Randomized phase 2 study to assess the role of single-agent nivolumab to maintain remission in acute myeloid leukemia

Authors: Pyzer, Athalia R. ¹, Dillon, Laura W. ², Sharon, Elad ³, Karrison, Theodore G. ⁴, Zha, Yuanyuan ¹, Fulton, Noreen ¹, Gui, Gege ^{2, 5}, Andrew, Georgia ², Streicher, Howard ³, Sweet, Kendra ⁶, Yaghmour, George ⁷, Liu, Jane Jijun ⁸, Jonas, Brian A. ⁹, Schimmer, Aaron D. ¹⁰, Grant, Steven ¹¹, Zeidan, Amer M. ¹², Hildebrandt, Gerhard C. ¹³, Lowrey, Christopher H. ¹⁴, Mattison, Ryan J. ¹⁵, Palmisiano, Neil ¹⁶, Salhotra, Amandeep ¹⁷, Tzachanis, Dimitrios ¹⁸, Baer, Maria R. ¹⁹, Lin, Tara L. ²⁰, Patel, Prapti ²¹, Chen, Helen ³, Stadler, Walter M. ¹, Odenike, Olatoyosi ¹, Larson, Richard A. ¹, Gajewski, Thomas F. ²², Hourigan, Christopher S. ^{2, 5}, Stock, Wendy ¹, Liu, Hongtao ^{1, 23, ∗}

Source: In Blood Advances December 2024

Targeting molecular pathways to control immune checkpoint inhibitor toxicities

Authors: Reschke, Robin ^{1, 2}, Sullivan, Ryan J. ³, Lipson, Evan J. ^{4, 5}, Enk, Alexander H. ¹, Gajewski, Thomas F. ^{6, 7, ⁎}, Hassel, Jessica C. ^{1, 2, ⁎}

Source: In Trends in Immunology January 2025 46(1):61-73

Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeutic efficacy

Authors: van Elsas, Marit J., Middelburg, Jim, Labrie, Camilla, Roelands, Jessica, Schaap, Gaby, Sluijter, Marjolein, Tonea, Ruxandra, Ovcinnikovs, Vitalijs, Lloyd, Katy, Schuurman, Janine, Riesenfeld, Samantha J., Gajewski, Thomas F., de Miranda, Noel F.C.C., van Hall, Thorbald, van der Burg, Sjoerd H.

Source: In Cancer Cell 10 June 2024 42(6):1032-1050

Batf3+ DCs and the 4-1BB/4-1BBL axis are required at the effector phase in the tumor microenvironment for PD-1/PD-L1 blockade efficacy

Authors: Ziblat, Andrea, Horton, Brendan L., Higgs, Emily F., Hatogai, Ken, Martinez, Anna, Shapiro, Jason W., Kim, Danny E.C., Zha, YuanYuan, Sweis, Randy F., Gajewski, Thomas F.

Source: In Cell Reports 28 May 2024 43(5)

Insights from a Rapidly Implemented COVID-19 Biobank Using Electronic Consent and Informatics Tools

Authors: Higgs, Emily F., Flood, Blake A., Pyzer, Athalia R., Rouhani, Sherin J., Trujillo, Jonathan A., Gajewski, Thomas F.

Source: Biopreservation and biobanking. 21(2):166-175

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100179769631.0x000001&indx=1&recIds=ETOCvdc_100179769631.0x000001

Germline immunomodulatory expression quantitative trait loci (ieQTLs) associated with immune-related toxicity from checkpoint inhibition

Authors: Ferguson, Robert, Chat, Vylyny, Morales, Leah, Simpson, Danny, Monson, Kelsey R., Cohen, Elisheva, Zusin, Sarah, Madonna, Gabriele, Capone, Mariaelena, Simeone, Ester, Pavlick, Anna, Luke, Jason J., Gajewski, Thomas F., Osman, Iman, Ascierto, Paolo, Weber, Jeffrey, Kirchhoff, Tomas

Source: In European Journal of Cancer August 2023 189

Lymphatic coagulation and neutrophil extracellular traps in lung-draining lymph nodes of COVID-19 decedents

Authors: MacDonald, Margo E., Weathered, Rachel K., Stewart, Emma C., Magold, Alexandra I., Mukherjee, Anish, Gurbuxani, Sandeep, Smith, Heather, McMullen, Phillip, Mueller, Jeffrey, Husain, Aliya N., Salles, Calixto M., Briquez, Priscilla S., Rouhani, Sherin J., Yu, Jovian, Trujillo, Jonathan, Pyzer, Athalia R., Gajewski, Thomas F., Sperling, Anne I., Kilarski, Witold W., Swartz, Melody A.

