MK-8776 and Olaparib Combination Acts Synergistically in Hepatocellular Carcinoma Cells, Demonstrating Lack of Adverse Effects on Liver Tissues in Ovarian Cancer PDX Model.

Authors: Bębenek, Wiktoria^1,2 (AUTHOR) wiktoria.bebenek@edu.uni.lodz.pl, Gajek, Arkadiusz¹ (AUTHOR) arkadiusz.gajek@biol.uni.lodz.pl, Marczak, Agnieszka¹ (AUTHOR) agnieszka.marczak@biol.uni.lodz.pl, Malý, Jan³ (AUTHOR) jan.maly@ujep.cz, Smejkal, Jiří³ (AUTHOR) jiri.smejkal@ujep.cz, Statkiewicz, Małgorzata⁴ (AUTHOR) malgorzata.statkiewicz@pib-nio.pl, Rusetska, Natalia⁵ (AUTHOR) natalia.rusetska@pib-nio.pl, Bryś, Magdalena⁶ (AUTHOR) magdalena.brys@biol.uni.lodz.pl, Rogalska, Aneta¹ (AUTHOR) aneta.rogalska@biol.uni.lodz.pl

Source: International Journal of Molecular Sciences. Jan2025, Vol. 26 Issue 2, p834. 21p.

Subject Terms: *CHECKPOINT kinase 1, *LIVER cancer, *HEPATOCELLULAR carcinoma, *THERAPEUTICS, *OVARIAN cancer

Molecular mechanisms restoring olaparib efficacy through ATR/CHK1 pathway inhibition in olaparib-resistant BRCA1/2MUT ovarian cancer models

Authors: Biegała, Łukasz, Statkiewicz, Małgorzata, Gajek, Arkadiusz, Szymczak-Pajor, Izabela, Rusetska, Natalia, Śliwińska, Agnieszka, Marczak, Agnieszka, Mikula, Michał, Rogalska, Aneta

Source: In BBA - Molecular Basis of Disease February 2025 1871(2)

Black etched electroless Ni–P coatings for enhanced efficiency towards alkaline water splitting

Authors: Flis-Kabulska, Iwona, Gajek, Arkadiusz

Source: In Materials Chemistry and Physics 1 December 2024 328

NaZnF3 as a low-pressure analogue of MgSiO3

Authors: Kurzydłowski, Dominik, Gajek, Arkadiusz, Mazej, Zoran

Subject Terms: Condensed Matter - Materials Science

Access URL: http://arxiv.org/abs/2111.02270

Targeted Nanocarrier-Based Drug Delivery Strategies for Improving the Therapeutic Efficacy of PARP Inhibitors against Ovarian Cancer.

Authors: Gralewska, Patrycja¹ (AUTHOR) patrycja.gralewska@biol.uni.lodz.pl, Gajek, Arkadiusz¹ (AUTHOR), Marczak, Agnieszka¹ (AUTHOR), Rogalska, Aneta¹ (AUTHOR) aneta.rogalska@biol.uni.lodz.pl

Source: International Journal of Molecular Sciences. Aug2024, Vol. 25 Issue 15, p8304. 29p.

Subject Terms: *CELL receptors, *CELL adhesion molecules, *VASCULAR endothelial growth factors, *EPIDERMAL growth factor, *DRUG delivery systems, *POLY ADP ribose

Olaparib Combined with DDR Inhibitors Effectively Prevents EMT and Affects miRNA Regulation in TP53 -Mutated Epithelial Ovarian Cancer Cell Lines.

