Desmoplastic Small Round Cell Tumors: Clinical Presentation, Molecular Characterization, and Therapeutic Approach of Seven Patients.

Authors: Gaidzik, Verena I.^1,2 (AUTHOR), Mayer-Steinacker, Regine¹ (AUTHOR), Wittau, Mathias³ (AUTHOR), Schultheiß, Markus⁴ (AUTHOR), v. Baer, Alexandra⁴ (AUTHOR), Oehl-Huber, Kathrin⁵ (AUTHOR), Dahlum, Sonja⁵ (AUTHOR), Fischer, Anja⁵ (AUTHOR), Gerstenmaier, Uwe⁶ (AUTHOR), Seufferlein, Thomas^2,7 (AUTHOR), Buck, Andreas⁸ (AUTHOR), Beer, Ambros⁹ (AUTHOR), Thaiss, Wolfgang⁹ (AUTHOR), Möller, Peter⁶ (AUTHOR), Döhner, Hartmut¹ (AUTHOR), Siebert, Reiner⁵ (AUTHOR), Marienfeld, Ralf⁶ (AUTHOR), Barth, Thomas F. E.⁶ (AUTHOR) thomas.barth@uniklinik-ulm.de, Chen, Tom (AUTHOR)

Source: Sarcoma. 10/8/2024, Vol. 2024, p1-8. 8p.

Subject Terms: *THERAPEUTIC use of antineoplastic agents, *SARCOMA, *GENOMICS, *RARE diseases, *SYMPTOMS, *DESCRIPTIVE statistics, *CELL cycle, *DECISION making in clinical medicine, *IMMUNOHISTOCHEMISTRY, *GENE expression, *CANCER chemotherapy, *FLUORESCENCE in situ hybridization, *MICROARRAY technology, *MOLECULAR biology, *CASE studies, *STAINS & staining (Microscopy), *SEQUENCE analysis, *DISEASE progression

Measurable residual disease monitoring in AML with FLT3-ITD treated with intensive chemotherapy plus midostaurin

Authors: Rücker, Frank G. ¹, Bullinger, Lars ², Cocciardi, Sibylle ¹, Skambraks, Sabrina ¹, Luck, Tamara J. ^{1, 2}, Weber, Daniela ¹, Krzykalla, Julia ³, Pozek, Ema ³, Schneider, Isabelle ¹, Corbacioglu, Andrea ¹, Gaidzik, Verena I. ¹, Meid, Annika ¹, Aicher, Sophia ¹, Stegelmann, Frank ¹, Schrade, Anika ¹, Theis, Frauke ¹, Fiedler, Walter ⁴, Salih, Helmut R. ⁵, Wulf, Gerald ⁶, Salwender, Hans ⁷, Schroeder, Thomas ⁸, Götze, Katharina S. ⁹, Kühn, Michael W. M. ¹⁰, Lübbert, Michael ¹¹, Schlenk, Richard F. ^{12, 13}, Benner, Axel ³, Thol, Felicitas ¹⁴, Heuser, Michael ¹⁴, Ganser, Arnold ¹⁴, Döhner, Hartmut ¹, Döhner, Konstanze ^{1, ∗}

Source: In Blood Advances 10 December 2024 8(23):6067-6080

Intensive chemotherapy with or without gemtuzumab ozogamicin in patients with NPM1-mutated acute myeloid leukaemia (AMLSG 09–09): a randomised, open-label, multicentre, phase 3 trial

Authors: Döhner, Hartmut, Weber, Daniela, Krzykalla, Julia, Fiedler, Walter, Kühn, Michael W.M., Schroeder, Thomas, Mayer, Karin, Lübbert, Michael, Wattad, Mohammad, Götze, Katharina, Fransecky, Lars, Koller, Elisabeth, Wulf, Gerald, Schleicher, Jan, Ringhoffer, Mark, Greil, Richard, Hertenstein, Bernd, Krauter, Jürgen, Martens, Uwe M., Nachbaur, David, Samra, Maisun Abu, Machherndl-Spandl, Sigrid, Basara, Nadezda, Leis, Claudia, Schrade, Anika, Kapp-Schwoerer, Silke, Cocciardi, Sibylle, Bullinger, Lars, Thol, Felicitas, Heuser, Michael, Paschka, Peter, Gaidzik, Verena I., Saadati, Maral, Benner, Axel, Schlenk, Richard F., Döhner, Konstanze, Ganser, Arnold, Kühn, Michael W M, Wattad, Mohammed, Martens, Uwe M, Gaidzik, Verena I, Schlenk, Richard F

