Identification of 8-(2-methyl phenyl)-9H-benzo[f]indeno[2,1-c]quinolin-9-one (C-5635020) as a novel and selective TGFβ RII kinase inhibitor for breast cancer therapy

Authors: Al Shahrani, Mesfer, Abohassan, Mohammad, Alshahrani, Mohammad, Gahtani, Reem M., Rajagopalan, Prasanna ^⁎

Source: In Biochemical and Biophysical Research Communications February 2025 746

Thermal optimization of ivermectin in supercritical carbon dioxide and ethanol to produce nano medicine

Authors: Gahtani, Reem M., Hani, Umme, Fatima, Farhat, Nadeem, Tariq, Osmani, Riyaz Ali

Source: In Case Studies in Thermal Engineering September 2024 61

Combating Parkinson's disease with plant-derived polyphenols: Targeting oxidative stress and neuroinflammation

Authors: Gahtani, Reem M., Shoaib, Shoaib, Hani, Umme, Jayachithra, R., Alomary, Mohammad N., Chauhan, Waseem, Jahan, Roshan, Tufail, Saba, Ansari, Mohammad Azam

Source: In Neurochemistry International September 2024 178

Pregabalin solubility in supercritical green solvent: A comprehensive experimental and theoretical-intelligent assessment

Authors: Gahtani, Reem M. ^{a, ⁎}, Talath, Sirajunisa ^b, Hani, Umme ^c, Rahamathulla, Mohamed ^c, Khalid, Awais ^d

Source: In Journal of Molecular Liquids 15 August 2024 408

Pioneering a paradigm shift in tissue engineering and regeneration with polysaccharides and proteins-based scaffolds: A comprehensive review

Authors: Angolkar, Mohit, Paramshetti, Sharanya, Gahtani, Reem M., Al Shahrani, Mesfer, Hani, Umme, Talath, Sirajunisa, Osmani, Riyaz Ali M., Spandana, Asha, Gangadharappa, Hosahalli Veerbhadrappa, Gundawar, Ravi

Source: In International Journal of Biological Macromolecules April 2024 265 Part 1

Augmented least squares, a powerful chemometric approach for the spectroscopic analysis of the antiretroviral therapy abacavir, lamivudine and dolutegravir in their ternary mixture

Authors: Alqahtani, Ali, Abdelazim, Ahmed H., Alqahtani, Taha, Gahtani, Reem M., Serag, Ahmed

Source: In Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 5 March 2024 308

Nanozymes and carbon-dots based nanoplatforms for cancer imaging, diagnosis and therapeutics: Current trends and challenges

Authors: Ansari, Mohammad Azam, Shoaib, Shoaib, Chauhan, Waseem, Gahtani, Reem M., Hani, Umme, Alomary, Mohammad N., Alasiri, Glowi, Ahmed, Nabeel, Jahan, Roshan, Yusuf, Nabiha, Islam, Najmul

Source: In Environmental Research 15 January 2024 241

Identification of potential inhibitors targeting Ebola virus VP35 protein: a computational strategy.

Authors: Chen, Yan-kun, Gahtani, Reem M., Al Shahrani, Mesfer, Hani, Umme, Alshabrmi, Fahad M., Alam, Sarfaraz, Almohaimeed, Hailah M., Basabrain, Ammar A., Shahab, Muhammad, Xie, Meng-zhou

Source: Journal of Biomolecular Structure & Dynamics; Apr(early)2025, Vol. 43 Issue 6, p2877-2889, 13p

Exploring dihydropyrimidone derivatives as modulators of carbohydrate catabolic enzyme to mitigate diabetes.