Authors: Gralewska, Patrycja, Biegała, Łukasz, Gajek, Arkadiusz, Szymczak-Pajor, Izabela, Marczak, Agnieszka, Śliwińska, Agnieszka, Rogalska, Aneta

Source: International Journal of Molecular Sciences; Jan2025, Vol. 26 Issue 2, p693, 17p

Subject Terms: GENE expression, OVARIAN epithelial cancer, RNA regulation, GYNECOLOGIC cancer, CELL cycle

Geographic Terms: GERMANY (East)

PARP inhibitor resistance in ovarian cancer: Underlying mechanisms and therapeutic approaches targeting the ATR/CHK1 pathway

Authors: Biegała, Łukasz, Gajek, Arkadiusz, Marczak, Agnieszka, Rogalska, Aneta

Source: In BBA - Reviews on Cancer December 2021 1876(2)

Understanding the Enhancement of Electrocatalytic Activity toward Hydrogen Evolution in Alkaline Water Splitting by Anodically Formed Oxides on Ni and C‐containing Ni

Authors: Flis‐Kabulska, Iwona, Gajek, Arkadiusz, Flis, Janusz

Source: ChemElectroChem. 8(17):3371-3378

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100131418621.0x000001&indx=1&recIds=ETOCvdc_100131418621.0x000001

Olaparib-Resistant BRCA2 MUT Ovarian Cancer Cells with Restored BRCA2 Abrogate Olaparib-Induced DNA Damage and G2/M Arrest Controlled by the ATR/CHK1 Pathway for Survival.

Authors: Biegała, Łukasz¹ (AUTHOR), Gajek, Arkadiusz¹ (AUTHOR), Marczak, Agnieszka¹ (AUTHOR), Rogalska, Aneta¹ (AUTHOR) aneta.rogalska@biol.uni.lodz.pl

Source: Cells (2073-4409). Apr2023, Vol. 12 Issue 7, p1038. 38p.

Subject Terms: *OVARIAN cancer, *BRCA genes, *DNA damage, *DOUBLE-strand DNA breaks, *CANCER cells, *DNA mismatch repair, *DNA repair

Application of new lysine-based peptide dendrimers D3K2 and D3G2 for gene delivery: Specific cytotoxicity to cancer cells and transfection in vitro

Authors: Gorzkiewicz, Michal, Konopka, Malgorzata, Janaszewska, Anna, Tarasenko, Irina I., Sheveleva, Nadezhda N., Gajek, Arkadiusz, Neelov, Igor M., Klajnert-Maculewicz, Barbara

Source: In Bioorganic Chemistry January 2020 95

Suppression of autophagy enhances preferential toxicity of epothilone A and epothilone B in ovarian cancer cells

Authors: Rogalska, Aneta, Gajek, Arkadiusz, Marczak, Agnieszka

Source: In Phytomedicine August 2019 61

Aclarubicin in subtoxic doses reduces doxorubicin cytotoxicity in human non-small cell lung adenocarcinoma (A549) and human hepatocellular carcinoma (HepG2) cells by decreasing DNA damage

Authors: Gajek, Arkadiusz, Rogalska, Aneta, Koceva-Chyła, Aneta

Source: In Toxicology in Vitro March 2019 55:140-150

Molecular mechanism of action of oxazolinoanthracyclines in cells derived from human solid tumors. Part 2

Authors: Denel-Bobrowska, Marta, Łukawska, Małgorzata, Bukowska, Barbara, Gajek, Arkadiusz, Oszczapowicz, Irena, Marczak, Agnieszka

Source: In Toxicology in Vitro February 2018 46:323-334

The Influence of PARP, ATR, CHK1 Inhibitors on Premature Mitotic Entry and Genomic Instability in High-Grade Serous BRCA MUT and BRCA WT Ovarian Cancer Cells.

Authors: Gralewska, Patrycja¹ (AUTHOR) patrycja.gralewska@edu.uni.lodz.pl, Gajek, Arkadiusz¹ (AUTHOR) arkadiusz.gajek@biol.uni.lodz.pl, Rybaczek, Dorota² (AUTHOR) dorota.rybaczek@biol.uni.lodz.pl, Marczak, Agnieszka¹ (AUTHOR) agnieszka.marczak@biol.uni.lodz.pl, Rogalska, Aneta¹ (AUTHOR) aneta.rogalska@biol.uni.lodz.pl

Source: Cells (2073-4409). Jun2022, Vol. 11 Issue 12, p1889-N.PAG. 24p.