Source: In The Lancet Haematology July 2023 10(7):e495-e509

Midostaurin plus intensive chemotherapy for younger and older patients with AML and FLT3 internal tandem duplications

Authors: Döhner, Hartmut ^*, Weber, Daniela, Krzykalla, Julia, Fiedler, Walter, Wulf, Gerald, Salih, Helmut, Lübbert, Michael, Kühn, Michael W.M., Schroeder, Thomas, Salwender, Hans, Götze, Katharina, Westermann, Jörg, Fransecky, Lars, Mayer, Karin, Hertenstein, Bernd, Ringhoffer, Mark, Tischler, Hans-Joachim, Machherndl-Spandl, Sigrid, Schrade, Anika, Paschka, Peter, Gaidzik, Verena I., Theis, Frauke, Thol, Felicitas, Heuser, Michael, Schlenk, Richard F., Bullinger, Lars, Saadati, Maral, Benner, Axel, Larson, Richard, Stone, Richard, Döhner, Konstanze, Ganser, Arnold

Source: In Blood Advances 27 September 2022 6(18):5345-5355

Trailblazing precision medicine in Europe: A joint view by Genomic Medicine Sweden and the Centers for Personalized Medicine, ZPM, in Germany

Authors: Lindstrand, Anna, Wedell, Anna, Gisselsson, David, Melén, Erik, Helenius, Gisela, Ehrencrona, Hans, Engstrand, Lars, Palmqvist, Lars, Levin, Lars-Åke, Lovmar, Lovisa, Landström, Maréne, Hallbeck, Martin, Wadelius, Mia, Sikora, Per, Beer, Ambros J., Illert, Anna L., Budczies, Jan, Nikolaou, Konstantin, Kohlbacher, Oliver, Horak, Peter, Kuhn, Peter, Schroeder, Christopher, Boerries, Melanie, Lassmann, Silke, Gaidzik, Verena I., Stenzinger, Albrecht ^*, Edsjö, Anders ^**, Ploeger, Carolin, Friedman, Mikaela, Fröhling, Stefan, Wirta, Valtteri, Seufferlein, Thomas, Botling, Johan, Duyster, Justus, Akhras, Michael, Thimme, Robert, Fioretos, Thoas, Bitzer, Michael, Cavelier, Lucia, Schirmacher, Peter, Malek, Nisar, Rosenquist, Richard

Source: In Seminars in Cancer Biology September 2022 84:242-254

Impact of myelodysplasia‐related and additional gene mutations in intensively treated patients with NPM1‐mutated AML.

Authors: Cocciardi, Sibylle, Saadati, Maral, Weiß, Nina, Späth, Daniela, Kapp‐Schwoerer, Silke, Schneider, Isabelle, Meid, Annika, Gaidzik, Verena I., Skambraks, Sabrina, Fiedler, Walter, Kühn, Michael W. M., Germing, Ulrich, Mayer, Karin T., Lübbert, Michael, Papaemmanuil, Elli, Thol, Felicitas, Heuser, Michael, Ganser, Arnold, Bullinger, Lars, Benner, Axel

Source: HemaSphere; Jan2025, Vol. 9 Issue 1, p1-12, 12p

Exploiting somatic oncogenic driver alterations in a patient with Li-Fraumeni syndrome– paving the path towards precision medicine: a case report.

Authors: Seeling, Carolin, Dahlum, Sonja, Marienfeld, Ralf, Jan, Vera, Rack, Brigitte, Gerstenmaier, Uwe, Beer, Ambros J., Mayer-Steinacker, Regine, Thaiss, Wolfgang, Barth, Thomas F. E., Seufferlein, Thomas, Gaisa, Nadine T., Stilgenbauer, Stephan, Janni, Wolfgang, Siebert, Reiner, Döhner, Hartmut, Gaidzik, Verena I.

