, Greg Glenn, Gale Smith, Kendra J. Alfson, Yenny Goez-Gazi, Ricardo Carrion

Source: Vaccines, Vol 10, Iss 8, p 1338 (2022)

Subject Terms: correlates of protection, PsVNA, ELISA, Marburg virus, Sudan virus, Ebola virus, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-393X/10/8/1338; https://doaj.org/toc/2076-393X

Access URL: https://doaj.org/article/9f5f0105e3644ef080388e11bc6aa289

Immunogenicity and safety of a respiratory syncytial virus fusion protein (RSV F) nanoparticle vaccine in older adults

Authors: Louis Fries, Vivek Shinde, Jeffrey J. Stoddard, D. Nigel Thomas, Eloi Kpamegan, Hanxin Lu, Gale Smith, Somia P. Hickman, Pedro Piedra, Gregory M. Glenn

Source: Immunity & Ageing, Vol 14, Iss 1, Pp 1-14 (2017)

Subject Terms: Anti-F IgG, F or fusion protein, Microneutralization, Nanoparticle vaccine, Palivizumab-competitive antibody (PCA), Recombinant, Immunologic diseases. Allergy, RC581-607, Geriatrics, RC952-954.6

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12979-017-0090-7; https://doaj.org/toc/1742-4933

Access URL: https://doaj.org/article/ede5a421c05f45379e58ee05f42f78c7

Flexible RSV Prefusogenic Fusion Glycoprotein Exposes Multiple Neutralizing Epitopes that May Collectively Contribute to Protective Immunity

Authors: Nita Patel, Jing-Hui Tian, Rhonda Flores, Kelsey Jacobson, Michelle Walker, Alyse Portnoff, Mimi Gueber-Xabier, Michael J. Massare, Greg Glenn, Larry Ellingsworth, Gale Smith

Source: Vaccines, Vol 8, Iss 4, p 607 (2020)

Subject Terms: respiratory syncytial virus, fusion glycoprotein, prefusogenic RSV F, cotton rat, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-393X/8/4/607; https://doaj.org/toc/2076-393X

Access URL: https://doaj.org/article/598d642f569b456488cf6ec1898051de

Structure basis of neutralization by a novel site II/IV antibody against respiratory syncytial virus fusion protein.

Authors: Qingqing Xie, Zhao Wang, Fengyun Ni, Xiaorui Chen, Jianpeng Ma, Nita Patel, Hanxin Lu, Ye Liu, Jing-Hui Tian, David Flyer, Michael J Massare, Larry Ellingsworth, Gregory Glenn, Gale Smith, Qinghua Wang

Source: PLoS ONE, Vol 14, Iss 2, p e0210749 (2019)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/cfdeb2d3629d4702a3334786e4caba93

Influenza Hemagglutinin Nanoparticle Vaccine Elicits Broadly Neutralizing Antibodies against Structurally Distinct Domains of H3N2 HA

Authors: Alyse D. Portnoff, Nita Patel, Michael J. Massare, Haixia Zhou, Jing-Hui Tian, Bin Zhou, Vivek Shinde, Gregory M. Glenn, Gale Smith

Source: Vaccines, Vol 8, Iss 1, p 99 (2020)

Subject Terms: influenza, hemagglutinin, nanoparticle, vaccine, antibody, Medicine

File Description: electronic resource

Relation: https://www.mdpi.com/2076-393X/8/1/99; https://doaj.org/toc/2076-393X

Access URL: https://doaj.org/article/ecfaff4913b34e2888ceb5da44359788

Respiratory syncytial virus fusion glycoprotein expressed in insect cells form protein nanoparticles that induce protective immunity in cotton rats.

Authors: Gale Smith, Rama Raghunandan, Yingyun Wu, Ye Liu, Michael Massare, Margret Nathan, Bin Zhou, Hanxin Lu, Sarathi Boddapati, Jingning Li, David Flyer, Gregory Glenn

Source: PLoS ONE, Vol 7, Iss 11, p e50852 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3511306?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/0a7aca2c825048ba8fb18a9332825bee

Cross-clade protective immune responses to influenza viruses with H5N1 HA and NA elicited by an influenza virus-like particle.

Authors: Rick A Bright, Donald M Carter, Corey J Crevar, Franklin R Toapanta, Jonathan D Steckbeck, Kelly S Cole, Niranjan M Kumar, Peter Pushko, Gale Smith, Terrence M Tumpey, Ted M Ross

Source: PLoS ONE, Vol 3, Iss 1, p e1501 (2008)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18231588/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/955caa07dde04c85bc395bf08c72d287

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