Authors: Ali, Syed Parween, Mansoor, Farheen, Albaayit, Shaymaa Fadhel Abbas, Ali, Farman, Dera, Ayed A., Shahbaz, Muhammad, Ullah, Jawad, Almohaimeed, Hailah M., Gahtani, Reem M., Abdulfattah, Ahmed M., Alshabrmi, Fahad M., Alam, Sarfaraz, Ullah, Saeed

Source: Scientific Reports; 12/30/2024, Vol. 14 Issue 1, p1-17, 17p

Subject Terms: BIOACTIVE compounds, CARBOHYDRATE metabolism, MOLECULAR kinetics, METABOLIC disorders, CYTOTOXINS

5-Fluorouracil-Loaded PLGA Nanoparticles: Formulation, Physicochemical Characterisation, and In VitroAnti-Cancer Activity.

Authors: Gahtani, Reem M.¹ (AUTHOR), Alqahtani, Ali² (AUTHOR), Alqahtani, Taha² (AUTHOR), Asiri, Saeed Ahmed³ (AUTHOR), Mohamed, Jamal Moideen Muthu⁴ (AUTHOR), Venkatesa Prabhu, S.⁵ (AUTHOR), Muluneh, Endalew Yaze⁶ (AUTHOR)

Source: Bioinorganic Chemistry & Applications. 4/17/2023, p1-11. 11p.

Subject Terms: *SMALL cell lung cancer, *NANOPARTICLES analysis, *NANOPARTICLES, *ANTINEOPLASTIC agents

Activation of estrogen-related receptor γ by calcium and cadmium.

Authors: Wang, Qiaochu, Huang, Nanxi, Psaltis, John B., Gahtani, Reem M., Yan, Gai, Lu, Dajun, Cahalan, Shannon R., Shi, Xu, Copeland, Robert L., Haddad, Bassem R., Martin, Mary Beth

Source: Frontiers in Endocrinology; 2024, p1-19, 19p

Subject Terms: MOLECULAR dynamics, CELL nuclei, LIGANDS (Chemistry), LIGANDS (Biochemistry), GLUCAGON

C-5401331 identified as a novel T-cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) inhibitor to control acute myeloid leukemia (AML) cell proliferation.

Authors: Al Shahrani, Mesfer, Gahtani, Reem M., Makkawi, Mohammed

Source: Medical Oncology; Mar2024, Vol. 41 Issue 3, p1-9, 9p

Identification by molecular dynamic simulation and in vitro validation of SISB-A1, N-[1-(4-bromophenyl)-3-methyl-1H-pyrazol-5-yl]-2-[(2-oxo-4-phenyl-2H-chromen-7-yl) oxy], as an inhibitor of the Abl^T315I mutant kinase to combat imatinib resistance in chronic myeloid leukemia

Authors: Al Shahrani, Mesfer, Gahtani, Reem M., Abohassan, Mohammad, Alasmari, Sultan, Makkawi, Mohammed

Source: Medical Oncology; Nov2023, Vol. 40 Issue 11, p1-7, 7p

Computational and Preclinical Analysis of 2-(4-Methyl)benzylidene-4,7-dimethyl Indan-1-one (IPX-18): A Novel Arylidene Indanone Small Molecule with Anti-Inflammatory Activity via NF-κB and Nrf2 Signaling.

Authors: Gahtani, Reem M., Shaikh, Ahmad, Kamli, Hossam

Source: Biomedicines; Mar2023, Vol. 11 Issue 3, p716, 14p

Subject Terms: NUCLEAR factor E2 related factor, SMALL molecules, MONONUCLEAR leukocytes, ANTI-inflammatory agents, MOLECULAR docking, FETAL hemoglobin

Design, Physical Characterizations, and Biocompatibility of Cationic Solid Lipid Nanoparticles in HCT-116 and 16-HBE Cells: A Preliminary Study.