Source: Journal of Cancer Research & Clinical Oncology; Jan2025, Vol. 151 Issue 1, p1-12, 12p

Clonal evolution of acute myeloid leukemia with FLT3-ITD mutation under treatment with midostaurin

Authors: Schmalbrock, Laura K., Dolnik, Anna, Cocciardi, Sibylle, Sträng, Eric, Theis, Frauke, Jahn, Nikolaus, Panina, Ekaterina, Blätte, Tamara J., Herzig, Julia, Skambraks, Sabrina, Rücker, Frank G., Gaidzik, Verena I., Paschka, Peter, Fiedler, Walter, Salih, Helmut R., Wulf, Gerald, Schroeder, Thomas, Lübbert, Michael, Schlenk, Richard F., Thol, Felicitas, Heuser, Michael, Larson, Richard A., Ganser, Arnold, Stunnenberg, Hendrik G., Minucci, Saverio, Stone, Richard M., Bloomfield, Clara D., Döhner, Hartmut, Döhner, Konstanze ^{*, *}, Bullinger, Lars ^*

Source: In Blood 3 June 2021 137(22):3093-3104

Posttransplantation MRD monitoring in patients with AML by next-generation sequencing using DTA and non-DTA mutations

Authors: Heuser, Michael ^{*, **}, Heida, Bennet ^*, Büttner, Konstantin, Wienecke, Clara Philine, Teich, Katrin, Funke, Carolin, Brandes, Maximilian, Klement, Piroska, Liebich, Alessandro, Wichmann, Martin, Neziri, Blerina, Chaturvedi, Anuhar, Kloos, Arnold, Mintzas, Konstantinos, Gaidzik, Verena I., Paschka, Peter, Bullinger, Lars, Fiedler, Walter, Heim, Albert, Puppe, Wolfram, Krauter, Jürgen, Döhner, Konstanze, Döhner, Hartmut, Ganser, Arnold, Stadler, Michael, Hambach, Lothar, Gabdoulline, Razif, Thol, Felicitas ^*

Source: In Blood Advances 11 May 2021 5(9):2294-2304

Standardized Response Assessment in Patients with Advanced Cholangiocarcinoma Treated with Personalized Therapy.

Authors: Ursprung, Stephan, Thaiss, Wolfgang, Beha, Janina, Möller, Yvonne, Malek, Nisar P., Beer, Meinrad, Gaidzik, Verena I., Seufferlein, Thomas, Beer, Ambros J., Nikolaou, Konstantin, Reinert, Christian Philipp

Source: Journal of Personalized Medicine; Dec2024, Vol. 14 Issue 12, p1143, 15p

Subject Terms: CANCER treatment, CHI-squared test, CHOLANGIOCARCINOMA, CISPLATIN, PHENOTYPES

Impact of gemtuzumab ozogamicin on MRD and relapse risk in patients with NPM1-mutated AML: results from the AMLSG 09-09 trial

Authors: Kapp-Schwoerer, Silke, Weber, Daniela, Corbacioglu, Andrea, Gaidzik, Verena I., Paschka, Peter, Krönke, Jan, Theis, Frauke, Rücker, Frank G., Teleanu, Maria-Veronica, Panina, Ekaterina, Jahn, Nikolaus, Herzig, Julia, Kubanek, Lena, Schrade, Anika, Göhring, Gudrun, Fiedler, Walter, Kindler, Thomas, Schroeder, Thomas, Mayer, Karin T., Lübbert, Michael, Wattad, Mohammed, Götze, Katharina S., Horst, Heinz A., Koller, Elisabeth, Wulf, Gerald, Schleicher, Jan, Bentz, Martin, Krauter, Jürgen, Bullinger, Lars, Krzykalla, Julia, Benner, Axel, Schlenk, Richard F., Thol, Felicitas, Heuser, Michael, Ganser, Arnold, Döhner, Hartmut, Döhner, Konstanze ^*

Source: In Blood 24 December 2020 136(26):3041-3050

Genomic heterogeneity in core-binding factor acute myeloid leukemia and its clinical implication

Authors: Jahn, Nikolaus, Terzer, Tobias, Sträng, Eric, Dolnik, Anna, Cocciardi, Sibylle, Panina, Ekaterina, Corbacioglu, Andrea, Herzig, Julia, Weber, Daniela, Schrade, Anika, Götze, Katharina, Schröder, Thomas, Lübbert, Michael, Wellnitz, Dominique, Koller, Elisabeth, Schlenk, Richard F., Gaidzik, Verena I., Paschka, Peter, Rücker, Frank G., Heuser, Michael, Thol, Felicitas, Ganser, Arnold, Benner, Axel, Döhner, Hartmut, Bullinger, Lars ^*, Döhner, Konstanze ^*