Source: In Blood Advances 27 December 2022 6(24):6249-6262

Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours

Authors: Melero, Ignacio, de Miguel Luken, Maria, de Velasco, Guillermo, Garralda, Elena, Martín-Liberal, Juan, Joerger, Markus, Alonso, Guzman, Goebeler, Maria-Elisabeth, Schuler, Martin, König, David, Dummer, Reinhard, Reig, Maria, Rodriguez Ruiz, Maria-Esperanza, Calvo, Emiliano, Esteban-Villarrubia, Jorge, Oberoi, Arjun, Sabat, Paula, Soto-Castillo, Juan José, Koster, Kira-Lee, Saavedra, Omar, Sayehli, Cyrus, Gromke, Tanja, Läubli, Heinz, Ramelyte, Egle, Fortuny, Marta, Landa-Magdalena, Ana, Moreno, Irene, Torres-Jiménez, Javier, Hernando-Calvo, Alberto, Hess, Dagmar, Racca, Fabricio, Richly, Heike, Schmitt, Andreas M., Eggenschwiler, Corinne, Sanduzzi-Zamparelli, Marco, Vilalta-Lacarra, Anna, Trojan, Jörg, Koch, Christine, Galle, Peter R., Foerster, Friedrich, Trajanoski, Zlatko, Hackl, Hubert, Gogolla, Falk, Koll, Florestan J., Wild, Peter, Chun, Felix Kyoung Hwan, Reis, Henning, Lloyd, Peter, Machacek, Matthias, Gajewski, Thomas F., Fridman, Wolf H., Eggermont, Alexander M. M., Bargou, Ralf, Schöniger, Sandra, Rüschoff, Josef, Tereshchenko, Anastasiia, Zink, Carina, da Silva, Antonio, Lichtenegger, Felix S., Akdemir, Julia, Rüdiger, Manfred, L’Huillier, Phil, Dutta, Aradhana, Haake, Markus, Auckenthaler, Alexandra, Gjorgjioska, Ana, Rössler, Bernhard, Hermann, Frank, Liebig, Mara, Reichhardt, Daniela, Schuberth-Wagner, Christine, Wischhusen, Jörg, Fettes, Petra, Auer, Marlene, Klar, Kathrin, Leo, Eugen

Source: Nature; January 2025, Vol. 637 Issue: 8048 p1218-1227, 10p

Cancer and the Microbiome—Influence of the Commensal Microbiota on Cancer, Immune Responses, and Immunotherapy

Authors: Matson, Vyara, Chervin, Carolina Soto, Gajewski, Thomas F.

Source: In Gastroenterology January 2021 160(2):600-613

COVIDOSE: A Phase II Clinical Trial of Low‐Dose Tocilizumab in the Treatment of Noncritical COVID‐19 Pneumonia

Authors: Strohbehn, Garth W., Heiss, Brian L., Rouhani, Sherin J., Trujillo, Jonathan A., Yu, Jovian, Kacew, Alec J., Higgs, Emily F., Bloodworth, Jeffrey C., Cabanov, Alexandra, Wright, Rachel C., Koziol, Adriana K., Weiss, Alexandra, Danahey, Keith, Karrison, Theodore G., Edens, Cuoghi C., Bauer Ventura, Iazsmin, Pettit, Natasha N., Patel, Bhakti K., Pisano, Jennifer, Strek, Mary E., Gajewski, Thomas F., Ratain, Mark J., Reid, Pankti D.

Source: Clinical pharmacology & therapeutics. 109(3):688-696

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115864700.0x000001&indx=1&recIds=ETOCvdc_100115864700.0x000001

Novel response to neoadjuvant anti-PD1 therapy for a patient with retrocaval melanotic schwannoma

Authors: Vining, Charles C., Hsu, Phillip J., Miller, Aaron, Olson, Daniel J., Gajewski, Thomas F., Pytel, Peter, Bauer, Bruce S., Millis, Michael J., Roggin, Kevin K.

Source: Melanoma research. 31(1):92-97

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184608675.0x000001&indx=1&recIds=ETOCvdc_100184608675.0x000001

Dietary modulation of the gut microbiome as an immunoregulatory intervention

Authors: Matson, Vyara, Gajewski, Thomas F.