Authors: Alamri, Ali, Alqahtani, Ali, Alqahtani, Taha, Al Fatease, Adel, Asiri, Saeed Ahmed, Gahtani, Reem M., Alnasser, Sulaiman Mohammed, Mohamed, Jamal Moideen Muthu, Menaa, Farid

Source: Molecules; Feb2023, Vol. 28 Issue 4, p1711, 12p

Subject Terms: CATIONIC lipids, NONIONIC surfactants, CATIONIC surfactants, SURFACE charges, BIOCOMPATIBILITY, NANOPARTICLES, NANOMEDICINE, PLASMIDS

Therapeutic Efficacy of a Formulation Prepared with Linum usitatissimum L., Plantago ovata Forssk., and Honey on Uncomplicated Pelvic Inflammatory Disease Analyzed with Machine Learning Techniques.

Authors: Qayyum, Sana, Sultana, Arshiya, Heyat, Md Belal Bin, Rahman, Khaleequr, Akhtar, Faijan, Haq, Amin ul, Alkhamis, Batool Abdulelah, Alqahtani, Mohammed Aedh, Gahtani, Reem M.

Source: Pharmaceutics; Feb2023, Vol. 15 Issue 2, p643, 26p

Subject Terms: FLAXSEED, PELVIC inflammatory disease, FLAX, MACHINE learning, TREATMENT effectiveness, HONEY

Pharmacological Validation for the Folklore Use of Ipomoea nil against Asthma: In Vivo and In Vitro Evaluation.

Authors: Alqahtani, Taha, Parveen, Sajida, Alghazwani, Yahia, Alharbi, Hanan M., Gahtani, Reem M., Hussain, Nadia, Rehman, Kashif ur, Hussain, Musaddique

Source: Molecules; Jul2022, Vol. 27 Issue 14, pN.PAG-N.PAG, 17p

Subject Terms: IPOMOEA, FLAVONOIDS, CHLOROGENIC acid, GALLIC acid, ASTHMA, RESPIRATORY agents, CALCIUM antagonists, IMMUNOGLOBULIN E

Antioxidant and Gastroprotective Activity of Suaeda fruticosa Forssk. Ex J.F.Gmel.

Authors: Ayaz, Afsheen, Jamil, QurratUlAin, Hussain, Musaddique, Anjum, Fayyaz, Sarfraz, Adeel, Alqahtani, Taha, Hussain, Nadia, Gahtani, Reem M., Dera, Ayed A., Alharbi, Hanan M., Iqbal, Shahid M.

Source: Molecules; Jul2022, Vol. 27 Issue 14, pN.PAG-N.PAG, 14p

Subject Terms: GASTRIC juice, STOMACH ulcers, STAINS & staining (Microscopy), OXIDANT status, GASTRIC mucosa, ANTIOXIDANTS, FLAVONOIDS

Geographic Terms: ASIA, AFRICA

GC-MS analysis of Taraxacum officinale flowers and investigation of antimicrobial, anti-pellicle & anti-biofilm activities.

Authors: Shumail, Hoor, Hassan, Tahira, Barkatullah, Khalid, Shah, Akhtar, Naveed, Al-Qahtani, Ali, Aldahish, Afaf, Alqahtani, Taha, Alharbi, Hanan M., Gahtani, Reem M.

Source: Main Group Chemistry; 2022, Vol. 21 Issue 3, p747-762, 16p

Subject Terms: COMMON dandelion, GAS chromatography/Mass spectrometry (GC-MS), PHYTOCHEMICALS, CHLOROFORM, METABOLITES, FLOWERS

Computational high-throughput screening and in vitro approaches identify CB-006-3; A novel PI3K-BRAF^V600E dual targeted inhibitor against melanoma.

Authors: TOBEIGEI, FAISAL HASSAN, GAHTANI, REEM M., SHAIKH, AHMAD, ALI, AMER A. L., KAMELI, NADER, KAMLI, HOSSAM, RAJAGOPALAN, PRASANNA

Source: Oncology Research; 2021, Vol. 29 Issue 5, p305-318, 14p

Subject Terms: HIGH throughput screening (Drug development), MOLECULAR dynamics, PHOSPHATIDYLINOSITOL 3-kinases, SMALL molecules, NUCLEAR fragmentation, PHOSPHOINOSITIDES, MICROPHTHALMIA-associated transcription factor