Source: In Blood Advances 22 December 2020 4(24):6342-6352

Conceptual framework for precision cancer medicine in Germany: Consensus statement of the Deutsche Krebshilfe working group ‘Molecular Diagnostics and Therapy’

Authors: Bargou (Würzburg), Ralf, Bläker (Leipzig), Hendrik, Börries (Freiburg), Melanie, Brandts (Frankfurt), Christian, von Bubnoff (Lübeck), Nikolas, Demes (Frankfurt), Melanie, Desuki (Mainz), Alexander, Döhner (Ulm), Hartmut, Duyster (Freiburg), Justus, Gaisa (Aachen), Nadine, Heine (Bonn), Annkristin, Heining (Dresden), Christoph, Horak (Heidelberg), Peter, Jelas (Berlin), Ivan, Jost (München), Philipp J., Jung (München), Andreas, Kirchner (München), Thomas, Klauschen (Berlin), Frederick, Kreutzfeldt (Heidelberg), Simon, Kumbrink (München), Jörg, Kunzmann (Würzburg), Volker, Lassmann (Freiburg), Silke, Metzeler (München), Klaus, Möller (Ulm), Peter, Ortiz-Brüchle (Aachen), Nadina, Paret (Mainz), Claudia, Pelusi (Bonn), Natalie, Peters (Freiburg), Christoph, Pfarr (München), Nicole, Richter (Dresden), Daniela, Riedmann (München), Kristina, Rieke (Berlin), Damian, Ritzel (Mainz), Christoph, Schadendorf (Essen), Dirk, Schildhaus (Essen), Hans-Ulrich, Schorle (Bonn), Hubert, Seufferlein (Ulm), Thomas, Simon (Hamburg), Ronald, Stenzinger (Heidelberg), Albrecht, Tabatabai (Tübingen), Ghazaleh, Velthaus (Hamburg), Janna-Lisa, Werner (Freiburg), Martin, Wild (Frankfurt), Peter J., Wolf (Köln), Jürgen, Westphalen, C. Benedikt, Bokemeyer, Carsten, Büttner, Reinhard, Fröhling, Stefan, Gaidzik, Verena I., Glimm, Hanno, Hacker, Ulrich T., Heinemann, Volker, Illert, Anna L., Keilholz, Ulrich, Kindler, Thomas, Kirschner, Martin, Schilling, Bastian, Siveke, Jens T., Schroeder, Thomas, Tischler, Verena, Wagner, Sebastian, Weichert, Wilko, Zips, Daniel, Loges, Sonja

Source: In European Journal of Cancer August 2020 135:1-7

Measurable residual disease monitoring in acute myeloid leukemia with t(8;21)(q22;q22.1): results from the AML Study Group

Authors: Rücker, Frank G. ^*, Agrawal, Mridul ^*, Corbacioglu, Andrea ^*, Weber, Daniela, Kapp-Schwoerer, Silke, Gaidzik, Verena I., Jahn, Nikolaus, Schroeder, Thomas, Wattad, Mohammed, Lübbert, Michael, Koller, Elisabeth, Kindler, Thomas, Götze, Katharina, Ringhoffer, Mark, Westermann, Jörg, Fiedler, Walter, Horst, Heinz A., Greil, Richard, Schroers, Roland, Mayer, Karin, Heinicke, Thomas, Krauter, Jürgen, Schlenk, Richard F., Thol, Felicitas, Heuser, Michael, Ganser, Arnold, Bullinger, Lars, Paschka, Peter, Döhner, Hartmut, Döhner, Konstanze

Source: In Blood 7 November 2019 134(19):1608-1618

Conceptual framework for precision cancer medicine in Germany: Consensus statement of the Deutsche Krebshilfe working group 'Molecular Diagnostics and Therapy'

Authors: Westphalen, Benedikt C., Bokemeyer, Carsten, Büttner, Reinhard, Fröhling, Stefan, Gaidzik, Verena I., Glimm, Hanno, Hacker, Ulrich T., Heinemann, Volker, Illert, Anna L., Keilholz, Ulrich, Kindler, Thomas, Kirschner, Martin, Schilling, Bastian, Siveke, Jens T., Schroeder, Thomas, Tischler, Verena, Wagner, Sebastian, Weichert, Wilko, Zips, Daniel, Loges, Sonja

Source: European journal of cancer. 135:1-7

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100116301106.0x000001&indx=1&recIds=ETOCvdc_100116301106.0x000001

Refinement of the prognostic impact of somatic CEBPA bZIP domain mutations in acute myeloid leukemia: Results of the AML Study Group (AMLSG).