Source: Cancer cell. 40(3):246-248

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100157519622.0x000001&indx=1&recIds=ETOCvdc_100157519622.0x000001

ACCELERATE and European Medicines Agency Paediatric Strategy Forum for medicinal product development of checkpoint inhibitors for use in combination therapy in paediatric patients

Authors: Pearson, Andrew D.J., Rossig, Claudia, Lesa, Giovanni, Diede, Scott J., Weiner, Susan, Anderson, John, Gray, Juliet, Geoerger, Birgit, Minard-Colin, Veronique, Marshall, Lynley V., Smith, Malcolm, Sondel, Paul, Bajars, Marcis, Baldazzi, Claudia, Barry, Elly, Blackman, Sam, Blanc, Patricia, Capdeville, Renaud, Caron, Hubert, Cole, Peter D., Jiménez, Jorge Camarero, Demolis, Pierre, Donoghue, Martha, Elgadi, Mabrouck, Gajewski, Thomas, Galluzzo, Sara, Ilaria, Robert, Jr., Jenkner, Alessandro, Karres, Dominik, Kieran, Mark, Ligas, Franca, Lowy, Israel, Meyers, Michael, Oprea, Corina, Peddareddigari, Vijay G.R., Sterba, Jaroslav, Stockman, Paul K., Suenaert, Peter, Tabori, Uri, van Tilburg, Cornelis, Yancey, Todd, Weigel, Brenda, Norga, Koenraad, Reaman, Gregory, Vassal, Gilles

Source: In European Journal of Cancer March 2020 127:52-66

Epacadostat plus pembrolizumab versus placebo plus pembrolizumab in patients with unresectable or metastatic melanoma (ECHO-301/KEYNOTE-252): a phase 3, randomised, double-blind study

Authors: Long, Georgina V, Dummer, Reinhard, Hamid, Omid, Gajewski, Thomas F, Caglevic, Christian, Dalle, Stephane, Arance, Ana, Carlino, Matteo S, Grob, Jean-Jacques, Kim, Tae Min, Demidov, Lev, Robert, Caroline, Larkin, James, Anderson, James R, Maleski, Janet, Jones, Mark, Diede, Scott J, Mitchell, Tara C

Source: In The Lancet Oncology August 2019 20(8):1083-1097

Distinct Graft-Specific TCR Avidity Profiles during Acute Rejection and Tolerance

Authors: Miller, Michelle L., McIntosh, Christine M., Williams, Jason B., Wang, Ying, Hollinger, Maile K., Isaad, Noel J., Moon, James J., Gajewski, Thomas F., Chong, Anita S., Alegre, Maria-Luisa

Source: In Cell Reports 21 August 2018 24(8):2112-2126

STING pathway agonism as a cancer therapeutic

Authors: Flood, Blake A., Higgs, Emily F., Li, Shuyin, Luke, Jason J., Gajewski, Thomas F.

Source: Immunological reviews. 290(1):24-38

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100087285088.0x000001&indx=1&recIds=ETOCvdc_100087285088.0x000001

Phase 1/2 study of epacadostat in combination with ipilimumab in patients with unresectable or metastatic melanoma

Authors: Gibney, Geoffrey, Hamid, Omid, Lutzky, Jose, Olszanski, Anthony, Mitchell, Tara, Gajewski, Thomas, Chmielowski, Bartosz, Hanks, Brent, Zhao, Yufan, Newton, Robert, Maleski, Janet, Leopold, Lance, Weber, Jeffrey

Source: Journal for immunotherapy of cancer. 7(1):1-13

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190703701.0x000001&indx=1&recIds=ETOCvdc_100190703701.0x000001

Exploring the emerging role of the microbiome in cancer immunotherapy

Authors: Fessler, Jessica, Matson, Vyara, Gajewski, Thomas

Source: Journal for immunotherapy of cancer. 7(1):1-15

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190704456.0x000001&indx=1&recIds=ETOCvdc_100190704456.0x000001

Perspectives in melanoma: meeting report from the Melanoma Bridge (November 29th–1 December 1st, 2018, Naples, Italy)

Authors: Ascierto, Paolo, Agarwala, Sanjiv, Botti, Gerardo, Budillon, Alfredo, Davies, Michael, Dummer, Reinhard, Ernstoff, Marc, Ferrone, Soldano, Formenti, Silvia, Gajewski, Thomas, Garbe, Claus, Hamid, Omid, Lo, Roger, Luke, Jason, Michielin, Oliver, Palmieri, Giuseppe, Zitvogel, Laurence, Marincola, Francesco, Masucci, Giuseppe, Caracò, Corrado, Thurin, Magdalena, Puzanov, Igor

Source: Journal of translational medicine. 17(1):1-18

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100189312975.0x000001&indx=1&recIds=ETOCvdc_100189312975.0x000001

The microbiome in cancer immunotherapy : Diagnostic tools and therapeutic strategies

Authors: Zitvogel, Laurence, Ma, Yuting, Raoult, Didier, Kroemer, Guido, Gajewski, Thomas F.

Source: Science, 2018 Mar . 359(6382), 1366-1372.

Access URL: https://www.jstor.org/stable/26409773