Tumor endothelial cell autophagy is a key vascular‐immune checkpoint in melanoma

Authors: Jelle Verhoeven, Kathryn A Jacobs, Francesca Rizzollo, Francesca Lodi, Yichao Hua, Joanna Poźniak, Adhithya Narayanan Srinivasan, Diede Houbaert, Gautam Shankar, Sanket More, Marco B Schaaf, Nikolina Dubroja Lakic, Maarten Ganne, Jochen Lamote, Johan Van Weyenbergh, Louis Boon, Oliver Bechter, Francesca Bosisio, Yasuo Uchiyama, Mathieu JM Bertrand, Jean Christophe Marine, Diether Lambrechts, Gabriele Bergers, Madhur Agrawal, Patrizia Agostinis

Source: EMBO Molecular Medicine, Vol 15, Iss 12, Pp 1-25 (2023)

Subject Terms: autophagy, cancer, immunotherapy, inflammation, tumor endothelial cells, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/bbcea8700d3946d0a54b3724c68d12c4

An autophagy program that promotes T cell egress from the lymph node controls responses to immune checkpoint blockade

Authors: Diede Houbaert, Apostolos Panagiotis Nikolakopoulos, Kathryn A. Jacobs, Odeta Meçe, Jana Roels, Gautam Shankar, Madhur Agrawal, Sanket More, Maarten Ganne, Kristine Rillaerts, Louis Boon, Magdalena Swoboda, Max Nobis, Larissa Mourao, Francesca Bosisio, Niels Vandamme, Gabriele Bergers, Colinda L.G.J. Scheele, Patrizia Agostinis

Source: Cell Reports, Vol 43, Iss 4, Pp 114020- (2024)

Subject Terms: CP: Immunology, CP: Cancer, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124724003486; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/dca7f3404ac04b61a443f7d540320e6d

The ins and outs of microglial cells in brain health and disease

Authors: Carla Pallarés-Moratalla, Gabriele Bergers

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: microglia, neuroinflammation, depletion, repopulation, re-education, stroke, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1305087/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/18c0129a30a74b188e313f66e3e50432

Lipid droplet degradation by autophagy connects mitochondria metabolism to Prox1-driven expression of lymphatic genes and lymphangiogenesis

Authors: Odeta Meçe, Diede Houbaert, Maria-Livia Sassano, Tania Durré, Hannelore Maes, Marco Schaaf, Sanket More, Maarten Ganne, Melissa García-Caballero, Mila Borri, Jelle Verhoeven, Madhur Agrawal, Kathryn Jacobs, Gabriele Bergers, Silvia Blacher, Bart Ghesquière, Mieke Dewerchin, Johan V. Swinnen, Stefan Vinckier, María S. Soengas, Peter Carmeliet, Agnès Noël, Patrizia Agostinis

Source: Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/6f053768112c4a3e957fc921d9943221

GBM tumors are heterogeneous in their fatty acid metabolism and modulating fatty acid metabolism sensitizes cancer cells derived from recurring GBM tumors to temozolomide

Authors: Sweta Parik, Juan Fernández-García, Francesca Lodi, Karen De Vlaminck, Marleen Derweduwe, Steven De Vleeschouwer, Raf Sciot, Wietse Geens, Linqian Weng, Francesca Maria Bosisio, Gabriele Bergers, Johnny Duerinck, Frederick De Smet, Diether Lambrechts, Jo A. Van Ginderachter, Sarah-Maria Fendt

Source: Frontiers in Oncology, Vol 12 (2022)

Subject Terms: glioblastoma, fatty acid metabolism, lipotoxicity, SCD1, FADS2, tumor heterogeneity, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2022.988872/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/9b367757c6e54473af57787cad0920a8

High Endothelial Venules: A Vascular Perspective on Tertiary Lymphoid Structures in Cancer

Authors: Gerlanda Vella, Sophie Guelfi, Gabriele Bergers

Source: Frontiers in Immunology, Vol 12 (2021)

Subject Terms: high endothelial venules, tertiary lymphoid structures, tumor endothelial cells, tumor immunity, immunotherapy, lymphotoxin beta receptor, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2021.736670/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/75cbcfa3ae744b388deb9f5b028ff3e6

Tumors vs. Chronic Wounds: An Immune Cell's Perspective

Authors: Yichao Hua, Gabriele Bergers

Source: Frontiers in Immunology, Vol 10 (2019)

Subject Terms: myeloid cells, macrophages, neutrophils, endothelial cells, tumor vessels, wound repair, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/article/10.3389/fimmu.2019.02178/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/0b3d7685b9b941c2aa9937742b24a286

Intratumoral Myeloid Cells Regulate Responsiveness and Resistance to Antiangiogenic Therapy

Authors: Lee B. Rivera, David Meyronet, Valérie Hervieu, Mitchell J. Frederick, Emily Bergsland, Gabriele Bergers

Source: Cell Reports, Vol 11, Iss 4, Pp 577-591 (2015)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124715003460; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/ee25e725c48742758930c38e4a3e7556

Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting.

Authors: Kristian Pietras, Jessica Pahler, Gabriele Bergers, Douglas Hanahan

Source: PLoS Medicine, Vol 5, Iss 1, p e19 (2008)

Subject Terms: Medicine

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18232728/?tool=EBI; https://doaj.org/toc/1549-1277; https://doaj.org/toc/1549-1676

Access URL: https://doaj.org/article/9c65748b24e944daa7f342557e9cccfa

Inhibitors of growth factor receptors, signaling pathways and angiogenesis as therapeutic molecular agents.

Authors: Jocelyn Holash, Gavin Thurston, John Rudge, George Yancopoulos, Alex Adjei, Gabriele Bergers, Bronislaw Pytowski, Mark Pegram, Michael Gordon

Source: Cancer & Metastasis Reviews; Jun2006, Vol. 25 Issue 2, p243-252, 10p