Authors: Rücker, Frank G., Corbacioglu, Andrea, Krzykalla, Julia, Cocciardi, Sibylle, Lengerke, Claudia, Germing, Ulrich, Wulf, Gerald, Samra, Maisun A., Teichmann, Lino L., Lübbert, Michael, Kühn, Michael W. M., Bentz, Martin, Westermann, Jörg, Bullinger, Lars, Gaidzik, Verena I., Meid, Annika, Aicher, Sophia, Stegelmann, Frank, Weber, Daniela, Schrade, Anika

Source: HemaSphere; Jul2024, Vol. 8 Issue 7, p1-5, 5p

Midostaurin added to chemotherapy and continued single-agent maintenance therapy in acute myeloid leukemia with FLT3-ITD

Authors: Schlenk, Richard F. ^*, Weber, Daniela, Fiedler, Walter, Salih, Helmut R., Wulf, Gerald, Salwender, Hans, Schroeder, Thomas, Kindler, Thomas, Lübbert, Michael, Wolf, Dominik, Westermann, Jörg, Kraemer, Doris, Götze, Katharina S., Horst, Heinz-August, Krauter, Jürgen, Girschikofsky, Michael, Ringhoffer, Mark, Südhoff, Thomas, Held, Gerhard, Derigs, Hans-Günter, Schroers, Roland, Greil, Richard, Grießhammer, Martin, Lange, Elisabeth, Burchardt, Alexander, Martens, Uwe, Hertenstein, Bernd, Marretta, Lore, Heuser, Michael, Thol, Felicitas, Gaidzik, Verena I., Herr, Wolfgang, Krzykalla, Julia, Benner, Axel, Döhner, Konstanze, Ganser, Arnold, Paschka, Peter, Döhner, Hartmut

Source: In Blood 21 February 2019 133(8):840-851

Measurable residual disease monitoring by NGS before allogeneic hematopoietic cell transplantation in AML

Authors: Thol, Felicitas, Gabdoulline, Razif, Liebich, Alessandro, Klement, Piroska, Schiller, Johannes, Kandziora, Christian, Hambach, Lothar, Stadler, Michael, Koenecke, Christian, Flintrop, Madita, Pankratz, Mira, Wichmann, Martin, Neziri, Blerina, Büttner, Konstantin, Heida, Bennet, Klesse, Sabrina, Chaturvedi, Anuhar, Kloos, Arnold, Göhring, Gudrun, Schlegelberger, Brigitte, Gaidzik, Verena I., Bullinger, Lars, Fiedler, Walter, Heim, Albert, Hamwi, Iyas, Eder, Matthias, Krauter, Jürgen, Schlenk, Richard F., Paschka, Peter, Döhner, Konstanze, Döhner, Hartmut, Ganser, Arnold, Heuser, Michael ^**

Source: In Blood 18 October 2018 132(16):1703-1713

The oligodendrocyte lineage transcription factor 2 (OLIG2) is epigenetically regulated in acute myeloid leukemia

Authors: Yalcin, Arzu, Kovarbasic, Marlon, Wehrle, Julius, Claus, Rainer, Becker, Heiko, Abdelkarim, Mahmoud, Gaidzik, Verena I., Schmidts, Andrea, Wäsch, Ralph, Pahl, Heike L., Döhner, Konstanze, Bullinger, Lars, Duyster, Justus, Lübbert, Michael, Hackanson, Björn ^*

Source: In Experimental Hematology November 2017 55:76-85

Cancer-specific changes in DNA methylation reveal aberrant silencing and activation of enhancers in leukemia

Authors: Qu, Ying ^*, Siggens, Lee ^*, Cordeddu, Lina, Gaidzik, Verena I., Karlsson, Kasper, Bullinger, Lars, Döhner, Konstanze, Ekwall, Karl, Lehmann, Sören, Lennartsson, Andreas

Source: In Blood 16 February 2017 129(7):e13-e25