Germline MBD4 deficiency causes a multi-tumor predisposition syndrome

Authors: Palles, Claire, West, Hannah D., Chew, Edward, Galavotti, Sara, Flensburg, Christoffer, Grolleman, Judith E., Jansen, Erik A.M., Curley, Helen, Chegwidden, Laura, Arbe-Barnes, Edward H., Lander, Nicola, Truscott, Rebekah, Pagan, Judith, Bajel, Ashish, Sherwood, Kitty, Martin, Lynn, Thomas, Huw, Georgiou, Demetra, Fostira, Florentia, Goldberg, Yael, Adams, David J., van der Biezen, Simone A.M., Christie, Michael, Clendenning, Mark, Thomas, Laura E., Deltas, Constantinos, Dimovski, Aleksandar J., Dymerska, Dagmara, Lubinski, Jan, Mahmood, Khalid, van der Post, Rachel S., Sanders, Mathijs, Weitz, Jürgen, Taylor, Jenny C., Turnbull, Clare, Vreede, Lilian, van Wezel, Tom, Whalley, Celina, Arnedo-Pac, Claudia, Caravagna, Giulio, Cross, William, Chubb, Daniel, Frangou, Anna, Gruber, Andreas J., Kinnersley, Ben, Noyvert, Boris, Church, David, Graham, Trevor, Houlston, Richard, Lopez-Bigas, Nuria, Sottoriva, Andrea, Wedge, David, Jenkins, Mark A., Kuiper, Roland P., Roberts, Andrew W., Cheadle, Jeremy P., Ligtenberg, Marjolijn J.L., Hoogerbrugge, Nicoline, Koelzer, Viktor H., Rivas, Andres Dacal, Winship, Ingrid M., Ponte, Clara Ruiz, Buchanan, Daniel D., Power, Derek G., Green, Andrew, Tomlinson, Ian P.M., Sampson, Julian R., Majewski, Ian J., de Voer, Richarda M.

Source: American journal of human genetics. 109(5):953-960

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100163384397.0x000001&indx=1&recIds=ETOCvdc_100163384397.0x000001

Long-Fiber Carbon Nanotubes Replicate Asbestos-Induced Mesothelioma with Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a/Arf)

Authors: Chernova, Tatyana, Murphy, Fiona A., Galavotti, Sara, Sun, Xiao-Ming, Powley, Ian R., Grosso, Stefano, Schinwald, Anja, Zacarias-Cabeza, Joaquin, Dudek, Kate M., Dinsdale, David, Le Quesne, John, Bennett, Jonathan, Nakas, Apostolos, Greaves, Peter, Poland, Craig A., Donaldson, Ken, Bushell, Martin, Willis, Anne E., MacFarlane, Marion

Source: In Current Biology 6 November 2017 27(21):3302-3314

A PML/Slit Axis Controls Physiological Cell Migration and Cancer Invasion in the CNS

Authors: Amodeo, Valeria, A, Deli, Betts, Joanne, Bartesaghi, Stefano, Zhang, Ying, Richard-Londt, Angela, Ellis, Matthew, Roshani, Rozita, Vouri, Mikaella, Galavotti, Sara, Oberndorfer, Sarah, Leite, Ana Paula, Mackay, Alan, Lampada, Aikaterini, Stratford, Eva Wessel, Li, Ningning, Dinsdale, David, Grimwade, David, Jones, Chris, Nicotera, Pierluigi, Michod, David, Brandner, Sebastian, Salomoni, Paolo

Source: In Cell Reports 11 July 2017 20(2):411-426

Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells

Authors: Bartesaghi, Stefano, Graziano, Vincenzo, Galavotti, Sara, Henriquez, Nick V., Betts, Joanne, Saxena, Jayeta, A, Deli, Karlsson, Anna, Martins, L. Miguel, Capasso, Melania, Nicotera, Pierluigi, Brandner, Sebastian, De Laurenzi, Vincenzo, Salomoni, Paolo

Source: Proceedings of the National Academy of Sciences of the United States of America, 2015 Jan . 112(4), 1059-1064.

Access URL: https://www.jstor.org/stable/26454232

The p53 Codon 72 Pro/Pro Genotype Identifies Poor-Prognosis Neuroblastoma Patients: Correlation with Reduced Apoptosis and Enhanced Senescence by the p53-72P Isoform

Authors: Cattelani, Sara, Ferrari-Amorotti, Giovanna, Galavotti, Sara, Defferrari, Raffaella, Tanno, Barbara, Cialfi, Samantha, Vergalli, Jenny, Fragliasso, Valentina, Guerzoni, Clara, Manzotti, Gloria, Rachele Soliera, Angela, Menin, Chiara, Bertorelle, Roberta, McDowell, Heather P., Inserra, Alessandro, Belli, Maria Luisa, Varesio, Luigi, Tweddle, Deborah, Tonini, Gian Paolo, Altavista, Pierluigi, Dominici, Carlo, Raschellà, Giuseppe, Calabretta, Bruno

Source: In Neoplasia July 2012 14(7):634

GWAS meta-analysis of 16 790 patients with Barrett’s oesophagus and oesophageal adenocarcinoma identifies 16 novel genetic risk loci and provides insights into disease aetiology beyond the single marker level