Subject Terms: *POLY ADP ribose, *CHECKPOINT kinase 1, *ADP-ribosylation, *BRCA genes, *OVARIAN cancer, *POLY(ADP-ribose) polymerase, *CANCER cells

Uncovering miRNA–mRNA Regulatory Networks Related to Olaparib Resistance and Resensitization of BRCA2 MUT Ovarian Cancer PEO1-OR Cells with the ATR/CHK1 Pathway Inhibitors.

Authors: Biegała, Łukasz, Kołat, Damian, Gajek, Arkadiusz, Płuciennik, Elżbieta, Marczak, Agnieszka, Śliwińska, Agnieszka, Mikula, Michał, Rogalska, Aneta

Source: Cells (2073-4409); May2024, Vol. 13 Issue 10, p867, 31p

Subject Terms: POLY ADP ribose, OLAPARIB, OVARIAN cancer, CELL cycle regulation, GENE expression, BRCA genes

Aggregation/Crystallization-Induced Emission in Naphthyridine-Based Carbazolyl-Modified Donor-Acceptor Boron Dyes Tunable by Fluorine Atoms.

Authors: Potopnyk, Mykhaylo A.^1,2, mykhaylo.potopnyk@icho.edu.plpotopnyk@gmail.com, Mech‐Piskorz, Justyna³, Angulo, Gonzalo³, gangulo@ichf.edu.pl, Ceborska, Magdalena⁴, Luboradzki, Roman³, Andresen, Elina⁵, Gajek, Arkadiusz³, Wisniewska, Agnieszka³, Resch‐Genger, Ute⁵, ute.resch@bam.de

Source: Chemistry - A European Journal; 4/16/2024, Vol. 30 Issue 22, p1-11, 11p

Epothilone B induces extrinsic pathway of apoptosis in human SKOV-3 ovarian cancer cells

Authors: Rogalska, Aneta, Gajek, Arkadiusz, Marczak, Agnieszka

Source: In Toxicology in Vitro June 2014 28(4):675-683

Participation of the ATR/CHK1 pathway in replicative stress targeted therapy of high-grade ovarian cancer.

Authors: Gralewska, Patrycja¹ (AUTHOR), Gajek, Arkadiusz¹ (AUTHOR), Marczak, Agnieszka¹ (AUTHOR), Rogalska, Aneta¹ (AUTHOR) aneta.rogalska@biol.uni.lodz.pl

Source: Journal of Hematology & Oncology. 4/21/2020, Vol. 13 Issue 1, p1-16. 16p.

Subject Terms: *OVARIAN cancer, *OVARIAN epithelial cancer, *CISPLATIN, *GYNECOLOGIC cancer, *POLY ADP ribose, *DNA repair, *GENETIC mutation, *CANCER relapse, *ATAXIA telangiectasia

Pro-apoptotic activity of new analog of anthracyclines – WP 631 in advanced ovarian cancer cell line

Authors: Gajek, Arkadiusz, Denel, Marta, Bukowska, Barbara, Rogalska, Aneta, Marczak, Agnieszka

Source: In Toxicology in Vitro March 2014 28(2):273-281

Interaction of cationic carbosilane dendrimers and their complexes with siRNA with erythrocytes and red blood cell ghosts

Authors: Wrobel, Dominika, Kolanowska, Katarzyna, Gajek, Arkadiusz, Gomez-Ramirez, Rafael, de la Mata, Javier, Pedziwiatr-Werbicka, Elżbieta, Klajnert, Barbara, Waczulikova, Iveta, Bryszewska, Maria

Source: In BBA - Biomembranes March 2014 1838(3):882-889