Authors: Schro¨der, Julia, Chegwidden, Laura, Maj, Carlo, Gehlen, Jan, Speller, Jan, Bo¨hmer, Anne C, Borisov, Oleg, Hess, Timo, Kreuser, Nicole, Venerito, Marino, Alakus, Hakan, May, Andrea, Gerges, Christian, Schmidt, Thomas, Thieme, Rene, Heider, Dominik, Hillmer, Axel M, Reingruber, Julian, Lyros, Orestis, Dietrich, Arne, Hoffmeister, Albrecht, Mehdorn, Matthias, Lordick, Florian, Stocker, Gertraud, Hohaus, Michael, Reim, Daniel, Kandler, Jennis, Mu¨ller, Michaela, Ebigbo, Alanna, Fuchs, Claudia, Bruns, Christiane J, Ho¨lscher, Arnulf H, Lang, Hauke, Grimminger, Peter P, Dakkak, Dani, Vashist, Yogesh, May, Sandra, Go¨rg, Siegfried, Franke, Andre, Ellinghaus, David, Galavotti, Sara, Veits, Lothar, Weismu¨ller, Josef, Dommermuth, Jens, Benner, Udo, Ro¨sch, Thomas, Messmann, Helmut, Schumacher, Brigitte, Neuhaus, Horst, Schmidt, Carsten, Wissinowski, Thadda¨us T, No¨then, Markus M, Dong, Jing, Ong, Jue-Sheng, Buas, Matthew F, Thrift, Aaron P, Vaughan, Thomas L, Tomlinson, Ian, Whiteman, David C, Fitzgerald, Rebecca Claire, Jankowski, Janusz, Vieth, Michael, Mayr, Andreas, Gharahkhani, Puya, MacGregor, Stuart, Gockel, Ines, Palles, Claire, Schumacher, Johannes

Source: Gut; 2023, Vol. 72 Issue: 4 p612-623, 12p

Increased somatic mutation burdens in normal human cells due to defective DNA polymerases

Authors: Robinson, Philip S., Coorens, Tim H. H., Palles, Claire, Mitchell, Emily, Abascal, Federico, Olafsson, Sigurgeir, Lee, Bernard C. H., Lawson, Andrew R. J., Lee-Six, Henry, Moore, Luiza, Sanders, Mathijs A., Hewinson, James, Martin, Lynn, Pinna, Claudia M. A., Galavotti, Sara, Rahbari, Raheleh, Campbell, Peter J., Martincorena, Iñigo, Tomlinson, Ian, Stratton, Michael R.

Source: Nature Genetics; October 2021, Vol. 53 Issue: 10 p1434-1442, 9p

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156 Nitrogen-Doped Multi-Walled Carbon Nanotubes show Attenuated Pathogenicity in a Mouse Model of Pleural Exposure

Authors: Zacarias-Cabeza, Joaquin, Chernova, Tatyana, Craxton, Andrew, Sun, Xiao-Ming, Galavotti, Sara, Beier, Sina, Self, Emily L, Greaves, Peter, Poland, Craig A, Tsuruoka, Shuji, Porter, Dale W, Willis, Anne E, MacFarlane, Marion

Source: The Annals of Occupational Hygiene; May 2023, Vol. 67 Issue: 1, Number 1 Supplement 1 pi76-i77, 2p

A novel genetic marker of fluoropyrimidine-induced cardiovascular toxicity.

Authors: Palles, Claire, Lucas, Marie, Watts, Katie, Galavotti, Sara, Chin, Ik Shin, Campbell, Cameron, Briggs, Sarah E W, Jaeger, Emma, Church, David, Taylor, Karen, Bliss, Judith, Fisher, David, Madi, Ayman, Cameron, David A., Maughan, Timothy S., Tomlinson, Ian, Iveson, Timothy, Kerr, David James, Kerr, Rachel, Cheadle, Jeremy

Source: Journal of Clinical Oncology; 2023 Supplement 16, Vol. 41, p3028-3028, 1p

96 Longitudinal Profiling of Carbon Nanotube-Induced Sporadic Mesothelioma Development: Defining the Adverse Outcome Pathway for Disease Progression

Authors: Cabeza, Joaquin Zacarias, Chernova, Tatyana, Sun, Xiao-Ming, Craxton, Andrew, Galavotti, Sara, Cauchy, Pierre, Beier, Sina, Spriggs, Ruth, Murphy, Fiona A, Greaves, Peter, Poland, Craig A, Willis, Anne E, MacFarlane, Marion

Source: The Annals of Occupational Hygiene; May 2023, Vol. 67 Issue: 1, Number 1 Supplement 1 pi61-i61, 1p

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Inhibition of Autophagy in Combination with Ponatinib or Dual PI3K/mTOR Inhibition to Improve Treatment Response for Both Bcr-Abl Dependent and Independent Mechanisms of TKI-Resistance in CML

Authors: Helgason, G.Vignir ^*, Allan, Elaine K ^*, Mariani, Samanta ^*, Mukhopadhyay, Arunima ^*, Karvela, Maria ^*, Galavotti, Sara ^*, Audia, Alessandra ^*, Hamilton, Ashley ^*, Nicolini, Franck E., Druker, Brian J., Salomoni, Paolo ^*, Calabretta, Bruno ^*, Holyoake, Tessa L.

Source: In Blood 16 November 2012 120(21):1664-1664

Targeting Autophagy Potentiates Imatinib-Induced Cell Death in Philadelphia Positive Cells Including Primary CML Stem Cells.

Authors: Bellodi, Cristian ^*, Lidonnici, Maria Rosa ^*, Hamilton, Ashley ^*, Helgason, Gudmundur V ^*, Soliera, Angela R ^*, Ronchetti, Mattia ^*, Galavotti, Sara ^*, Young, Kenneth W ^*, Selmi, Tommaso ^*, Van Etten, Richard A. ^*, Donato, Nicholas, Hunter, Ann ^*, Dinsdale, David ^*, Tirro', Elena ^*, Vigneri, Paolo ^*, Nicotera, Pierluigi ^*, Dyer, Martin J.S., Holyoake, Tessa, Calabretta, Bruno ^*, Salomoni, Paolo ^*

Source: In Blood 16 November 2008 112(11):1070-1070

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